Electric Literature of 115144-40-6,Some common heterocyclic compound, 115144-40-6, name is 3,4-Difluoroanisole, molecular formula is C7H6F2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Preparation 3; 1-FLUORO-4-METHOXY-2-METHYLSULFANYL-BENZENE; 1, 2-Difluoro-4-methoxy-benzene (100mg, 0. 69MMOL) and sodium methanethiolate (148mg, 2. 08MMOL) were dissolved in N, N-dimethylformamide (2mL) and the reaction mixture stirred at 60C for 18 hours. Additional sodium METHANETHIOLATE (99mg, 139MMOL) was added and the reaction mixture heated to 100C for 18 hours. The reaction mixture was diluted with water and extracted with ether (x2). The ether extracts were washed with water (x2), dried over magnesium sulphate and concentrated in vacuo. The residue was taken up in pentane: ether 1: 1 mixture (2mL) and filtered through a plug of silica in a pipette, washing through with pentane: ether 1: 1 mixture (5mL). The solution was concentrated in vacuo to yield the title product as a colourless oil, 135mg. HNMR (CDC13, 300MHZ) : A = 2.45 (s, 3H), 3.80 (s, 3H), 6.65 (dd, 1 H), 6.80 (dd, 1 H), 6.95 (t, 1 H) ppm
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3,4-Difluoroanisole, its application will become more common.
Reference:
Patent; PFIZER LIMITED; PFIZER INC.; WO2005/9966; (2005); A1;,
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