Month: October 2022

On March 6, 2020, Ling, Fei; Song, Dingguo; Chen, Linlin; Liu, Tao; Yu, Mengyao; Ma, Yan; Xiao, Lian; Xu, Min; Zhong, Weihui published an article.SDS of cas: 157869-15-3 The title of the article was Syntheses of N-Alkyl 2-Arylindoles from Saturated Ketones and 2-Arylethynylanilines via Cu-Catalyzed Sequential Dehydrogenation/aza-Michael Addition/Annulation Cascade. And the article contained the following:

A Cu-catalyzed and 4-OH-TEMPO-mediated sequential dehydrogenation/aza-Michael addition/annulation cascade reaction for the construction of N-alkyl 2-arylindoles I (R = H, 2-F, 3-OMe, 4-Cl, etc.; R1 = H, F, Cl, OMe, C(O)OCH3; R2 = H; R3 = H, Cl; R2R3 = -CH=CHCH=CH-; R4 = Ph, Me, pyridin-3-yl, thiophen-2-yl, etc.) and from facilely available saturated ketones R4C(O)CH2CH3 and 2-arylethynylanilines 2-RC6H4CC-4-R1-5-R2-6-R3C6HNH2 was described. This reaction shows high regioselectivity and tolerates a variety of functional groups. Moreover, 3-alkyl-substituted indoles II (R5 = Bu, tert-Bu, pentyl, propyl) can also be obtained when using 2-alkylethynylanilines 2-R5CCC6H4NH2 as starting materials. The experimental process involved the reaction of 2-((4-Methoxyphenyl)ethynyl)aniline(cas: 157869-15-3).SDS of cas: 157869-15-3

The Article related to alkyl arylindole preparation regioselective, arylethynylaniline preparation ketone dehydrogenation michael cyclization tandem copper catalyst, alkylethynylaniline preparation ketone dehydrogenation michael cyclization tandem copper catalyst and other aspects.SDS of cas: 157869-15-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On April 27, 2020, Zhang, Dao; Yu, Jueqin published an article.Safety of 2-Methoxynaphthalene The title of the article was Fine Tuning of Chiral Bis(N-heterocyclic carbene) Palladium Catalysts for Asymmetric Suzuki-Miyaura Cross-Coupling Reactions: Exploring the Ligand Modification. And the article contained the following:

Novel chiral N,N’-bisaryl bis(NHC) ligand precursors H2[(S)-2]Cl2 on a spiro scaffold and H2[(S)-3b-g]Cl2 with a binaphthyl linkage were rationally designed and their cyclometalated cis-chelated NHC Pd complexes (S)-5, (S)-6, and (S)-7b-g were synthesized and fully characterized. Complexes 6 and 7b were further confirmed by x-ray single-crystal anal. Both complexes adopted a slightly distorted square planar geometry around the Pd(II) center. The structure of 6 consists of a rare dimeric arrangement incorporating two Pd(II) centers bonded through a short metal-metal bond (2.853(2) Å), indicating a PdII-PdII intramol. interaction (<3.00 Å). These N,N'-bisaryl-bis(NHC)-Pd complexes together with N,N'-bisalkyl analogs {[(S)-1a-d]PdX2} (X = I, (S)-4a; X = Br, (S)-4b-d) were used in the asym. aryl-aryl cross-coupling reactions of arylboronic acids and aryl halides. The enantioselectivity of the biaryl products was greatly improved within 24 h (up to 74% ee) when complexes 7a-g were used as catalysts. For these types of bis(NHC) Pd catalysts the structural characters of the chiral scaffolds play a decisive role in the enantioselectivities of cross-coupling reactions. The experimental process involved the reaction of 2-Methoxynaphthalene(cas: 93-04-9).Safety of 2-Methoxynaphthalene

The Article related to spirobiindenediylbisdiamine palladacycle carbene complex preparation catalyst suzuki reaction, crystal structure spirobiindenediylbisdiamine palladacycle carbene complex, mol structure spirobiindenediylbisdiamine palladacycle carbene complex and other aspects.Safety of 2-Methoxynaphthalene

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On June 30, 2014, Soleiman-Beigi, Mohammad; Kazemi, Mosstafa; Aryan, Reza; Shiri, Lotfi published an article.Quality Control of Benzyl(4-bromophenyl)sulfane The title of the article was TBAOH mediated: An efficient and simple procedure for alkylation of alcohols, phenols and thiols under neat aqueous conditions. And the article contained the following:

Aqueous Bu4NOH (TBAOH) solution was used as a green reaction medium and efficient catalyst for the O-alkylation of alcs. and phenols as well as S-alkylation of thiols under a novel, mild, and convenient procedure. Herein, TBAOH was used as a strong base, medium of reaction, and phase transfer reagent. The experimental process involved the reaction of Benzyl(4-bromophenyl)sulfane(cas: 53136-21-3).Quality Control of Benzyl(4-bromophenyl)sulfane

The Article related to alc alkyl halide alkylation butylammonium hydroxide water, phenol alkyl halide alkylation butylammonium hydroxide water, thiol alkyl halide alkylation butylammonium hydroxide water, ether preparation green chem, thioether preparation green chem and other aspects.Quality Control of Benzyl(4-bromophenyl)sulfane

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On December 31, 2022, Ji, Peng; Davies, Cassondra C.; Gao, Feng; Chen, Jing; Meng, Xiang; Houk, Kendall N.; Chen, Shuming; Wang, Wei published an article.Computed Properties of 93-04-9 The title of the article was Selective skeletal editing of polycyclic arenes using organophotoredox dearomative functionalization. And the article contained the following:

A general organophotoredox approach for the chemo- and regioselective dearomatization of structurally diverse polycyclic aromatics, including quinolines, isoquinolines, quinoxalines, naphthalenes, anthracenes and phenanthrenes was described. The success of the method for chemoselective oxidative rupture of aromatic moieties relies on precise manipulation of the electronic nature of the fused polycyclic arenes. Mechanistic studies show that the addition of a hydrogen atom transfer (HAT) agent helps favor the dearomatization pathway over the more thermodynamically downhill aromatization pathway. This strategy was applied to rapid synthesis of biol. valued targets and late-stage skeletal remodeling en route to complex structures. The experimental process involved the reaction of 2-Methoxynaphthalene(cas: 93-04-9).Computed Properties of 93-04-9

The Article related to arene azole acridinium photocatalyst chemoselective regioselective dearomatization, azolyl dihydroarene preparation, carboxylic acid arene acridinium photocatalyst chemoselective regioselective dearomatization, dihydroaryl alkanoate preparation and other aspects.Computed Properties of 93-04-9

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Zhang, He; Cao, Tongxiang; Luo, Hejiang; Chen, Lianfen; Zhu, Shifa published an article in 2019, the title of the article was Enynone-enabled migratory insertion and Schmittel cyclization cascade for the synthesis of furan-fused fluorenes.Category: ethers-buliding-blocks And the article contains the following content:

A new method for the synthesis of furan-/benzo-fused fluorenes through copper(I)-catalyzed coupling of conjugated enynones or α-diazocarbonyl compounds with dialkynylbenzenes were developed. This process included 5-exo-dig cyclization, carbene migratory insertion, Schmittel cyclization and 1,5-H transfer. The obvious advantages of wide substrate scopes, mild reaction conditions and high atom efficiency make this system highly appealing for the construction of six-substituted benzofuran-embedded fluorenes in a one-pot manner. The experimental process involved the reaction of 2-((4-Methoxyphenyl)ethynyl)aniline(cas: 157869-15-3).Category: ethers-buliding-blocks

The Article related to propynylidene alkane dione dialkynylbenzene preparation copper tandem regioselective cyclization, carbonyl fluorenofuran preparation, diazo phenylacetate dialkynylbenzene preparation copper tandem cyclization, benzofluorene carboxylate preparation and other aspects.Category: ethers-buliding-blocks

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On April 6, 2004, Neef, C. J.; Ferraris, J. P. published an article.Application of 146370-51-6 The title of the article was MEH-PPV: improved synthetic procedure and molecular weight control. [Erratum to document cited in CA132:308756]. And the article contained the following:

In Table 2 on page 2313, the polydispersity (PD) values for the polymerizations using 1.05 and 2.0% 4-methoxyphenol are listed as 1.52 and 1.14, resp. The correct PD values are 1.14 for 1.0% 4-methoxyphenol and 1.52 for 2.0% 4-methoxyphenol. The corrected table is given. The corrected values show a clear relation between the amount of 4-methoxyphenol and polymerization yield, mol. weights, and PD values. The experimental process involved the reaction of 1-((2-Ethylhexyl)oxy)-4-methoxybenzene(cas: 146370-51-6).Application of 146370-51-6

The Article related to erratum polyphenylenevinylene methoxy ethylhexyloxy conjugated polymer preparation, chain transfer agent anthracene polyphenylenevinylene preparation erratum, nucleophile methoxyphenol polyphenylenevinylene anionic polymerization preparation erratum and other aspects.Application of 146370-51-6

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On July 23, 2009, Hartz, Richard A.; Ahuja, Vijay T.; Arvanitis, Argyrios G.; Rafalski, Maria; Yue, Eddy W.; Denhart, Derek J.; Schmitz, William D.; Ditta, Jonathan L.; Deskus, Jeffrey A.; Brenner, Allison B.; Hobbs, Frank W.; Payne, Joseph; Lelas, Snjezana; Li, Yu-Wen; Molski, Thaddeus F.; Mattson, Gail K.; Peng, Yong; Wong, Harvey; Grace, James E.; Lentz, Kimberley A.; Qian-Cutrone, Jingfang; Zhuo, Xiaoliang; Shu, Yue-Zhong; Lodge, Nicholas J.; Zaczek, Robert; Combs, Andrew P.; Olson, Richard E.; Bronson, Joanne J.; Mattson, Ronald J.; Macor, John E. published an article.Quality Control of (S)-1-Methoxypropan-2-amine hydrochloride The title of the article was Synthesis, Structure-Activity Relationships, and In Vivo Evaluation of N3-Phenylpyrazinones as Novel Corticotropin-Releasing Factor-1 (CRF1) Receptor Antagonists. And the article contained the following:

Evidence suggested that corticotropin-releasing factor-1 (CRF1) receptor antagonists may offer therapeutic potential for the treatment of diseases associated with elevated levels of CRF such as anxiety and depression. A pyrazinone-based chemotype of CRF1 receptor antagonists was discovered. Structure-activity relationship studies led to the identification of numerous potent analogs including I, a highly potent and selective CRF1 receptor antagonist with an IC50 value of 0.26 nM. The pharmacokinetic properties of I were assessed in rats and Cynomolgus monkeys. Compound I was efficacious in the defensive withdrawal test (an animal model of anxiety) in rats. The synthesis, structure-activity relationships and in vivo properties of compounds, e.g., I, within the pyrazinone chemotype were described. The experimental process involved the reaction of (S)-1-Methoxypropan-2-amine hydrochloride(cas: 1162054-86-5).Quality Control of (S)-1-Methoxypropan-2-amine hydrochloride

The Article related to pyrazinone arylamino asym preparation corticotropin releasing factor receptor antagonist, arylamino pyrazinone corticotropin releasing factor receptor antagonist sar activity, anxiolytic agent pyrazinone arylamino crf receptor antagonist sar activity and other aspects.Quality Control of (S)-1-Methoxypropan-2-amine hydrochloride

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On September 6, 2021, Quan, Qinzhi; Ma, Mingyu; Wang, Zongtao; Gu, Yu; Chen, Mao published an article.Computed Properties of 929-37-3 The title of the article was Visible-Light-Enabled Organocatalyzed Controlled Alternating Terpolymerization of Perfluorinated Vinyl Ethers. And the article contained the following:

Polymerizations of perfluorinated vinyl ethers (PFVEs) provide an important category of fluoropolymers that have received considerable interests in applications. In this work, we report the development of an organocatalyzed controlled radical alternating terpolymn. of PFVEs and vinyl ethers (VEs) under visible-light irradiation This method not only enables the synthesis of a broad scope of fluorinated terpolymers of low dispersities and high chain-end fidelity, facilitating tuning the chem. compositions by rationally choosing the type and/or ratio of comonomers, but also allows temporal control of chain-growth, as well as the preparation of a variety of novel fluorinated block copolymers. To showcase the versatility of this method, fluorinated alternating terpolymers were synthesized and customized to simultaneously display a variety of desirable properties for solid polymer electrolyte design, creating new opportunities in high-performance energy storage devices. The experimental process involved the reaction of 2-(2-(Vinyloxy)ethoxy)ethanol(cas: 929-37-3).Computed Properties of 929-37-3

The Article related to visible light organocatalyst radical alternating terpolymn perfluorinated vinyl ether, fluoropolymer alternating copolymer block electrolyte solid electrolyte, controlled radical polymerization, fluorine, photocatalysis, synthetic methods, terpolymer and other aspects.Computed Properties of 929-37-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Minoda, Masahiko; Otsubo, Tomomi; Yamamoto, Yohei; Zhao, Jianxin; Honda, Yoshitomo; Tanaka, Tomonari; Motoyanagi, Jin published an article in 2019, the title of the article was The First Synthesis of Periodic and Alternating Glycopolymers by RAFT Polymerization: A Novel Synthetic Pathway for Glycosaminoglycan Mimics.Electric Literature of 929-37-3 And the article contains the following content:

This study concerned the controlled synthesis of periodic glycopolymers by reversible addition-fragmentation chain transfer (RAFT) copolymerization To this end, maltose- and lactose-substituted vinyl ethers (MalVE and LacVE, resp.) and maltose-substituted maleimide (MalMI) were newly synthesized. RAFT copolymerization of MalVE and Et maleimide (EtMI) (monomer feed ratio: MalVE:EtMI = 1:1) afforded periodic glycopolymers (poly(MalVE-co-EtMI)) consisting of major parts of alternating structure (-(MalVE-EtMI)n-) and a small part of consecutive sequences of EtMI (-EtMI-EtMI-). Occurrence of the latter sequences was caused by the homopolymerizability of maleimide under the present polymerization condition, and the formation of the consecutive sequences of EtMI was successfully suppressed by varying the monomer feed ratio. RAFT copolymerization of LacVE and EtMI was also found to proceed and similarly yielded periodic glycopolymers (poly(LacVE-co-EtMI)). Moreover, RAFT copolymerization of LacVE and MalMI (monomer feed ratio: LacVE:MalMI = 1:1) was performed to give copolymers (poly(LacVE-co-MalMI)) having composition ratio of LacVE/MalMI ≈ 36/64. The resultant periodic glycopolymers poly(MalVE-co-EtMI) and poly(LacVE-co-EtMI) were subjected to lectin binding assay using Con A and peanut agglutinin, exhibiting the glycocluster effect. Moreover, these glycopolymers obtained from the copolymerization of VE and MI were found to be non-cytotoxic. The experimental process involved the reaction of 2-(2-(Vinyloxy)ethoxy)ethanol(cas: 929-37-3).Electric Literature of 929-37-3

The Article related to glycosaminoglycan mimics glycopolymer raft polymerization, cuaac click reaction, raft copolymerization, alternating glycopolymer, carbohydrate-substituted maleimide, carbohydrate-substituted vinyl ether, glycosaminoglycan mimics, periodic glycopolymer and other aspects.Electric Literature of 929-37-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Taglang, Celine; Martinez-Prieto, Luis Miguel; del Rosal, Iker; Maron, Laurent; Poteau, Romuald; Philippot, Karine; Chaudret, Bruno; Perato, Serge; Sam Lone, Anais; Puente, Celine; Dugave, Christophe; Rousseau, Bernard; Pieters, Gregory published an article in 2015, the title of the article was Enantiospecific C-H activation using ruthenium nanocatalysts.Safety of (S)-1-Methoxypropan-2-amine hydrochloride And the article contains the following content:

The activation of C-H bonds has revolutionized modern synthetic chem. However, no general strategy for enantiospecific C-H activation has been developed to date. We herein report an enantiospecific C-H activation reaction followed by deuterium incorporation at stereogenic centers. Mechanistic studies suggest that the selectivity for the α-position of the directing heteroatom results from a four-membered dimetallacycle as the key intermediate. This work paves the way to novel mol. chem. on nanoparticles. The experimental process involved the reaction of (S)-1-Methoxypropan-2-amine hydrochloride(cas: 1162054-86-5).Safety of (S)-1-Methoxypropan-2-amine hydrochloride

The Article related to enantiospecific ch activation reaction deuterium incorporation ruthenium nanocatalyst nanoparticle, langmuir hinshelwood deuteration mechanism ab initio dimetallacycle, ch activation, ab initio calculations, deuterium, isotopic labeling, nanoparticles and other aspects.Safety of (S)-1-Methoxypropan-2-amine hydrochloride

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem