Month: October 2022

In 2022,Rakipov, Ilnaz T.; Semenov, Konstantin N.; Petrov, Artem A.; Akhmadiyarov, Aydar A.; Khachatrian, Artashes A.; Gainutdinova, Aliya Z.; Varfolomeev, Mikhail A. published an article in Thermochimica Acta. The title of the article was 《Thermochemistry of hydrogen bonding of ethers with aliphatic alcohols》.Application of 33100-27-5 The author mentioned the following in the article:

In present work an enthalpies of solution at infinite dilution and solvation of ethers (di-Et ether, diglyme, 1,4-dioxane, 12-crown-4 and 15-crown-5) in aliphatic alcs. at 298.15 K and enthalpies of aliphatic alcs., alkanes in ethers were determined The enthalpies of hydrogen bonding for these systems were calculated using exptl. data. The hydrogen bond enthalpies of ethers in alcs. are significantly lower by absolute values than the enthalpies of hydrogen bonding in the complexes 1:1 of alcs. in ethers solution due to reorganization effects of aliphatic alcs. as a solvent (breaking of solvent-solvent hydrogen bonds). The cooperative effects in multi-particle complexes of alcs. with ethers were evaluated taking into account reorganization effect.1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5Application of 33100-27-5) was used in this study.

1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5) is a member of crown ether Ligands. Crown-ethers are macrocyclic polyethers capable of forming host-guest complexes, especially with inorganic and organic cations. Crown-ethers can incorporate protonated primary amine compounds by formation of ion-dipole bonds with the oxygen atoms of the chiral selector. Crown-ethers have been widely used for the separation of several pharmaceuticals both in aqueous and non-aqueous media. Application of 33100-27-5

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2022,Gu, Jia; Xiao, Pan-Lei; Wang, Jie; Zhong, Liang; Nie, Xu-Liang; Peng, Da-Yong published an article in Journal of Molecular Structure. The title of the article was 《Synthesis, crystal structure, spectroscopic characterization and anti-fungal activity of Ethyl 2-Oxo-2H-chromene-3-carboxylate Derivatives》.Quality Control of m-Methoxyphenol The author mentioned the following in the article:

A series of Et 2-oxo-2H-chromene-3-carboxylate derivatives I [R1 = H, CH3, Br, etc.; R2 = H, OCH3] was synthesized by the ester cyclization of di-Et malonate and salicylaldehydes which was obtained from corresponding phenols. The single crystal of compounds I [R1 = OCF3, OCH3; R2 = H] were obtained and characterized by X-ray. Compound I [R1 = OCF3; R2 = H] crystallized in the triclinic system with space group P-1 and compound I [R1 = OCH3; R2 = H] crystallized in the monoclinic system with space group P21/c. The potential anti-fungal activities of the synthesized compounds was studied against five kinds of common fungi at concentrations of 200 ppm and 500 ppm and results showed that the target compounds exhibited certain anti-fungal activity against tested strains. The inhibition rate of compound I [R1 = CH3; R2 = H] was the highest against Fusarium oxysporum, up to 60.29% at 500 ppm. Compound I [R1 = CH3; R2 = H] was promising to become the lead compound of pesticide in the future. In the experiment, the researchers used m-Methoxyphenol(cas: 150-19-6Quality Control of m-Methoxyphenol)

m-Methoxyphenol(cas: 150-19-6) may be used in synthesis of:C(4) symmetric calix[4]resorcinarene, 2-nitroso-5-methoxyphenol, 6-methoxy-2(3H)-benzoxazoloneQuality Control of m-Methoxyphenol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Application In Synthesis of m-MethoxyphenolIn 2019 ,《Development of an efficient phenolic sensor based on facile Ag2O/Sb2O3 nanoparticles for environmental safety》 was published in Nanoscale Advances. The article was written by Rahman, Mohammed M.; Alam, M. M.; Asiri, Abdullah M.. The article contains the following contents:

The facile hydrothermal method was used to prepare low-dimensional doped Ag2O/Sb2O3 nanoparticles (NPs) at low temperature in alk. medium. The calcined NPs were characterized in detail by FTIR, UV/vis, FESEM, XPS, EDS, and XRD. A thin layer of Ag2O/Sb2O3 NPs was deposited onto a glassy carbon electrode (GCE) using Nafion (5% Nafion suspension in ethanol) conducting binder, which formed the working electrode of the selective 3-methoxyphenol electrochem. sensor probe. The proposed chem. sensor exhibits high sensitivity, long-term stability, and enhanced electrochem. responses towards 3-methoxyphenol. Response to 3-methoxyphenol is linear over the concentration range (LDR) of 0.09 nM to 0.09 mM. The anal. parameters of the sensor such as sensitivity, stability, response time, linearity, LDR, robustness, selectivity etc. were evaluated by an electrochem. approach. The sensor probe fabricated with Ag2O/Sb2O3 NPs seems to be a promising candidate for effective and reliable electrochem. detection of hazardous and carcinogenic chems. in the environment and health care fields in large scales. In addition to this study using m-Methoxyphenol, there are many other studies that have used m-Methoxyphenol(cas: 150-19-6Application In Synthesis of m-Methoxyphenol) was used in this study.

m-Methoxyphenol(cas: 150-19-6) may be used as an analytical standard for the determination of the analyte in wine, coffee beans, wood samples, and mainstream smoke by gas chromatography (GC) based techniques.Application In Synthesis of m-Methoxyphenol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Product Details of 882-33-7In 2022 ,《NFSI-catalyzed S-S bond exchange reaction for the synthesis of unsymmetrical disulfides》 was published in Chinese Chemical Letters. The article was written by Song, Mengjie; Hu, Qingyue; Li, Zheng-Yi; Sun, Xiaoqiang; Yang, Ke. The article contains the following contents:

The metal-free S-S bond exchange reaction of sym. disulfides catalyzed by NFSI was described. This novel protocol provided a facile and efficient approach to accessing important unsym. disulfides. Furthermore, this strategy could also be utilized in the late-stage functionalization of amino acids, drugs, and natural products. The broad substrate scope, good functional group tolerance and easy accessibility of catalyst indicate that this strategy afforded a green and practical complementary method to various unsym. disulfides.1,2-Diphenyldisulfane(cas: 882-33-7Product Details of 882-33-7) was used in this study.

1,2-Diphenyldisulfane(cas: 882-33-7) belongs to ethers.The C-O bonds that comprise simple ethers are strong. Product Details of 882-33-7 They are unreactive toward all but the strongest bases. Although generally of low chemical reactivity, they are more reactive than alkanes.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Vanadium-Catalyzed Oxidative Intramolecular Coupling of Tethered Phenols: Formation of Phenol-Dienone Products》 was written by Gilmartin, Philip H.; Kozlowski, Marisa C.. Computed Properties of C9H12O2 And the article was included in Organic Letters on April 17 ,2020. The article conveys some information:

A mild and efficient method for the vanadium-catalyzed intramol. coupling of tethered free phenols is described. The corresponding phenol-dienone products are prepared directly in good yields with low catalyst loadings. Electronically diverse tethered phenol precursors are well tolerated, and the catalytic method was effectively applied as the key step in syntheses of three natural products and a synthetically useful morphinan alkaloid precursor. The experimental part of the paper was very detailed, including the reaction process of (3-Methoxy-2-methylphenyl)methanol(cas: 33797-34-1Computed Properties of C9H12O2)

(3-Methoxy-2-methylphenyl)methanol(cas: 33797-34-1) belongs to ethers.Computed Properties of C9H12O2Although ethers resist hydrolysis, they are cleaved by hydrobromic acid and hydroiodic acid. Hydrogen chloride cleaves ethers only slowly.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2012,Gule, Nonjabulo P.; Bshena, Osama; de Kwaadsteniet, Michele; Cloete, Thomas E.; Klumperman, Bert published 《Immobilized Furanone Derivatives as Inhibitors for Adhesion of Bacteria on Modified Poly(styrene-co-maleic anhydride)》.Biomacromolecules published the findings.SDS of cas: 139115-91-6 The information in the text is summarized as follows:

The ability of brominated furanones and other furanone compounds with 2(3H) and 2(5H) cores to inhibit bacterial adhesion of surfaces as well deactivate (destroy) them has been previously reported. The furanone derivatives 4-(2-(2-aminoethoxy))-2,5-dimethyl-3(2H)-furanone and 5-(2-(2-aminoethoxy)-ethoxy)methyl-2(5H)-furanone were synthesized in our laboratory These furanone derivatives were then covalently immobilized onto poly(styrene-co-maleic anhydride) (SMA) and electrospun to fabricate nonwoven nanofibrous mats with antimicrobial and cell-adhesion inhibition properties. The electrospun nanofibrous mats were tested for their ability to inhibit cell attachment by strains of bacteria commonly found in water (Klebsiella pneumoniae Xen 39, Staphylococcus aureus Xen 36, E. coli Xen 14, Pseudomonas aeruginosa Xen 5, and Salmonella typhimurium Xen 26). 1H NMR, electrospray mass spectroscopy (ES-MS), and attenuated total reflectance FTIR spectroscopy (ATR-FTIR) were used to confirm the structures of the synthesized furanones as well as their successful immobilization on SMA. To ascertain that the immobilized furanone compounds do not leach into filtered water, samples of water, filtered through the nanofibrous mats were analyzed using gas chromatog. coupled with mass spectroscopy (GC-MS). The morphol. of the electrospun nanofibers was characterized using SEM.tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6SDS of cas: 139115-91-6) was used in this study.

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers. Ethers lack the hydroxyl groups of alcohols. SDS of cas: 139115-91-6 Without the strongly polarized O―H bond, ether molecules cannot engage in hydrogen bonding with each other.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2015,Wold, Erik D.; Axup, Jun Y.; Felding, Brunhilde H.; Smider, Vaughn V. published 《Fc-small molecule antibody mimetics》.Bioconjugate Chemistry published the findings.Synthetic Route of C9H19NO4 The information in the text is summarized as follows:

Antibody therapeutics are a promising drug class due to their high specificity and favorable pharmacokinetics. While there are many methods for the development of antibodies specific to disease associated antigens, selecting antibodies against functional epitopes with high specificity and affinity can be difficult for certain epitopes. We describe a generalizable method for synthesizing antibody mimetics by site specifically conjugating small mols. (with high affinity and specificity to disease associated antigens) to an Fc fragment to develop drugs with the benefits of an antibody. As a proof of concept, an E269pAcPhe Fc antibody Fc fragment was produced and subsequently site-specifically labeled with a linker-modified folic acid compound to generate an Fc-folic acid antibody-mimetic. This was chosen as the model system because the high-affinity folate receptor FR-α is highly expressed in a number of cancer types including breast and ovarian cancer. The specificity of the Fc-folic acid conjugate was assessed via flow cytometry with the folate-receptor pos. breast cancer cell line MDA-MB-231 by measuring Fc-folic acid binding in both the absence and presence of an excess of folic acid. Fc-small mol. conjugates could be developed into a unique class of antibody-like therapeutics. In addition to this study using tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate, there are many other studies that have used tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6Synthetic Route of C9H19NO4) was used in this study.

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers.Synthetic Route of C9H19NO4Although ethers resist hydrolysis, they are cleaved by hydrobromic acid and hydroiodic acid. Hydrogen chloride cleaves ethers only slowly.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2016,Yamaura, Kei; Kiyonaka, Shigeki; Numata, Tomohiro; Inoue, Ryuji; Hamachi, Itaru published 《Discovery of allosteric modulators for GABAA receptors by ligand-directed chemistry》.Nature Chemical Biology published the findings.Electric Literature of C9H19NO4 The information in the text is summarized as follows:

The fast inhibitory actions of γ-aminobutyric acid (GABA) are mainly mediated by GABAA receptors (GABAARs) in the brain. The existence of multiple ligand-binding sites and a lack of structural information have hampered the efficient screening of drugs capable of acting on GABAARs. The authors have developed semisynthetic fluorescent biosensors for orthosteric and allosteric GABAAR ligands on live cells via coupling of affinity-based chem. labeling reagents to a bimol. fluorescence quenching and recovery system. These biosensors were amenable to the high-throughput screening of a chem. library, leading to the discovery of new small mols. capable of interacting with GABAARs. Electrophysiol. measurements revealed that one hit, 4,4′,4”-(4-propyl-[1H]-pyrazole-1,3,5-triyl)trisphenol (PPT), was a novel neg. allosteric modulator capable of strongly suppressing GABA-induced chloride currents. Thus, these semisynthetic biosensors represent versatile platforms for screening drugs to treat GABAAR-related neurol. disorders, and this strategy can be extended to structurally complicated membrane proteins. After reading the article, we found that the author used tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6Electric Literature of C9H19NO4)

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers.The C-O bonds that comprise simple ethers are strong. Electric Literature of C9H19NO4 They are unreactive toward all but the strongest bases. Although generally of low chemical reactivity, they are more reactive than alkanes.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2019,Drug Delivery Letters included an article by Jain, Divya D.; Desai, Namita D.. SDS of cas: 106685-40-9. The article was titled 《Development and Evaluation of Particulate Microcarriers of Adapalene as a Topical Delivery System》. The information in the text is summarized as follows:

Microparticulate drug delivery can play a major role in reducing side effects and providing better patient compliance due to targeted delivery. Methods: Adapalene microparticles were prepared using quasi emulsion solvent diffusion method. The effects of formulation variables including polymer ratios, amounts of emulsifier, drug loading and process variables such as stirring time and speed on the phys. characteristics of microparticles were investigated. The developed microparticles were characterized by DSC and SEM. Adapalene microparticles were incorporated into Carbopol 971 NF gel for ease of topical delivery. Results: Adapalene microparticulate topical gel showed sustained drug release over 8 h in in vitro studies. The amount of drug retained in the rat skin during ex vivo studies was higher in the microparticulate topical gel (227.43 ± 0.83 μg/cm2) as compared to the marketed formulation (81.4 ± 1.11 μg/cm2) after 8 h indicating localized and sustained drug action that can be useful in treating acne vulgaris. The safety of optimized Adapalene gel determined by skin irritation studies performed on Sprague Dawley rats showed no irritation potential. Conclusion: Microparticles can provide promising carrier systems to deliver Adapalene, improving patient compliance due to enhanced skin deposition, localized and sustained action with reduced associated irritant effects. The experimental part of the paper was very detailed, including the reaction process of 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas: 106685-40-9SDS of cas: 106685-40-9)

6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas:106685-40-9) may be used as a pharmaceutical reference standard for the quantification of the analyte in topical gel formulations using high-performance liquid chromatography technique.SDS of cas: 106685-40-9

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2019,Organic Chemistry Frontiers included an article by Song, Zehua; Wang, Guotong; Li, Wei; Li, Shengkun. Recommanded Product: m-Methoxyphenol. The article was titled 《Innate pharmacophore assisted selective C-H functionalization to therapeutically important nicotinamides》. The information in the text is summarized as follows:

The application of the pre-validated pharmacophore 2-(2-oxazolinyl)anilines (R)/(S)-I (R = H, Me, Et, benzyl) as an innate directing group in the C-H etherification and amination of nicotinamides II for the efficient synthesis of drug- and agrochem.-like mols. was determined An operationally simple, and regioselective C-H functionalization of nicotinamides (R)/(S)-II was first accomplished using a complicated variation of copper salts. All the specific procedures used were easy to utilize, without external oxidants or ligands. The feasibility is highlighted using an alternative synthesis of diflufenican with a rapid synthesis of niacin related pharmaceuticals or analogs III (R1 = H, 3-CH3OC6H4O, 2-methoxy-4-(prop-2-en-1-yl)phenyl, 4-methylpiperidin-1-yl, etc.; R2 = H, 2-methoxy-4-(prop-2-en-1-yl)phenyl, 3-methylpiperidin-1-yl, etc.). In the experiment, the researchers used many compounds, for example, m-Methoxyphenol(cas: 150-19-6Recommanded Product: m-Methoxyphenol)

m-Methoxyphenol(cas: 150-19-6) may be used in synthesis of:C(4) symmetric calix[4]resorcinarene, 2-nitroso-5-methoxyphenol, 6-methoxy-2(3H)-benzoxazoloneRecommanded Product: m-Methoxyphenol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem