Month: October 2022

On October 12, 2006, Connolly, Stephen; Linnanen, Tero; Skrinjar, Marco published a patent.Recommanded Product: 66855-92-3 The title of the patent was Preparation of novel diazaspiroalkanes and their use for treatment of CCR8 mediated diseases. And the patent contained the following:

The title compounds I [R = II, III (wherein R2, R3 = NR8C(O)CO2H, O(alkyl)CO2H, alkyl(CO2H), CO2H; R4, R5 = halo, CF3, alkyl; p, q = 0-2; R8 = H, alkyl); R1 = IV, V; R6, R7 = H, OMe, OEt], useful in treating CCR8 mediated diseases such as asthma, COPD and rhinitis, were prepared E.g., a multi-step synthesis of VI, starting from tert-Bu 3,9-diazaspiro[5.5]undecane-3-carboxylate hydrochloride and 2-phenoxybenzaldehyde, was given. VI showed IC50 of 0.643 μM against human recombinant chemokine CCR8 receptor binding. Pharmaceutical compositions containing compounds I and their use in therapy are disclosed. The experimental process involved the reaction of 3-(2-Methoxyphenoxy)benzaldehyde(cas: 66855-92-3).Recommanded Product: 66855-92-3

The Article related to diazaspiroalkane diazaspiroundecane preparation chemokine ccr8 mediated disease treatment, antiasthmatic diazaspiroalkane diazaspiroundecane preparation, chronic obstructive pulmonary disease diazaspiroalkane diazaspiroundecane preparation, rhinitis diazaspiroalkane diazaspiroundecane preparation and other aspects.Recommanded Product: 66855-92-3

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On February 17, 2017, Ali, Wajid; Dahiya, Anjali; Pandey, Ramdhari; Alam, Tipu; Patel, Bhisma K. published an article.Electric Literature of 157869-15-3 The title of the article was Microwave-Assisted Cascade Strategy for the Synthesis of Indolo[2,3-b]quinolines from 2-(Phenylethynyl)anilines and Aryl Isothiocyanates. And the article contained the following:

Indoloquinolines I (R = Ph, 4-MeC6H4, 4-MeOC6H4, 4-FC6H4, 1-naphthyl; R1 = H, Me, F, Br; R2 = H, Me, t-Bu, MeO, Cl, F) were prepared in 59-83% yields by the cyclocondensation of o-(arylalkynyl)anilines 2-(RCC)-4-R1C6H3NH2 (R = Ph, 4-MeC6H4, 4-MeOC6H4, 4-FC6H4, 1-naphthyl; R1 = H, Me, F, Br) with aryl isothiocyanates 4-R2C6H4NCS (R2 = H, Me, t-Bu, MeO, Cl, F) mediated by Ag2CO3 in DMSO under microwave irradiation at 130°. A phenylethynylphenyl Ph thiourea underwent cyclocondensation in the presence of Ag2CO3, while a phenylethynylphenyl Ph carbodiimide underwent cyclization in both the presence of absence of Ag2CO3; Ag2S was formed as a monoclinic acanthite phase from the reaction as characterized by powder X-ray diffraction and energy-dispersive X-ray diffraction. The experimental process involved the reaction of 2-((4-Methoxyphenyl)ethynyl)aniline(cas: 157869-15-3).Electric Literature of 157869-15-3

The Article related to indoloquinoline preparation, silver mediated cyclocondensation aryl isothiocyanate arylalkynylaniline microwave irradiation, cascade reaction aryl isothiocyanate arylalkynylaniline mediated silver carbonate, mechanism cascade reaction aryl isothiocyanate arylalkynylaniline mediated silver carbonate and other aspects.Electric Literature of 157869-15-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On May 24, 2021, Ftouh, Soumia; Bourgeade-Delmas, Sandra; Belkadi, Mohamed; Deraeve, Celine; Hemmert, Catherine; Valentin, Alexis; Gornitzka, Heinz published an article.COA of Formula: C13H11BrS The title of the article was Synthesis, Characterization, and Antileishmanial Activity of Neutral Gold(I) Complexes with N-heterocyclic Carbene Ligands Bearing Sulfur-Containing Side Arms. And the article contained the following:

With an estimated annual incidence of one million cases, leishmaniasis is one of the top five vector-borne diseases. Currently available medical treatments involve side effects, including toxicity, nonspecific targeting, and resistance development. Thus, new antileishmanial chem. entities are of the utmost importance to fight against this disease. The authors showed in previous studies that Au(I) complexes bearing N-heterocyclic carbene (NHC) ligands with N- or S-containing side arms have interesting biol. activities in the field of cancer, malaria and leishmaniasis. The present study evaluates the in vitro antileishmanial effects on L. infantum axenic amastigotes and their cytotoxicity for the human THP1 cell line of a new family of six new imidazolium salts and their corresponding neutral (NHC)AuICl complexes. All new compounds were characterized by classical anal. methods, and five Au complexes were analyzed by x-ray structure determinations One proligand has moderate activity (IC50 = 8.24μM) while four of the six Au complexes have IC50 values in the low or sub μM range (0.15-1.3μM), including three with selectivity index (SI) values between 46 and 108. These results suggest remarkable leishmanicidal activity in vitro for three new neutral (NHC)Au(I)Cl complexes, making them candidates for further in vivo studies, which are under study. The experimental process involved the reaction of Benzyl(4-bromophenyl)sulfane(cas: 53136-21-3).COA of Formula: C13H11BrS

The Article related to gold arylimidazolylidene complex sulfur side arm preparation antileishmanial activity, crystal structure gold arylimidazolylidene complex sulfur containing side arm, mol structure gold arylimidazolylidene complex sulfur containing side arm, arylimidazolylidene ligand preparation reaction gold chloride and other aspects.COA of Formula: C13H11BrS

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On March 20, 2020, Mi, Yan; Yao, Jiabin; Ma, Jingyu; Dai, Ling; Xiao, Chao; Wu, Wanhua; Yang, Cheng published an article.Electric Literature of 150-78-7 The title of the article was Fulleropillar[4]arene: The Synthesis and Complexation Properties. And the article contained the following:

A pillar[4]arene monoquinone (prepared by oxidation of permethylpillar[5]arene) underwent ring opening mediated by Cs2CO3 in DMF to yield the multihydroquinone ether dialdehyde I in 5% yield. The regioselective Prato reaction of I with fullerene C60-Ih and sarcosine yielded a trans-4 macrocyclic bisadduct as the major product in 12% yield. The fulleropillararene macrocycle formed a 1:1 complex with 4,4′-bis(dodecyl)-1,1′-bipyridinium dibromide with a binding constant of > 6500 M-1, a significantly stronger affinity than the binding of the viologen to either permethyl pillar[5]arene or the parent pillararene monoquinone. The experimental process involved the reaction of 1,4-Dimethoxybenzene(cas: 150-78-7).Electric Literature of 150-78-7

The Article related to multihydroquinone ether aldehyde preparation, fullerene pillararene macrocycle regioselective preparation complexation viologen, base mediated ring opening pillararene, regioselective prato reaction c60 fullerene multihydroquinone ether aldehyde, complexation dodecylviologen fullerene pillararene macrocycle and other aspects.Electric Literature of 150-78-7

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On April 30, 2022, Toupalas, Georgios; Morandi, Bill published an article.Recommanded Product: 93-04-9 The title of the article was Non-innocent electrophiles unlock exogenous base-free coupling reactions. And the article contained the following:

Introduced a unifying strategy that eliminates the need for an exogenous base through the use of non-innocent electrophiles (NIE), which were equipped with a masked base that was released in a controlled fashion during the reaction. The universal applicability of this concept were demonstrated by turning multiple, traditionally base-dependent, catalytic reactions into exogenous base-free homogeneous processes. Furthermore, the advantageous features of NIEs were demonstrated in multiple applications, such as in a micromole-scale fluorescence-based assay. This led to the discovery of a Ni-catalyzed deoxygenation reaction of aryl carbamates using isopropanol as a benign reductant. In a broader context, this work provided a conceptual blueprint for the strategic utilization of NIEs in catalysis. The experimental process involved the reaction of 2-Methoxynaphthalene(cas: 93-04-9).Recommanded Product: 93-04-9

The Article related to aryl isopropylcarbamate amine nickel catalyst buchwald hartwig amination fluorescence, arylamine preparation, terminal alkene aryl isopropylcarbamate nickel catalyst mizoroki heck reaction, arylalkene preparation, arylboronic acid aryl isopropylcarbamate nickel catalyst suzuki miyaura coupling, biaryl preparation and other aspects.Recommanded Product: 93-04-9

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Roesner, Stefan; Buchwald, Stephen L. published an article in 2016, the title of the article was Continuous-Flow Synthesis of Biaryls by Negishi Cross-Coupling of Fluoro- and Trifluoromethyl-Substituted (Hetero)arenes.Reference of 1-Fluoro-2-methoxybenzene And the article contains the following content:

A continuous-flow method for the regioselective arylation of fluoroarenes and fluoropyridines has been developed. The telescoped procedure reported here consists of a three-step metalation, zincation, and Negishi cross-coupling sequence, providing efficient access to a variety of functionalized 2-fluorobiaryl products. Precise temperature control of the metalation step, made possible by continuous-flow technol., allowed for the efficient preparation of the arylated products in high yields and short residence times. Addnl., several examples of the regioselective arylation of benzotrifluoride derivatives are also provided. The experimental process involved the reaction of 1-Fluoro-2-methoxybenzene(cas: 321-28-8).Reference of 1-Fluoro-2-methoxybenzene

The Article related to fluorinated biaryl continuous flow synthesis sonication regioselective arylation, metalation zincation negishi coupling sequence fluoroarene bromoarene sonication, fluoropyridine metalation zincation negishi coupling sequence bromoarene sonication, biaryls, cross-coupling, flow chemistry, palladium, synthetic methods and other aspects.Reference of 1-Fluoro-2-methoxybenzene

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On April 4, 2021, Hofmann, Julian; Ginex, Tiziana; Espargaro, Alba; Scheiner, Matthias; Gunesch, Sandra; Arago, Marc; Stigloher, Christian; Sabate, Raimon; Luque, F. Javier; Decker, Michael published an article.Recommanded Product: 91-16-7 The title of the article was Azobioisosteres of Curcumin with Pronounced Activity against Amyloid Aggregation, Intracellular Oxidative Stress and Neuroinflammation. And the article contained the following:

Many (poly-)phenolic natural products, for example, curcumin and taxifolin, had been studied for their activity against specific hallmarks of neurodegeneration, such as amyloid-β 42 (Aβ42) aggregation and neuroinflammation. Due to their drawbacks, arising from poor pharmacokinetics, rapid metabolism and even instability in aqueous medium, the biol. activity of azobenzene compounds carrying a pharmacophoric catechol group I [R = H, Cl, NO2, MeO, EtO, Oi-Pr; R1 = OH, MeO], which had been designed as bioisoteres of curcumin had been examined Mol. simulations revealed the ability of these compounds to form a hydrophobic cluster with Aβ42, which adopts different folds, affecting the propensity to populate fibril-like conformations. Furthermore, the curcumin bioisosteres exceeded the parent compound in activity against Aβ42 aggregation inhibition, glutamate-induced intracellular oxidative stress in HT22 cells and neuroinflammation in microglial BV-2 cells. The most active compound prevented apoptosis of HT22 cells at a concentration of 2.5μM (83% cell survival), whereas curcumin only showed very low protection at 10μM (21% cell survival). The experimental process involved the reaction of 1,2-Dimethoxybenzene(cas: 91-16-7).Recommanded Product: 91-16-7

The Article related to azobioisostere curcumin diastereoselective preparation intracellular oxidative stress neuroinflammation, amyloid aggregation neurotoxicity neuroprotection docking azobioisostere curcumin diastereoselective preparation, amyloid beta, bioisosterism, natural products, neuroprotectivity, replica-exchange molecular dynamics and other aspects.Recommanded Product: 91-16-7

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On July 3, 2008, Adams, Ruth S.; Duffey, Matthew; Gould, Alexandra E.; Greenspan, Paul D.; Kulkarni, Bheemashankar A.; Vos, Tricia J. published a patent.Related Products of 887581-09-1 The title of the patent was Preparation of pyrazoline derivatives with Raf kinase inhibitory activity. And the patent contained the following:

The present invention provides certain pyrazoline compounds (shown as I; variables defined below; e.g. 2-[3-(pyridin-3-yl)-1-[[5-(pyridin-2-yl)-2-thienyl]carbonyl]-4,5-dihydro-1H-pyrazol-5-yl]phenol) useful as inhibitors of Raf kinases. The invention also provides pharmaceutical compositions and methods of using the compositions in the treatment of cancer. Semiquant. IC50 values for B-Raf kinase are reported for many examples of I. For I: R1 is a (un)substituted 5- or 6-membered N-containing heteroaryl ring, which ring optionally is fused to an aryl, heteroaryl, heterocyclyl, or cycloaliphatic ring, each of which is (un)substituted. R2 is a (un)substituted 5- or 6-membered aryl or heteroaryl ring, which ring optionally is fused to an aryl, heteroaryl, heterocyclyl, or cycloaliphatic ring, each of which is (un)substituted. R3 = H, fluoro, C1-4 aliphatic, and C1-4 fluoroaliph.; R4 is H, fluoro, or a C1-4 aliphatic or C1-4 fluoroaliph. (un)substituted, or R3 and R4, taken together with the C to which they are bound, form an (un)substituted 3- to 6-membered cycloaliphatic or 4- to 7-membered heterocyclic ring. L1 = -C(O)NRa(CRbRc)m-, -C(O)C(Rb):C(Rb)(CRbRc)m-, -C(O)(CRbRc)m-, and -SO2(CRbRc)m-, wherein the C(O) or SO2 functionality, resp., is bound to the N of the pyrazoline ring; Cy1 is a bivalent radical derived from a ring system = (un)substituted 5- or 6-membered aromatic rings having 0-4 ring N atoms and optionally 1-2 addnl. ring heteroatoms = O and S, which 5- or 6-membered aromatic ring optionally is fused to an aryl, heteroaryl, heterocyclyl, or cycloaliphatic ring, each of which is (un)substituted; et al. L2 is -(CRbRc)- or -(CRbRc)nX(CRbRc)n-; X = -O-, -C(O)-, -S-, -SO-, -SO2-, -NRa-, -C(Rf):C(Rf)-, -CC-, -NRaC(O)-, – C(O)NRa-, -SO2NRa, -NRaSO2-, and -NRaC(O)NRa-; Cy2 is a radical derived from a ring system = (un)substituted 5- or 6-membered aromatic rings having 0-4 ring N atoms and optionally 1-2 addnl. ring heteroatoms = O and S, which 5- or 6-membered aromatic ring optionally is fused to an aryl, heteroaryl, heterocyclyl, or cycloaliphatic ring, each of which is (un)substituted; et al; provided that R1 is not 6-bromo-1,2-dihydro-2-oxo-4-phenyl-3-quinolinyl; addnl. details are given in the claims. Although the methods of preparation are not claimed, preparations and/or characterization data for >400 examples of I are included. For example, 2-[3-(pyridin-3-yl)-1-[[5-(pyridin-2-yl)-2-thienyl]carbonyl]-4,5-dihydro-1H-pyrazol-5-yl]phenol was prepared in 3 steps (73, 94, and 72 % yields, resp.) starting from salicylaldehyde and 1-(pyridin-3-yl)ethanone and involving the following intermediates: (2E)-3-(2-hydroxyphenyl)-1-(pyridin-3-yl)prop-2-en-1-one and 2-[5-(pyridin-3-yl)-4,5-dihydro-1H-pyrazol-3-yl]phenol. The experimental process involved the reaction of (2-Bromo-5-methoxyphenyl)methanamine(cas: 887581-09-1).Related Products of 887581-09-1

The Article related to pyrazoline derivative preparation raf kinase inhibitor potential cancer drug, phenol pyrazolinyl preparation raf kinase inhibitor potential cancer drug, semicarbazone heterocyclic preparation raf kinase inhibitor potential cancer drug, alkylidenehydrazide heterocyclic preparation raf kinase inhibitor potential cancer drug and other aspects.Related Products of 887581-09-1

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On April 29, 2022, Li, Yang; Wang, Yanan; Ye, Zhegao; Zhang, Shangbiao; Ye, Xiaodong; Yuan, Zheliang published an article.Computed Properties of 93-04-9 The title of the article was Trifluoromethyl Selenoxides: Electrophilic Reagents for C-H Trifluoromethylselenolation of (Hetero)Arene. And the article contained the following:

Herein, designed and synthesized the new electrophilic trifluoromethylselenolation reagents, trifluoromethyl selenoxides I [X = H, CF3, CN], which were easy to prepare and easy-to-handle and were not moisture or air sensitive. The selenoxides are successfully applied to metal-free C-H trifluoromethylselenolation of a series of (hetero)arenes to gave ((trifluoromethyl)selanyl)aryl ArSeCF3 [Ar = 4-HOC6H4, 1H-indol-3-yl, (5-methoxycarbonyl-1H-pyrrol-3-yl), etc.]. The experimental process involved the reaction of 2-Methoxynaphthalene(cas: 93-04-9).Computed Properties of 93-04-9

The Article related to selanyl hetero aryl trifluoromethyl regioselective preparation, hetero aryl methyl oxido trifluoromethyl selenonium carbon hydrogen trifluoromethylselenolation, trifluoromethyl selanyl aryl regioselective preparation, aromatic compound aryl methyl oxido trifluoromethyl selenonium carbon hydrogen, trifluoromethylselenolation and other aspects.Computed Properties of 93-04-9

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Shi, Jiale; Yuan, Tao; Wang, Rong; Zheng, Meifang; Wang, Xinchen published an article in 2021, the title of the article was Boron carbonitride photocatalysts for direct decarboxylation: the construction of C(sp3)-N or C(sp3)-C(sp2) bonds with visible light.Application In Synthesis of 2-Methoxynaphthalene And the article contains the following content:

A metal-free protocol was established for the decarboxylative N-H or C(sp2)-H functionalization of acids via metal-free boron carbon nitride (BCN) photocatalysis, delivering the desired products under ambient conditions. This methodol.was applicable to the late-stage modification of pharmaceutical mols. and gram-scale experiments as well as in the recovery and reuse of the photocatalysts without the loss of reactivity. The developed photochem. reaction system fulfills the requirements of green and sustainable chem. The experimental process involved the reaction of 2-Methoxynaphthalene(cas: 93-04-9).Application In Synthesis of 2-Methoxynaphthalene

The Article related to boroncarbonitride photocatalyst preparation pore size distribution, pyrazole phenylacetic acid heterogeneous catalyst decarboxylation c n activation, benzyl pyrazole preparation green chem, methoxybenzene phenylacetic acid heterogeneous catalyst decarboxylation c h activation, benzylmethoxyarylbenzene preparation green chem and other aspects.Application In Synthesis of 2-Methoxynaphthalene

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem