Month: October 2022

Mondal, Haripriyo; Sk, Raja Md; Maji, Modhu Sudan published an article in 2020, the title of the article was Cooperativity within the catalyst: alkoxyamide as a catalyst for bromocyclization and bromination of (hetero)aromatics.Recommanded Product: 2-Methoxynaphthalene And the article contains the following content:

N-Methoxy-1-butanesulfonamide was a recyclable catalyst for the activation of N-bromosuccinimide to perform bromocyclization and bromination reactions of unsaturated carboxylic acids, alkenes and indoles with pendant nucleophiles, and arenes in heptane, where adequate suppression of the background reactions was observed, to yield bromolactones, bromomethyl-substituted heterocycles, fused indolines such as pyrroloindolines, and aryl bromides. The key feature of the active site is the alkoxy group attached to the sulfonamide moiety, which facilitates the acceptance as well as the delivery of bromonium species from the bromine source to the substrates. The experimental process involved the reaction of 2-Methoxynaphthalene(cas: 93-04-9).Recommanded Product: 2-Methoxynaphthalene

The Article related to bromolactone aryl bromide chemoselective preparation, methoxybutanesulfonamide catalyst bromosuccinimide mediated bromocyclization bromination, chemoselective bromination bromocyclization methoxysulfonamide catalyst bromosuccinimide and other aspects.Recommanded Product: 2-Methoxynaphthalene

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On March 28, 2022, Zhang, Dao; Yu, Jueqin published an article.Reference of 2-Methoxynaphthalene The title of the article was Effect of the Dihedral Angle of Biaryl-Bridged Bis(N-Heterocylic Carbene) Ligands on Enantioselectivity in Pd-Catalyzed Asymmetric Aryl-Aryl Cross-Coupling. And the article contained the following:

New biaryl-bridged bis(N-heterocylic carbene) Pd complexes were synthesized and applied in asym. Suzuki cross-coupling of aryl halide and aryl boronic acid. X-ray crystallog. studies of square-planar Pd complexes of four of these bis(NHC) ligands revealed that the dihedral angle of the bridging biaryl moiety depends on its identity and lies 79.65-92.69°. A linear correlation between the dihedral angle in these Pd complexes and cross-coupling enantioselectivity is 1st reported. Also, larger Ccarbene-Pd-Ccarbene bite angles lead to increased enantioselectivity in a 1st fast and then slow growing tendency. The experimental process involved the reaction of 2-Methoxynaphthalene(cas: 93-04-9).Reference of 2-Methoxynaphthalene

The Article related to chiral biarylbenzimidazolylidene palladacycle complex preparation suzuki reaction catalyst, crystal structure chiral biarylbenzimidazolylidene palladacycle complex, mol structure chiral biarylbenzimidazolylidene palladacycle complex and other aspects.Reference of 2-Methoxynaphthalene

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Kondoh, Azusa; Terada, Masahiro published an article in 2018, the title of the article was Bronsted Base-Catalyzed Umpolung Intramolecular Cyclization of Alkynyl Imines.Safety of 2-((4-Methoxyphenyl)ethynyl)aniline And the article contains the following content:

A novel “umpolung” intramol. cyclization of alkynyl imines, in which the electrophilic imine sp2-carbon formally serves as a nucleophilic site, was developed under Bronsted base catalysis. The reaction involves the unprecedented catalytic generation of α-aminoester enolates from α-iminoesters via the 1,2-addition of the anion of a secondary phosphite to an imine moiety followed by the [1,2]-rearrangement of a dialkoxyphosphoryl moiety from carbon to nitrogen, which is a formal umpolung process, and the intramol. addition to an alkyne. This is a rare example of a [1,2]-rearrangement of a dialkoxyphosphoryl moiety from carbon to nitrogen to generate an α-amino carbanion and the first catalytic carbon-carbon bond forming reaction utilizing the resulting carbanion as a nucleophile. The experimental process involved the reaction of 2-((4-Methoxyphenyl)ethynyl)aniline(cas: 157869-15-3).Safety of 2-((4-Methoxyphenyl)ethynyl)aniline

The Article related to bronsted base catalyst umpolung intramol cyclization alkynyl imine, crystal structure mol phosphonate indoline preparation stereoselective, brønsted base catalysis, intramolecular cyclization, organocatalysts, rearrangement, umpolung and other aspects.Safety of 2-((4-Methoxyphenyl)ethynyl)aniline

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On March 1, 2022, Sahoo, Kanchanbala; Panda, Niranjan published an article.Application In Synthesis of 2-Methylanisole The title of the article was Iron(III) Chloride Mediated para-Selective C-H Functionalization: Access to C5-Chloro and C5,C7-Dichloro/Dianisyl Substituted 2-Arylbenzoxazoles. And the article contained the following:

Iron(III) chloride mediated para-selective C-H chlorination and subsequent annulation of 2-amidophenol to synthesize C5- and C5, C7-chlorinated benzoxazoles was developed. Further, the oxidative cross-dehydrogenative coupling of amidophenol with anisole by ferric chloride was explored to achieve the remotely anisylated benzoxazoles. The experimental process involved the reaction of 2-Methylanisole(cas: 578-58-5).Application In Synthesis of 2-Methylanisole

The Article related to amidophenol iron chloride regioselective chlorination heterocyclization, chloro benzoxazole preparation, methoxybenzene amidophenol iron chloride heterocyclization cross dehydrogenative coupling, methoxyphenyl benzoxazole preparation and other aspects.Application In Synthesis of 2-Methylanisole

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Nguyen, Ngoc-Lan Thi; Nguyen, Quoc-Anh; Le, Tien Khoa; Luu, Thi Xuan Thi; Tran, Kim-Ngan Thi; Pham, Phuoc-Bao published an article in 2022, the title of the article was Chloroaluminate Ionic Liquid Immobilized on Magnetic Nanoparticles as a Heterogeneous Lewis Acidic Catalyst for the Friedel-Crafts Sulfonylation of Aromatic Compounds.Synthetic Route of 150-78-7 And the article contains the following content:

Chloroaluminate ionic liquid bound on magnetic nanoparticles (Fe3O4@O2Si[PrMIM]Cl·AlCl3) was prepared and used as a heterogenous Lewis acidic catalyst for the Friedel-Crafts sulfonylation of aromatic compounds with sulfonyl chlorides or p-toluenesulfonic anhydride. The catalyst′s stability, efficiency, easy recovery, and high recyclability without considerable loss of catalytic capability after four recycles were evidence of its advantages. Furthermore, the stoichiometry, wide substrate scope, short reaction time, high yield of sulfones, and solvent-free reaction condition also made this procedure practical, ecofriendly, and economical. The experimental process involved the reaction of 1,4-Dimethoxybenzene(cas: 150-78-7).Synthetic Route of 150-78-7

The Article related to chloroaluminate ionic liquid immobilization magnetic nanoparticle, heterogeneous lewis acidic catalyst friedel crafts sulfonylation aromatic compound, ionic liquids, magnetic nanoparticles, sulfones, sulfonic anhydride, sulfonylation and other aspects.Synthetic Route of 150-78-7

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Mandrelli, Francesca; Blond, Aurelie; James, Thomas; Kim, Hyejin; List, Benjamin published an article in 2019, the title of the article was Deracemizing α-Branched Carboxylic Acids by Catalytic Asymmetric Protonation of Bis-Silyl Ketene Acetals with Water or Methanol.Electric Literature of 81616-80-0 And the article contains the following content:

We report a highly enantioselective catalytic protonation of bis-silyl ketene acetals. Our method delivers α-branched carboxylic acids, including nonsteroidal anti-inflammatory arylpropionic acids such as Ibuprofen, in high enantiomeric purity and high yields. The process can be incorporated in an overall deracemization of α-branched carboxylic acids, involving a double deprotonation and silylation followed by the catalytic asym. protonation. The experimental process involved the reaction of (S)-2-(2-Methoxyphenyl)propanoic acid(cas: 81616-80-0).Electric Literature of 81616-80-0

The Article related to alpha branched carboxylic acid catalytic asym protonation deracemization, enantioselective catalytic protonation bissilyl ketene acetal, brønsted acids, bis-silyl ketene acetals, deracemization, deuteration, disulfonimide, protonation and other aspects.Electric Literature of 81616-80-0

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Xie, Jialin; Guo, Zhonglin; Huang, Yuanqiong; Qu, Yi; Song, Hongjian; Song, Haibin; Liu, Yuxiu; Wang, Qingmin published an article in 2019, the title of the article was One-Pot Copper-Catalyzed Cascade Bicyclization Strategy for Synthesis of 2-(1H-Indol-1-yl)-4,5-dihydrothiazoles and 2-(1H-Indol-1-yl)thiazol-5-yl Aryl Ketones with Molecular Oxygen as an Oxygen Source.Reference of 2-((4-Methoxyphenyl)ethynyl)aniline And the article contains the following content:

An atom-economical method for synthesizing N-heterocyclic indoles from readily available o-alkynylphenyl isothiocyanates and propargylamine derivatives is reported. This method involves a copper-catalyzed cascade bicyclization process consisting of an intramol. 5-exo-dig hydrothiolation reaction and an intramol. hydroamination reaction and, depending on whether or not mol. oxygen is present, selectively affords Z-isomers of 2-(1H-indol-1-yl)-4,5-dihydrothiazoles, e.g., I (X-rays single crystal structure shown), or 2-(1H-indol-1-yl)thiazol-5-yl aryl ketones in satisfactory yields. Mechanistic studies indicate that mol. oxygen acts as the oxygen source for the ketone moiety in the products. The experimental process involved the reaction of 2-((4-Methoxyphenyl)ethynyl)aniline(cas: 157869-15-3).Reference of 2-((4-Methoxyphenyl)ethynyl)aniline

The Article related to alkynylphenyl isothiocyanate propargylamine cascade bicyclization copper, indolyl dihydrothiazole preparation mol crystal structure, aryl ketone indolylthiazolyl preparation mol crystal structure, copper cascade bicyclization catalyst and other aspects.Reference of 2-((4-Methoxyphenyl)ethynyl)aniline

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On March 1, 2022, Dalai, Pallaba Ganjan; Palit, Kuntal; Panda, Niranjan published an article.Synthetic Route of 93-04-9 The title of the article was Generation of Dimethyl Sulfoxide Coordinated Thermally Stable Halogen Cation Pools for C-H Halogenation. And the article contained the following:

A method to generate halogen cation pools from the reaction of 1,2-dihaloethanes (hal=Br, I) and DMSO (DMSO) for C-H halogenation of arenes and heteroarenes was reported. The initial reaction of DMSO and 1,2-dihaloethane generates the sulfur ylide, which undergoes pyrolytic elimination of ethylene by affording halonium ions. These ions were accumulated and stabilized by DMSO through coordination by forming halogen cation pools for the halogenation reaction. This protocol was selective for electrophilic monohalogenation of arenes at room temperature; however, polyhalogenated products were formed by raising the reaction temperature Late-stage halogenation of heteroarenes and some commonly marketed drugs signifies the synthetic utility of this protocol in pharmaceutical chem. Unlike the classical methods, the in-situ generated electrophilic bromonium ion was further exploited for the direct synthesis of α-diketones from the alkenes under base-free conditions. The experimental process involved the reaction of 2-Methoxynaphthalene(cas: 93-04-9).Synthetic Route of 93-04-9

The Article related to arene dmso coordinated halogen halogenation, haloarene preparation, alkene dmso coordinated bromide halogenation, dibromoalkane preparation, diketone preparation, enamide dmso coordinated bromide intramol cyclization, oxazole preparation and other aspects.Synthetic Route of 93-04-9

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Hernandez-Vazquez, Eduardo; Miranda, Luis D. published an article in 2016, the title of the article was Practical synthesis and cytotoxic evaluation of the pyrazino[1,2-b]-isoquinoline ring system.Electric Literature of 887581-09-1 And the article contains the following content:

A practical three-step protocol for the synthesis of pyrazino[1,2-b]isoquinolines I [R1 = H, 4-Me, 5-MeO, 5-F, etc.; R2 = t-Bu, cyclohexyl, 2,6-diMeC6H3, benzyl, etc.] was reported. This approach included a one-pot parallel cyclization/cyclization parallel process followed by a non-common 6-endo Heck cyclization that transformed previously constructed Ugi adducts into diversely decorated tricyclic systems. Compounds bearing a t-Bu or 2,6-dimethylphenyl substituent showed significant cytotoxic activity. The most active analog I (R1 = CH2O2; R2 = 2,6-diMeC6H3) showed significant activity against HCT-15 and K562 (IC50 = 41.8 ± 3.3 and 57.7 ± 2.1 μM, resp.) with no cytotoxicity against human gingival fibroblasts. The experimental process involved the reaction of (2-Bromo-5-methoxyphenyl)methanamine(cas: 887581-09-1).Electric Literature of 887581-09-1

The Article related to benzylamine isocyanide benzoyloxy acetaldehyde chloroacetic acid ugi reaction, bromo chloroacetylamiono oxopropylamino benzoate preparation heck reaction, pyrazinoisoquinoline preparation antitumor activity structure activity relationship and other aspects.Electric Literature of 887581-09-1

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Yu, Liu-Zhu; Wei, Yin; Shi, Min published an article in 2017, the title of the article was Copper-catalyzed trifluoromethylazidation and rearrangement of aniline-linked 1,7-enynes: access to CF3-substituted azaspirocyclic dihydroquinolin-2-ones and furoindolines.Electric Literature of 157869-15-3 And the article contains the following content:

A set of reactions involving copper-catalyzed trifluoromethylazidation and then rearrangement of aniline-linked 1,7-enynes with the relatively poorly reactive Togni reagent and TMSN3 was developed, and provided facile access to structurally diverse and useful CF3-substituted azaspirocyclic dihydroquinolin-2-ones I [R1 = H, 4-Cl, 4-CN, etc.; R2 = Ph, 4-ClC6H4, 2-naphthyl, etc.; R3 = Ms, Bn, Ts, etc.; R4 = Me, Ph] bearing two adjacent quaternary carbon centers. These products were also obtained on a large scale. Moreover, the obtained products were further transformed into a range of synthetically valuable furoindolines bearing three consecutive quaternary carbon centers after reduction by NaBH4. Also, the delivery of multi-functionalized aziridines as a result of alcoholysis and LiAlH4-reduction of corresponding dihydroquinolin-2-ones I [R1 = H, R2 = Ph, R3 = Ts, R4 = Me] demonstrated the synthetic value of this newly developed protocol. The experimental process involved the reaction of 2-((4-Methoxyphenyl)ethynyl)aniline(cas: 157869-15-3).Electric Literature of 157869-15-3

The Article related to arylethynyl phenyl acrylamide copper catalyst regioselective trifluoromethylaziridination rearrangement, trifluromethyl azaspirocyclic dihydroquinolinone diastereoselective preparation sodium borohydride reduction, furoindoline preparation and other aspects.Electric Literature of 157869-15-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem