Month: October 2022

Ethers can again be classified into two varieties: if the alkyl or aryl groups are the same on both sides of the oxygen atom, 530-59-6, formula is C11H12O5, Name is 3,5-Dimethoxy-4-hydroxycinnamic acid. Then it is a simple or symmetrical ether, whereas if they are different, the ethers are called mixed or unsymmetrical ethers. Related Products of 530-59-6.

Pokkanta, Piramon;Yuenyong, Jitkunya;Mahatheeranont, Sugunya;Jiamyangyuen, Sudarat;Sookwong, Phumon research published 《 Microwave treatment of rice bran and its effect on phytochemical content and antioxidant activity》, the research content is summarized as follows. An alternative approach for rice bran stabilization is microwave treatment. However, the effects of the microwave treatment on the contents of bioactive compounds and antioxidant activities of the rice bran have rarely been reported in detail. In this study, microwave pretreatment (130-880 W for 0.5-5.0 min) of rice bran was proposed where the antioxidant activity, total flavonoids, and total phenolic contents were determined using UV-Vis spectrometry. Tocols, γ-oryzanols, squalene, phytosterols and phenolic compounds were quantified using high-performance liquid chromatog. The results showed an increase in the antioxidant activity (0.5 folds), total phenolic contents (1.3 folds), total flavonoid contents (0.9 folds), total tocols (2.6 folds), total γ-oryzanols (1.6 folds), and total phytosterols (1.4 folds). Phytochems. were enhanced, especially trans-p-coumaric acid (10.3 folds) and kaempferol (8.6 folds). The microwave treatment at 440 W for 2.5 min provided the best contents of the bioactive compounds and antioxidant activity. This work revealed the microwave treatment as a potential tool for stabilizing rice bran and increasing the usability of its phytochems., which applies to several industries concerning the use of rice bran as an ingredient.

Related Products of 530-59-6, Sinapinic acid is a chemical compound that is the dihydroxybenzoic acid derivative of sinapic acid. It has been shown to have anti-inflammatory properties in vitro and in vivo. Sinapinic acid inhibits the activity of various enzymes, such as cyclooxygenase (COX), lipoxygenase (LOX), and 5-lipoxygenase-activating protein (FLAP). It also decreases levels of adhesion molecules and downregulates inflammatory response genes. Sinapinic acid has been shown to reduce inflammation by inhibiting the formation of proinflammatory mediators, such as prostaglandin E2 or leukotriene B4, in endothelial cells and mammary epithelial cells.
Sinapic acid is a phenylpropanoid hydroxycinnamic acid with diverse biological activities. Sinapic acid inhibits collagen-induced human platelet aggregation by up to 70% in vitro (IC50 = 1.03 mM). It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; ) and 2,2′-azino-bis-(3-ethylbenzothiazoline-6-sulfonate) (ABTS) free radicals with IC50 values of 8.3 and 5.4 μg/ml, respectively. Sinapic acid (200 μM) reduces colony formation of SW480 human colon carcinoma cells by 4-fold. It also inhibits colony formation of E. coli, S. enteritidis, and S. aureus on agar (MICs = 2.2, 2, and 1.8 mM, respectively). In vivo, sinapic acid (4 mg/kg, p.o.) increases the time spent in the open arms of the elevated plus maze by approximately 15% in mice, an effect that can be blocked by the GABAA receptor antagonists flumazenil and bicuculline. Sinapic acid is also commonly used as a matrix in protein mass spectrometry.
Sinapic acid analytical standard provided with w/w absolute assay, to be used for quantitative titration.
Sinapic acid is an hydroxycinnamic acid derivative that occurs naturally in Brassicaceae species.
cis-Sinapic acid, also known as cis-sinapate or synapitic acid, belongs to the class of organic compounds known as hydroxycinnamic acids. Hydroxycinnamic acids are compounds containing an cinnamic acid where the benzene ring is hydroxylated. cis-Sinapic acid is considered to be a practically insoluble (in water) and relatively neutral molecule. Within the cell, cis-sinapic acid is primarily located in the cytoplasm. Outside of the human body, cis-sinapic acid can be found in common pea and pulses. This makes cis-sinapic acid a potential biomarker for the consumption of these food products.
Cis-sinapic acid is a 3-(4-hydroxy-3,5-dimethoxyphenyl)prop-2-enoic acid in which the double bond has cis-configuration. It has been isolated from the shoots of alfalfa. It has a role as a plant metabolite., 530-59-6.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. 111-90-0, formula is C6H14O3, Name is Diethylene Glycol Monoethyl Ether. The barrier to rotation about the C–O bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3. Computed Properties of 111-90-0.

Pires, Patricia C.;Fazendeiro, Ana C.;Rodrigues, Marcio;Alves, Gilberto;Santos, Adriana O. research published 《 Nose-to-brain delivery of phenytoin and its hydrophilic prodrug fosphenytoin combined in a microemulsion – formulation development and in vivo pharmacokinetics.》, the research content is summarized as follows. Phenytoin is a low aqueous solubility antiepileptic drug, but its phosphate ester prodrug fosphenytoin is soluble, although less permeable. In a previous study, the intranasal administration of aqueous-based formulations of fosphenytoin led to high but delayed phenytoin bioavailability compared to the i.v. route. In this work, we hypothesized that formulating an association of the prodrug fosphenytoin and the drug phenytoin (the active and diffusible form), could result in a faster and/or more effective brain targeting. Hence, nano or microemulsions containing both active drug and prodrug were developed and characterized regarding viscosity, osmolality, pH, mean size and in vitro drug release. Then, in vivo pharmacokinetics of a selected microemulsion containing fosphenytoin and phenytoin was evaluated in mice following intranasal administration and compared with a similar microemulsion containing fosphenytoin only. Both microemulsions led to higher brain drug levels at short time points than previously developed simpler aqueous based fosphenytoin formulations, likely due to the microemulsion′s permeation enhancing effect. In addition, having a small amount of phenytoin in the formulation led to an equivalent maximum brain drug concentration and an overall higher absolute bioavailability, with a prolonged drug exposure. Hence, it can be concluded that if there is a need for a fast and prolonged therapeutic effect, a drug/phosphate ester prodrug combination in a microemulsion is ideal, but if a fast effect is all that is needed, having the prodrug alone could be enough, while considering a formulation with permeation enhancing components.

111-90-0, Diethylene glycol monoethyl ether appears as a colorless, slightly viscous liquid with a mild pleasant odor. Flash point near 190°F. Used to make soaps, dyes, and other chemicals.
Diethylene glycol monoethyl ether is a primary alcohol that is ethanol substituted by a 2-ethoxyethoxy group at position 2. It has a role as a protic solvent. It is a diether, a primary alcohol and a hydroxypolyether. It derives from a diethylene glycol., Computed Properties of 111-90-0

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ethers can again be classified into two varieties: if the alkyl or aryl groups are the same on both sides of the oxygen atom, 111-90-0, formula is C6H14O3, Name is Diethylene Glycol Monoethyl Ether. Then it is a simple or symmetrical ether, whereas if they are different, the ethers are called mixed or unsymmetrical ethers. HPLC of Formula: 111-90-0.

Pipertzis, Achilleas;Papamokos, George;Sachnik, Oskar;Allard, Sybille;Scherf, Ullrich;Floudas, George research published 《 Ionic Conductivity in Polyfluorene-Based Diblock Copolymers Comprising Nanodomains of a Polymerized Ionic Liquid and a Solid Polymer Electrolyte Doped with LiTFSI》, the research content is summarized as follows. Diblock copolymer electrolytes based on a π-conjugated polyfluorene (PF) backbone were synthesized comprising nanodomains of a polymerized ionic liquid (PIL) and of a solid polymer electrolyte (SPE). The former consists of a single-ion conductor based on an imidazolium alkyl chain with a [Br]^– counteranion grafted on the PF backbone. The latter consists of short ethylene oxide (EO) chains, grafted on the PF backbone and further doped with LiTFSI. The two nanophases support ionic conductivity, whereas the rigid PF backbone provides the required mech. stability. In the absence of LiTFSI, ionic conductivity in the PIL nanophase is low and exhibits an Arrhenius temperature dependence. LiTFSI substitution enhances ionic conductivity by about 3 orders of magnitude and further changes to a Vogel-Fulcher-Tammann temperature dependence. However, at ambient temperature, ionic conductivity is lower than in the corresponding PEO/LiTFSI electrolytes. X-ray studies and thermal anal. revealed that the conjugated backbone imparts liquid-crystalline order that can be fine-tuned through the EO side group length. Ionic conductivity measurements performed as a function of pressure identified local jumps of [Li]⁺ and [Br]^– ions in the resp. SPE/PIL nanophases as responsible for the ionic conductivity Between the two ions, it is [Li]⁺ that has the major contribution to the ionic conductivity The current results provide designing rules for new copolymers that comprise two different ionic nanodomains (PIL and SPE) and a conjugated backbone that can further support electronic conduction.

HPLC of Formula: 111-90-0, Diethylene glycol monoethyl ether appears as a colorless, slightly viscous liquid with a mild pleasant odor. Flash point near 190°F. Used to make soaps, dyes, and other chemicals.
Diethylene glycol monoethyl ether is a primary alcohol that is ethanol substituted by a 2-ethoxyethoxy group at position 2. It has a role as a protic solvent. It is a diether, a primary alcohol and a hydroxypolyether. It derives from a diethylene glycol., 111-90-0.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ethers are a class of organic compounds that contain an ether group—an oxygen atom connected to two alkyl or aryl groups. 38256-93-8, formula is C4H11NO, Name is 2-Methoxy-N-methylethanamine.They have the general formula R–O–R′, where R and R′ represent the alkyl or aryl groups. Computed Properties of 38256-93-8.

Pinto, Donald J. P.;Orwat, Michael J.;Smith, Leon M.;Quan, Mimi L.;Lam, Patrick Y. S.;Rossi, Karen A.;Apedo, Atsu;Bozarth, Jeffrey M.;Wu, Yiming;Zheng, Joanna J.;Xin, Baomin;Toussaint, Nathalie;Stetsko, Paul;Gudmundsson, Olafur;Maxwell, Brad;Crain, Earl J.;Wong, Pancras C.;Lou, Zhen;Harper, Timothy W.;Chacko, Silvi A.;Myers, Joseph E.;Sheriff, Steven;Zhang, Huiping;Hou, Xiaoping;Mathur, Arvind;Seiffert, Dietmar A.;Wexler, Ruth R.;Luettgen, Joseph M.;Ewing, William R. research published 《 Discovery of a Parenteral Small Molecule Coagulation Factor XIa Inhibitor Clinical Candidate (BMS-962212)》, the research content is summarized as follows. Factor XIa (FXIa) is a blood coagulation enzyme that is involved in the amplification of thrombin generation. Mounting evidence suggests that direct inhibition of FXIa can block pathol. thrombus formation while preserving normal hemostasis. Preclin. studies using a variety of approaches to reduce FXIa activity, including direct inhibitors of FXIa, have demonstrated good antithrombotic efficacy without increasing bleeding. Based on this potential, the authors targeted the efforts at identifying potent inhibitors of FXIa with a focus on discovering an acute antithrombotic agent for use in a hospital setting. Herein the authors describe the discovery of a potent FXIa clin. candidate, I (FXIa Ki = 0.7 nM), with excellent preclin. efficacy in thrombosis models and aqueous solubility suitable for i.v. administration. BMS-962212 is a reversible, direct, and highly selective small mol. inhibitor of FXIa.

Computed Properties of 38256-93-8, 2-Methoxy-N-methylethanamine is a useful research compound. Its molecular formula is C4H11NO and its molecular weight is 89.14 g/mol. The purity is usually 95%.
2-Methoxy-N-methylethanamine is a drug that binds to the cannabinoid receptor CB1. It has been shown to be effective in the treatment of cardiac arrhythmia and may also be used as an anti-inflammatory drug. 2MEMEA has been shown to have pharmacokinetic properties that are different from those of other amines, which may be due to its ability to form hydrogen bonds with water molecules. 2MEMEA also has diversified effects on some types of cancer cells, including hyperproliferative and amine-dependent cancers., 38256-93-8.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. 38256-93-8, formula is C4H11NO, Name is 2-Methoxy-N-methylethanamine. The barrier to rotation about the C–O bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3. Name: 2-Methoxy-N-methylethanamine.

Pinaud, Marine;Le Gall, Erwan;Presset, Marc research published 《 Mixed Aliphatic Organozinc Reagents as Nonstabilized C_sp³-Nucleophiles in the Multicomponent Mannich Reaction》, the research content is summarized as follows. The use of mixed aliphatic organozinc reagents in the multicomponent Mannich reaction was described. A large variety of primary, secondary and tertiary organozinc reagents, secondary amines and aromatic or aliphatic aldehydes could be used for the straightforward preparation of densely substituted amines. The three-component reaction could addnl. be performed starting from alkyl halides under reductive (Barbier-type) conditions.

38256-93-8, 2-Methoxy-N-methylethanamine is a useful research compound. Its molecular formula is C4H11NO and its molecular weight is 89.14 g/mol. The purity is usually 95%.
2-Methoxy-N-methylethanamine is a drug that binds to the cannabinoid receptor CB1. It has been shown to be effective in the treatment of cardiac arrhythmia and may also be used as an anti-inflammatory drug. 2MEMEA has been shown to have pharmacokinetic properties that are different from those of other amines, which may be due to its ability to form hydrogen bonds with water molecules. 2MEMEA also has diversified effects on some types of cancer cells, including hyperproliferative and amine-dependent cancers., Name: 2-Methoxy-N-methylethanamine

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ethers are a class of organic compounds that contain an ether group—an oxygen atom connected to two alkyl or aryl groups. 530-59-6, formula is C11H12O5, Name is 3,5-Dimethoxy-4-hydroxycinnamic acid.They have the general formula R–O–R′, where R and R′ represent the alkyl or aryl groups. Formula: C11H12O5.

Pico, Joana;Yan, Yifan;Gerbrandt, Eric M.;Castellarin, Simone D. research published 《 Determination of free and bound phenolics in northern highbush blueberries by a validated HPLC/QTOF methodology》, the research content is summarized as follows. Blueberry consumption has increased in recent years, partially due to the health benefits attributed to their phenolic content. This study aimed to optimize and validate a high-performance liquid chromatog./quadrupole-time of flight mass spectrometry (HPLC/QTOF-MS) methodol. for the determination of free (i.e., solvent extractable) and bound (i.e., covalently bound to the plant cellular structures) phenolics in northern highbush blueberries. A total of 31 phenolics, including anthocyanins, flavonols, flavan-3-ols, and phenolic acids, were targeted in the pos. electrospray ionization mode [ESI (+)], including MS/MS confirmation of their product ions. Free phenolics determination was validated in terms of sensitivity, reproducibility, linearity, and accuracy, and 21 free phenolic compounds were found above their limits of detection among six com. blueberry cultivars, which were quantified with correction for the matrix effect. ‘Elliott’ presented the highest free phenolic and anthocyanin contents (3640 and 3430 mg kg^-1 fresh weight, resp.). Malvidin-3-O-galactoside was the most abundant free phenolic for ‘Duke’, ‘Draper’, ‘Elliott’, and ‘Last Call’ while chlorogenic acid predominated for ‘Bluecrop’ and ‘Calypso’. Syringetin-3-O-glucoside was the most abundant bound phenolic compound among the six blueberry cultivars.

530-59-6, Sinapinic acid is a chemical compound that is the dihydroxybenzoic acid derivative of sinapic acid. It has been shown to have anti-inflammatory properties in vitro and in vivo. Sinapinic acid inhibits the activity of various enzymes, such as cyclooxygenase (COX), lipoxygenase (LOX), and 5-lipoxygenase-activating protein (FLAP). It also decreases levels of adhesion molecules and downregulates inflammatory response genes. Sinapinic acid has been shown to reduce inflammation by inhibiting the formation of proinflammatory mediators, such as prostaglandin E2 or leukotriene B4, in endothelial cells and mammary epithelial cells.
Sinapic acid is a phenylpropanoid hydroxycinnamic acid with diverse biological activities. Sinapic acid inhibits collagen-induced human platelet aggregation by up to 70% in vitro (IC50 = 1.03 mM). It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; ) and 2,2′-azino-bis-(3-ethylbenzothiazoline-6-sulfonate) (ABTS) free radicals with IC50 values of 8.3 and 5.4 μg/ml, respectively. Sinapic acid (200 μM) reduces colony formation of SW480 human colon carcinoma cells by 4-fold. It also inhibits colony formation of E. coli, S. enteritidis, and S. aureus on agar (MICs = 2.2, 2, and 1.8 mM, respectively). In vivo, sinapic acid (4 mg/kg, p.o.) increases the time spent in the open arms of the elevated plus maze by approximately 15% in mice, an effect that can be blocked by the GABAA receptor antagonists flumazenil and bicuculline. Sinapic acid is also commonly used as a matrix in protein mass spectrometry.
Sinapic acid analytical standard provided with w/w absolute assay, to be used for quantitative titration.
Sinapic acid is an hydroxycinnamic acid derivative that occurs naturally in Brassicaceae species.
cis-Sinapic acid, also known as cis-sinapate or synapitic acid, belongs to the class of organic compounds known as hydroxycinnamic acids. Hydroxycinnamic acids are compounds containing an cinnamic acid where the benzene ring is hydroxylated. cis-Sinapic acid is considered to be a practically insoluble (in water) and relatively neutral molecule. Within the cell, cis-sinapic acid is primarily located in the cytoplasm. Outside of the human body, cis-sinapic acid can be found in common pea and pulses. This makes cis-sinapic acid a potential biomarker for the consumption of these food products.
Cis-sinapic acid is a 3-(4-hydroxy-3,5-dimethoxyphenyl)prop-2-enoic acid in which the double bond has cis-configuration. It has been isolated from the shoots of alfalfa. It has a role as a plant metabolite., Formula: C11H12O5

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ethers can again be classified into two varieties: if the alkyl or aryl groups are the same on both sides of the oxygen atom, 111-90-0, formula is C6H14O3, Name is Diethylene Glycol Monoethyl Ether. Then it is a simple or symmetrical ether, whereas if they are different, the ethers are called mixed or unsymmetrical ethers. Recommanded Product: Diethylene Glycol Monoethyl Ether.

Phillips, Robert;Whelton, Andrew J.;Eckelman, Matthew J. research published 《 Incorporating use phase chemical leaching and water quality testing for life cycle toxicity assessment of cross-linked polyethylene (PEX) piping》, the research content is summarized as follows. Life cycle assessment (LCA) is increasingly being considered in material selection decisions for residential drinking water piping, but chem. leaching during the use phase has typically been excluded, even though the delivery of safe water is the core function of water distribution infrastructure. We have quantified the contribution of leached organics to life cycle human toxicity of piping materials through the integration of empirical leaching data within LCA. Eight cross-linked polyethylene (PEX) pipe brands were examined Upstream emissions from PEX pipe production were combined with empirical total organic carbon (TOC) data from leaching tests for new pipes. The total mass of organic contaminants ingested over the pipe′s lifetime was estimated by fitting leaching data with kinetic models and integrating leaching concentrations and daily water use over time, rather than using an initial concentration that does not accurately depict actual lifetime exposures. Potential human toxicity from use phase ingestion was evaluated using a range of human effect factors from the consensus USEtox model to create plausible bounds of toxicity through different exposure and effect scenarios. New non-carcinogenic human toxicol. effect factors were derived for approx. half of the 62 leached organic compounds identified. Results indicate that potential human toxicity from upstream pipe production generally exceeds use phase toxicity, but that leached contaminants can be a substantial contributor to overall life cycle toxicity, depending on the PEX brand, particularly for carcinogenic effects. Deleterious effects can be reduced both by thorough system flushing after initial installation and periods of stagnation, but also through improvements in manufacturing processes that reduce upstream emissions. The bounding approach demonstrates a viable method for considering water quality in LCA when comprehensive characterization and concentration data are not available.

Recommanded Product: Diethylene Glycol Monoethyl Ether, Diethylene glycol monoethyl ether appears as a colorless, slightly viscous liquid with a mild pleasant odor. Flash point near 190°F. Used to make soaps, dyes, and other chemicals.
Diethylene glycol monoethyl ether is a primary alcohol that is ethanol substituted by a 2-ethoxyethoxy group at position 2. It has a role as a protic solvent. It is a diether, a primary alcohol and a hydroxypolyether. It derives from a diethylene glycol., 111-90-0.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. 122775-35-3, formula is C8H11BO4, Name is 3,4-Dimethoxyphenylboronic acid. The barrier to rotation about the C–O bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3. Category: ethers-buliding-blocks.

Percec, Virgil;Wang, Shitao;Huang, Ning;Partridge, Benjamin E.;Wang, Xuefeng;Sahoo, Dipankar;Hoffman, David J.;Malineni, Jagadeesh;Peterca, Mihai;Jezorek, Ryan L.;Zhang, Na;Daud, Hina;Sung, Paul D.;McClure, Emily R.;Song, Se Lin research published 《 An Accelerated Modular-Orthogonal Ni-Catalyzed Methodology to Symmetric and Nonsymmetric Constitutional Isomeric AB₂ to AB₉ Dendrons Exhibiting Unprecedented Self-Organizing Principles》, the research content is summarized as follows. Three libraries consisting of 30 sym. and nonsym. constitutional isomeric phenolic acids with unprecedented sequenced patterns, including two AB₂, three AB₃, eight AB₄, five AB₅, six AB₆, three AB₇, two AB₈, and one AB₉ synthesized by accelerated modular-orthogonal Ni-catalyzed borylation and cross-coupling were reported. A single etherification step with 4-(n-dodecyloxy)benzyl chloride transformed all these phenolic acids, of interest also for other applications, into self-assembling dendrons. Despite this synthetic simplicity, they led to a diversity of unprecedented self-organizing principles: lamellar structures of interest for biol. membrane mimics, helical columnar assemblies from rigid-solid angle dendrons forming Tobacco Mosaic Virus-like assemblies, columnar organizations from adaptable-solid angle dendrons forming disordered micellar-like nonhelical columns, columns from supramol. spheres, five body-centered cubic phases displaying supramol. orientational memory, rarely encountered in previous libraries forming predominantly Frank-Kasper phases, and two Frank-Kasper phases. Lessons from these self-organizing principles, discovered within a single generation of self-assembling dendrons, might help elaborate design principles for complex helical and nonhelical organizations of synthetic and biol. matter.

Category: ethers-buliding-blocks, 3,4-Dimethoxyphenylboronic acid is a useful research compound. Its molecular formula is C8H11BO4 and its molecular weight is 181.98 g/mol. The purity is usually 95%.
3,4-Dimethoxyphenylboronic acid contains varying amounts of anhydride.
3,4-Dimethoxyphenylboronic acid is a bacterial mutagen. A useful intermediate for organic synthesis.
3,4-Dimethoxyphenylboronic acid is a boronate ester that has been shown to be an effective coupling partner for the Suzuki reaction. It has also been used in cancer therapy and as a photochemical probe for the study of biological properties. 3,4-Dimethoxyphenylboronic acid has been shown to demethylate DNA and inhibit methionine aminopeptidase activity. It also cross-couples with halides, such as chlorides or iodides, and activates tertiary alcohols. 3,4-Dimethoxyphenylboronic acid is soluble in organic solvents and can be used in supramolecular chemistry., 122775-35-3.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ethers do have nonbonding electron pairs on their oxygen atoms, 122775-35-3, formula is C8H11BO4, Name is 3,4-Dimethoxyphenylboronic acid. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds. COA of Formula: C8H11BO4.

Peng, Xiaopeng;Li, Ling;Chen, Jingxuan;Ren, Yichang;Liu, Jin;Yu, Ziwen;Cao, Hao;Chen, Jianjun research published 《 Discovery of Novel Histone Deacetylase 6 (HDAC6) Inhibitors with Enhanced Antitumor Immunity of Anti-PD-L1 Immunotherapy in Melanoma》, the research content is summarized as follows. A series of 2-phenylthiazole analogs I (R = 3,4,5-trimethoxyphenyl, naphthalen-2-yl, 2-fluorophenyl, etc.; n = 1, 2, 3, 4, 5, 6), II (R¹ = anthracen-9-yl, 1H-indol-6-yl, 4-chlorophenyl, etc.; R² = OH, 2-aminophenyl) were designed and synthesized as potential histone deacetylase 6 (HDAC6) inhibitors based on an HDAC6/tubulin dual inhibitor discovered recently and CAY10603 (a known HDAC6 inhibitor). Among them, compound I [R = 2,3-dimethoxyphenyl, n = 6 (III)] was the most potent HDAC6 inhibitor with an IC₅₀ of 31 nM and excellent HDAC6 selectivity (SI = 338 for HDAC6 over HDAC3). Compound III also displayed high antiproliferative activity against various cancer cell lines including the HDACi-resistant YCC3/7 gastric cancer cells (IC₅₀ = 0.16-2.31μM), better than CAY10603. Further, compound III (50 mg/kg) exhibited significant antitumor efficacy in a melanoma tumor model with a tumor growth inhibition (TGI) of 63% without apparent toxicity. Moreover, compound III efficiently enhanced the in vivo antitumor immune response when combined with a small-mol. PD-L1 inhibitor, as demonstrated by the increased tumor-infiltrating lymphocytes and reduced PD-L1 expression levels. The above results suggest that compound III is a promising HDAC6 inhibitor deserving further investigation.

COA of Formula: C8H11BO4, 3,4-Dimethoxyphenylboronic acid is a useful research compound. Its molecular formula is C8H11BO4 and its molecular weight is 181.98 g/mol. The purity is usually 95%.
3,4-Dimethoxyphenylboronic acid contains varying amounts of anhydride.
3,4-Dimethoxyphenylboronic acid is a bacterial mutagen. A useful intermediate for organic synthesis.
3,4-Dimethoxyphenylboronic acid is a boronate ester that has been shown to be an effective coupling partner for the Suzuki reaction. It has also been used in cancer therapy and as a photochemical probe for the study of biological properties. 3,4-Dimethoxyphenylboronic acid has been shown to demethylate DNA and inhibit methionine aminopeptidase activity. It also cross-couples with halides, such as chlorides or iodides, and activates tertiary alcohols. 3,4-Dimethoxyphenylboronic acid is soluble in organic solvents and can be used in supramolecular chemistry., 122775-35-3.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ethers do have nonbonding electron pairs on their oxygen atoms, 111-90-0, formula is C6H14O3, Name is Diethylene Glycol Monoethyl Ether. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds. Formula: C6H14O3.

Pelo, Sharon Pauline;Adebo, Oluwafemi Ayodeji;Green, Ezekiel research published 《 Chemotaxonomic profiling of fungal endophytes of Solanum mauritianum (alien weed) using gas chromatography high resolution time-of-flight mass spectrometry (GC-HRTOF-MS)》, the research content is summarized as follows. Since ancient times medicinal plants have been used as medicine in many parts of the world to promote human health and longevity. In recent years many novel secondary metabolites of plants have been isolated and reported to provide lead compounds for new drug discoveries. Solanum mauritianum Scopoli is native to South America. It is reported to be used by native South Americans during famine as a vegetable and as medicine to cure various diseases. In South Africa the plant is viewed as weed and is facing eradication, however, this plant is a valuable subject for research into its potential pharmaceutical and chem. uses. This study elucidated the metabolic profile of fungal endophytes that have promising bioactive secondary metabolites against pathogenic microorganisms, including mycobacterium species. Fungal endophytes from a weed Solanum mauritianum Scop. were used to synthesize secondary metabolites. Gas chromatograph high-resolution time-of-flight mass spectrometry (GC-HRTOF-MS) was used to analyze volatile compounds to prove that potentially fungal endophytes could be extracted from this weed. Extracts obtained with Et acetate were screened for phytochems. and analyzed using a gas chromatograph high-resolution time-of-flight mass spectrometry system. Principal component anal. was used to compare the gas chromatograph high-resolution time-of-flight mass spectrometry data for differences/similarities in their clustering. Phytochem. screening was conducted on the crude extracts of fungal endophytes obtained from different parts of Solanum mauritianum Scopoli (leaves, ripe fruit, unripe fruit and stems). Phytochem. screening indicated the presents of alkaloids, flavonoids, glycosides, phenols, quinones and saponins. Quinones were not present in the crude extracts of Fusarium sp. A total of 991 compounds were observed in the fungal endophytes, and Cladosporium sp. (23.8%) had the highest number of compounds, compared to Paracamarosporium leucadendri (1.7%) and Talaromyces sp. (1.5%). Some volatile compounds such as eicosane, 2-pentadecanone, 2-methyloctacosane, hexacosane and tridecanoic acid Me ester with antibacterial activity were also observed Compositional variations between the plant and fungal endophyte phytochems. were observed The results of this study indicate that fungal endophytes from Solanum mauritianum Scop. contain compounds that can be exploited for numerous pharmaceutical and medicinal applications.

111-90-0, Diethylene glycol monoethyl ether appears as a colorless, slightly viscous liquid with a mild pleasant odor. Flash point near 190°F. Used to make soaps, dyes, and other chemicals.
Diethylene glycol monoethyl ether is a primary alcohol that is ethanol substituted by a 2-ethoxyethoxy group at position 2. It has a role as a protic solvent. It is a diether, a primary alcohol and a hydroxypolyether. It derives from a diethylene glycol., Formula: C6H14O3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem