Month: October 2022

Yu, Weiwei; Hu, Zhiru; Fu, Xinyu; Li, Yanchun; Su, Junfeng; Yang, Ting; Li, Songrui; Song, Zhiguang; Feng, Guodong published an article in 2021. The article was titled 《Phenanthroline derivative fluorescent probe for rapid and sensitive detection of silver(I)》, and you may find the article in Analytical Sciences.Quality Control of 2-Methoxybenzaldehyde The information in the text is summarized as follows:

In the present work, a phenanthroline derivative (2-(2-methoxyphenyl)-4-phenyl-1,10-phenanthroline, MPP), as a fluorescent probe, was synthesized to realize a rapid, simple and sensitive detection of silver(I). The detection conditions of Ag+ were optimized. This fluorescent probe has the advantages of a fast reaction time, a wide pH applicable range, and a low detection limit, exhibiting a good linear response between the fluorescence intensity and the concentration in the range of 0.05 – 1.5 μmol/L for Ag+. The detection limit is as low as 3.38 x 10-8 mol/L (S/N = 3). This probe had been used to detect Ag+ in real samples, and the recovery efficiency of spiked Ag+ had been also tested. The recovery efficiency is satisfactory, ranging from 92.0 to 105.4%. Therefore, this fluorescent probe should provide a new choice for the quant. detection of silver ions in environmental water samples. In the part of experimental materials, we found many familiar compounds, such as 2-Methoxybenzaldehyde(cas: 135-02-4Quality Control of 2-Methoxybenzaldehyde)

2-Methoxybenzaldehyde(cas: 135-02-4) is found in cassia oil, cinnamon bark, and cinnamon bark oil. It is a clear colorless liquid with a strong aroma. It has been used to examine the acaricidal activity of Periploca sepium oil and its active component against Tyrophagus putrescentiae.Quality Control of 2-Methoxybenzaldehyde

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Zhang, Zhenhao; Sabat, Nazarii; Frison, Gilles; Marinetti, Angela; Guinchard, Xavier published an article in 2022. The article was titled 《Enantioselective Au(I)-Catalyzed Multicomponent Annulations via Tethered Counterion-Directed Catalysis》, and you may find the article in ACS Catalysis.Category: ethers-buliding-blocks The information in the text is summarized as follows:

Gold(I) complexes of a chiral phosphoric acid-functionalized phosphine of the CPA-Phos series enable the enantioselective multicomponent reactions between aldehydes, hydroxylamines, and cyclic yne-enones, leading to 3,4-dihydro-1H-furo[3,4-d][1,2]oxazines. This represents a rare example of a highly enantioselective multicomponent reaction in gold(I) catalysis. The reactions proceed at a low catalyst loading and provide high yields, total diastereoselectivity, and enantiomeric excesses up to 99%. Silver-free conditions was applied. The method had a very broad scope as it applies to both aliphatic and aromatic aldehydes and hydroxylamines, to a variety of cyclic yne-enones, and to yne-enone-derived oximes. DFT calculations complement this study to enlighten reactivity issues and mechanistic pathways. The experimental part of the paper was very detailed, including the reaction process of 2-(Benzyloxy)acetaldehyde(cas: 60656-87-3Category: ethers-buliding-blocks)

2-(Benzyloxy)acetaldehyde(cas: 60656-87-3) may be used in the following syntheses: (3S,5S)-methyl 6-benzyloxy-3,5-dihydroxyhexanoate ,(S)-5-benzyloxy-4-hydroxypentan-2-one, myxothiazols.Category: ethers-buliding-blocks

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Jung, Woo-Ok; Yoo, Minjin; Migliozzi, Madyson M.; Zbieg, Jason R.; Stivala, Craig E.; Krische, Michael J. published an article in 2022. The article was titled 《Regio- and Enantioselective Iridium-Catalyzed Amination of Alkyl-Substituted Allylic Acetates with Secondary Amines》, and you may find the article in Organic Letters.Computed Properties of C9H10O2 The information in the text is summarized as follows:

Robust air-stable cyclometalated π-allyliridium C,O-benzoates modified by (S)-tol-BINAP catalyze the reaction of secondary aliphatic amines with racemic alkyl-substituted allylic acetates to furnish products of allylic amination with high levels of enantioselectivity. Complete branched regioselectivities were observed despite the formation of more highly substituted C-N bonds. The experimental part of the paper was very detailed, including the reaction process of 2-(Benzyloxy)acetaldehyde(cas: 60656-87-3Computed Properties of C9H10O2)

2-(Benzyloxy)acetaldehyde(cas: 60656-87-3) may be used in the following syntheses: (3S,5S)-methyl 6-benzyloxy-3,5-dihydroxyhexanoate ,(S)-5-benzyloxy-4-hydroxypentan-2-one, myxothiazols.Computed Properties of C9H10O2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2022,Wu, Kai; Yang, Ke; Wang, Siyu; Yu, Jiajun; Chu, Chenyang; Luo, Bingbing; Zhang, Huiyan published an article in Bioresource Technology. The title of the article was 《The enrichment of sugars and phenols from fast pyrolysis of bamboo via ethanol-Fenton pretreatment》.Quality Control of m-Methoxyphenol The author mentioned the following in the article:

The high-purity compounds (e.g., sugars and phenols) are important raw materials and chems., which can be produced by biomass pyrolysis. However, the direct biomass pyrolysis produces complex compounds and thus inhibiting its large-scale utilization. To increase the yield and enrichment of sugars and phenols, a green coupling process based on ethanol-Fenton pretreatment combined with fast pyrolysis is firstly proposed. The bamboo was effectively separated into the ethanol-Fenton pretreated bamboo (EF-bamboo), lignin-rich fractions, and hemicellulose-degradation intermixts. with the massive removal of inorganic metals via this process. Compared with the fast pyrolysis of raw bamboo, the levoglucosan yield of EF-bamboo increased 5.4 times and the enrichment of sugars improved from 7.6% to 59.7%. Similarly, the yield of monophenols from lignin-rich fractions increased around 0.6 times and the enrichment of monophenols increased from 25.7% to 63.5%. This work provides a green and efficient route to produce high-yield and high-enrichment sugars and phenols. In the experiment, the researchers used many compounds, for example, m-Methoxyphenol(cas: 150-19-6Quality Control of m-Methoxyphenol)

m-Methoxyphenol(cas: 150-19-6) may be used in synthesis of:C(4) symmetric calix[4]resorcinarene, 2-nitroso-5-methoxyphenol, 6-methoxy-2(3H)-benzoxazoloneQuality Control of m-Methoxyphenol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2022,Hu, Zhitao; Cao, Xiaohui; Zhang, Xiaohui; Wu, Bin; Luo, Wenjun; Huang, Huahua; Li, Le; Chen, Yongming published an article in ACS Macro Letters. The title of the article was 《Catalytically Controlled Ring-Opening Polymerization of 2-Oxo-15-crown-5 for Degradable and Recyclable PEG-Like Polyesters》.Computed Properties of C10H20O5 The author mentioned the following in the article:

Poly(ethylene glycol) (PEG) has been extensively used in diverse applications. However, it is not biodegradable and shows abnormal immune responses. Herein, a fast, controlled, ring-opening polymerization (ROP) of 2-oxo-15-crown-5 (O-15C5) is reported to prepare well-defined PEG-like polyesters, poly(O-15C5). This approach relies on a coordination between the macrocyclic monomer and Na+ that increases the electrophilicity of the carbonyl group of O-15C5 and leads to a fast controlled ROP (dispersity, DM < 1.2). Both computational and mechanistic studies show that the selective Na+ binding to the monomer over poly(O-15C5) allows the ring-opening initiation and propagation to be more energetically favorable than side transesterifications. This is the key to control the challenging entropy-driven ROP of O-15C5. Moreover, with the aid of Na+ and organic base, poly(O-15C5) depolymerized readily into O-15C5 in 2 h. Also, it degraded in a buffer of pH 7.4 by hydrolysis. After reading the article, we found that the author used 1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5Computed Properties of C10H20O5)

1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5) is a member of crown ether Ligands. Crown-ethers are macrocyclic polyethers capable of forming host-guest complexes, especially with inorganic and organic cations. Crown-ethers can incorporate protonated primary amine compounds by formation of ion-dipole bonds with the oxygen atoms of the chiral selector. Crown-ethers have been widely used for the separation of several pharmaceuticals both in aqueous and non-aqueous media. Computed Properties of C10H20O5

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2022,Rather, Ishfaq Ahmad; Ali, Rashid published an article in ACS Omega. The title of the article was 《An Efficient and Versatile Deep Eutectic Solvent-Mediated Green Method for the Synthesis of Functionalized Coumarins》.Application of 150-19-6 The author mentioned the following in the article:

Herein, we report a green and efficient synthetic route for the construction of diverse functionalized coumarins in good-to-excellent yields (60-98%) via the Pechmann condensation. The optimized synthetic route involves a biodegradable, reusable, and inexpensive deep eutectic solvent (DES) of choline chloride and L-(+)-tartaric acid in a ratio of 1:2 at 110°C. Interestingly, phloroglucinol and Et acetoacetate, upon reaction, furnished the functionalized coumarin (I) in 98% yield within 10 min. On the other front, the same DES at relatively lower reaction temperature (90°C) was found to provide the bis-coumarins in decent yields (81-97%) within 20-45 min. Moreover, this particular method was found to be quite effective for large-scale coumarin synthesis without noteworthy reduction in the yields of the desired products. Noticeably, in this versatile approach, the DES plays a dual role as solvent as well as catalyst, and it was effectively recycled and reused four times with no significant drop-down in the yield of the product. After reading the article, we found that the author used m-Methoxyphenol(cas: 150-19-6Application of 150-19-6)

m-Methoxyphenol(cas: 150-19-6) may be used as an analytical standard for the determination of the analyte in wine, coffee beans, wood samples, and mainstream smoke by gas chromatography (GC) based techniques.Application of 150-19-6

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Quality Control of N,N-Dimethylformamide Dimethyl AcetalIn 2020 ,《Pyrazolo[1,5-a]pyrimidines-based fluorophores: a comprehensive theoretical-experimental study》 appeared in RSC Advances. The author of the article were Tigreros, Alexis; Aranzazu, Sandra-L.; Bravo, Nestor-F.; Zapata-Rivera, Jhon; Portilla, Jaime. The article conveys some information:

Fluorescent mols. are crucial tools for studying the dynamics of intracellular processes, chemosensors, and the progress of organic materials. In this study, a family of pyrazolo[1,5-a]pyrimidines (PPs) 4a-g has been identified as strategic compounds for optical applications due to several key characteristics such as their simpler and greener synthetic methodol. (RME: 40-53%) as compared to those of BODIPYS (RME: 1.31-17.9%), and their tunable photophys. properties (going from ε = 3320 M-1 cm-1 and φF = 0.01 to ε = 20 593 M-1 cm-1 and φF = 0.97), in which electron-donating groups (EDGs) at position 7 on the fused ring improve both the absorption and emission behaviors. The PPs bearing simple aryl groups such as 4a (4-Py), 4b (2,4-Cl2Ph), 4d (Ph) and 4e (4-MeOPh), allow good solid-state emission intensities (QYSS = 0.18 to 0.63) in these compounds and thus, solid-state emitters can be designed by proper structural selection. The properties and stability found in 4a-g are comparable to com. probes such as coumarin-153, prodan and rhodamine 6G. Ultimately, the electronic structure anal. based on DFT and TD-DFT calculations revealed that EDGs at position 7 on the fused ring favor large absorption/emission intensities as a result of the ICT to/from this ring; however, these intensities remain low with electron-withdrawing groups (EWGs), which is in line with the exptl. data and allows us to understand the optical properties of this fluorophore family. In the experimental materials used by the author, we found N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Quality Control of N,N-Dimethylformamide Dimethyl Acetal)

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. The reaction of alkyl halides, R―X, where X is a halogen, or analogous reagents with ammonia (or amines) is useful with certain compounds. Not all alkyl halides are effective reagents; the reaction is sluggish with secondary alkyl groups and fails with tertiary ones. Its usefulness is largely confined to primary alkyl halides (those having two hydrogen atoms on the reacting site).Quality Control of N,N-Dimethylformamide Dimethyl Acetal

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Recommanded Product: 2-Hydroxy-4-methoxybenzaldehydeIn 2021 ,《A ratiometric photoelectrochemical microsensor based on a small-molecule organic semiconductor for reliable in vivo analysis》 was published in Chemical Science. The article was written by Xiang, Yunhui; Kong, Yao; Feng, Wenqi; Ye, Xiaoxue; Liu, Zhihong. The article contains the following contents:

Photoelectrochem. (PEC) sensing has been developing quickly in recent years, while its in vivo application is still in the infancy. The complexity of biol. environments poses a high challenge to the specificity and reliability of PEC sensing. We herein proposed the concept of small-mol. organic semiconductor (SMOS)-based ratiometric PEC sensing making use of the structural flexibility as well as readily tunable energy band of SMOS. Xanthene skeleton-based CyOH was prepared as a photoactive mol., and its absorption band and corresponding PEC output can be modulated by an intramol. charge transfer process. As such, the target mediated shift of absorption offered the opportunity to construct a ratiometric PEC sensor. A proof-of-concept probe CyOThiols was synthesized and assembled on a Ti wire electrode (TiWE) to prepare a highly selective microsensor for thiols. Under two monochromatic laser excitation (808 nm and 750 nm), CyOThiols/TiWE offered a ratiometric signal (j808/j750), which exhibited pronounced capacity to offset the disturbance of environmental factors, guaranteeing its reliability for application in vivo. The ratiometric PEC sensor achieved the observation of bio-thiol release induced by cytotoxic edema and fluctuations of thiols in drug-induced epilepsy in living rat brains. In the experiment, the researchers used many compounds, for example, 2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3Recommanded Product: 2-Hydroxy-4-methoxybenzaldehyde)

2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is the main component of root bark essential oil of Periploca sepium Bunge. It is a potential tyrosinase inhibitor present in African medicinal plants. 2-Hydroxy-4-methoxybenzaldehyde was used in the synthesis of Schiff base ligand.Recommanded Product: 2-Hydroxy-4-methoxybenzaldehyde

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Related Products of 882-33-7In 2019 ,《Using sulfur bridge oxidation to control electronic coupling and photochemistry in covalent anthracene dimers》 was published in Chemical Science. The article was written by Cruz, Chad D.; Yuan, Jennifer; Climent, Claudia; Tierce, Nathan T.; Christensen, Peter R.; Chronister, Eric L.; Casanova, David; Wolf, Michael O.; Bardeen, Christopher J.. The article contains the following contents:

Covalently tethered bichromophores provide an ideal proving ground to develop strategies for controlling excited state behavior in chromophore assemblies. In this work, optical spectroscopy and electronic structure theory are combined to demonstrate that the oxidation state of a sulfur linker between anthracene chromophores gives control over not only the photophysics but also the photochem. of the mols. Altering the oxidation state of the sulfur linker does not change the geometry between chromophores, allowing electronic effects between chromophores to be isolated. Previously, we showed that excitonic states in sulfur-bridged terthiophene dimers were modulated by electronic screening of the sulfur lone pairs, but that the sulfur orbitals were not directly involved in these states. In the bridged anthracene dimers that are the subject of the current paper, the AOs of the unoxidized S linker can actively mix with the anthracene MOs to form new electronic states with enhanced charge transfer character, different excitonic coupling, and rapid (sub-nanosecond) intersystem crossing that depends on solvent polarity. However, the fully oxidized SO2 bridge restores purely through-space electronic coupling between anthracene chromophores and inhibits intersystem crossing. Photoexcitation leads to either internal conversion on a sub-20 ps timescale, or to the creation of a long-lived emissive state that is the likely precursor of the intramol. [4 + 4] photodimerization. These results illustrate how chem. modification of a single atom in the covalent bridge can dramatically alter not only the photophysics but also the photochem. of mols. The experimental part of the paper was very detailed, including the reaction process of 1,2-Diphenyldisulfane(cas: 882-33-7Related Products of 882-33-7)

1,2-Diphenyldisulfane(cas: 882-33-7) belongs to ethers.Oxygen is more electronegative than carbon, thus the alpha hydrogens of ethers are more acidic than those of simple hydrocarbons. Related Products of 882-33-7 They are far less acidic than alpha hydrogens of carbonyl groups (such as in ketones or aldehydes), however.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Cu-Catalyzed four-component polymerization of alkynes, sulfonyl azides, nucleophiles and electrophiles》 was published in Polymer Chemistry in 2021. These research results belong to He, Junnan; Zheng, Nan; Li, Ming; Zheng, YuBin; Song, Wangze. Safety of 1,4-Diethynyl-2,5-dimethoxybenzene The article mentions the following:

Multicomponent polymerization has emerged as a promising strategy to develop functional polymers with versatile structures. In this work, a Cu-catalyzed four-component polymerization was developed using diynes, sulfonyl azides, nucleophiles, and a variety of electrophiles including alkyl glyoxylates, nitroalkenes, and Morita-Baylis-Hillman adducts to successfully synthesize a library of α-functionalized poly(N-sulfonylimidates)s with a wide substrate scope and high mol. weights (up to 20 000 g mol-1) in high yields (up to 86%). Such α-functionalized poly(N-sulfonylimidates)s could be further post-modified or utilized for the design of multi-functional and biodegradable polymers. In the experiment, the researchers used 1,4-Diethynyl-2,5-dimethoxybenzene(cas: 74029-40-6Safety of 1,4-Diethynyl-2,5-dimethoxybenzene)

1,4-Diethynyl-2,5-dimethoxybenzene(cas: 74029-40-6) belongs to ethers.The C-O bonds that comprise simple ethers are strong. Safety of 1,4-Diethynyl-2,5-dimethoxybenzene They are unreactive toward all but the strongest bases. Although generally of low chemical reactivity, they are more reactive than alkanes.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem