Month: October 2022

Sun, Lihe; Ouyang, Juan; Ma, Yunqing; Zeng, Zhuo; Zeng, Cheng; Zeng, Fang; Wu, Shuizhu published an article in 2021. The article was titled 《An Activatable Probe with Aggregation-Induced Emission for Detecting and Imaging Herbal Medicine Induced Liver Injury with Optoacoustic Imaging and NIR-II Fluorescence Imaging》, and you may find the article in Advanced Healthcare Materials.Application In Synthesis of Bis(4-methoxyphenyl)amine The information in the text is summarized as follows:

Whilte herbal medicines are widely used for health promotion and therapy for chronic conditions, inappropriate use of them may cause adverse effects like liver injury, and accurately evaluating their hepatotoxicity is of great significance for public health. Herein, an activatable probe QY-N for diagnosing herbal-medicine-induced liver injury by detecting hepatic NO with NIR-II fluorescence and multispectral optoacoustic tomog. (MSOT) imaging is demonstrated. The probe includes a bismethoxyphenyl-amine-containing dihydroxanthene serving as electron donor, a quinolinium as electron acceptor, and a butylamine as recognition group and fluorescence quencher. The hepatic level of NO reacts with butylamine, thereby generating the activated probe QY-NO which exhibits a red-shifted absorption band (700-850 nm) for optoacoustic imaging and generates strong emission (910-1110 nm) for NIR-II fluorescence imaging. QY-NO is aggregation-induced-emission (AIE) active, which ensures strong emission in aggregated state. QY-N is utilized in the triptolide-induced liver injury mouse model, and exptl. results demonstrate the QY-N can be activated by hepatic NO and thus be used in detecting herbal-medicine-induced liver injury. The temporal and spatial information provided by three-dimensional MSOT images well delineates the site and size of liver injury. Moreover, QY-N has also been employed to monitor rehabilitation of liver injury during treatment process.Bis(4-methoxyphenyl)amine(cas: 101-70-2Application In Synthesis of Bis(4-methoxyphenyl)amine) was used in this study.

Bis(4-methoxyphenyl)amine(cas: 101-70-2) is a diphenylamine derivative used as a chemical additive for cured rubber.Bis(4-methoxyphenyl)amine is highly toxic and may potentially induce chromosome abberation.Application In Synthesis of Bis(4-methoxyphenyl)amine

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Bonnin, Maxime A.; Feldmann, Claus published an article in 2021. The article was titled 《Insights of the Structure and Luminescence of Mn2+/Sn2+-Containing Crown-Ether Coordination Compounds》, and you may find the article in Inorganic Chemistry.Reference of 1,4,7,10,13-Pentaoxacyclopentadecane The information in the text is summarized as follows:

Crown-ether coordination compounds with Mn2+ and Sn2+ as cations and 12-crown-4, 15-crown-5, and 18-crown-6 as ligands are synthesized. Their luminescence properties and quantum yields are compared and correlated with their structural features. Thus, MnI2(15-crown-5) (1), MnCl2(15-crown-5) (2), [Mn(12-crown-4)2]2[N(Tf)2]2(12-crown-4) (3), Sn3I6(15-crown-5)2 (4), and SnI2(18-crown-6) (5) are obtained by an ionic-liquid-based reaction of MX2 (M: Mn, Sn; X: Cl, I) and the resp. crown ether. Whereas 1, 2, and 5 exhibit a centric coordination of Mn2+/Sn2+ by the crown ether, 3 and 4 show a sandwich-like coordination of the cation with two crown-ether mols. All title compounds show visible emission, whereof 1, 2, and 5 have good luminescence efficiencies with quantum yields of 47, 39, and 21%, resp. These luminescence properties are compared with recently realized compounds such as Mn3Cl6(18-crown-6)2, MnI2(18-crown-6), Mn3I6(18-crown-6)2, or Mn2I4(18-crown-6), which have significantly higher quantum yields of 98 and 100%. Based on a comparison of altogether nine crown-ether coordination compounds, the structural features can be correlated with the luminescence efficiency, which allows extraction of those conditions encouraging intense emission and high quantum yields. The results came from multiple reactions, including the reaction of 1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5Reference of 1,4,7,10,13-Pentaoxacyclopentadecane)

1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5) is a member of crown ether Ligands. Crown-ethers are macrocyclic polyethers capable of forming host-guest complexes, especially with inorganic and organic cations. Crown-ethers can incorporate protonated primary amine compounds by formation of ion-dipole bonds with the oxygen atoms of the chiral selector. Crown-ethers have been widely used for the separation of several pharmaceuticals both in aqueous and non-aqueous media. Reference of 1,4,7,10,13-Pentaoxacyclopentadecane

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Xu, Baijie; Liu, Zhihao; Xu, Qiaofei; Han, Xiao; Ma, Xinyi; Wang, Jiawei; Kannan, Thirumurthy; Ma, Pengtao; Wang, Jingping; Niu, Jingyang published an article in 2021. The article was titled 《Polyoxomolybdates as efficient catalysts for Knoevenagel condensation reaction of benzaldehyde and ethyl cyanoacetate under mild condition》, and you may find the article in Journal of Materials Science.Application In Synthesis of 2-Methoxybenzaldehyde The information in the text is summarized as follows:

The development of new heterogeneous catalysts for Knoevenagel condensation reaction is critical for practical applications. Herein, authors prepared three organophosphonate-functionalized polyoxomolybdates, Cs2Na9H9[{Co(H2O)4}(TeMo6O21)2{Co(OOCCH2NCH2PO3)2}3]·41H2O (1), Cs2Na8[H6{Co(H2O)4}3(SeMo6O21)2{Co(OOCCH2NCH2PO3)2}3]·31H2O (2) and Cs2Na9H3[H6{Ni(H2O)4}(SeMo6O21)2{Ni(OOCCH2NCH2PO3)2}3]·28H2O (3), which exhibit high catalytic activity for gram-scale Knoevenagel condensation of benzaldehyde with Et cyanoacetate. Especially, under the optimal conditions, compound 1 can achieve a satisfactory yield (98%) and show high TON value (1960), which is superior to that of compounds 2 and 3. Notably, the TON value is much higher than that of previously reported catalysts. Such high catalytic performance could be attributed to the co-existence of Lewis acid and Lewis base sites in catalysts. In addition, based on substrates screening and recyclability tests, 1 has exhibited broad catalytic generality and good recyclability. In the experiment, the researchers used many compounds, for example, 2-Methoxybenzaldehyde(cas: 135-02-4Application In Synthesis of 2-Methoxybenzaldehyde)

2-Methoxybenzaldehyde(cas: 135-02-4) is found in cassia oil, cinnamon bark, and cinnamon bark oil. It is a clear colorless liquid with a strong aroma. It has been used to examine the acaricidal activity of Periploca sepium oil and its active component against Tyrophagus putrescentiae.Application In Synthesis of 2-Methoxybenzaldehyde

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ghasemisarabbadieh, Mostafa; Gizurarson, Sveinbjorn; Sveinbjornsson, Benjamin Ragnar published an article in 2021. The article was titled 《Effect of 18-Crown-6 on Oxytocin Stability in Aqueous Buffer Solutions》, and you may find the article in ACS Omega.Application In Synthesis of 1,4,7,10,13-Pentaoxacyclopentadecane The information in the text is summarized as follows:

In this study, the effect of 18-crown-6 on the stability of oxytocin in aqueous solution was explored. The study found that while 12-crown-4 and 15-crown-5 do not stabilize oxytocin, 18-crown-6 does have a stabilizing effect in citrate/phosphate buffer at pH 4.5. However, in acetate buffer at the same pH, the presence of 18-crown-6 had a destabilizing effect, possibly leading to a different degradation pathway. Both the stabilizing and destabilizing effects, depending on the buffer used, are concentration dependent where a higher concentration of 18-crown-6 is linked to a stronger effect. It is hypothesized that this effect may be linked to 18-crown-6 binding to the protonated ammonium group of oxytocin. Upon changing the mobile phase used in high-performance liquid chromatog. experiments, we observed evidence supporting this binding hypothesis. When an acidic mobile phase was used (0.01% trifluoroacetic acid (TFA)), a partial shift in oxytocin retention time was observed for samples in acetate buffers in the presence of 18-crown-6 when using a 150 mm column (C18). The amount of the peak that shifted depended on the 18-crown-6 concentration used. A similar shift in oxytocin peak retention time was observed for samples in both acetate and citrate/phosphate buffers when using a 250 mm column (C18), but the peak completely shifted in those samples. When using an even more acidic mobile phase (0.1% TFA), the oxytocin peaks all had the same retention time again. UV and NMR spectroscopy experiments also showed that the presence of 18-crown-6 has an observable effect on the resulting oxytocin spectra. In the experiment, the researchers used many compounds, for example, 1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5Application In Synthesis of 1,4,7,10,13-Pentaoxacyclopentadecane)

1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5) is a member of crown ether Ligands. Crown-ethers are macrocyclic polyethers capable of forming host-guest complexes, especially with inorganic and organic cations. Crown-ethers can incorporate protonated primary amine compounds by formation of ion-dipole bonds with the oxygen atoms of the chiral selector. Crown-ethers have been widely used for the separation of several pharmaceuticals both in aqueous and non-aqueous media. Application In Synthesis of 1,4,7,10,13-Pentaoxacyclopentadecane

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Shin, Seung-Jae; Kim, Dong Hyun; Bae, Geunsu; Ringe, Stefan; Choi, Hansol; Lim, Hyung-Kyu; Choi, Chang Hyuck; Kim, Hyungjun published an article in 2022. The article was titled 《On the importance of the electric double layer structure in aqueous electrocatalysis》, and you may find the article in Nature Communications.COA of Formula: C10H20O5 The information in the text is summarized as follows:

To design electrochem. interfaces for efficient elec.-chem. energy interconversion, it is critical to reveal the elec. double layer (EDL) structure and relate it with electrochem. activity; nonetheless, this has been a long-standing challenge. Of particular, no mol.-level theories have fully explained the characteristic two peaks arising in the potential-dependence of the EDL capacitance, which is sensitively dependent on the EDL structure. We herein demonstrate that our first-principles-based mol. simulation reproduces the exptl. capacitance peaks. The origin of two peaks emerging at anodic and cathodic potentials is unveiled to be an electrosorption of ions and a structural phase transition, resp. We further find a cation complexation gradually modifies the EDL structure and the field strength, which linearly scales the carbon dioxide reduction activity. This study deciphers the complex structural response of the EDL and highlights its catalytic importance, which bridges the mechanistic gap between the EDL structure and electrocatalysis. In the experimental materials used by the author, we found 1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5COA of Formula: C10H20O5)

1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5) is a member of crown ether Ligands. Crown-ethers are macrocyclic polyethers capable of forming host-guest complexes, especially with inorganic and organic cations. Crown-ethers can incorporate protonated primary amine compounds by formation of ion-dipole bonds with the oxygen atoms of the chiral selector. Crown-ethers have been widely used for the separation of several pharmaceuticals both in aqueous and non-aqueous media. COA of Formula: C10H20O5

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2022,Chaves-Carballo, Katherine; Lamoureux, Guy V.; Perez, Alice L.; Bella Cruz, Alexandre; Cechinel Filho, Valdir published an article in RSC Advances. The title of the article was 《Novel one-pot synthesis of a library of 2-aryloxy-1,4-naphthoquinone derivatives. Determination of antifungal and antibacterial activity》.Name: m-Methoxyphenol The author mentioned the following in the article:

The development of new antibiotics and inexpensive antifungals is an important field of research. Based on the privileged pharmacophore of lawsone, a series of phenolic ether derivatives of 1,4-naphthoquinone I (R = H, CH3, OCH3, etc.; R1 = H, NO2, Cl, etc.; R2 = H, OCH3, Br, etc.; R3 = H, Cl, CH3, etc.; R4 = H, Br, Cl, etc.) were synthesized easily in one step in reasonable yields. All the new compounds were characterized and tested as potential antifungal and antibacterial agents. Compound I (R1, R2, R4 = H; R3 = Cl; R = 2,4-Cl2C6H3O) has significant antibacterial action (as good as or better than the controls) against E. coli and S. aureus. Against C. albicans, compounds I (R1, R2, R3, R4 = H; R = Br), (R1, R2, R3, R4 = H; R = Cl), (R, R2, R3, R4 = H; R1 = Cl), (R, R2, R3, R4 = H; R1 = CH3) were the best candidates as antifungals. Using a qual. structure-activity anal., a correlation between molar mass and antimicrobial activity was identified, regardless of the substituent group on the phenolic moiety, except for I (R1, R2, R4 = H; R3 = Cl; R = 2,4-Cl2C6H3O) and (R1, R3, R4 = H; R, R2 = Cl) where electronic effects seem more important. An in silico evaluation of the absorption, distribution, metabolism and excretion (ADME) for I (R, R2, R3, R4 = H; R1 = NO2), (R1, R2, R3, R4 = H; R = NO2), (R1, R2, R4 = H; R3 = Cl; R = 2,4-Cl2C6H3O) and (R1, R3, R4 = H; R, R2 = Cl) was made, indicating that the classic Lipinski’s rule of five applies in all cases. In the experiment, the researchers used m-Methoxyphenol(cas: 150-19-6Name: m-Methoxyphenol)

m-Methoxyphenol(cas: 150-19-6) may be used in synthesis of:C(4) symmetric calix[4]resorcinarene, 2-nitroso-5-methoxyphenol, 6-methoxy-2(3H)-benzoxazoloneName: m-Methoxyphenol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2022,Singh, Pooja S.; Ghadiyali, Mohammed; Chacko, Sajeev; Kamble, Rajesh M. published an article in Journal of Luminescence. The title of the article was 《D-A-D based pyrido-pyrazino[2,3-b]indole amines as blue-red fluorescent dyes: Photophysical, aggregation-induced emission, electrochemical and theoretical studies》.Product Details of 101-70-2 The author mentioned the following in the article:

Herein donor-acceptor-donor (D-A-D) structured, pyridopyrazino[2,3-b]indole amines 2-6 were designed and synthesized via C-N coupled Buchwald-Hartwig amination reaction and characterized by spectroscopic methods. C-N coupling in mols. offers intramol. charge transfer (ICT) transitions at longer wavelengths (λmax = 400-459 nm) in absorption spectra reminiscent D-A assembly. Dyes covers broad range of emission and emit in blue to red region with emission maxima 433-600 nm in solvent and solid film. Dyes 2, 5 and 6 explore the aggregation-induced emission (AIE) characteristics. Further C-N blending of various donor with pyridopyrazino[2,3-b]indole acceptor results in suppressed band gap (1.99-2.43 eV) and comparable HOMO (-5.17 to -5.71 eV) and LUMO (-3.18 to -3.28 eV) energies with reported small organic ambipolar materials. DFT and TDDFT calculations agree with the exptl. opto-electrochem. data. Moreover, computed small singlet and triplet excitation energy difference (ΔEST (0.01-0.14 eV)) suggest thermally activated delayed fluorescent (TADF) emitting properties of dyes. Thus pyridopyrazino[2,3-b]indole amine dyes propose their potential application in optoelectronic devices. After reading the article, we found that the author used Bis(4-methoxyphenyl)amine(cas: 101-70-2Product Details of 101-70-2)

Bis(4-methoxyphenyl)amine(cas: 101-70-2) is a diphenylamine derivative used as a chemical additive for cured rubber.Bis(4-methoxyphenyl)amine is highly toxic and may potentially induce chromosome abberation.Product Details of 101-70-2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Computed Properties of C12H10S2In 2019 ,《Synthesis of Symmetrical Diorganyl Disulfides Employing WEB as an Eco-friendly Oxidative System》 was published in ChemistrySelect. The article was written by Leitemberger, Andrielli; Boehs, Lucas Martins C.; Rosa, Clarissa Helena; Silva, Cleiton Da; Galetto, Fabio Z.; Godoi, Marcelo. The article contains the following contents:

A straightforward and environmentally benign methodol. for the preparation of sym. diorganyl disulfides via oxidation of thiols, under open atm. was reported. Water Extract of Banana peel ash (WEB) was conveniently employed as a selective and eco-friendly system for the oxidative dimerization of thiols, affording the corresponding disulfides in very good yields. The experimental process involved the reaction of 1,2-Diphenyldisulfane(cas: 882-33-7Computed Properties of C12H10S2)

1,2-Diphenyldisulfane(cas: 882-33-7) belongs to ethers.Computed Properties of C12H10S2Although ethers resist hydrolysis, they are cleaved by hydrobromic acid and hydroiodic acid. Hydrogen chloride cleaves ethers only slowly.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Tressler, Caitlin M.; Zondlo, Neal J. published their research in Organic Letters on December 16 ,2016. The article was titled 《Synthesis of Perfluoro-tert-butyl Tyrosine, for Application in 19F NMR, via a Diazonium-Coupling Reaction》.Formula: C24H22N2O4 The article contains the following contents:

A practical synthesis of the novel highly fluorinated amino acid Fmoc-perfluoro-tert-Bu tyrosine was developed. The sequence proceeds in two steps from com. available Fmoc-4-NH2-phenylalanine via diazotization followed by diazonium coupling reaction with perfluoro-tert-butanol. In peptides, perfluoro-tert-Bu tyrosine was detected in 30 s by NMR spectroscopy at 500 nM peptide concentration due to nine chem. equivalent fluorines that are a sharp singlet by 19F NMR. Perfluoro-tert-Bu ether has an estimated σp Hammett substituent constant of +0.30. In addition to this study using Fmoc-D-Phe(4-NH2)-OH, there are many other studies that have used Fmoc-D-Phe(4-NH2)-OH(cas: 324017-21-2Formula: C24H22N2O4) was used in this study.

Fmoc-D-Phe(4-NH2)-OH(cas: 324017-21-2) belongs to ethers.The C-O bonds that comprise simple ethers are strong. They are unreactive toward all but the strongest bases. Although generally of low chemical reactivity, they are more reactive than alkanes. Formula: C24H22N2O4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2017,Hao, Hongye; Deng, Ya; Wu, Yingke; Liu, Siyuan; Lin, Weiwei; Li, Jiehua; Luo, Feng; Tan, Hong published 《Synthesis of biodegradable waterborne phosphatidylcholine polyurethanes for soft tissue engineering applications》.Regenerative Biomaterials published the findings.HPLC of Formula: 139115-91-6 The information in the text is summarized as follows:

To further improve the biocompatibility of polyurethanes, a new lysine 2-(2-aminoethoxy)ethanol phosphatidylcholine (LAPC) is synthesized to use as chain extender for preparing a series of phosphatidylcholine polyurethanes (PCPUs). Poly (ε-caprolactone) (PCL) and poly(ethylene glycol) (PEG) are used as soft segments, and L-lysine Et ester diisocyanate (LDI), LAPC and L-lysine are used as hard segments. The obtained PCPUs exhibit appropriate mech. properties with break elongation of 1000-1700%, tensile strength of 7-22 MPa, and relatively high elastic modulus of 11-18 MPa, which could admirably satisfy the requirement for soft tissue engineering scaffolds. The phosphatidylcholine structures can increase the hydrophilicity of PCPU surfaces, which effectively reduce protein adsorption and platelet adhesion while promoting the cell proliferation. In addition, the LAPC chain extender, PCPU films and ultimate degradation products of PCPUs are proved to be nontoxic in cytotoxicity test. More interestingly, the cytokine release test of macrophages manifests that both LAPC and PCPU degradation products could effectively improve the proliferation of macrophages and induce them into a wound-healing phenotype. Thus, the obtained PCPUs have greatly potential applications of soft tissue engineering scaffolds for tissue repair and wound healing. After reading the article, we found that the author used tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6HPLC of Formula: 139115-91-6)

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers.Oxygen is more electronegative than carbon, thus the alpha hydrogens of ethers are more acidic than those of simple hydrocarbons. HPLC of Formula: 139115-91-6 They are far less acidic than alpha hydrogens of carbonyl groups (such as in ketones or aldehydes), however.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem