Month: October 2022

In 2019,European Polymer Journal included an article by Zupanc, Anze; Kotnik, Tomaz; Stanfel, Ursa; Brodnik Zugelj, Helena; Kristl, Anja; Rucigaj, Ales; Matoh, Lev; Pahovnik, David; Groselj, Uros; Opatz, Till; Pozgan, Franc; Stefane, Bogdan; Zagar, Ema; Svete, Jurij. Related Products of 4637-24-5. The article was titled 《Chemical recycling of polyenaminones by transamination reaction via amino-enaminone polymerization/depolymerization》. The information in the text is summarized as follows:

Novel oligo- and polyenaminones with Mw-3000 Da were prepared in excellent yields by amino-enaminone ‘click’ polymerization of 1,3- and 1,4-bis[3-(dimethylamino)acryloyl]arenes with 1,3- and 1,4-phenylenediamine. The obtained oligomers and polymers were depolymerized quant. to the starting bis-enaminones and diamines by treatment with excess dimethylamine in ethanol at 50°C. This simple polymerization/depolymerization method allows for a closed-loop recycling of polyenaminone-based materials. UV light absorbance at wavelengths below 470 nm indicates promising optical properties of these polymers. After reading the article, we found that the author used N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Related Products of 4637-24-5)

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. In organic chemistry, amines are compounds and functional groups that contain a basic nitrogen atom with a lone pair. Amines are formally derivatives of ammonia (NH3), wherein one or more hydrogen atoms have been replaced by a substituent such as an alkyl or aryl group (these may respectively be called alkylamines and arylamines; amines in which both types of substituent are attached to one nitrogen atom may be called alkylarylamines).Related Products of 4637-24-5

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

The author of 《Synthesis of α-Trifluoromethylacrylates by Ligand-Free Palladium-Catalyzed Mizoroki-Heck Reaction》 were Xiao, Pan; Schlinquer, Claire; Pannecoucke, Xavier; Bouillon, Jean-Philippe; Couve-Bonnaire, Samuel. And the article was published in Journal of Organic Chemistry in 2019. Formula: C7H7IO The author mentioned the following in the article:

Efficient ligand-free palladium catalyzed Mizoroki-Heck reaction allowed the formation of trisubstituted α-trifluoromethylacrylates. The reaction showed good chem. tolerance and furnished moderate to excellent yields of reaction. Silver salt additive proved to be essential for the reaction. The reaction has been then applied to the formation of 3-trifluoromethyl coumarins and analogs of therapeutic agents. In the experimental materials used by the author, we found 1-Iodo-2-methoxybenzene(cas: 529-28-2Formula: C7H7IO)

1-Iodo-2-methoxybenzene(cas: 529-28-2) participates in palladium catalyzed enantioselective Heck arylation of 2,3-dihydrofuran in the presence of chiral ionic liquids containing L-prolinate and L-lactate anions and non-chiral quaternary ammonium cations.Formula: C7H7IO

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

The author of 《Orthogonal Oriented Bisanthrancene-Bridged Bis(Triarylamine) Diradical Dications: Isolation, Characterizations and Crystal Structures》 were Wang, Lei; Zhang, Li; Fang, Yong; Zhao, Yue; Tan, Gengwen; Wang, Xinping. And the article was published in Chemistry – An Asian Journal in 2019. Safety of Bis(4-methoxyphenyl)amine The author mentioned the following in the article:

Two bis(triarylamine) diradical dication salts 12+2[Al(ORF)4]- and 22+2[Al(ORF)4]- bridged with an orthogonal oriented bisanthrancene motif were synthesized. Their solid state and electronic structures were studied by various exptl. approaches in conjunction with theor. calculations Superconducting quantum interference device measurements and d. functional theory calculations reveal that both of 12+ and 22+ feature open-shell singlet ground states with rather small singlet-triplet energy gaps; thus, they can be regarded as nearly pure diradicals (biradicals). Their diradical characters are enhanced by the orthogonal configuration of the bisanthrancene moiety which demonstrates the importance of the geometry of bridging units in turning the electronic structures of bis(triarylamine) dications. In the experimental materials used by the author, we found Bis(4-methoxyphenyl)amine(cas: 101-70-2Safety of Bis(4-methoxyphenyl)amine)

Bis(4-methoxyphenyl)amine(cas: 101-70-2) is a diphenylamine derivative used as a chemical additive for cured rubber.Bis(4-methoxyphenyl)amine is highly toxic and may potentially induce chromosome abberation.Safety of Bis(4-methoxyphenyl)amine

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

The author of 《Bioinspired Palladium Nanoparticles Supported on Soil-Derived Humic Acid Coated Iron-Oxide Nanoparticles as Catalyst for C-C Cross-Coupling and Reduction Reactions》 were Chinchole, Anurag N.; Dubey, Abhishek V.; Kumar, A. Vijay. And the article was published in Catalysis Letters in 2019. HPLC of Formula: 529-28-2 The author mentioned the following in the article:

Palladium supported on humic acid-coated magnetite nanoparticles was prepared as a recyclable catalyst for Suzuki coupling reactions of aryl iodides, bromides, and diazonium tetrafluoroborates with arylboronic acids, for stereoselective Heck reactions of styrene with aryl bromides and iodides, and for hydrogenation reactions of diaryl alkenes using aqueous ethanol or methanol as solvents. In the experimental materials used by the author, we found 1-Iodo-2-methoxybenzene(cas: 529-28-2HPLC of Formula: 529-28-2)

1-Iodo-2-methoxybenzene(cas: 529-28-2) participates in palladium catalyzed enantioselective Heck arylation of 2,3-dihydrofuran in the presence of chiral ionic liquids containing L-prolinate and L-lactate anions and non-chiral quaternary ammonium cations.HPLC of Formula: 529-28-2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Enantioselective three-component Ugi reaction catalyzed by chiral phosphoric acid》 was published in Science China: Chemistry in 2020. These research results belong to Zhang, Jian; Wang, Yi-Yan; Sun, He; Li, Shao-Yu; Xiang, Shao-Hua; Tan, Bin. Safety of 2-(Benzyloxy)acetaldehyde The article mentions the following:

A catalytic enantioselective three-component Ugi reaction was developed. SPINOL-derived phosphoric acid with bulky 2,4,6-tricyclohexylphenyl groups at the 6,6′ positions I was found to be the best catalyst to afford α-amino amide derivatives, e.g., II in good to excellent yields (62% to 99%) and enantiocontrol (81% to >99% enantiomeric excess). This asym. reaction was applicable well to an array of aliphatic aldehydes. The gram-scale synthesis, modification of dapsone, and enantioselective synthesis of (R)-Lacosamide underline the general utility of this methodol. Influence of dihedral angles and substituents of the chiral phosphoric acids on the enantioselectivity was also discussed in this article. After reading the article, we found that the author used 2-(Benzyloxy)acetaldehyde(cas: 60656-87-3Safety of 2-(Benzyloxy)acetaldehyde)

2-(Benzyloxy)acetaldehyde(cas: 60656-87-3) may be used in the following syntheses: (3S,5S)-methyl 6-benzyloxy-3,5-dihydroxyhexanoate ,(S)-5-benzyloxy-4-hydroxypentan-2-one, myxothiazols.Safety of 2-(Benzyloxy)acetaldehyde

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Rapid Discovery of Aspartyl Protease Inhibitors Using an Anchoring Approach》 was published in ChemMedChem in 2020. These research results belong to Konstantinidou, Markella; Magari, Francesca; Sutanto, Fandi; Haupenthal, Joerg; Jumde, Varsha R.; Uenver, M. Yagiz; Heine, Andreas; Camacho, Carlos Jamie; Hirsch, Anna K. H.; Klebe, Gerhard; Doemling, Alexander. Category: ethers-buliding-blocks The article mentions the following:

Pharmacophore searches that include anchors, fragments contributing above average to receptor binding, combined with one-step syntheses are a powerful approach for the fast discovery of novel bioactive mols. Here, the authors are presenting a pipeline for the rapid and efficient discovery of aspartyl protease inhibitors. First, the authors hypothesized that hydrazine could be a multi-valent warhead to interact with the active site Asp carboxylic acids. The authors incorporated the hydrazine anchor in a multicomponent reaction and created a large virtual library of hydrazine derivatives synthetically accessible in one-step. Next, the authors performed anchor-based pharmacophore screening of the libraries and resynthesized top-ranked compounds The inhibitory potency of the mols. was finally assessed by an enzyme activity assay and the binding mode confirmed by several soaked crystal structures supporting the validity of the hypothesis and approach. The herein reported pipeline of tools will be of general value for the rapid generation of receptor binders beyond Asp proteases.2-(Benzyloxy)acetaldehyde(cas: 60656-87-3Category: ethers-buliding-blocks) was used in this study.

2-(Benzyloxy)acetaldehyde(cas: 60656-87-3) may be used in the following syntheses: (3S,5S)-methyl 6-benzyloxy-3,5-dihydroxyhexanoate ,(S)-5-benzyloxy-4-hydroxypentan-2-one, myxothiazols.Category: ethers-buliding-blocks

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Palladium-catalyzed selective defluorinative sulfenylation for the synthesis of fluorovinylthioethers》 was written by He, Shi-Yu; Zhang, Xing-Guo. Formula: C12H10S2 And the article was included in Organic Chemistry Frontiers in 2020. The article conveys some information:

An efficient transformation of trifluoromethylated compounds to monofluoroalkenes RCH=C(F)SR1 [R = Ph, 4-MeC6H4, 3-FC6H4, etc.; R1 = Ph, Bn, 2-thienyl, etc.] was developed through Pd-catalyzed selective defluorinative sulfenylation. Variety of α-fluorovinylthioethers RCH=C(F)SR1 were prepared in good yields from α-trifluoromethylated benzyl bromides and odorless disulfides. In addition to this study using 1,2-Diphenyldisulfane, there are many other studies that have used 1,2-Diphenyldisulfane(cas: 882-33-7Formula: C12H10S2) was used in this study.

1,2-Diphenyldisulfane(cas: 882-33-7) belongs to ethers.Although ethers resist hydrolysis, they are cleaved by hydrobromic acid and hydroiodic acid. Hydrogen chloride cleaves ethers only slowly. Formula: C12H10S2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Buyens, Dominique M. S.; Pilcher, Lynne A.; Roduner, Emil published their research in ChemPhysChem in 2021. The article was titled 《Towards a Molecular Understanding of Cation-Anion Interactions and Self-aggregation of Adeninate Salts in DMSO by NMR and UV Spectroscopy and Crystallography》.Application of 33100-27-5 The article contains the following contents:

Rare anionic forms of nucleic acids play a significant biol. role and lead to spontaneous mutations and replication and translational errors. There is a lack of information surrounding the stability and reactivity of these forms. Ion pairs of mono-sodium and -potassium salts of adenine exist in DMSO solution with possible cation coordination sites at the N1, N7 and N9 atoms of the purine ring. At increasing concentrations π-π stacked dimers are the predominant species of aggregates followed by higher order aggregation governed by coordination to metal cations in which the type of counter ion present has a central role in the aggregate formation. In addition to this study using 1,4,7,10,13-Pentaoxacyclopentadecane, there are many other studies that have used 1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5Application of 33100-27-5) was used in this study.

1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5) is a member of crown ether Ligands. Crown-ethers are macrocyclic polyethers capable of forming host-guest complexes, especially with inorganic and organic cations. Crown-ethers can incorporate protonated primary amine compounds by formation of ion-dipole bonds with the oxygen atoms of the chiral selector. Crown-ethers have been widely used for the separation of several pharmaceuticals both in aqueous and non-aqueous media. Application of 33100-27-5

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Yadav, Preeti; Bhatt, Bharat; Balaji, Kithiganahalli Narayanaswamy published an article in 2021. The article was titled 《Selective activation of MST1/2 kinases by retinoid agonist adapalene abrogates AURKA-regulated septic arthritis》, and you may find the article in Journal of Immunology.Safety of 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid The information in the text is summarized as follows:

Septic arthritis is a chronic inflammatory disorder caused by Staphylococcus aureus invasion of host synovium, which often progresses to impairment of joint functions. Although it is known that disease progression is intricately dependent on dysregulated inflammation of the knee joint, identification of mol. events mediating such imbalance during S. aureus-induced septic arthritis still requires detailed investigation. In this article, we report that Aurora kinase A (AURKA) responsive WNT signaling activates S. aureus infection-triggered septic arthritis, which results in inflammation of the synovium. In this context, treatment with adapalene, a synthetic retinoid derivative, in a mouse model for septic arthritis shows significant reduction of proinflammatory mediators with a simultaneous decrease in bacterial burden and prevents cartilage loss. Mechanistically, adapalene treatment inhibits WNT signaling with concomitant activation of HIPPO signaling, generating alternatively activated macrophages. Collectively, we establish adapalene as a promising strategy to suppress S. aureus-induced irreversible joint damage. In the experiment, the researchers used many compounds, for example, 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas: 106685-40-9Safety of 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid)

6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas:106685-40-9) is a third-generation synthetic retinoid and a highly lipophilic compound derived from naphthoic acid. It is widely used in the treatment of acne.Safety of 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Garnes-Portoles, Francisco; Miguelez, Ruben; Grayson, Matthew N.; Barrio, Pablo published an article in 2022. The article was titled 《Heteroatom-Tethered ω-Alkenylallylboronates: Stereoselective Synthesis of Heterocyclic Derived Alcohols》, and you may find the article in Synthesis.Reference of 2-(Benzyloxy)acetaldehyde The information in the text is summarized as follows:

The synthesis of ω-alkenylallylboronates using a heteroatom tether to join both functional groups was described for the first time. Then, these unprecedented compounds were used in a tandem Bronsted acid catalyzed allylboration/ring-closing metathesis (RCM) reaction affording heterocyclic derived alcs. as single diastereoisomers. The low enantioselectivity observed in the asym. version using a chiral phosphoric acid catalyst was studied theor. The results came from multiple reactions, including the reaction of 2-(Benzyloxy)acetaldehyde(cas: 60656-87-3Reference of 2-(Benzyloxy)acetaldehyde)

2-(Benzyloxy)acetaldehyde(cas: 60656-87-3) may be used in the following syntheses: (3S,5S)-methyl 6-benzyloxy-3,5-dihydroxyhexanoate ,(S)-5-benzyloxy-4-hydroxypentan-2-one, myxothiazols.Reference of 2-(Benzyloxy)acetaldehyde

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem