Month: October 2022

《Study and reduction of matrix effects in flowing liquid anode – Atmospheric pressure glow discharge – Optical emission spectrometry》 was written by Greda, Krzysztof; Szymczycha-Madeja, Anna; Pohl, Pawel. Reference of 1,4,7,10,13-Pentaoxacyclopentadecane And the article was included in Analytica Chimica Acta in 2020. The article conveys some information:

The effect of different interfering elements, i.e., Na, K, Mg, Ca, Al, Cu, Fe, Mn, Ni, and Zn, on the anal. performance of flowing liquid anode atm. pressure glow discharge optical emission spectrometry (FLA-APGD OES) was extensively studied. In the presence of interfering ions, the emission from analytes was suppressed by ∼10% in the case of Hg and Tl, ∼20% for Cd and Ag, and up to ∼80% for Zn and Pb. This study revealed that interfering elements did not affect the atomization/excitation conditions, and the reason for the observed decrease in anal. response was the impaired efficiency of analytes transport from liquid to plasma phase. To reduce matrix effects, the use of different masking agents capable of complexing the interfering ions, e.g., organic acids, crown ethers, chelating agents, and other compounds, was studied. FLA-APGD appeared to be quite susceptible to the presence of masking agents and only their small amounts could be added (limiting the effectiveness of this approach). Despite this, it was possible to significantly reduce the matrix effects originating from transition metals and alkali/alk. earth metals. Based on the results presented herein, different sample treatment procedures, aimed at the minimization of matrix effects in microplasma excitation sources, can be developed. As an example, a method for the determination of trace amounts of Zn and Pb in the Fe-rich matrix was shown. Using the selected masking agents, the recovery of Zn and Pb was improved 5.6-fold (from 10.4 to 57.8%) and 2.8-fold (from 13.6 to 38.0%), resp. Despite the presence of Fe-rich matrix, the detection limits of Zn and Pb were quite low (0.1 and 0.8μg L-1, resp.) and they were apparently lower than offered by ICP OES. In the experiment, the researchers used 1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5Reference of 1,4,7,10,13-Pentaoxacyclopentadecane)

1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5) is a member of crown ether Ligands. Crown-ethers are macrocyclic polyethers capable of forming host-guest complexes, especially with inorganic and organic cations. Crown-ethers can incorporate protonated primary amine compounds by formation of ion-dipole bonds with the oxygen atoms of the chiral selector. Crown-ethers have been widely used for the separation of several pharmaceuticals both in aqueous and non-aqueous media. Reference of 1,4,7,10,13-Pentaoxacyclopentadecane

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《meta-Selective C-H functionalisation of aryl boronic acids directed by a MIDA-derived boronate ester》 was written by Williams, Alexander F.; White, Andrew J. P.; Spivey, Alan C.; Cordier, Christopher J.. Formula: C7H9BO3 And the article was included in Chemical Science in 2020. The article conveys some information:

N-Methyliminodiacetic acid (MIDA) boronates are boronic acid derivatives which are stable to reduction, oxidation and transmetalation. This has led to their widespread use as boronic acid protecting groups (PGs) and in iterative cross-couplings. authors describe herein the development of a novel MIDA derivative that acts in a dual manner, as a protecting group and a directing group (DG) for meta C(sp2)-H functionalisation of arylboronic acids. Palladium catalyzed C-H alkenylations, acetoxylations and arylations are possible, at room temperature and under aerobic conditions. Deprotection to reveal the functionalized boronic acids is rapid and allows for full recovery of the DG. The technique allows the facile diversification of aryl boronic acids and their subsequent use in a range of reactions or in iterative processes. After reading the article, we found that the author used 3-Methoxyphenylboronic acid(cas: 10365-98-7Formula: C7H9BO3)

3-Methoxyphenylboronic acid(cas: 10365-98-7) belongs to boronic acids. Boronic acids are mild Lewis acids which are generally stable and easy to handle, making them important to organic synthesis.Formula: C7H9BO3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Condensation of ninhydrin with phenols: Regioselective formation of diverse organic scaffolds and crystal structure studies》 was written by Das, Purak; Maity, Suvendu; Ghosh, Prasanta; Dutta, Arpita; Das, Suven. Name: m-Methoxyphenol And the article was included in Journal of Molecular Structure in 2020. The article conveys some information:

A range of phenolic compounds were reacted with ninhydrin in acid medium to afford different indanone-based mols. via regioselective C-C bond formation were studied. Ninhydrin reacts with 2,7-Dihydroxynaphthalene and 4-cyanophenol in AcOH producing ortho selective adducts in cyclic hemiketal structure and ring-opened diketo forms. On the other hand, ortho-substituted phenols like o-cresol, guaiacol, o-chloro/iodophenol condense with ninhydrin to accomplish para selective diarylated adducts, whereas 3-methoxy phenol provided corresponding monoarylated adduct as the major product. Different hydroxy benzoic acids delivered versatile scaffolds like diarylated indanone, indenofuran, benzofuran or spirolactone depending upon the substitution pattern and acidity of the reaction medium. All the compounds are characterized by 1H and 13C NMR spectra. In the solid state, scissors-shaped mol. diarylated adduct has been found to form inclusion complex with disordered o-cresol mol. and function as building unit of supramol. network. In the crystal structure of spirolactone, anti-parallel motif of dipolar···dipolar (C=O(δ-)···C(δ+) = O) interaction results ladder-like arrangement. In the experimental materials used by the author, we found m-Methoxyphenol(cas: 150-19-6Name: m-Methoxyphenol)

m-Methoxyphenol(cas: 150-19-6) may be used as an analytical standard for the determination of the analyte in wine, coffee beans, wood samples, and mainstream smoke by gas chromatography (GC) based techniques.Name: m-Methoxyphenol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Decalepis salicifolia (Bedd. ex Hook. f.) Venter: A steno-endemic and critically endangered medicinal and aromatic plant from Western Ghats, India.》 was written by Rodrigues, Vereena; Kumar, Amit; Gokul, Sivaraman; Shukla, Ashutosh K; Ravikumar, Kaliamoorthy; Sundaresan, Velusamy. Computed Properties of C8H8O3 And the article was included in Journal of biosciences in 2021. The article conveys some information:

Decalepis salicifolia (Bedd. ex Hook. f.) Venter is a potential medicinal and highly aromatic plant species confined to the southernmost part of the Western Ghats of India. The plant is well known for its traditional uses among the various tribal communities of south India. The tubers of the plant possess characteristic vanillin-like aroma due to the presence of the compound 2-hydroxy-4-methoxybenzaldehyde. The tubers are used to substitute Hemidesmus indicus in various herbal formulations. The plants in the wild are continuously uprooted for their roots, leading to the irreversible destruction of the whole plant. The resulting tremendous loss of populations in the wild led to the species being declared as critically endangered by IUCN. Our group is working on the various aspects of this species including population status, distribution mapping, prospection, and conservation management. In the present review, we have brought out the available information till date on D. salicifolia, including taxonomy, ethno-medicinal uses, phytochemistry, pharmacology, population status, and conservation efforts along with research gap and lacunae to provide direction for further research into this less explored medicinal and aromatic plant. After reading the article, we found that the author used 2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3Computed Properties of C8H8O3)

2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is employed in the synthesis of Schiff base ligand. It is applied as a reactant in the synthesis of LPA1R antagonists used in the inhibition of LPA-induced proliferation and contraction of normal human lung fibroblasts. Also used in the synthesis of tyrosine kinase 6 proteinase inhibitors.Computed Properties of C8H8O3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Xu, Hang; Yamaguchi, Sho; Mitsudome, Takato; Mizugaki, Tomoo published their research in Organic & Biomolecular Chemistry in 2021. The article was titled 《A copper nitride catalyst for the efficient hydroxylation of aryl halides under ligand-free conditions》.Name: 1-Iodo-2-methoxybenzene The article contains the following contents:

Copper nitride(Cu3N) was used as a heterogeneous catalyst for the hydroxylation of aryl halides RX (R = 4-methoxyphenyl, Ph, 1-naphthyl, pyridin-3-yl, etc.; X = I, Br, Cl) under ligand-free conditions. The cubic Cu3N nanoparticles showed high catalytic activity, comparable to those of conventional Cu catalysts with nitrogen ligands, demonstrating that the nitrogen atoms in Cu3N act as functional ligands that promote hydroxylation. In the part of experimental materials, we found many familiar compounds, such as 1-Iodo-2-methoxybenzene(cas: 529-28-2Name: 1-Iodo-2-methoxybenzene)

1-Iodo-2-methoxybenzene(cas: 529-28-2) is a useful synthetic intermediate. It can be used in the synthesis of piperidinyl diaminopyrimidines as cyclin-dependent kinase inhibitors with antitumor activity and polysubstituted benzofuran derivatives as novel inhibitors of parasitic growth.Name: 1-Iodo-2-methoxybenzene

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Schlegel, Mark K.; Matsuda, Shigeo; Brown, Christopher R.; Harp, Joel M.; Barry, Joseph D.; Berman, Daniel; Castoreno, Adam; Schofield, Sally; Szeto, John; Manoharan, Muthiah; Charisse, Klaus; Egli, Martin; Maier, Martin A. published an article in 2021. The article was titled 《Overcoming GNA/RNA base-pairing limitations using isonucleotides improves the pharmacodynamic activity of ESC+ GalNAc-siRNAs》, and you may find the article in Nucleic Acids Research.Category: ethers-buliding-blocks The information in the text is summarized as follows:

We recently reported that RNAi-mediated off-target effects are important drivers of the hepatotoxicity observed for a subset of GalNAc-siRNA conjugates in rodents, and that these findings could be mitigated by seed-pairing destabilization using a single GNA nucleotide placed within the seed region of the guide strand. Here, we report further investigation of the unique and poorly understood GNA/RNA cross-pairing behavior to better inform GNA-containing siRNA design. A reexamination of published GNA homoduplex crystal structures, along with a novel structure containing a single (S)-GNA-A residue in duplex RNA, indicated that GNA nucleotides universally adopt a rotated nucleobase orientation within all duplex contexts. Such an orientation strongly affects GNA-C and GNA-G but not GNA-A or GNA-T pairing in GNA/RNA heteroduplexes. Transposition of the hydrogen-bond donor/acceptor pairs using the novel (S)-GNA-isocytidine and -isoguanosine nucleotides could rescue productive base-pairing with the complementary G or C ribonucleotides, resp. GalNAc-siRNAs containing these GNA isonucleotides showed an improved in vitro activity, a similar improvement in off-target profile, and maintained in vivo activity and guide strand liver levels more consistent with the parent siRNAs than those modified with isomeric GNA-C or -G, thereby expanding our toolbox for the design of siRNAs with minimized off-target activity. In addition to this study using N,N-Dimethylformamide Dimethyl Acetal, there are many other studies that have used N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Category: ethers-buliding-blocks) was used in this study.

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Amines can be classified according to the nature and number of substituents on nitrogen. Aliphatic amines contain only H and alkyl substituents. Aromatic amines have the nitrogen atom connected to an aromatic ring.Important amines include amino acids, biogenic amines, trimethylamine, and aniline. Inorganic derivatives of ammonia are also called amines, such as monochloramine (NClH2).Category: ethers-buliding-blocks

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Chen, Wangchao; Zhang, Hanyu; Sun, Jianjun; Ghadari, Rahim; Zhang, Zhengguo; Pan, Fei; Lv, Kai; Sun, Xun; Guo, Fuling; Shi, Chengwu published an article in 2021. The article was titled 《Molecular tailor-making of zinc phthalocyanines as dopant-free hole-transporting materials for efficient and stable perovskite solar cells》, and you may find the article in Journal of Power Sources.Synthetic Route of C7H9BO3 The information in the text is summarized as follows:

Four Zinc (II) phthalocyanines (ZnPcs) derivatives, ZnPH13, ZnPH14, ZnPH15 and ZnPH22, decorated with elaborate mol. tailor-making on the phenyl-based peripheral substituents of Pc scaffolds are synthesized and acted as dopant-free hole-transporting materials (HTMs) in perovskite solar cells (PSCs). The detailed electrochem., photophys. characteristics, theor. geometric/electronic features, hole mobility, charge carrier extraction, collection and transporting dynamic processes of these HTMs are cautiously unveiled. The heuristic probe into the substantial relations and dependences between the Pc organic scaffold structure and properties at mol. level are investigated. The mixed-ion PSC utilizing the ZnPH22 containing the benzo[d] [1,3]dioxole peripheral substituent with cyclic/planar conformation presents a most competitive power conversion efficiency (PCE) of 18.3% associating with excellent reproducibility and superior long-period stability. These results reveal that the eventual solar cell performance can be decipherable through the intrinsic electronic and structural effects originating from the peripheral substituents modifications. This work thus exploits the new insights into the advanced mol. building of efficient phthalocyanines HTMs for high performance and stable PSCs. In the experiment, the researchers used many compounds, for example, 3-Methoxyphenylboronic acid(cas: 10365-98-7Synthetic Route of C7H9BO3)

3-Methoxyphenylboronic acid(cas: 10365-98-7) belongs to boronic acids. Boronic acids are mild Lewis acids which are generally stable and easy to handle, making them important to organic synthesis.Synthetic Route of C7H9BO3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Huang, Huoming; Li, Xinwei; Guo, Wei; Zhu, Chen; Qian, Yuanyuan; Shen, Qing; Xu, Xuejun; Li, Wei; Wang, Yujun; Fu, Wei published an article in 2021. The article was titled 《Design, Synthesis, and Structure-Activity Relationship Exploration of Alkyl/Phenylalkyl Piperidine Analogues as Novel Highly Potent and Selective μ Opioid Receptor Agonists》, and you may find the article in ACS Chemical Neuroscience.Application of 2398-37-0 The information in the text is summarized as follows:

Pain was implicated in many diseases. Despite effectiveness to treat moderate to severe pain, opioid analgesics elicited many side effects, greatly limiting their prescription in clinics. Based on M1, an active metabolite of tramadol, 3-((dimethylamino)methyl)-4-(3-hydroxyphenyl)piperidin-4-ol analogs were designed, synthesized, and evaluated in vitro. Among all the compounds tested, compound 23 was found to be a novel, highly selective, and potent MOR agonist (Ki MOR = 0.0034 nM, EC50 MOR = 0.68 nM, Emax = 206.5%; Ki DOR = 41.67 nM; Ki KOR = 7.9 nM). Structure-activity relationship exploration showed that the linker between the piperidine ring and the Ph ring as well as substituent pattern of the Ph ring played a pivotal role in binding affinity and selectivity. (3R, 4S)-23(I) (Ki MOR = 0.0021 ± 0.0001 nM, EC50 MOR = 0.0013 ± 0.0001 nM, Emax = 209.1 ± 1.4%; Ki DOR = 18.4 ± 0.7 nM, EC50 DOR = 74.5 ± 2.8 nM, Emax = 267.1 ± 1.4%; Ki KOR = 25.8 ± 0.2 nM, EC50 DOR = 116.2 ± 4.4 nM, Emax = 209.5 ± 1.4%) had more potent activity for opioid receptors than its enantiomer (3S, 4R)-23 and was found to be a potent, highly selective MOR agonist with novel scaffold. High binding affinity and selectivity of (3R, 4S)-23 for MOR over KOR and DOR and its mechanism of activating MOR were proposed by docking and mol. dynamics simulations, resp. In the experiment, the researchers used many compounds, for example, 1-Bromo-3-methoxybenzene(cas: 2398-37-0Application of 2398-37-0)

1-Bromo-3-methoxybenzene(cas: 2398-37-0) can be used in chemical reaction as intermediates to obtain target materials such as dyes, pharmaceuticals, perfumes, photoinitiators and agrochemicals.Application of 2398-37-0

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Xiong, Biquan; Xu, Shipan; Xu, Weifeng; Liu, Yu; Zhang, Limin; Tang, Ke-Wen; Yin, Shuang-Feng; Wong, Wai-Yeung published an article in 2022. The article was titled 《Silver-catalyzed regioselective 1,6-hydroarylation of para-quinone methides with anilines and phenols》, and you may find the article in Organic Chemistry Frontiers.Quality Control of m-Methoxyphenol The information in the text is summarized as follows:

A simple and efficient method for the silver-catalyzed regioselective 1,6-hydroarylation of para-quinone methides (p-QMs) with anilines and phenols has been established. Without the need for pre-protection, a broad range of anilines (primary amine, secondary amine and tertiary amine), phenols and para-quinone methides are well tolerated under mild conditions, giving the corresponding 1,6-hydroarylation products with moderate to good yields. Moreover, a series of modified natural products can be synthesized via this simple method. Control experiments were also performed to gain insights into the plausible reaction mechanism. This protocol has high atom economy, and may have significant implications for the formation of C(sp3)-C(sp2) bonds in organic synthesis.m-Methoxyphenol(cas: 150-19-6Quality Control of m-Methoxyphenol) was used in this study.

m-Methoxyphenol(cas: 150-19-6) may be used in synthesis of:C(4) symmetric calix[4]resorcinarene, 2-nitroso-5-methoxyphenol, 6-methoxy-2(3H)-benzoxazoloneQuality Control of m-Methoxyphenol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2022,Yuan, Sitian; Ye, Xiaoling; Cai, Jingyu; Song, Zhibin; Tan, Yuxing; Peng, Yiyuan; Ding, Qiuping published an article in Journal of Organic Chemistry. The title of the article was 《DMF-Assisted Radical Cyclization of o-Isocyanodiaryl Ethers via 1,5-Aryl Migration: Construction of 2-Arylbenzoxazoles》.Quality Control of m-Methoxyphenol The author mentioned the following in the article:

A novel DMF-assisted radical cyclization of o-isocyanodiaryl ethers 2-CN-3-R1-4-R2 -5-R3 C6HOR (R = 2-tert-butylphenyl, 2-phenylphenyl, pyridin-2-yl; R1 = H, Me, Cl; R2 = H, Me, Cl; R3 = H, Me) via 1,5-aryl migration has been developed for the synthesis of a series of 2-arylbenzoxazoles I and 2-phenyloxazolo[4,5-b]pyridine by the FeCl3/TBHP/Et3N catalytic system in DMF. However, N,N-dimethylbenzo[d]thiazole-2-carboxamide and N,N-dimethylbenzo[d]selenazole-2-carboxamide were obtained from the corresponding substrate 2-isocyanophenyl p-methoxyphenyl thioether and 2-isocyanodiphenyl selenoether under the same conditions. A possible mechanism may involve aryl 1,5-migration and DMF-assisted radical cyclization of o-isocyanodiaryl ethers I. The results came from multiple reactions, including the reaction of m-Methoxyphenol(cas: 150-19-6Quality Control of m-Methoxyphenol)

m-Methoxyphenol(cas: 150-19-6) may be used in synthesis of:C(4) symmetric calix[4]resorcinarene, 2-nitroso-5-methoxyphenol, 6-methoxy-2(3H)-benzoxazoloneQuality Control of m-Methoxyphenol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem