Month: October 2022

Younes, Maged; Aquilina, Gabriele; Castle, Laurence; Engel, Karl-Heinz; Fowler, Paul; Frutos Fernandez, Maria Jose; Fuerst, Peter; Guertler, Rainer; Gundert-Remy, Ursula; Husoey, Trine; Manco, Melania; Moldeus, Peter; Passamonti, Sabina; Shah, Romina; Waalkens-Berendsen, Ine; Wolfle, Detlef; Wright, Matthew; Benigni, Romualdo; Chipman, Kevin; Cordelli, Eugenia; Degen, Gisela; Carfi, Maria; Vianello, Giorgia; Mennes, Wim published an article in 2021. The article was titled 《Scientific opinion on flavoring group evaluation 414 (FGE .414): 2-hydroxy-4-methoxybenzaldehyde》, and you may find the article in EFSA Journal.Product Details of 673-22-3 The information in the text is summarized as follows:

The EFSA Panel on Food Additives and Flavorings (FAF) was requested to evaluate the safety of the substance 2-hydroxy-4-methoxybenzaldehyde [FL -no: 05.229] as a new flavoring substance, in accordance with Regulation (EC) No 1331/2008. 2-Hydroxy-4-methoxybenzaldehyde belongs to chem. group 23 (Commission Regulation (EC) No 1565/2000) and is structurally related to the hydroxy- and alkoxy-ring substituted benzyl derivatives evaluated in FGE .52 and in FGE .20Rev4. The Panel considered the structural/metabolic similarity sufficient to evaluate the candidate substance following a group-based approach according to the EFSA Guidance on the data required for the risk assessment of flavorings to be used in or on foods. The information provided on the manufacturing process, the composition and the stability of [FL -no: 05.229] was considered sufficient. From studies carried out with this substance, the Panel concluded that there is no concern with respect to genotoxicity. Based on QSAR evaluation of possible metabolism, and based on information from structurally related substances, various metabolic routes can be anticipated, which only result in the formation of innocuous metabolites. The exposure estimates for [FL -no: 05.229] (24 and 60 μg/person per day for children and adults, resp.) were below the Threshold of Toxicol. Concern (TTC) for its structural class (I). Accordingly, toxicity studies are not required and the Panel concluded at step A3 of the Procedure that 2-hydroxy-4-methoxybenzaldehyde is not of safety concern when used as a flavoring substance at the intended uses and use levels. Cumulative exposure estimates for 2-hydroxy-4-methoxybenzaldehyde and three structurally related substances (2.4 and 6.2 mg/kg body weight (bw) per day for adults and children, resp.) are above the TTC for structural class I, but below the ADI (acceptable daily intake) of 0-10 mg/kg bw per day for vanillin, which is one of these structurally related substances. Therefore, the cumulative exposure to these four substances [FL -no: 05.015, 05.018, 05.229 and 09.749] also does not raise a safety concern. After reading the article, we found that the author used 2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3Product Details of 673-22-3)

2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is the main component of root bark essential oil of Periploca sepium Bunge. It is a potential tyrosinase inhibitor present in African medicinal plants. 2-Hydroxy-4-methoxybenzaldehyde was used in the synthesis of Schiff base ligand.Product Details of 673-22-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Li, Wenwei; Zhou, Honggui; He, Yequan; Zeng, Ge; Zheng, Yumeng; Hu, Yangni; Chen, Zhongyan; Ge, Jing-Yuan; Lv, Ningning; Chen, Jiuxi published an article in 2022. The article was titled 《Synthesis of Diverse γ-Lactams via Rh-Catalyzed C(sp2)-H Addition to Aliphatic Nitriles》, and you may find the article in Organic Letters.Quality Control of m-Methoxyphenol The information in the text is summarized as follows:

An unprecedented pathway to access γ-lactams I [R1 = H, 6-Me, 5-Ph, etc.; R2 = Ph, 4-MeC6H4, 3-MeOC6H4, etc.], II [R3 = H, 5-F, 5-MeO, 5-N(CH3)2; R4 = Ph, 4-MeC6H4, Bn, etc.] and III [R5 = Me, 4-MeC6H4, 3-MeOC6H4, etc.; R6 = Me, Ph, Bn, etc.] using acetonitrile analogs as coupling partners without oxidants, ligands, and Lewis acids was reported. The reaction undergoes Rh-catalyzed C(sp2)-H addition to carbon-bound nitriles with the aid of an amide traceless auxiliary followed by an annulation sequence, featuring a broad substrate scope, good functional group tolerance, and excellent chemo/stereoselectivity. Scale-up reactions and late-stage derivatizations highlighted the potential synthetic utility of this methodol. A plausible mechanism was proposed based on mechanistic investigations. The results came from multiple reactions, including the reaction of m-Methoxyphenol(cas: 150-19-6Quality Control of m-Methoxyphenol)

m-Methoxyphenol(cas: 150-19-6) may be used in synthesis of:C(4) symmetric calix[4]resorcinarene, 2-nitroso-5-methoxyphenol, 6-methoxy-2(3H)-benzoxazoloneQuality Control of m-Methoxyphenol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2022,Marrot, Laetitia; Meile, Kristine; Zouari, Mariem; DeVallance, David; Sandak, Anna; Herrera, Rene published an article in Molecules. The title of the article was 《Characterization of the compounds released in the gaseous waste stream during the slow pyrolysis of hemp (Cannabis sativa L.)》.Category: ethers-buliding-blocks The author mentioned the following in the article:

This study aims to characterize and valorize hemp residual biomass by a slow pyrolysis process. The volatile byproducts of hemp carbonization were characterized by several methods (TGA, UV-VIS, TLC, Flash Prep-LC, UHPLC, QTOF-MS) to understand the pyrolysis reaction mechanisms and to identify the chem. products produced during the process. The obtained carbon yield was 29%, generating a gaseous stream composed of phenols and furans which was collected in four temperature ranges (F1 at 20-150°C, F2 at 150-250°C, F3 at 250-400°C and F4 at 400-1000°C). The obtained liquid fractions were separated into subfractions by flash chromatog. The total phenolic content (TPC) varied depending on the fraction but did not correlate with an increase in temperature or with a decrease in pH value. Compounds present in fractions F1, F3 and F4, being mainly phenolic mols. such as guaiacyl or syringyl derivatives issued from the lignin degradation, exhibit antioxidant capacity. The temperature of the pyrolysis process was pos. correlated with detectable phenolic content, which can be explained by the decomposition order of the hemp chem. constituents. A detailed understanding of the chem. composition of pyrolysis products of hemp residuals allows for an assessment of their potential valorization routes and the future economic potential of underutilized biomass.m-Methoxyphenol(cas: 150-19-6Category: ethers-buliding-blocks) was used in this study.

m-Methoxyphenol(cas: 150-19-6) may be used in synthesis of:C(4) symmetric calix[4]resorcinarene, 2-nitroso-5-methoxyphenol, 6-methoxy-2(3H)-benzoxazoloneCategory: ethers-buliding-blocks

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2022,Luo, Xiaosheng; Feng, Qiping; Wang, Ping published an article in Synthesis. The title of the article was 《Radical Addition of 4-Hydroxyquinazolines and Alkylation of Quinones by the Electro-Induced Homolysis of 4-Alkyl-1,4-dihydropyridines》.HPLC of Formula: 60656-87-3 The author mentioned the following in the article:

The formation of C(sp3)-centered radicals via the electro-induced homolysis of 4-alkyl-1,4-dihydropyridines (alkyl-DHPs) is reported. The resulting alkyl radicals reacted with 4-hydroxyquinazolines or quinones to afford 2-alkyldihydroquinazolinones or alkylated quinones. A broad range of alkyl DHPs could be used as versatile radical precursors under electrolysis conditions. This alterative strategy provided a simple and effective pathway for the construction of C(sp2)-C(sp3) and C(sp3)-C(sp3) bonds under mild conditions. In the experiment, the researchers used many compounds, for example, 2-(Benzyloxy)acetaldehyde(cas: 60656-87-3HPLC of Formula: 60656-87-3)

2-(Benzyloxy)acetaldehyde(cas: 60656-87-3) may be used in the following syntheses: (3S,5S)-methyl 6-benzyloxy-3,5-dihydroxyhexanoate ,(S)-5-benzyloxy-4-hydroxypentan-2-one, myxothiazols.HPLC of Formula: 60656-87-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2022,Yimyaem, Jirapat; Chantana, Chayamon; Boonmee, Suthimon; Jaratjaroonphong, Jaray published an article in Synlett. The title of the article was 《Expedient Access to Indolyl-Substituted Tri- and Diarylmethanes and (±)-Colletotryptin E by Silica Sulfuric Acid Catalyzed Transindolylation》.Name: 2-(Benzyloxy)acetaldehyde The author mentioned the following in the article:

An expedient access to a series of nonsym. bis(indolyl)methanes (BIMs) through transindolylation of readily available sym. 3,3′-BIMs with various indoles catalyzed by silica-supported sulfuric acid has been established. This approach not only provides a useful strategy for the synthesis of structurally diverse BIMs, but also provides examples of nucleophilic substitution of BIMs with aromatic and nonaromatic π-systems, leading to a library of indolyl-substituted tri- and diarylmethanes. Moreover, this method was successfully applied in the first total synthesis of the 2,3′-BIM alkaloid (±)-colletotryptin E (I) in three steps with an overall yield of 46%. The features of this procedure include a metal-free process, an inexpensive and environmentally friendly catalyst, mild reaction conditions, broad functional-group tolerance, good yields, and gram-scalable preparations In the experiment, the researchers used many compounds, for example, 2-(Benzyloxy)acetaldehyde(cas: 60656-87-3Name: 2-(Benzyloxy)acetaldehyde)

2-(Benzyloxy)acetaldehyde(cas: 60656-87-3) is a non-natural aldehyde. It undergoes enantioselective Mukaiyama aldol reaction with silylketene acetal nucleophiles in the presence of C2-symmetric bis(oxazolinyl)pyridine Cu(II) complex (catalyst).Name: 2-(Benzyloxy)acetaldehyde

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2022,Ma, Na-Na; Ren, Jing-Ao; Liu, Xiang; Chu, Xue-Qiang; Rao, Weidong; Shen, Zhi-Liang published an article in Organic Letters. The title of the article was 《Nickel-Catalyzed Direct Cross-Coupling of Aryl Sulfonium Salt with Aryl Bromide》.Recommanded Product: 1-Bromo-3-methoxybenzene The author mentioned the following in the article:

The direct cross-couplings of aryl sulfonium salts with aryl halides was achieved by using nickel as a reaction catalyst. The reactions proceeded efficiently via C-S bond activation in the presence of magnesium turnings and lithium chloride in THF at ambient temperature to afford the corresponding biaryls in moderate to good yields, potentially served as an attractive alternative to conventional cross-coupling reactions employing preprepared organometallic reagents. After reading the article, we found that the author used 1-Bromo-3-methoxybenzene(cas: 2398-37-0Recommanded Product: 1-Bromo-3-methoxybenzene)

1-Bromo-3-methoxybenzene(cas: 2398-37-0) can be used in chemical reaction as intermediates to obtain target materials such as dyes, pharmaceuticals, perfumes, photoinitiators and agrochemicals.Recommanded Product: 1-Bromo-3-methoxybenzene

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2022,Moschona, Fotini; Misirlaki, Christina; Karadimas, Nikolaos; Koutiva, Maria; Savvopoulou, Ioanna; Rassias, Gerasimos published an article in Symmetry. The title of the article was 《Organocatalytic Asymmetric Halocyclization of Allylic Amides to Chiral Oxazolines Using DTBM-SEGPHOS-Mechanistic Implications from Hammett Plots》.Product Details of 2398-37-0 The author mentioned the following in the article:

The intramol. halocyclization of alkenes possessing an internal heteroatom nucleophile leads to multifunctional heterocycles which are useful versatile intermediates in organic synthesis. The asym. chlorocyclization of 2-substituted allylic amides ArC(O)NHCH2C(=CH2)R (R = Ph, 4-FC6H4, pyridin-3-yl, naphthalen-1-yl, etc.; Ar = Ph, 4-MeOC6H4, 4-MeC6H4, etc.) gives access to chiral oxazolines I (X = Cl) bearing a chloromethyl moiety for further synthetic manipulation. The literature reports on this transformation involve complex syntheses of the 2-substituted allylic amides and cryogenic temperatures for achieving high enantioselectivities in the organocatalyzed halocyclization step. Based on the Heck reaction of aryl bromides ArBr (Ar = Ph, 4-CNC6H4, pyridin-3-yl, naphthalen-1-yl, etc.;) and Boc-protected allylamine or allylamine benzamides, a practical synthesis of 2-substituted allylic amides that does not require chromatog. was developed and accomplished their asym. halocyclization reaction with 24-92%ee under practical conditions (5°C, CpME) catalyzed by (S)-(+)-DTBM-SEGPHOS. In addition, using appropriately substituted substrates, Hammett plots were generated and formulated a consistent mechanism for the halocyclization reaction which involves two competing modes of formation of the haliranium intermediate whose relative kinetics are governed by the electronic properties of the substrate. The experimental process involved the reaction of 1-Bromo-3-methoxybenzene(cas: 2398-37-0Product Details of 2398-37-0)

1-Bromo-3-methoxybenzene(cas: 2398-37-0) can be used in chemical reaction as intermediates to obtain target materials such as dyes, pharmaceuticals, perfumes, photoinitiators and agrochemicals.Product Details of 2398-37-0

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2022,Yamaguchi, Hinano; Kondo, Mizuho; Sasaki, Tomoyuki; Sakamoto, Moritsugu; Ono, Hiroshi; Kawatsuki, Nobuhiro published an article in Langmuir. The title of the article was 《Polarized Fluorescence of N-Salicylideneaniline Derivatives Formed by In Situ Exchange from N-Benzylideneaniline Side Groups in Photoaligned Liquid Crystalline Copolymer Films》.Electric Literature of C8H8O3 The author mentioned the following in the article:

Polarized fluorescence of oriented N-salicylideneaniline (SA) derivatives is explored based on the thermally stimulated photoinduced mol. reorientation of liquid crystalline (LC) copolymethacrylate with N-benzylideneaniline derivative (NBA2) and benzoic acid (BA) side groups. The LC copolymer films show significant cooperative mol. reorientation of the NBA2 and BA side groups (D > 0.7). Subsequent thermal hydrolysis of the NBA2 side groups yields free phenylamine moieties. These moieties can form oriented SA derivatives via in situ condensation with 2-hydroxybenzaldehyde derivatives The excited-state intermol. proton transfer of the oriented SA mols. induces polarized fluorescence at 510-548 nm with a polarization ratio up to 6.2. Direct in situ exchange from the oriented NBA2 to SA derivatives achieves polarized fluorescence similar to that of the SA side groups. In addition to this study using 2-Hydroxy-4-methoxybenzaldehyde, there are many other studies that have used 2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3Electric Literature of C8H8O3) was used in this study.

2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is the main component of root bark essential oil of Periploca sepium Bunge. It is a potential tyrosinase inhibitor present in African medicinal plants. 2-Hydroxy-4-methoxybenzaldehyde was used in the synthesis of Schiff base ligand.Electric Literature of C8H8O3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Electric Literature of C12H10S2In 2019 ,《A synthesis of sulfoxides and disulfides under classical and ultrasonic conditions in presence of recoverable inorganic-organic hybrid magnetism nanocatalysts Fe3O4@Tryptophan-M (M: Cu, Co and Fe)》 was published in Polyhedron. The article was written by Moeini, Nazanin; Ghadermazi, Mohammad; Ghorbani-Choghamarani, Arash. The article contains the following contents:

Three inorganic-organic hybrid magnetic nanocatalysts have been reported as new catalysts for the synthesis of sulfoxides and disulfides. Also, the effect of ultrasound irradiation on the synthesis of sulfoxides and disulfides was checked. The time of reaction was reduced and the yield was improved in the ultrasonic method compared with the conventional method. Magnetic nanoparticles were used for several times without any significant change in activity. Easy synthesis, high catalytic activity, mild reaction conditions, eco-friendliness, ease of separation of the catalysts and good reusability are their advantages. In the part of experimental materials, we found many familiar compounds, such as 1,2-Diphenyldisulfane(cas: 882-33-7Electric Literature of C12H10S2)

1,2-Diphenyldisulfane(cas: 882-33-7) belongs to ethers. Ethers lack the hydroxyl groups of alcohols. Without the strongly polarized O―H bond, ether molecules cannot engage in hydrogen bonding with each other. Electric Literature of C12H10S2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

COA of Formula: C12H10S2In 2021 ,《PdCl2/DMSO-Catalyzed Thiol-Disulfide Exchange: Synthesis of Unsymmetrical Disulfide》 was published in Organic Letters. The article was written by Guo, Jimin; Zha, Jianjian; Zhang, Tao; Ding, Chang-Hua; Tan, Qitao; Xu, Bin. The article contains the following contents:

Unsym. disulfides was effectively prepared through thiol exchange with sym. disulfides employed a simple PdCl2/DMSO catalytic system. The given method featured excellent functional group tolerance, a broad substrate scope, and operational simplicity. This reaction is especially useful for late-stage functionalization of bioactive scaffolds such as peptides and pharmaceuticals. Disulfide-containing organic dyes was also prepared This transformation would be extended to thiol-diselenide or thiol-ditelluride exchange afforded RS-SeR’ or RS-TeR’. In the part of experimental materials, we found many familiar compounds, such as 1,2-Diphenyldisulfane(cas: 882-33-7COA of Formula: C12H10S2)

1,2-Diphenyldisulfane(cas: 882-33-7) belongs to ethers.Ethers do have nonbonding electron pairs on their oxygen atoms, and they can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.COA of Formula: C12H10S2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem