Month: October 2022

The author of 《Green-light activatable, water-soluble red-shifted coumarin photocages》 were Bojtar, Marton; Kormos, Attila; Kis-Petik, Katalin; Kellermayer, Miklos; Kele, Peter. And the article was published in Organic Letters in 2019. Recommanded Product: N,N-Dimethylformamide Dimethyl Acetal The author mentioned the following in the article:

Easily accessible green-light activatable (>500 nm) photocages based on red-shifted, π-extended coumarin scaffolds are developed with uncaging efficiencies similar to those of recently introduced BODIPY derivatives The photocages possess increased aqueous solubility, high absorption coefficients within the 450-600 nm range, and exceptionally high two-photon cross sections. In addition to this study using N,N-Dimethylformamide Dimethyl Acetal, there are many other studies that have used N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Recommanded Product: N,N-Dimethylformamide Dimethyl Acetal) was used in this study.

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Amines can be classified according to the nature and number of substituents on nitrogen. Aliphatic amines contain only H and alkyl substituents. Aromatic amines have the nitrogen atom connected to an aromatic ring.Important amines include amino acids, biogenic amines, trimethylamine, and aniline. Inorganic derivatives of ammonia are also called amines, such as monochloramine (NClH2).Recommanded Product: N,N-Dimethylformamide Dimethyl Acetal

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Phosphine-Mediated MBH-Type/Umpolung Addition Domino Sequence: Divergent Construction of Coumarins》 was published in Organic Letters in 2020. These research results belong to Deng, Zhi-Xiong; Zheng, Yu; Xie, Zhen-Zhen; Gao, Yue-Heng; Xiao, Jun-An; Xie, Si-Qi; Xiang, Hao-Yue; Chen, Xiao-Qing; Yang, Hua. Safety of 2-Hydroxy-4-methoxybenzaldehyde The article mentions the following:

A phosphine-mediated domino process of MBH-type reaction/umpolung γ-addition through the rational integration of the privileged reactivities of alkynoate is reported. Simply by manipulating the nucleophilic reagent, the developed protocol offers a facile, diversity-oriented construction of a wide range of three-substituted coumarins. In the part of experimental materials, we found many familiar compounds, such as 2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3Safety of 2-Hydroxy-4-methoxybenzaldehyde)

2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is employed in the synthesis of Schiff base ligand. It is applied as a reactant in the synthesis of LPA1R antagonists used in the inhibition of LPA-induced proliferation and contraction of normal human lung fibroblasts. Also used in the synthesis of tyrosine kinase 6 proteinase inhibitors.Safety of 2-Hydroxy-4-methoxybenzaldehyde

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Copper-Mediated Regioselective C-H Sulfenylation and Selenation of Phenols with Phenanthroline Bidentate Auxiliary》 was published in Organic Letters in 2020. These research results belong to Kajiwara, Rikuo; Takamatsu, Kazutaka; Hirano, Koji; Miura, Masahiro. Application of 882-33-7 The article mentions the following:

A copper-mediated,phenanthroline-directed highly ortho-selective C-H sulfenylation of phenols with diaryl disulfides proceeds to form the corresponding unsym. diaryl sulfides in good yield. He key to success is the introduction of a phenanthroline directing group of the bidentate-chelating nature, which is easily attachable,detachable, and even recyclable. Moreover, the same strategy is applicable to the C-H selenation, giving the diaryl selenides with high efficiency and regioselectivity.1,2-Diphenyldisulfane(cas: 882-33-7Application of 882-33-7) was used in this study.

1,2-Diphenyldisulfane(cas: 882-33-7) belongs to ethers.The C-O bonds that comprise simple ethers are strong. They are unreactive toward all but the strongest bases. Although generally of low chemical reactivity, they are more reactive than alkanes. Application of 882-33-7

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Copper-catalyzed arylated etherification of 2,2-difluoroethanol and its mechanistic study》 was written by Huang, Shuaishuai; Nie, Yixue; Yang, Jingjing; Zheng, Zhanjiang; Cao, Jian; Xu, Zheng; Xu, Liwen. SDS of cas: 2398-37-0 And the article was included in Youji Huaxue in 2020. The article conveys some information:

A mild and efficient method for the preparation of difluoroethyl aryl ethers was developed by the copper-catalyzed Ullmann-type arylated etherification reaction of aryl bromides or iodides with 2,2-difluoroethanol. This reaction proceeded smoothly in the presence of CuI and 8-hydroxyquinoline/t-BuOK and has a broad substrate scope. ESI-MS anal. supported the existence of LCu(III)Ar(OR) species during this catalytic reaction. Further d. functional theory (DFT) calculations suggested a proposed mechanism of arylated etherification reaction involving oxidative addition, followed by nucleophile substitution and reductive elimination would be rational. The experimental part of the paper was very detailed, including the reaction process of 1-Bromo-3-methoxybenzene(cas: 2398-37-0SDS of cas: 2398-37-0)

1-Bromo-3-methoxybenzene(cas: 2398-37-0) can be used in chemical reaction as intermediates to obtain target materials such as dyes, pharmaceuticals, perfumes, photoinitiators and agrochemicals.SDS of cas: 2398-37-0

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Diastereoselective olefin amidoacylation via photoredox PCET/nickel-dual catalysis: reaction scope and mechanistic insights》 was written by Zheng, Shuai; Zhang, Shuo-Qing; Saeednia, Borna; Zhou, Jiawang; Anna, Jessica M.; Hong, Xin; Molander, Gary A.. Formula: C9H10O2 And the article was included in Chemical Science in 2020. The article conveys some information:

Synthesis of cyclic amides such as I via regio- and diastereoselective amidoacylation of unactivated olefins by using photoredox proton-coupled electron transfer (PCET)/Ni dual-catalysis was developed. Various acyl electrophiles were compatible, including alkyl- and aryl acyl chlorides and anhydrides, as well as in situ activated carboxylic acids. Hammett studies and other mechanistic experiments to elucidate features of the diastereoselectivity, a transient absorption study of the PCET step, as well as computational evidence, provide an in-depth understanding of the disclosed transformation. In the experiment, the researchers used many compounds, for example, 2-(Benzyloxy)acetaldehyde(cas: 60656-87-3Formula: C9H10O2)

2-(Benzyloxy)acetaldehyde(cas: 60656-87-3) is a non-natural aldehyde. It undergoes enantioselective Mukaiyama aldol reaction with silylketene acetal nucleophiles in the presence of C2-symmetric bis(oxazolinyl)pyridine Cu(II) complex (catalyst).Formula: C9H10O2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Ni-Catalyzed reductive amination of phenols with ammonia or amines into cyclohexylamines》 was written by Cuypers, Thomas; Morias, Thomas; Windels, Simon; Marquez, Carlos; Van Goethem, Cedric; Vankelecom, Ivo; De Vos, Dirk E.. Computed Properties of C7H8O2 And the article was included in Green Chemistry in 2020. The article conveys some information:

Phenol and its derivatives, which naturally occur in lignocellulose, can be considered as a renewable feedstock not only for aromatic, but also for alicyclic compounds, such as primary and N-substituted cyclohexylamines. So far, the latter are mostly produced from non-renewable starting materials like benzene via problematic nitration/reduction or cross-coupling routes. Herein, an efficient reductive amination of phenol with ammonia or amines is demonstrated, for the first time without the need for rare and expensive noble metals and without using any additives. Various supported Ni catalysts were screened and we elucidated the influence of the key parameters, including the acid-base properties of the supporting material. Acquired knowledge was then applied to different phenol-ammonia/amine combinations, resulting in the synthesis of various primary, secondary and tertiary cyclohexylamines in fair to very high yields. In addition to this study using m-Methoxyphenol, there are many other studies that have used m-Methoxyphenol(cas: 150-19-6Computed Properties of C7H8O2) was used in this study.

m-Methoxyphenol(cas: 150-19-6) may be used as an analytical standard for the determination of the analyte in wine, coffee beans, wood samples, and mainstream smoke by gas chromatography (GC) based techniques.Computed Properties of C7H8O2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Development and Evaluation of Topical Delivery of Microemulsions Containing Adapalene (MEs-Ap) for Acne》 was written by Shao, Bing; Sun, Lixin; Xu, Na; Gu, Hongwei; Ji, Hongyu; Wu, Linhua. Synthetic Route of C28H28O3 And the article was included in AAPS PharmSciTech in 2021. The article conveys some information:

The main objective of the study was to prepare the microemulsions containing adapalene (MEs-Ap) to enhance epidermal penetration, dermal retention, and local bioavailability compared with the com. preparation The optimal formulations were selected by solubility experiments, pseudo-ternary phase diagram, and percutaneous permeation experiments and the physiochem. properties were also investigated. Then, the study of permeability, retention, safety, pharmacodynamics, and pharmacokinetics in the skin for MEs-Ap compared with the com. preparation were researched. The optimized formulation was developed as follows: the ratio of AP, iso-Pr myristate, polyoxyethylene hydrogenated castor oil, ethanol, and water was 0.01:1:1.25:3.75:4 (weight/weight). The globule size and average viscosity of the optimized MEs-Ap were 99.34 nm and 1.7 mPa·s, resp., which was oil-in-water microemulsion without serious irritation or allergy for skin. The Js, Qn, and Qretention of MEs-Ap (0.81 ± 0.19μg/cm2/h, 24.73 ± 4.24μg/cm2, 2.08 ± 0.18μg/cm2) were apparently higher than Differin (0.022 ± 0.009μg/cm2/h, 0.536 ± 0.103μg/cm2, and 0.523 ± 0.130μg/cm2) resp. The local bioavailability study showed that the AUC0 → 36h of the MEs-Ap in the dermal (19.6 ± 1.22μg/cm2) was significantly improved comparing to Differin (13.9 ± 1.73μg/cm2) (p < 0.01). The pharmacodynamics study showed that the therapeutic effect of MEs-Ap was better than that of Differin in the acne model of rabbit auricle. These results suggested that the MEs-Ap could be considered as a having higher epidermal penetrability, dermal retention, local bioavailability, efficacy, and safety topical preparations for acne. The experimental part of the paper was very detailed, including the reaction process of 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas: 106685-40-9Synthetic Route of C28H28O3)

6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas:106685-40-9) may be used as a pharmaceutical reference standard for the quantification of the analyte in topical gel formulations using high-performance liquid chromatography technique.Synthetic Route of C28H28O3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Pramanik, Milan; Mathuri, Ashis; Sau, Sudip; Das, Monojit; Mal, Prasenjit published their research in Organic Letters in 2021. The article was titled 《Chlorinative Cyclization of Aryl Alkynoates Using NCS and 9-Mesityl-10-methylacridinium Perchlorate Photocatalyst》.Electric Literature of C7H8O2 The article contains the following contents:

In a chlorinative cyclization, Mes-Acr-MeClO4 acted as a visible-light photocatalyst to obtain 3-chlorocoumarins I [Ar = Ph, 4-ClC6H4, 1-naphthyl, etc.; R = H, 7-Me, 6-MeO, etc.] from aryl alkynoates and N-chlorosuccinimide (NCS). The radical initiated reaction proceeded in a cascading manner via Cl- addition to alkynoates. Next, 5-exo-trig spirocyclization and subsequent 1,2-ester migration led to the formation of C-C and C-Cl bonds. In the experiment, the researchers used m-Methoxyphenol(cas: 150-19-6Electric Literature of C7H8O2)

m-Methoxyphenol(cas: 150-19-6) may be used in synthesis of:C(4) symmetric calix[4]resorcinarene, 2-nitroso-5-methoxyphenol, 6-methoxy-2(3H)-benzoxazoloneElectric Literature of C7H8O2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Zhu, Hongwei; Shen, Zhongjin; Pan, Linfeng; Han, Jianlei; Eickemeyer, Felix T.; Ren, Yameng; Li, Xianggao; Wang, Shirong; Liu, Hongli; Dong, Xiaofei; Zakeeruddin, Shaik M.; Hagfeldt, Anders; Liu, Yuhang; Gratzel, Michael published their research in ACS Energy Letters in 2021. The article was titled 《Low-Cost Dopant Additive-Free Hole-Transporting Material for a Robust Perovskite Solar Cell with Efficiency Exceeding 21%》.Related Products of 101-70-2 The article contains the following contents:

Developing hole-transporting materials (HTMs) with appropriate mol. configuration and charge mobility is important to improve perovskite solar cell (PSC) photovoltaic performance and their feasibility for commercialization. In this work, a novel pyramidal-shaped low-cost HTM coded MeOTTVT is prepared through extension of π-conjugation based on a triphenylamine core. Carbon-carbon double bonds are introduced between the core and p-methoxyl triphenylamine to improve the planarity of the HTM, favoring intermol. stacking of MeOTTVT and thus improving the hole mobility of the corresponding hole-transporting layer (HTL). The p-methoxyl triphenylamine-endowed HTM benefits from a HOMO level well-aligned with the perovskite active layer, facilitating effective hole extraction The champion PSC using an MeOTTVT-based dopant additive-free HTL yielded a power conversion efficiency (PCE) up to 21.30%, which is considered one of the best-performing PSCs employing a dopant additive-free small mol. HTM. In addition, the MeOTTVT-based dopant additive-free HTL exhibits outstanding thermal stability and high glass-transition temperature (Tg = 137.1 °C), combined with a more hydrophobic surface; PSCs based on an MeOTTVT dopant additive-free HTL exhibit outstanding stability against moisture, 1 sun illumination, and thermal stress. In the experiment, the researchers used Bis(4-methoxyphenyl)amine(cas: 101-70-2Related Products of 101-70-2)

Bis(4-methoxyphenyl)amine(cas: 101-70-2) is a diphenylamine derivative used as a chemical additive for cured rubber.Bis(4-methoxyphenyl)amine is highly toxic and may potentially induce chromosome abberation.Related Products of 101-70-2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Dong, Yubao; Zhu, Li; Yin, Bing; Zhu, Xinrui; Li, Dongfeng published their research in Dalton Transactions in 2021. The article was titled 《Regulating the magnetic properties of seven-coordinated Dy(III) single-ion magnets through the effect of positional isomers on axial crystal-field》.Category: ethers-buliding-blocks The article contains the following contents:

Six Dy(III) single-ion magnets (SIMs) [Dy(n-OMe-bbpen)X] were synthesized by a solvothermal reaction with three positional isomers (ortho, meta, and para) of ligands n-OMe-H2bbpen and dysprosium halides DyX3, (n-OMe-H2bbpen = N,N′-bis(2-hydroxy-n-methoxybenzyl)-N,N′-bis(2-methylpyridyl)ethylenediamine; n = 3, X = Cl, 1; n = 3, X = Br, 2; n = 4, X = Cl, 3; n = 4, X = Br, 4; n = 5, X = Cl, 5; n = 5, X = Br, 6). Dynamic magnetic measurements revealed that the six complexes possess notably different effective barriers of magnetic reversal: 872.0 K (1), 1210.1 K (2), 137.9 K (3), 602.6 K (4), 907.0 K (5) and 1216.7 K (6). 6 showed the best performance as SIMs among the six Dy(III) complexes. Moreover, the magnetic hysteresis loops of 6 remained open at 21 K. The crystal structures indicate the switching of local symmetry around Dy(III) ion, aroused by the variation in intermol. interactions and steric effects. This switch is primarily correlated with the distinction of magnetic properties. In addition, ab initio calculations confirmed that the different electrostatic potential around Dy(III) ion stemming from the electronic effect of the OMe-substituted group is another factor leading to the distinction in magnetic properties. This work warns us that when designing ligands for Dy-SIMs, the effect of positional isomerism on magnetic performance must be considered, which is one of the factors that can easily be overlooked.2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3Category: ethers-buliding-blocks) was used in this study.

2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is employed in the synthesis of Schiff base ligand. It is applied as a reactant in the synthesis of LPA1R antagonists used in the inhibition of LPA-induced proliferation and contraction of normal human lung fibroblasts. Also used in the synthesis of tyrosine kinase 6 proteinase inhibitors.Category: ethers-buliding-blocks

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem