Month: October 2022

On September 1, 2000, Park, Lee Soon; Han, Yoon Soo; Hwang, Jin Sang; Kim, Sang Dae published an article.Application of 146370-51-6 The title of the article was Synthesis of conjugated polymers containing anthracene moiety and their electro-optical properties. And the article contained the following:

Both fully conjugated polymer poly[2-methoxy-5-(2-ethylhexyloxy)-1,4-phenylene vinylene-alt-9,10-anthrylene vinylene] [poly(MEHPV-AV)] and conjugated/non-conjugated block copolymers poly(alkanedioxy-2-methoxy-1,4-phenylene-1,2-ethenylene-9,10-anthrylene-1,2-ethenylene-3-methoxy-1,4-phenylene)[poly(BFMPx-AV), (x = 4, 8, and 12)] were synthesized by Horner-Emmons reaction utilizing potassium tert-butoxide. Of these synthesized polymers poly(BFMP4-AV) and poly(BFMP8-AV), which has four and six methylene groups as solubility spacer in the main chain exhibited liquid crystalline to isotropic transition in addition to the two first order transitions. Light-emitting diode (LED)s made from the organic solvent soluble poly(BFMP12-AV) as emitting layer showed blue shift in the emission spectrum compared to the one made from fully conjugated poly(MEHPV-AV). Although poly(BFMP12-AV) had higher barrier to the electron injection from cathode than poly(MEHPV-AV), the luminance efficiency of LED made from poly(BFMP12-AV) was about 25 times higher than the one made from poly(MEHPV-AV), which had fully conjugated structure. LEDs fabricated by both poly(BFMP12-AV) and poly(MEHPV-AV) exhibited Stoke’s shift in the range of 155 to 168 nm from the absorption maximum due to the excimer formation between the ground and excited state anthracene groups. The experimental process involved the reaction of 1-((2-Ethylhexyl)oxy)-4-methoxybenzene(cas: 146370-51-6).Application of 146370-51-6

The Article related to anthracene containing aromatic dialdehyde diphosphonate polymerization potassium tertbutoxide catalyst, liquid crystalline anthracene containing polyphenylenevinylene synthesis, electroluminescence light emitting diode anthracene containing partially conjugated polymer and other aspects.Application of 146370-51-6

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On November 11, 2010, Kanzawa, Keizo; Kawaguchi, Kenichi; Matsumoto, Shunichiro; Nomura, Takaho; Susumu, Takashi; Seo, Tatsushi published a patent.Category: ethers-buliding-blocks The title of the patent was Preparation of azolecarboxamide compounds or their salts as antagonists of neurotrophic factor receptors (TrkA). And the patent contained the following:

N-Ph, N-pyridyl, or N-pyrazolylthiazole-4-carboxamides and oxazole-4-carboxamides the title compounds [I; X = S, O; R1 = Q, Q1, 3-methoxymethylmorpholin-4-yl, NR1cR1d; R1a = H, HO, lower alkoxy, cycloalkyloxy; R1b = H, lower alkoxy; R1c = H, lower alkyl; R1d = lower alkyl optionally substituted by lower alkoxy; R2 = H, lower alkyl optionally substituted by F or lower alkoxy, 3-tetrahydrofuryl, 4-tetrahydropyranyl; A = R2, Q3, Q4; R3 = CO2Me, Q5, CH2R3B; R00 = lower alkyl; R3B = OH, lower alkoxy, Q6, Q7, Q8, Q10, hexahydro-1H-pyrrolo[1,2-a]pyrazin-2-yl; R0 = H, lower alkyl; m = 1,2; Ra = H, F, Ph, lower alkoxy-lower alkyl; R4 = lower alkyl optionally substituted by lower alkoxy] or salts thereof are prepared These compounds possess potent inhibitory activity against neurotrophic factor receptors (TrkA) and provide therapeutic and/or preventive agents for various lower urinary tract diseases accompanied by lower urinary tract pains such as interstitial cystitis and chronic prostatitis, urinary frequency accompanied by various lower urinary tract diseases including overactive bladder, feeling of micturition urgency, urinary incontinence, and various diseases accompanied by pain based on the TrkA-inhibitory activity. Thus, 67 mg (8aR)-octahydropyrrolo[1,2-a]pyrazine and 216 mg Cs2CO3 were added to a mixture of 200 mg N-[4-(chloromethyl)-2-[(2-methoxyethyl)carbamoyl]phenyl]-2-((3S)-3-methoxypyrrolidin-1-yl)-1,3-thiazole-4-carboxamide and 2 mL DMF and the resulting mixture was stirred at room temperature for 18 h to give, after workup and silica gel chromatog. and salt formation with fumaric acid, N-[4-[((8aR)-hexahydro-1H-pyrrolo[1,2-a]pyrazin-2-yl)methyl]-2-[(2-methoxyethyl)carbamoyl]phenyl]-2-((3S)-3-methoxypyrrolidin-1-yl)-1,3-thiazole-4-carboxamide (II) difumarate. II difumarate and N-phenylthiazole-4-carboxamide derivative (III) in vitro inhibited the NGF-induced increase in cellular calcium ion in HEK293 cells stably expressing human trkA receptor with IC50 of 19 and 16 nM, resp. The experimental process involved the reaction of (S)-1-Methoxypropan-2-amine hydrochloride(cas: 1162054-86-5).Category: ethers-buliding-blocks

The Article related to azolecarboxamide preparation antagonist neurotrophic factor receptor trka, thiazolecarboxamide oxazolecarboxamide preparation antagonist neurotrophic factor receptor trka, pain urinary tract disease treatment prevention thiazolecarboxamide oxazolecarboxamide preparation and other aspects.Category: ethers-buliding-blocks

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On December 31, 2021, Wang, Weijin; Li, Xinyao; Yang, Xiaoxue; Ai, Lingsheng; Gong, Zhiwen; Jiao, Ning; Song, Song published an article.Application In Synthesis of 2-Methoxynaphthalene The title of the article was Oxoammonium salts are catalysing efficient and selective halogenation of olefins, alkynes and aromatics. And the article contained the following:

Herein, TEMPO (2,2,6,6-tetramethylpiperidine nitroxide) and its derivatives are disclosed as active catalysts for electrophilic halogenation of olefins e.., prop-1-en-1-ylbenzene, alkynes R1CCR2 (R1 = octyl, Ph; R2 = H, Me, n-Bu, Ph), and aromatics R3H (R3 = 3-(carboxymethyl)-4-methoxybenzen-1-yl, 2-[ethoxy(oxo)methane]-1H-indol-3-yl, 5-phenylthiophen-2-yl, etc.). These catalysts are stable, readily available, and reactive enough to activate haleniums including Br+, I+ and even Cl+ reagents. This catalytic system is applicable to various halogenations including haloarylation of olefins or dibromination of alkynes, which were rarely realized in previous Lewis base catalysis or Lewis acid catalysis. The high catalytic ability is attributed to a synergistic activation model of electrophilic halogenating reagents, where the carbonyl group and the halogen atom are both activated by present TEMPO catalysis. The experimental process involved the reaction of 2-Methoxynaphthalene(cas: 93-04-9).Application In Synthesis of 2-Methoxynaphthalene

The Article related to dibromoolefin preparation, olefin halogenation tetramethylpiperidine nitroxide catalyst, dibromoalkyne preparation, alkyne halogenation tetramethylpiperidine nitroxide catalyst, haloarene preparation regioselective, aromatic halogenation tetramethylpiperidine nitroxide catalyst and other aspects.Application In Synthesis of 2-Methoxynaphthalene

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ajarul, Sk; Kayet, Anirban; Pati, Tanmay K.; Maiti, Dilip K. published an article in 2020, the title of the article was A competitive and highly selective 7-, 6- and 5-annulation with 1,3-migration through C-H and N-H – alkyne coupling.COA of Formula: C15H13NO And the article contains the following content:

A highly competitive and selective C-C and N-C cross-coupled 7-, 6- and 5-annulation was described utilizing 2-ethynylanilides to afford functionalized 1H-benzo[b]azepin-2(5H)-ones I [R1 = Me, Et, Ph, 4-O2NC6H4; R2 = Ph, 4-MeC6H4, 4-FC6H4, etc.; R3 = H, 7-Me, 7-Cl, 8-Cl], 2-quinolinones II [R4 = Me, Et, Ph, etc.; R5 = H, Ph, 4-O2NC6H4, etc.; R6 = H, 6-Me, 7-Cl, etc.] and 3-acylindoles III [R7 = Me, Et, Ph, 4-MeC6H4; R8 = Ph, 4-MeOC6H4, 4-BrC6H4; R9 = H, Me, Cl, Br] resp., with high yields and operational simplicity. Zinc chloride was found to be the smart catalyst for 7- and 5-annulation with 1,3-migration through C-H and N-H functionalization, resp., whereas mol. iodine performed the C-H functionalized 6-annulation with a non-conventional 1,3 H-shift. The mechanism was investigated by intermediate trapping, control and labeling experiments The experimental process involved the reaction of 2-((4-Methoxyphenyl)ethynyl)aniline(cas: 157869-15-3).COA of Formula: C15H13NO

The Article related to benzoazepinone selective preparation, alkynyl aniline dicarbonyl compound annulation zinc catalyst, quinolinone selective preparation, aniline dicarbonyl compound alkynyl annulation iodine catalyst, acylindole selective preparation, acyl alkynyl aniline annulation zinc catalyst and other aspects.COA of Formula: C15H13NO

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On January 1, 2021, Hao, Guiyun; Li, Hao; Yang, Fei; Dong, Duoling; Li, Zezhong; Ding, Yingying; Pan, Wei; Wang, Enduo; Liu, Rujuan; Zhou, Huchen published an article.Computed Properties of 53136-21-3 The title of the article was Discovery of benzhydrol-oxaborole derivatives as Streptococcus pneumoniae leucyl-tRNA synthetase inhibitors. And the article contained the following:

1-Hydroxy-2,1-benzoxaboroles I were prepared and examined for inhibitory activity against leucyl-tRNA synthetase (LeuRS) and antibacterial activity against multidrug-resistant S. pneumoniae pathogen. Pneumonia caused by bacterium S. pneumoniae is a severe acute respiratory infectious disease with high morbidity and mortality, especially for children and immunity-compromised patients. The emergence of multidrug-resistant S. pneumoniae also presents a challenge to human health. Leucyl-tRNA synthetase (LeuRS) catalyzes the attachment of L-leucine to tRNALeu, which plays an essential role in protein translation and is considered an attractive antimicrobial drug target. In the present work, benzhydrol-oxaborole hybrid compounds were designed and synthesized as inhibitors of S. pneumoniae LeuRS. Exploration of the Ph ring near Lysine 389 eventually yielded compounds 46 and 54 with submicromolar inhibitory potency. The co-crystal of compound 54 in the editing domain pocket of SpLeuRS was obtained and confirmed the formation of an addnl. hydrogen bond between the carbonyl of 54 and Lysine 389. It also showed anti-pneumococcal activity in vitro. The structure-activity relationship was discussed. This work will provide an essential foundation for the further development of anti-pneumococcal agents by targeting LeuRS. The experimental process involved the reaction of Benzyl(4-bromophenyl)sulfane(cas: 53136-21-3).Computed Properties of 53136-21-3

The Article related to benzoxaborole boronate preparation leucyl trna synthetase inhibitor antibacterial agent, streptococcus pneumoniae leucyl trna synthetase inhibitor antibacterial agent preparation, anti-pneumonia, benzhydrol-oxaborole, s. pneumonia leurs (spleurs), structure-activity relationship and other aspects.Computed Properties of 53136-21-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On May 11, 2020, Gevorgyan, Ashot; Hopmann, Kathrin H.; Bayer, Annette published an article.Category: ethers-buliding-blocks The title of the article was Formal C-H Carboxylation of Unactivated Arenes. And the article contained the following:

A formal C-H carboxylation of unactivated arenes e.g., I using CO2 in green solvents is described. The present strategy combines a sterically controlled Ir-catalyzed C-H borylation followed by a Cu-catalyzed carboxylation of the in situ generated organoboronates. The reaction is highly regioselective for the C-H carboxylation of unactivated arenes e.g., I (1,3-disubstituted and 1,2,3-trisubstituted benzenes, 1,2- or 1,4-sym. substituted benzenes, fluorinated benzenes and different heterocycles). The developed methodol. was applied to the late-stage C-H carboxylation of com. drugs and ligands. The experimental process involved the reaction of 1,4-Dimethoxybenzene(cas: 150-78-7).Category: ethers-buliding-blocks

The Article related to carboxyl unactivated arene preparation green chem regioselective, unactivated arene carbon dioxide carboxylation copper catalyst, carbon dioxide aryl boronate carboxylation copper catalyst, c−h activation, carbon dioxide, carboxylation, green solvent, late-stage functionalization and other aspects.Category: ethers-buliding-blocks

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On May 11, 2020, Gevorgyan, Ashot; Hopmann, Kathrin H.; Bayer, Annette published an article.Reference of 1,2-Dimethoxybenzene The title of the article was Formal C-H Carboxylation of Unactivated Arenes. And the article contained the following:

A formal C-H carboxylation of unactivated arenes e.g., I using CO2 in green solvents is described. The present strategy combines a sterically controlled Ir-catalyzed C-H borylation followed by a Cu-catalyzed carboxylation of the in situ generated organoboronates. The reaction is highly regioselective for the C-H carboxylation of unactivated arenes e.g., I (1,3-disubstituted and 1,2,3-trisubstituted benzenes, 1,2- or 1,4-sym. substituted benzenes, fluorinated benzenes and different heterocycles). The developed methodol. was applied to the late-stage C-H carboxylation of com. drugs and ligands. The experimental process involved the reaction of 1,2-Dimethoxybenzene(cas: 91-16-7).Reference of 1,2-Dimethoxybenzene

The Article related to carboxyl unactivated arene preparation green chem regioselective, unactivated arene carbon dioxide carboxylation copper catalyst, carbon dioxide aryl boronate carboxylation copper catalyst, c−h activation, carbon dioxide, carboxylation, green solvent, late-stage functionalization and other aspects.Reference of 1,2-Dimethoxybenzene

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Vonnegut, Chris L.; Shonkwiler, Airlia M.; Khalifa, Muhammad M.; Zakharov, Lev N.; Johnson, Darren W.; Haley, Michael M. published an article in 2015, the title of the article was Facile Synthesis and Properties of 2-λ5-Phosphaquinolines and 2-λ5-Phosphaquinolin-2-ones.HPLC of Formula: 157869-15-3 And the article contains the following content:

Treatment of 2-ethynylanilines with P(OPh)3 gives either 2,2-diphenoxy-2-λ5-phosphaquinolines or 2-phenoxy-2-λ5-phosphaquinolin-2-ones under transition-metal-free conditions. This reaction offers access to an underexplored heterocycle, which opens up the study of the fundamental nature of the N:PV double bond and its potential for delocalization within a cyclic π-electron system. This heterocycle can serve as a carbostyril mimic, with application as a bioisostere for pharmaceuticals based on the 2-quinolinone scaffold. It also holds promise as a new fluorophore, since initial screening reveals quantum yields upwards of 40 %, Stokes shifts of 50-150 nm, and emission wavelengths of 380-540 nm. The phosphaquinolin-2-ones possess one of the strongest solution-state dimerization constants for a D-A system (130 Μ-1) owing to the close proximity of a strong acceptor (P:O) and a strong donor (phosphonamidate N-H), which suggests that they might hold promise as new H bonding hosts for optoelectronic sensing. The experimental process involved the reaction of 2-((4-Methoxyphenyl)ethynyl)aniline(cas: 157869-15-3).HPLC of Formula: 157869-15-3

The Article related to crystal structure optimized phosphaquinoline phosphaquinolinone preparation fluorescence dimerization, mol structure optimized phosphaquinoline phosphaquinolinone preparation fluorescence dimerization, alkynes, dimerization, fluorescent probes, phosphazenes, phosphorus heterocycles and other aspects.HPLC of Formula: 157869-15-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On August 22, 2019, Stoessel, Philipp; Auch, Armin published a patent.Category: ethers-buliding-blocks The title of the patent was Iridium complexes with hexadentate tris-cyclometalated arylpyridine ligands as triplet emitters for organic electroluminescent devices. And the patent contained the following:

Iridium complexes with hexadentate 1,3,5-benzenetriyl-bridged tris-cyclometalated arylpyridine ligands, e.g., of the type I (1, X = H, D; Ar = Ph, 4-PhC6H4, 4-PhC6H4C6H4, heterocyclyl; R1 = Me, Ph, tBu, CD3, cyclopenteno, etc.) were prepared by Sonogashira coupling of 1-chloro-3,5-diethynylbenzene with arylpyridine bromides with subsequent hydrogenation or deuteration and Suzuki coupling with appropriate aryl bromides or boronates. Bromination of the complexes in 4-position relative to cyclometalation site with subsequent cyanation or Suzuki coupling afforded modified complexes 1. The complexes 1 were examined for their electroluminescence by constructing test OLED devices according to standard protocol by either vacuum or solution-based processes. The experimental process involved the reaction of 2-(3-Methoxy-4-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(cas: 1417036-28-2).Category: ethers-buliding-blocks

The Article related to iridium cyclometalated arylpyridine hexadentate benzenetriyl bridged complex preparation electroluminescence, suzuki sonogashira coupling cyclometalation preparation iridium hexadentate arylpyridine complex, triplet emitter oled iridium hexadentate cyclometalated arylpyridine complex and other aspects.Category: ethers-buliding-blocks

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On April 28, 2021, Nilova, Aleksandra; Sibbald, Paul A.; Valente, Edward J.; Gonzalez-Montiel, Gisela A.; Richardson, H. Camille; Brown, Kevin S.; Cheong, Paul Ha-Yeon; Stuart, David R. published an article.Synthetic Route of 321-28-8 The title of the article was Regioselective Synthesis of 1,2,3,4-Tetrasubstituted Arenes by Vicinal Functionalization of Arynes Derived from Aryl(Mes)iodonium Salts. And the article contained the following:

Herein, the synthesis of 1,2,3,4-tetrasubstituted benzenoid rings, motifs found in pharmaceutical, agrochem., and natural products, is described. In the past, the regioselective syntheses of such compounds have been a significant challenge. This work reports a method using substituted arynes derived from aryl(Mes)iodonium salts to access a range of densely functionalized 1,2,3,4-tetrasubstituted benzenoid rings. Significantly, it was found that halide substituents are compatible under these conditions, enabling post-synthetic elaboration via palladium-catalyzed coupling. This concise strategy is predicated on two regioselective events: 1) ortho-deprotonation of aryl(Mes)iodonium salts to generate a substituted aryne intermediate, and 2) regioselective trapping of said arynes, thereby improving previously reported reaction conditions to generate arynes at room temperature and in shorter reaction times. D. functional theory (DFT) computations and linear free energy relationship (LFER) anal. suggest the regioselectivity of deprotonation is influenced by both proximal and distal ring substituents on the aryne precursor. A competition experiment further reveals the role of arene substituents on relative reactivity of aryl(Mes)iodoniums as aryne precursors. The experimental process involved the reaction of 1-Fluoro-2-methoxybenzene(cas: 321-28-8).Synthetic Route of 321-28-8

The Article related to tetrasubstituted arene preparation regioselective transition state structure dft, aryl mesyl iodonium tosylate aryne arylation, substituent effect linear free energy relationship regioselectivity aryne formation, arylation, aryne, deprotonation, diaryliodonium salt, hypervalent iodine and other aspects.Synthetic Route of 321-28-8

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem