Month: October 2022

Reference of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamateIn 2020 ,《Effects of modifying thioflavin T at the N3-position on its G4 binding and fluorescence emission》 was published in Molecules. The article was written by Kataoka, Yuka; Fujita, Hiroto; Endoh, Tamaki; Sugimoto, Naoki; Kuwahara, Masayasu. The article contains the following contents:

We previously synthesized thioflavin T (ThT) with a hydroxyethyl group introduced at the N3-position (ThT-HE), which binds predominantly to the parallel G-quadruplex (G4) structure found in c-Myc and emits strong fluorescence. In this study, to investigate the effects of introduced substituents on G4 binding and fluorescence emission, a ThT derivative in which the hydroxyl group of ThT-HE was replaced with an amino group (ThT-AE) was synthesized for the first time. Furthermore, three other N3-modified ThT derivatives (ThT-OE2, ThT-SP, and ThT-OE11) having different substituent structures were synthesized by the N-acylation of the terminal amino group of ThT-AE, and their G4-binding and emission properties were investigated. The results showed that, although ThT-AE shows binding selectivity depending on the type of G4, its emission intensity is significantly decreased as compared to that of ThT-HE. However, ThT-OE11, which features an 11-unit oxyethylene chain attached to the terminal amino group of ThT-AE, regained about one-half of the emission intensity of ThT-HE while retaining selectivity for G4s. Accordingly, ThT-OE11 may be used as a key intermediate for synthesizing the conjugates of G4 binders and probes. In the part of experimental materials, we found many familiar compounds, such as tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6Reference of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate)

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers. Ethers lack the hydroxyl groups of alcohols. Without the strongly polarized O―H bond, ether molecules cannot engage in hydrogen bonding with each other. Reference of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Convenient Unsymmetrical Disulfane Synthesis: Basic Zeolite-Catalyzed Thiol-Disulfane Exchange Reaction》 was written by Yamamoto, Eiji; Kawai, Yasutaka; Takakura, Kei; Kimura, Moemi; Murayama, Haruno; Matsueda, Hironobu; Otsuki, Shujiro; Sakata, Hiroshi; Tokunaga, Makoto. COA of Formula: C12H10S2This research focused onunsym disulfane preparation; thiol disulfide exchange reaction zeolite catalyst. The article conveys some information:

Convenient catalytic synthetic methods for the preparation of unsym. disulfanes RSSR1 (R = dodecyl, cyclohexyl, benzyl, furan-2-yl, etc.; R1 = Me, cyclohexyl, benzyl, pyridin-2-yl, etc.) are described. Na-exchanged X type zeolite (Na-X), com. available as MS-13X, effectively catalyzes thiol-disulfane exchange reactions with 1.0 equiv of thiols RSH and 2.5-3.0 equiv of disulfanes R1SSR1 at 10°C to room temperature under air. The reactions of sterically-hindered disulfanes or electron-deficient thiol substrates require high temperatures under inert atmospheres to maintain the good product yields. Various functionalized thiols and disulfanes are tolerant in the present catalytic systems, affording the corresponding unsym. disulfanes in good-to-high yields (up to 96%). The Na-X catalyst was successfully recycled 10 times without loss of yield. Preliminary mechanistic studies suggest the involvement of base-catalyzed SN2-S displacement and/or addition-elimination mechanisms, assisted by hydrogen-bonding interactions. The results came from multiple reactions, including the reaction of 1,2-Diphenyldisulfane(cas: 882-33-7COA of Formula: C12H10S2)

1,2-Diphenyldisulfane(cas: 882-33-7) belongs to ethers.Ethers do have nonbonding electron pairs on their oxygen atoms, and they can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. COA of Formula: C12H10S2 The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Investigation of DNA binding and bioactivities of thioether containing Schiff base Copper(II), Cobalt(II) and Palladium(II) complexes: Synthesis, characterization, spectrochemical study, viscosity measurement》 was written by Maiti, Subir Kr; Kalita, Mukul; Singh, Anmol; Deka, Jahnabi; Barman, Pranjit. Recommanded Product: 673-22-3This research focused ontransition metal Schiff salicylaldehyde benzylthioaniline complex preparation bactericide; DNA binding transition metal Schiff salicylaldehyde benzylthioaniline complex; crystal structure transition metal salicylaldehyde benzylthioaniline complex. The article conveys some information:

Three complexes of an ONS donor ligand of the Schiff base [C21H19NO2S] (HL), [Cu(C21H18NO2S)2] (1) [Co(C21H18NO2S)2] (2) and [Pd(C21H18NO2SCl)] (3), were synthesized and characterized by elemental anal., FT-IR, 1H NMR, UV-Visible spectroscopy and single-crystal X-ray diffraction anal. Single crystal X-ray diffraction anal. reveals that the copper complex acquires a distorted pyramidal structure and the palladium complex acquires a square planar structure. All the compounds are stable at room temperature and they show very good antibacterial activities against gram-pos. and gram-neg. bacteria. DNA binding activities of the ligand and its Cu(II), Pd(II) and Co(II) complexes with CT-DNA were carried out in DMF and tris-buffer (5 mM, pH 7.3) solution; all the three complexes along with the ligand show a very good intercalative mode of DNA interaction with Kb values of 1.56(±0.03) x 105 for 1 and 1.02(±0.09) x 105 for 3. The DNA binding activity was confirmed by a hydrodynamic study (viscosity). The order of DNA binding activity is 1 > 3 > 2.2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3Recommanded Product: 673-22-3) was used in this study.

2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is the main component of root bark essential oil of Periploca sepium Bunge. It is a potential tyrosinase inhibitor present in African medicinal plants. 2-Hydroxy-4-methoxybenzaldehyde was used in the synthesis of Schiff base ligand.Recommanded Product: 673-22-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Phthalimide-Carried Disulfur Transfer To Synthesize Unsymmetrical Disulfanes via Copper Catalysis》 was written by Zou, Jiaoxia; Chen, Jinhong; Shi, Tao; Hou, Yongsheng; Cao, Fei; Wang, Yongqiang; Wang, Xiaodong; Jia, Zhong; Zhao, Quanyi; Wang, Zhen. Formula: C12H10S2This research focused onunsym disulfane preparation; phthalimide disulfur boronic acid cross coupling copper catalyst. The article conveys some information:

A versatile Cu-catalyzed cross-coupling reaction to various unsym. disulfanes R1SSR2 (R1 = Bn, Ph, 4-ClC6H4, etc.; R2 = 4-BrC6H4, 4-NCC6H4, 2-naphthyl, etc.) has been presented, from phthalimide-carried disulfur transfer reagents and com. available boronic acids under mild and practical conditions. The method features the unprecedented use of phthalimide-carried disulfurating reagents (Harpp reagent) in cross-coupling chem. and is highlighted by the broad substrate scopes, even applicable for the transfer of aryl-disulfur moieties (ArSS-). Notably, the robustness of this methodol. is shown by the late-stage modification of bioactive scaffolds of coumarin, estrone, and captopril. The results came from multiple reactions, including the reaction of 1,2-Diphenyldisulfane(cas: 882-33-7Formula: C12H10S2)

1,2-Diphenyldisulfane(cas: 882-33-7) belongs to ethers.Ethers do have nonbonding electron pairs on their oxygen atoms, and they can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.Formula: C12H10S2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2014,Magano, Javier; Conway, Brian G.; Farrand, Douglas; Lovdahl, Michael; Maloney, Mark T.; Pozzo, Mark J.; Teixeira, John J.; Rizzo, John; Tumelty, David published 《Scalable and cost-effective synthesis of a linker for bioconjugation with a peptide and a monoclonal antibody》.Synthesis published the findings.Application of 139115-91-6 The information in the text is summarized as follows:

An efficient, scalable, and cost-effective synthesis of a linker, that can be employed in a bioconjugation process with a peptide and a monoclonal antibody, is presented. Several routes were investigated that resulted in the identification of a short synthesis to a key acid intermediate from inexpensive and readily available starting materials. The final coupling of this acid with an aniline to afford the desired linker has been optimized to produce multi-gram quantities of material for clin. studies. The very limited purifications needed for both intermediates and final product make this route amenable to scale. The experimental process involved the reaction of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6Application of 139115-91-6)

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers.The C-O bonds that comprise simple ethers are strong. They are unreactive toward all but the strongest bases. Although generally of low chemical reactivity, they are more reactive than alkanes. Application of 139115-91-6

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2019,Green Chemistry included an article by Xu, Yu-Ting; Li, Chen-Yuan; Huang, Xiao-Bo; Gao, Wen-Xia; Zhou, Yun-Bing; Liu, Miao-Chang; Wu, Hua-Yue. Synthetic Route of C7H8O2. The article was titled 《Photoinduced hydroxylation of arylboronic acids with molecular oxygen under photocatalyst-free conditions》. The information in the text is summarized as follows:

Photoinduced hydroxylation of boronic acids RB(OH)2 (R = octyl, 1-naphthyl, thianthren-1-yl, benzo[d][1,3]dioxol-5-yl, 9-phenyl-9H-carbazol-2-yl, etc.) with mol. oxygen under photocatalyst-free conditions is reported, providing a green entry to a variety of phenols and aliphatic alcs. ROH in a highly concise fashion. This new protocol features photocatalyst-free conditions, wide substrate scope and excellent functional group compatibility. The results came from multiple reactions, including the reaction of m-Methoxyphenol(cas: 150-19-6Synthetic Route of C7H8O2)

m-Methoxyphenol(cas: 150-19-6) may be used in synthesis of:C(4) symmetric calix[4]resorcinarene, 2-nitroso-5-methoxyphenol, 6-methoxy-2(3H)-benzoxazoloneSynthetic Route of C7H8O2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2019,ACS Catalysis included an article by Peng, Jin-Bao; Wu, Fu-Peng; Li, Da; Geng, Hui-Qing; Qi, Xinxin; Ying, Jun; Wu, Xiao-Feng. Safety of 1-Iodo-2-methoxybenzene. The article was titled 《Palladium-Catalyzed Regioselective Carbonylative Coupling/Amination of Aryl Iodides with Unactivated Alkenes: Efficient Synthesis of β-Aminoketones》. The information in the text is summarized as follows:

The carbonylative coupling of aryl halides with unactivated alkenes remains a challenge, because of the low reactivity of acyl-palladium intermediate to the olefins. A palladium-catalyzed carbonylative coupling/amination of aryl iodides with unactivated alkenes for the synthesis of β-aminoketone derivatives was developed. With the assistance of a directing group (8-aminoquinoline, AQ), the coordination of the olefin to acyl-palladium complex can be enhanced, thereby promoting the acylpalladation across the C:C double bonds. A broad range of β-aminoketone derivatives were prepared in moderate to excellent yields with complete regioselectivity by using 4-pentenoic and 2-vinylbenzoic amide derivatives as the starting materials. This methodol. involves the formation of two C-C bonds as well as one C-N bond, and provided a method for the carbonylative difunctionalization of unactivated alkenes. In addition to this study using 1-Iodo-2-methoxybenzene, there are many other studies that have used 1-Iodo-2-methoxybenzene(cas: 529-28-2Safety of 1-Iodo-2-methoxybenzene) was used in this study.

1-Iodo-2-methoxybenzene(cas: 529-28-2) is a useful synthetic intermediate. It can be used in the synthesis of piperidinyl diaminopyrimidines as cyclin-dependent kinase inhibitors with antitumor activity and polysubstituted benzofuran derivatives as novel inhibitors of parasitic growth.Safety of 1-Iodo-2-methoxybenzene

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2019,ACS Omega included an article by Grattan, Vincent; Vaino, Andrew R.; Prensky, Zachary; Hixon, Mark S.. Application of 4637-24-5. The article was titled 《Antipsychotic benzamides amisulpride and LB-102 display polypharmacy as racemates, S enantiomers engage receptors D2 and D3, while R enantiomers engage 5-HT7》. The information in the text is summarized as follows:

Benzamide antipsychotics such as amisulpride are dosed as racemates though efficacy is assumed to be mediated through S enantiomer binding to D2 receptors. At prescribed doses, the benzamides likely display polypharmacy since brain exposure should be sufficient to engage the 5-HT7 receptors, as well. Curiously, the studies herein reveal that racemic dosing is required to engage both targets since the D2 receptor has an almost 40-fold selectivity for the S enantiomer, while the 5-HT7 receptor has greater than 50-fold preference for the R enantiomer. The experimental part of the paper was very detailed, including the reaction process of N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Application of 4637-24-5)

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Reduction of nitro compounds, RNO2, by hydrogen or other reducing agents produces primary amines cleanly (i.e., without a mixture of products), but the method is mostly used for aromatic amines because of the limited availability of aliphatic nitro compounds. Reduction of nitriles and oximes (R2C=NOH) also yields primary amines.Application of 4637-24-5

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2019,Dyes and Pigments included an article by Liu, Yuan; Tao, Chen; Xie, Guohua; Van Der Velden, Jeroen; Marras, Sergio; Luo, Zhenghui; Zeng, Xuan; Petrozza, Annamaria; Yang, Chuluo. Product Details of 101-70-2. The article was titled 《Hexa-substituted benzene derivatives as hole transporting materials for efficient perovskite solar cells》. The information in the text is summarized as follows:

Two low cost hexa-substituted benzene derivatives, HFB-OMeDPA and HPB-OMeDPA, have been successfully used as hole transporting materials (HTMs) for efficient perovskite solar cells (PSCs). The relations between mol. structure, electronic properties of the semiconductor and eventually the photovoltaic performance are studied. The planar PSCs employing HPB-OMeDPA as HTM exhibit excellent power conversion efficiencies exceeding 16% under AM 1.5 G illumination conditions, which are comparable to the reference cells based on spiro-OMeTAD.Bis(4-methoxyphenyl)amine(cas: 101-70-2Product Details of 101-70-2) was used in this study.

Bis(4-methoxyphenyl)amine(cas: 101-70-2) is a diphenylamine derivative used as a chemical additive for cured rubber.Bis(4-methoxyphenyl)amine is highly toxic and may potentially induce chromosome abberation.Product Details of 101-70-2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2019,ChemPhysChem included an article by Demaison, Jean; Vogt, Natalja; Saragi, Rizalina Tama; Juanes, Marcos; Rudolph, Heinz Dieter; Lesarri, Alberto. Quality Control of 1,2-Diphenyldisulfane. The article was titled 《The S-S Bridge: A Mixed Experimental-Computational Estimation of the Equilibrium Structure of Diphenyl Disulfide》. The information in the text is summarized as follows:

The disulfide bridge (-S-S-) is an important structural motif in organic and protein chem., but only a few accurate equilibrium structures are documented. We report the results of supersonic-jet microwave spectroscopy experiments on the rotational spectra of di-Ph disulfide, C6H5-S-S-C6H5 (including all 13C and 34S monosubstituted isotopologues), and the determination of the equilibrium structure by the mixed estimation (ME) method. A single conformation of C2 symmetry was observed in the gas phase. This disulfide is a challenging target since its structure is determined by 34 independent parameters. Addnl., ab initio calculations revealed the presence of three low-frequency vibrations (<50 cm-1) associated to Ph torsions which would prevent the calculation of an accurate force field. For this reason, instead of the semiexperimental method, we used the mass-dependent (rm) method to fit the structural parameters concurrently to moments of inertia and predicate parameters, affected with appropriate uncertainties. The predicates were obtained by high-level quantum-chem. computations. A careful anal. of the results of different fits and a comparison with the ab initio optimizations confirms the validity of the used methods, providing detailed structural information on the title compound and the disulfide bridge. In the experimental materials used by the author, we found 1,2-Diphenyldisulfane(cas: 882-33-7Quality Control of 1,2-Diphenyldisulfane)

1,2-Diphenyldisulfane(cas: 882-33-7) belongs to ethers.The C-O bonds that comprise simple ethers are strong. Quality Control of 1,2-Diphenyldisulfane They are unreactive toward all but the strongest bases. Although generally of low chemical reactivity, they are more reactive than alkanes.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem