Month: October 2022

《A phosphoryl radical-initiated Atherton-Todd-type reaction under open air》 was written by Ou, Yingcong; Huang, Yuanting; He, Zhenlin; Yu, Guodian; Huo, Yanping; Li, Xianwei; Gao, Yang; Chen, Qian. Name: m-Methoxyphenol And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2020. The article conveys some information:

A phosphoryl radical-initiated Atherton-Todd-type reaction using air as the radical initiator and CHCl3 as the halogenating reagent for the phosphorylation of alcs., phenols, and amines has been developed. This novel transformation provides a highly efficient route to important phosphinates, phosphinic amides, and phosphoramidates in up to 99% yield with a broad substrate scope under very mild conditions (48 examples). In the experiment, the researchers used m-Methoxyphenol(cas: 150-19-6Name: m-Methoxyphenol)

m-Methoxyphenol(cas: 150-19-6) may be used as an analytical standard for the determination of the analyte in wine, coffee beans, wood samples, and mainstream smoke by gas chromatography (GC) based techniques.Name: m-Methoxyphenol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Gorgieva, Selestina; Osmic, Azra; Hribernik, Silvo; Bozic, Mojca; Svete, Jurij; Hacker, Viktor; Wolf, Sigrid; Genorio, Bostjan published their research in International Journal of Molecular Sciences in 2021. The article was titled 《Efficient chitosan/nitrogen-doped reduced graphene oxide composite membranes for direct alkaline ethanol fuel cells》.Recommanded Product: N,N-Dimethylformamide Dimethyl Acetal The article contains the following contents:

Herein, we prepared a series of nanocomposite membranes based on chitosan (CS) and three compositionally and structurally different N-doped graphene derivatives Two-dimensional (2D) and quasi 1D N-doped reduced graphene oxides (N-rGO) and nanoribbons (N-rGONRs), as well as 3D porous N-doped graphitic polyenaminone particles (N-pEAO), were synthesized and characterized fully to confirm their graphitic structure, morphol., and nitrogen (pyridinic, pyrrolic, and quaternary or graphitic) group contents. The largest (0.07%) loading of N-doped graphene derivatives impacted the morphol. of the CS membrane significantly, reducing the crystallinity, tensile properties, and the KOH uptake, and increasing (by almost 10-fold) the ethanol permeability. Within direct alk. ethanol test cells, it was found that CS/N rGONRs (0.07%) membrane (Pmax. = 3.7 mWcm-2) outperformed the pristine CS membrane significantly (Pmax. = 2.2 mWcm-2), suggesting the potential of the newly proposed membranes for application in direct ethanol fuel cells. In the part of experimental materials, we found many familiar compounds, such as N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Recommanded Product: N,N-Dimethylformamide Dimethyl Acetal)

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime.Typically the presence of an amine functional group is deduced by a combination of techniques, including mass spectrometry as well as NMR and IR spectroscopies. 1H NMR signals for amines disappear upon treatment of the sample with D2O. In their infrared spectrum primary amines exhibit two N-H bands, whereas secondary amines exhibit only one.Recommanded Product: N,N-Dimethylformamide Dimethyl Acetal

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Jafari, Mehrafshan G.; Park, Yerin; Pudasaini, Bimal; Kurogi, Takashi; Carroll, Patrick J.; Kaphan, David M.; Kropf, Jeremy; Delferro, Massimiliano; Baik, Mu-Hyun; Mindiola, Daniel J. published their research in Angewandte Chemie, International Edition in 2021. The article was titled 《Phosphorus-Atom Transfer from Phosphaethynolate to an Alkylidyne》.Recommanded Product: 1,4,7,10,13-Pentaoxacyclopentadecane The article contains the following contents:

A low-spin and mononuclear V complex, (Menacnac)V(CO)(η2-PCtBu) (2) (Menacnac- = [ArNCMe]2CH, Ar = 2,6-iPr2C6H3), was prepared upon treatment of the V neopentylidyne complex (Menacnac)VCtBu(OTf) (1) with Na(OCP)(diox)2.5 (diox = 1,4-dioxane), while the isoelectronic ate-complex [Na(15-crown-5)]{([ArNC(CH2)]CH[CMeNAr])V(CO)(η2-PCtBu)} (4), was obtained via the reaction of Na(OCP)(diox)2.5 and ([ArNC(CH2)]CH[CMeNAr])VCtBu(OEt2) (3) in the presence of crown-ether. Computational studies suggest that the P-atom transfer proceeds by [2+2]-cycloaddition of the PC bond across the VCtBu moiety, followed by a reductive decarbonylation to form the V-CO linkage. The nature of the electronic ground state in diamagnetic complexes, 2 and 4, was further studied both theor. and exptl., using a combination of d. functional theory (DFT) calculations, UV/visible and NMR spectroscopies, cyclic voltammetry, x-ray absorption spectroscopy (XAS) measurements, and comparison of salient bond metrics derived from X-ray single-crystal structural characterization. In combination, these data are consistent with a low-valent V ion in complexes 2 and 4. This study represents the 1st example of a metathesis reaction between the P-atom of [PCO]- and an alkylidyne ligand.1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5Recommanded Product: 1,4,7,10,13-Pentaoxacyclopentadecane) was used in this study.

1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5) is a member of crown ether Ligands. Crown-ethers are macrocyclic polyethers capable of forming host-guest complexes, especially with inorganic and organic cations. Crown-ethers can incorporate protonated primary amine compounds by formation of ion-dipole bonds with the oxygen atoms of the chiral selector. Crown-ethers have been widely used for the separation of several pharmaceuticals both in aqueous and non-aqueous media. Recommanded Product: 1,4,7,10,13-Pentaoxacyclopentadecane

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Recommanded Product: 139115-91-6In 2017 ,《NanoSOSG: a Nanostructured Fluorescent Probe for the Detection of Intracellular Singlet Oxygen》 was published in Angewandte Chemie, International Edition. The article was written by Ruiz-Gonzalez, Ruben; Bresoli-Obach, Roger; Gulias, Oscar; Agut, Montserrat; Savoie, Huguette; Boyle, Ross W.; Nonell, Santi; Giuntini, Francesca. The article contains the following contents:

A biocompatible fluorescent nanoprobe for singlet oxygen (1O2) detection in biol. systems was designed, synthesized, and characterized, that circumvents many of the limitations of the mol. probe Singlet Oxygen Sensor Green (SOSG). This widely used com. singlet oxygen probe was covalently linked to a polyacrylamide nanoparticle core using different architectures to optimize the response to 1O2. In contrast to its mol. counterpart, the optimum SOSG-based nanoprobe, which we call NanoSOSG, is readily internalized by E. coli cells and does not interact with bovine serum albumin. Furthermore, the spectral characteristics do not change inside cells, and the probe responds to intracellularly generated 1O2 with an increase in fluorescence. After reading the article, we found that the author used tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6Recommanded Product: 139115-91-6)

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers.Oxygen is more electronegative than carbon, thus the alpha hydrogens of ethers are more acidic than those of simple hydrocarbons. They are far less acidic than alpha hydrogens of carbonyl groups (such as in ketones or aldehydes), however. Recommanded Product: 139115-91-6

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

The author of 《Diabetes impairs the angiogenic capacity of human adipose-derived stem cells by reducing the CD271+ subpopulation in adipose tissue》 were Inoue, Oto; Usui, Soichiro; Takashima, Shin-ichiro; Nomura, Ayano; Yamaguchi, Kosei; Takeda, Yusuke; Goten, Chiaki; Hamaoka, Takuto; Ootsuji, Hiroshi; Murai, Hisayoshi; Kaneko, Shuichi; Takamura, Masayuki. And the article was published in Biochemical and Biophysical Research Communications in 2019. Category: ethers-buliding-blocks The author mentioned the following in the article:

Type 2 diabetes mellitus is an important risk factor for cardiovascular diseases (CVDs). Therapeutic angiogenesis using adipose-derived stem cells (ADSCs) is attractive for CVD therapy. However, although it would be critical for ADSC application on CVD therapy, whether and how diabetes impairs human ADSC therapeutic potential is still uncertain. In this study, we aimed to investigate the impact of diabetes on the angiogenic potential of ADSCs in patients with CVDs, with special focus on stemness-related genes and cellular alteration of ADSCs. This paper established cultured ADSCs from diabetic (DM-ADSCs) and non-diabetic patients (nonDM-ADSCs) with CVDs. DM-ADSCs demonstrated limited proliferative capacity and reduced paracrine capacity of VEGF, with lower expression of the stemness gene SOX2. Angiogenic capacity and ADSC engraftment were assessed using xenograft experiments in a hindlimb ischemia model of athymic nude mice. Consistent with the results of in vitro assays, DM-ADSCs did not rescue limb ischemia. In contrast, nonDM-ADSCs induced neovascularization with enhanced engraftment. To elucidate the mechanism underlying these ADSC changes, we compared the surface marker profiles of freshly isolated ADSCs obtained from diabetic and non-diabetic patients by flow cytometry. Among studied subsets, the CD34+CD31-CD271+ subpopulation was reduced in the adipose tissues of diabetic patients. In addition, SOX2 expression and proliferative capacity were considerably reduced in nonDM-ADSCs derived from the stromal vascular fraction (SVF) with depletion of CD271+ cells (p < 0.01). Our observations elucidated that reduced CD271+ subpopulation is critical for the impairment of ADSCs in diabetic patients. Further investigations on the CD271+ subset of ADSCs might provide novel insights into the mechanisms and solutions for diabetes-related ADSC dysfunction in cell therapy. In the part of experimental materials, we found many familiar compounds, such as 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas: 106685-40-9Category: ethers-buliding-blocks)

6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas:106685-40-9) is a third-generation synthetic retinoid and a highly lipophilic compound derived from naphthoic acid. It is widely used in the treatment of acne.Category: ethers-buliding-blocks

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

The author of 《Efficient Strategy for the Synthesis and Modification of 2-Hydroxyethylluciferin for Highly Sensitive Bioluminescence Imaging of Endogenous Hydrogen Sulfide in Cancer Cells and Nude Mice》 were Li, Xuewei; Wang, Anni; Wang, Jinyi; Lu, Jianzhong. And the article was published in Analytical Chemistry (Washington, DC, United States) in 2019. Quality Control of 2-(Benzyloxy)acetaldehyde The author mentioned the following in the article:

Bioluminescence (BL) imaging is among the most popular methods for visualizing biol. processes in vitro, in live cells, and even in the whole organism. The alkylation of aminoluciferin at the 6′-amino site (2-hydroxyethyl luciferin, HE-AL) can emit more enhanced and sustained BL signals than D-luciferin and aminoluciferin, which is suitable for approaches that require long integration time such as three-dimensional animal BL imaging. Nevertheless, the drawback of HE-AL is that the synthesis procedure is complex, which leads to few BL probes based on HE-AL. In this Article, an efficient and facile approach to synthesize HE-AL was first established with an appreciate yield of 64% as compared with 15% previously reported. Then, designing HE-AL as a small mol. probe (R)-2-(6-((2-((2-((2,4-dinitrophenyl)thio)benzoyl)oxy)ethyl)amino)benzo[d]thiazol-2-yl)-4,5-dihydrothiazole-4-carboxylic acid (DNPT-HS) was designed to detect endogenous hydrogen sulfide (H2S) in cancer cells and nude mice for further exploration of the biol. roles of H2S in physiol. and pathol. processes. It was observed that DNPT-HS had excellent sensitivity in the luciferase-transfected cancer cells and nude mice, and the signal-to-noise ratios of DNPT-HS in cells and nude mice were 26 (Huh7 cells), 21 (MDA-MB-231 cells), and 7 (mice), which was the most efficient probe for imaging endogenous H2S. Overall, the excellent imaging properties of DNPT-HS for endogenous H2S make it a potentially powerful tool for further elucidating H2S biol. functions. In the experiment, the researchers used 2-(Benzyloxy)acetaldehyde(cas: 60656-87-3Quality Control of 2-(Benzyloxy)acetaldehyde)

2-(Benzyloxy)acetaldehyde(cas: 60656-87-3) is a non-natural aldehyde. It undergoes enantioselective Mukaiyama aldol reaction with silylketene acetal nucleophiles in the presence of C2-symmetric bis(oxazolinyl)pyridine Cu(II) complex (catalyst).Quality Control of 2-(Benzyloxy)acetaldehyde

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

The author of 《Kinetics of Ozonation of Phenol and Substituted Phenols》 were Bhosale, Ghanshyam S.; Vaidya, Prakash D.; Joshi, Jyeshtharaj B.; Patil, Raosaheb N.. And the article was published in Industrial & Engineering Chemistry Research in 2019. COA of Formula: C7H8O2 The author mentioned the following in the article:

When treating phenol/substituted phenol-containing wastewater, an intermediate chem. step of partial oxidation is often used to facilitate the downstream biodegradation process. Ozonation is a candidate method for partial oxidation of phenolic compounds This work assessed the kinetics of ozonation reactions of 20 substituted phenols using the renowned theory of mass transfer with chem. reaction. A stirred (Lewis) cell with flat interface was used as a model contactor. Second-order rate constants for reactions with the selected phenolic compounds were in the 104-107/M-s range. The rate constant for phenol ozonation was 5.06 × 106/M-s. The liquid-side mass transfer coefficient, estimated using the chem. method, was (kL = 0.052 cm/s) in line with those typical of stirred-cell reactors. This work is useful to design, operate, and scale-up ozonation wastewater treatment reactors. In addition to this study using m-Methoxyphenol, there are many other studies that have used m-Methoxyphenol(cas: 150-19-6COA of Formula: C7H8O2) was used in this study.

m-Methoxyphenol(cas: 150-19-6) may be used in synthesis of:C(4) symmetric calix[4]resorcinarene, 2-nitroso-5-methoxyphenol, 6-methoxy-2(3H)-benzoxazoloneCOA of Formula: C7H8O2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Construction of sequence-defined polytriazoles by IrAAC and CuAAC reactions》 was published in Chemical Communications (Cambridge, United Kingdom) in 2020. These research results belong to Ju, Changhong; Meng, Congcong; Ma, Jiahao; Zhang, Xueyan; Ding, Shengtao. Application In Synthesis of 1,2-Diphenyldisulfane The article mentions the following:

Here we report the first synthesis of sequence-defined polytriazoles, in which different side groups are sequentially anchored to the C-5 position of 1,2,3-triazole rings. By using efficient synthetic strategies based on IrAAC and CuAAC, different monodispersed polytriazoles with up to ∼5.3 kDa and 31-mer were constructed. Structural characterization via NMR, SEC, MALDI-TOF-MS, tandem MS and FTICR-MS evidenced the formation of polytriazoles with the desired specified sequences and exact chain lengths.1,2-Diphenyldisulfane(cas: 882-33-7Application In Synthesis of 1,2-Diphenyldisulfane) was used in this study.

1,2-Diphenyldisulfane(cas: 882-33-7) belongs to ethers.Application In Synthesis of 1,2-DiphenyldisulfaneAlthough ethers resist hydrolysis, they are cleaved by hydrobromic acid and hydroiodic acid. Hydrogen chloride cleaves ethers only slowly.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Fukasawa, Yuto; Kaneko, Masashi; Nakashima, Satoru published their research in Journal of Radioanalytical and Nuclear Chemistry in 2021. The article was titled 《Density functional study on Am(III)/Eu(III) selectivity using crown ether type ligands》.COA of Formula: C10H20O5 The article contains the following contents:

D. functional theory calculations were applied to understand the selectivity between Am3+ and Eu3+ ions with the crown ethers type ligands. 18C6 is predicted to form the most stable complex with Eu3+ and show the higher stability for Am3+ over Eu3+, being consistent with previously reported Am3+/Eu3+ selectivity. The authors modeled N- and S-donor complexes by using framework of 18C6 complex and analyzed the complexation Gibbs energies, indicating that 18C6 with N-donor atoms is suitable for both complexation and higher Am3+ stability over Eu3+ due to the stronger covalent interaction. In the experimental materials used by the author, we found 1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5COA of Formula: C10H20O5)

1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5) is a member of crown ether Ligands. Crown-ethers are macrocyclic polyethers capable of forming host-guest complexes, especially with inorganic and organic cations. Crown-ethers can incorporate protonated primary amine compounds by formation of ion-dipole bonds with the oxygen atoms of the chiral selector. Crown-ethers have been widely used for the separation of several pharmaceuticals both in aqueous and non-aqueous media. COA of Formula: C10H20O5

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Cao, Haijie; Wang, Kuikui; Yang, Zhengqiang; Wu, Shijie; Han, Dandan published an article in 2021. The article was titled 《Quantum chemical study on the ozonolysis mechanism of guaiacol and the structure-reactivity relationship of phenols with hydroxyl, methoxy, and methyl substituents》, and you may find the article in Chemical Engineering Journal (Amsterdam, Netherlands).Related Products of 150-19-6 The information in the text is summarized as follows:

Quantum chem. calculations with the M06-2X method were performed to uncover the ozonolysis mechanism of guaiacol and several hydroxylated, methoxylated, and methylated phenols to improve the understanding of the ozone-induced attenuation of phenolic compounds The detailed kinetic properties were obtained by the transition state theory (TST) and the Rice – Ramsperger – Kassel – Marcus (RRKM) theory. Results confirm that the primary ozonides originated from guaiacol occupy considerably long retention time than the short-lived primary ozonides formed from vinyl-type compounds in the air. The TST rate constant of guaiacol ozonolysis is calculated with a value of 8.81 x 10-20 cm3 mol.-1 s-1 at room temperature The RRKM results prove that the rate constant is pos. dependent on temperature but shows no relation with pressure. The reactivity of substituted phenols exhibits a strong correlation with the ozone affinity of carbon atoms and the orbital energy difference (ELo-Hac) between the LUMO of O3 and the HOMO of phenols. The substituents can reduce the value of ELo-Hac and improve the phenols’ reactivity, especially when they locate at the ortho- and para-position. The substituents also improve the ozone affinity of carbon atoms due to the electron-withdrawing effect. The Me group delivers a moderate impact on the reactivity compared to hydroxyl and methoxy groups. The results came from multiple reactions, including the reaction of m-Methoxyphenol(cas: 150-19-6Related Products of 150-19-6)

m-Methoxyphenol(cas: 150-19-6) may be used in synthesis of:C(4) symmetric calix[4]resorcinarene, 2-nitroso-5-methoxyphenol, 6-methoxy-2(3H)-benzoxazoloneRelated Products of 150-19-6

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem