Month: October 2022

The author of 《A MedChem toolbox for cereblon-directed PROTACs》 were Steinebach, Christian; Sosic, Izidor; Lindner, Stefanie; Bricelj, Alesa; Kohl, Franziska; Ng, Yuen Lam Dora; Monschke, Marius; Wagner, Karl G.; Kroenke, Jan; Guetschow, Michael. And the article was published in MedChemComm in 2019. Application In Synthesis of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate The author mentioned the following in the article:

A modular chem. toolbox was developed for cereblon-directed PROTACs. A variety of linkers was attached to a CRBN ligand via the 4-amino position of pomalidomide. We used linkers of different constitution to modulate physicochem. properties. We equipped one terminus of the linker with a set of functional groups, e.g. protected amines, protected carboxylic acids, alkynes, chloroalkanes, and protected alcs., all of which are considered to be attractive for PROTAC design. We also highlight different opportunities for the expansion of the medicinal chemists’ PROTAC toolbox towards heterobifunctional mols., e.g. with biotin, fluorescent, hydrophobic and peptide tags. In the experimental materials used by the author, we found tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6Application In Synthesis of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate)

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers.Application In Synthesis of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamateAlthough ethers resist hydrolysis, they are cleaved by hydrobromic acid and hydroiodic acid. Hydrogen chloride cleaves ethers only slowly.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

The author of 《A green, catalyst-free synthesis of pyrazolopyranopyrimidines in polyethylene glycol as a biodegradable medium at ambient temperature》 were Kardooni, Rezvan; Kiasat, Ali Reza. And the article was published in Molecular Diversity in 2019. HPLC of Formula: 135-02-4 The author mentioned the following in the article:

A facile, efficient and environmentally safe strategy for the synthesis of pyrazolopyranopyrimidines via one-pot, four-component reaction of hydrazine hydrate, barbituric acid, Et acetoacetate and aromatic aldehydes in polyethylene glycol (PEG) as a safe solvent in the absence of catalyst at ambient temperature were described. The advantages of the present protocol, such as simplicity, mild conditions, high yields of products, straightforward workup procedure, a green and biodegradable reaction medium, made this process an attractive to current methodologies. The results came from multiple reactions, including the reaction of 2-Methoxybenzaldehyde(cas: 135-02-4HPLC of Formula: 135-02-4)

2-Methoxybenzaldehyde(cas: 135-02-4) is found in cassia oil, cinnamon bark, and cinnamon bark oil. It is a clear colorless liquid with a strong aroma. It has been used to examine the acaricidal activity of Periploca sepium oil and its active component against Tyrophagus putrescentiae.HPLC of Formula: 135-02-4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Silver nanoparticles-decorated Preyssler functionalized cellulose biocomposite as a novel and efficient catalyst for the synthesis of 2-amino-4H-pyrans and spirochromenes》 was published in Scientific Reports in 2020. These research results belong to Saneinezhad, Sara; Mohammadi, Leila; Zadsirjan, Vahideh; Bamoharram, Fatemeh F.; Heravi, Majid M.. Category: ethers-buliding-blocks The article mentions the following:

Silver nanoparticles-decorated Preyssler functionalized cellulose biocomposite (PC/AgNPs) was prepared and fully characterized by FTIR, UV-vis, SEM, and TEM techniques. The preparation of PC/AgNPs was studied systematically to optimize the processing parameters by Taguchi method using the amount of PC, reaction temperature, concentration of silver nitrate and pH of medium. Taguchi’s L9 orthogonal (4 parameters, 4 level) was used for the exptl. design. The SEM anal. confirmed the presence of the Preyssler as a white cloud as well as spherical AgNPs on the surface of cellulose. The formation of AgNPs on the surface was observed by changing of the color from yellow to deep brown and confirmed by UV-vis spectroscopy. The best yield of AgNPs forming was obtained in pH 12.5 at 80°C in 20 min. TEM anal. confirmed the formation of spherical AgNPs with a size of 50 nm, at the 1% weight loading of Preyssler. This easily prepared PC/AgNPs was successfully employed as an efficient, green, and reusable catalyst in the synthesis of a wide range of 2-amino-4H-pyran I (R = Ph, 3-nitrophenyl, 4-chlorophenyl, etc.; X = CN, CO2Et), II (R1 = Ph, 2-methoxyphenyl, 4-chlorophenyl, etc.), III (R2 = Ph, 4-hydroxyphenyl, 4-chlorophenyl, etc.), IV (R3 = Ph, 2-nitrophenyl, 3-bromophenyl, etc.) and V and functionalized spirochromene derivatives via a one-pot, multicomponent reaction. The chief merits realized for this protocol were the utilization of com. available or easily accessible starting materials, operational simplicity, facile work-up procedure, obtaining of high to excellent yields of the products and being done under green conditions. The catalyst could be easily separated from the reaction mixture and reused several times without observing any appreciable loss in its efficiency. In the experiment, the researchers used many compounds, for example, 2-Methoxybenzaldehyde(cas: 135-02-4Category: ethers-buliding-blocks)

2-Methoxybenzaldehyde(cas: 135-02-4) is used as a flavor agent in foods including nonalcoholic/alcoholic beverages, baked goods, chewing gum, confections, frozen dairy, fruit ices, hard/soft candy, instant coffee, tea, Jams, jellies, and milk products. It also has been used to obtain good enantioselectivities using Cu(OAc)(2)-bis(oxazolines) via hydrogen bonding in asymmetric Henry reaction.Category: ethers-buliding-blocks

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Structural characterization of new zinc(II) complexes with N2O2 chelating thiosemicarbazidato ligands; investigation of the relationship between their DNA interaction and in vitro antiproliferative activity towards human cancer cells》 was published in New Journal of Chemistry in 2020. These research results belong to Kaya, Busra; Yilmaz, Zehra Kubra; Sahin, Onur; Aslim, Belma; Ulkuseven, Bahri. Computed Properties of C8H8O3 The article mentions the following:

Two new zinc(II) complexes were synthesized by condensation of 4,4,4-trifluoro-1-(2-thienyl)-1,3-butanedione-S-methyl-thiosemicarbazone with salicylaldehyde or 4-methoxy-salicylaldehyde. Structures of the N2O2-chelate complexes, Zn1 and Zn2, were explicated by IR, 1H NMR, ESI-MS and X-ray crystallog. Electronic spectral anal. was performed to assign the nature of the interaction between the complexes and calf thymus DNA (CT-DNA). DNA cleavage activities of the complexes were investigated by gel electrophoresis (pBR322 DNA). The results indicated that the complexes bind to CT-DNA via an intercalation mode and the binding of Zn2 is stronger than that of Zn1. Relatively high concentrations of the zinc complexes were found to encourage the cleavage of DNA from supercoiled form (Form I) to nicked circular form (Form II). The antiproliferative activity of the complexes was determined against human colorectal adenocarcinoma (HT-29) and human cervical carcinoma (HeLa) cell lines by MTT assay. The tests revealed that the complex Zn2 exhibited a higher antiproliferative effect than Zn1 on HT-29 and HeLa cells, analogical to the data from DNA interaction experiments The studies demonstrated that complex Zn2 could be a good candidate as a chemotherapeutic drug targeting DNA. In the experiment, the researchers used 2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3Computed Properties of C8H8O3)

2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is employed in the synthesis of Schiff base ligand. It is applied as a reactant in the synthesis of LPA1R antagonists used in the inhibition of LPA-induced proliferation and contraction of normal human lung fibroblasts. Also used in the synthesis of tyrosine kinase 6 proteinase inhibitors.Computed Properties of C8H8O3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《CD271 promotes STZ-induced diabetic wound healing and regulates epidermal stem cell survival in the presence of the pTrkA receptor》 was published in Cell & Tissue Research in 2020. These research results belong to Zhang, Min; Zhang, Rui; Li, Xiaohong; Cao, Yongqian; Huang, Kaifeng; Ding, Jun; Liu, Mengyao; Feng, Zhang; Yin, Siyuan; Ma, Jiaxu; Zhang, Huayu; Wang, Yibing. HPLC of Formula: 106685-40-9 The article mentions the following:

Diabetes mellitus (DM) often causes delayed wound healing in patients, which can lead to limb loss, disability, and even death. Many conventional therapeutic strategies have been proposed, but there is still no effective therapy for DM wounds. This study aimed to explore the effects of CD271 and phosphorylated tyrosine kinase receptor A (pTrkA) on the migration and proliferation abilities of epidermal stem cells (eSCs) and on the activation of DM wound healing. We investigated the interventional effects of CD271-overexpressing eSC (CD271 eSC) treatment and pTrkA inhibition (through k252a treatment) on delayed wound healing using mice with streptozotocin-induced DM. The migration and proliferation abilities of control eSCs, CD271 eSCs, and k252a-treated CD271 eSCs were observed under high-glucose conditions. Decreases in CD271 and increases in pTrkA were observed in DM mouse skin compared with control mouse skin; in addition, the rate of wound closure in DM mice was promoted by CD271 eSC treatment but delayed by pTrkA inhibition. Furthermore, the CD271 eSC migration and proliferation were greater than of control eSCs. Compared with that of CD271 eSCs, the number of CD271+k252a eSCs decreased significantly under high-glucose conditions. In parallel, the expression levels of the pERK, pAkt, and pJNK pathways increased in CD271 eSCs and decreased in CD271+k252a eSCs under high glucose. Our findings demonstrate that CD271 and pTrkA affect DM wound closure by promoting the eSC migration and proliferation. This mechanism involving the pERK, pAkt, and pJNK pathways might be a new therapeutic target for the treatment of delayed wound re-epithelialization in DM. In the experimental materials used by the author, we found 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas: 106685-40-9HPLC of Formula: 106685-40-9)

6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas:106685-40-9) is a third-generation synthetic retinoid and a highly lipophilic compound derived from naphthoic acid. It is widely used in the treatment of acne.HPLC of Formula: 106685-40-9

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Binding Interaction Between Boronic Acid Derivatives with Monosaccharaides colon Effect of Structural Change of Monosaccharaides Upon Binding Using S hyphen V Plots》 was published in Macromolecular Symposia in 2020. These research results belong to Bhavya, P.; Melavanki, Raveendra; Narayanappa, C. K.; Kusanur, Raviraj; U., Meghana; B., Suma. Application In Synthesis of 3-Methoxyphenylboronic acid The article mentions the following:

Sugar sensing and continuous monitoring of glucose (CGM) play an important and vital role in controlling diabetes. The present enzyme-based sugar sensors have their own drawbacks. Problems associated with them have encouraged alternate approaches to design new sensors. Among many, fluorescent intensity change based sensors are drawing more attention. Fluorescence sensors based on boronic acid derivatives are more popular because of their ability to reversibly bind diol-containing compounds Here, the binding ability of two boronic acid derivatives, namely 2-methylphenyl boronic acid (B1) and 3-methoxyphenyl boronic acid (B2) with mono saccharides (sugars), is under investigation. The sugar concentration is kept nearly 1000 times more than that of boronic acid. The interactions of B1 and B2 with three saccharides (D-sorbitol, dextrose, and fructose) are studied by absorbance and steady-state fluorescence. Both B1 and B2 fluorescence is quenched by formation of esters with saccharides. The results of absorbance and fluorescence measurements indicate that the studied sugars can be ordered by their affinity to B1 as: D-sorbitol > xylose > dextrose and for B2 as: dextrose > xylose > D-sorbitol. In each case, slope of modified S-V plots is nearly one indicating only a single binding site in boronic acids for sugars. After reading the article, we found that the author used 3-Methoxyphenylboronic acid(cas: 10365-98-7Application In Synthesis of 3-Methoxyphenylboronic acid)

3-Methoxyphenylboronic acid(cas: 10365-98-7) belongs to boronic acids. Boronic acids are mild Lewis acids which are generally stable and easy to handle, making them important to organic synthesis.Application In Synthesis of 3-Methoxyphenylboronic acid

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Visible-light photoredox-catalyzed C-O bond cleavage of diaryl ethers by acridinium photocatalysts at room temperature》 was published in Nature Communications in 2020. These research results belong to Tan, Fang-Fang; He, Xiao-Ya; Tian, Wan-Fa; Li, Yang. Recommanded Product: 150-19-6 The article mentions the following:

Visible-light photoredox-catalyzed C-O bond cleavage of diaryl ethers by an acidolysis with an aryl carboxylic acid and a following one-pot hydrolysis was reported. Two mols. of phenols were obtained from one mol. of diaryl ether at room temperature The aryl carboxylic acid used for the acidolysis was recovered. The key to success of the acidolysis was merging visible-light photoredox catalysis using an acridinium photocatalyst and Lewis acid catalysis using Cu(TMHD)2. Preliminary mechanistic studies indicated that the catalytic cycle occurred via a rare selective electrophilic attack of the generated aryl carboxylic radical on the electron-rich aryl ring of the di-Ph ether. This transformation was applied to a gram-scale reaction and the model of 4-O-5 lignin linkages.m-Methoxyphenol(cas: 150-19-6Recommanded Product: 150-19-6) was used in this study.

m-Methoxyphenol(cas: 150-19-6) may be used in synthesis of:C(4) symmetric calix[4]resorcinarene, 2-nitroso-5-methoxyphenol, 6-methoxy-2(3H)-benzoxazoloneRecommanded Product: 150-19-6

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Increased flare of acne caused by long-time mask wearing during COVID-19 pandemic among general population》 was written by Han, Changxu; Shi, Jialiang; Chen, Yan; Zhang, Zhenying. Application In Synthesis of 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid And the article was included in Dermatologic Therapy in 2020. The article conveys some information:

Wearing a mask is encouraged for preventing dispersal of droplets during talking, sneezing and coughing. Therefore, it is thought to reduce the risk of environmental contamination by SARS-CoV-2 (COVID-19) based on the precautionary principles. However, longtime mask wearing could increase the flare of acne due to higher temperature and humidity on the surface of facial skin caused by expired air and the perspiration. Higher temperature has a close correlation with the flare of acne,which can be explained by the effect of higher temperature on the sebum excretion rate. Increased flare of acne caused by long-time mask wearing during COVID-19 pandemic among general population were noted here. Although wearing mask is extremely important to our fight against COVID-19, general public should be aware of proper and rational mask wearing. In the experimental materials used by the author, we found 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas: 106685-40-9Application In Synthesis of 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid)

6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas:106685-40-9) is a third-generation synthetic retinoid and a highly lipophilic compound derived from naphthoic acid. It is widely used in the treatment of acne.Application In Synthesis of 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Regenerated Hoof Keratin from 1-Ethyl-3-Methylimidazolium Acetate and Insights into Disulfide-Ionic Liquid Interactions from MD Simulation》 was written by Apostolidou, Christina. Safety of 1,2-Diphenyldisulfane And the article was included in ChemistryOpen in 2020. The article conveys some information:

Regeneration of the hoof keratin from ionic liquids was never successful in the past because the ionic liquids were not strong enough. However, this biomaterial starts to play a central role for the preparation of biofilms in the future. In the present study, hoof keratin was regenerated for the first time from an ionic liquid by experiment and characterized by FTIR spectroscopy, Differential Scanning Calorimetry (DSC) and SEM (SEM). As 1-Ethyl-3-methylimidazolium acetate is strong enough to dissolve hooves, which have a lot of disulfide bonds, a Mol. Dynamics (MD) simulation was performed with this ionic liquid and di-Ph disulfide. The MD simulation reveals that not only the cation as postulated after experiments were carried out, but also the anion is very important for the dissolution process. This complete picture was and is not accessible via experiments and is therefore valuable for future investigations. The anion always interacts with the disulfide bond, whereas the cation prefers in some situations a strong H-O interaction with the anion. If the cations and the anions are separated from each other so that the cation can not interact with the anion, both interact with the disulfide bond. The high solvation power of this solvent is shown by the fact that the cation interacts from the left and right side and the anion from above and below the disulfide bond. The experimental part of the paper was very detailed, including the reaction process of 1,2-Diphenyldisulfane(cas: 882-33-7Safety of 1,2-Diphenyldisulfane)

1,2-Diphenyldisulfane(cas: 882-33-7) belongs to ethers.Ethers do have nonbonding electron pairs on their oxygen atoms, and they can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. Safety of 1,2-Diphenyldisulfane The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Suppressing Li dendrites via electrolyte engineering by crown ethers for lithium metal batteries》 was written by Zhang, Shanqing. Reference of 1,4,7,10,13-Pentaoxacyclopentadecane And the article was included in Nano-Micro Letters in 2020. The article conveys some information:

Electrolyte engineering is considered as an effective strategy to establish stable solid electrolyte interface (SEI), and thus to suppress the growth of lithium dendrites. In a recent study reported in Advanced Functional Materials by Ma group, discovered that strong coordination force could be founded between 15-Crown-5 ether (15-C-5) and Li+, which facilitates the crown ether (15-C-1) to participate in the solvation structure of Li+ in the electrolyte for the same purpose. Such a novel strategy might impact the design of high-performance and safe lithium metal batteries (LMBs). In the experiment, the researchers used many compounds, for example, 1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5Reference of 1,4,7,10,13-Pentaoxacyclopentadecane)

1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5) is a member of crown ether Ligands. Crown-ethers are macrocyclic polyethers capable of forming host-guest complexes, especially with inorganic and organic cations. Crown-ethers can incorporate protonated primary amine compounds by formation of ion-dipole bonds with the oxygen atoms of the chiral selector. Crown-ethers have been widely used for the separation of several pharmaceuticals both in aqueous and non-aqueous media. Reference of 1,4,7,10,13-Pentaoxacyclopentadecane

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem