Month: October 2022

In 2022,Li, Wen-Xin; Yang, Bo-Wen; Ying, Xuan; Zhang, Zhuo-Wen; Chu, Xue-Qiang; Zhou, Xiaocong; Ma, Mengtao; Shen, Zhi-Liang published an article in Journal of Organic Chemistry. The title of the article was 《Nickel-Catalyzed Direct Cross-Coupling of Diaryl Sulfoxide with Aryl Bromide》.Recommanded Product: 2398-37-0 The author mentioned the following in the article:

The direct cross-couplings of diaryl sulfoxides with aryl bromides via C-S bond cleavage could be readily accomplished using nickel(II) as the catalyst, 1,2-bis(diphenylphosphino)ethane (dppe) as the ligand, and magnesium turnings as the reducing metal in THF, leading to the corresponding biaryls RR1 [R = Ph, 4-MeC6H4, 2-naphthyl, etc.; R1 = 4-MeOC6H4, 2-pyridyl, benzofuran-5-yl, etc.] in moderate to good yields. The reaction exhibited a broad substrate scope and could be applied to a gram-scale synthesis. The ”one-pot” reaction, which avoided the utility of presynthesized and moisture-labile organometallic compounds, was operationally simple and step-economic.1-Bromo-3-methoxybenzene(cas: 2398-37-0Recommanded Product: 2398-37-0) was used in this study.

1-Bromo-3-methoxybenzene(cas: 2398-37-0) is a compound useful in organic synthesis and other chemical processes. It is an intermediate used for pharmaceuticals, perfumes and agrochemicals.Recommanded Product: 2398-37-0

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2022,Chen, Yin-Jun; Xu, Hui-Bei; Liu, Hao; Dong, Lin published an article in Organic Chemistry Frontiers. The title of the article was 《Highly-selective synthesis of functionalized spirobenzofuranones and diketones》.Reference of m-Methoxyphenol The author mentioned the following in the article:

A convenient and atom-economical rhodium(III)-catalyzed highly-selective hydroacylation for the synthesis of spirobenzofuranones and diketones was successfully developed. Ortho-hydroxyl-group-assisted aldehyde C-H cascade [4+1] annulation makes the formation of spiro compounds more efficient. In addition to this study using m-Methoxyphenol, there are many other studies that have used m-Methoxyphenol(cas: 150-19-6Reference of m-Methoxyphenol) was used in this study.

m-Methoxyphenol(cas: 150-19-6) may be used in synthesis of:C(4) symmetric calix[4]resorcinarene, 2-nitroso-5-methoxyphenol, 6-methoxy-2(3H)-benzoxazoloneReference of m-Methoxyphenol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2022,Miyazaki, Akira; Taki, Tomoki; Takeichi, Takuya; Kono, Michihiro; Yagi, Hiroaki; Akiyama, Masashi published an article in Journal of Dermatology. The title of the article was 《Darier disease successfully treated with a topical agent containing vitamin A (retinyl palmitate), vitamin E, and urea》.Product Details of 106685-40-9 The author mentioned the following in the article:

Darier disease (DD), also called keratosis follicularis, is an autosomal dominant hereditary keratinization disorder that manifests as keratotic papules with plaques in seborrheic areas. There are no validated curative treatments for DD, with the majority of cases treated symptomatically. We report the efficacy of a topical over-the-counter agent which contains retinyl palmitate, vitamin E, and urea for a patient with DD. A 13-yr-old girl had brown papules on her scalp, neck, shoulders, and axillae since entering elementary school. A skin biopsy revealed hyperkeratosis, suprabasal acantholysis, and dyskeratosis manifested as corps ronds and grains in the epidermis. Sanger sequencing found the previously reported heterozygous mutation c.1484C>T in ATP2A2. The application of an over-the-counter topical agent containing retinyl palmitate 2750 μg/g (5000 IU/g), tocopheryl acetate 20 mg/g, urea 200 mg/g, and monoammonium glycyrrhizinate 5 mg/g twice daily for 2 mo improved the papules without serious adverse events. Oral or topical aromatic vitamin A analogs (retinoids) are often used to treat DD. However, several adverse events are associated with retinoid treatment, and many patients only undergo their intermittent use or discontinue the treatments. Retinyl palmitate is more stable and has a lower irritative profile than other retinoic acids. When applied topically, however, retinyl palmitate cannot penetrate the skin as well as retinol can. Some reports have noted that vitamin E increases the biol. availability of vitamin A and that urea helps mech. percutaneous drug delivery. Our case suggests that retinyl palmitate has a sufficient therapeutic effect when combined with vitamin E and urea. In conclusion, we propose that topical agents containing retinyl palmitate, vitamin E, and urea might have a satisfactory effect on the skin lesions of DD patients, without the serious risks of adverse events. The experimental part of the paper was very detailed, including the reaction process of 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas: 106685-40-9Product Details of 106685-40-9)

6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas:106685-40-9) is a third-generation synthetic retinoid and a highly lipophilic compound derived from naphthoic acid. It is widely used in the treatment of acne.Product Details of 106685-40-9

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthetic Route of C10H20O5In 2020 ,《Oriented proton-conductive nano-sponge-facilitated polymer electrolyte membranes》 appeared in Energy & Environmental Science. The author of the article were Liu, Xin; Zhang, Junfeng; Zheng, Chenyang; Xue, Jiandang; Huang, Tong; Yin, Yan; Qin, Yanzhou; Jiao, Kui; Du, Qing; Guiver, Michael D.. The article conveys some information:

Achieving high power output from proton exchange membrane fuel cells (PEMFCs) requires efficient proton transport in proton exchange membranes (PEMs). Since proton conductivity is closely related to membrane moisture content, operation at low relative humidity (RH) and elevated temperature has become a critical bottleneck for the practical application of PEMFCs due to severe PEM dehydration. While several strategies have sought to mitigate this, including external thermal and water management, coating of nano-cracked hydrophobic layers and optimization of membrane intrinsic water retention, only partial improvements have been realized. Here, using a membrane formulation of ferrocyano-coordinated poly(4-vinylpyridine) (CP4VP), phosphotungstic acid (PWA) and polysulfone (PSf), novel highly water-retentive PEMs are fabricated via a strong magnetic field. During magnetic-assisted membrane casting, CP4VP and PWA form a microporous Prussian blue analog (PBA) framework with the new type of Fe-C≡N-W bonding, which is paramagnetic and is thus simultaneously aligned in the through-plane (TP) direction of the membrane. The neutral PSf membrane component affords mech. strength to the embedded TP-aligned conducting channels. This new type of microporous PBA framework is highly hydrophilic and proton conductive, with micropores of ∼5.4 Å diameter, which act as nano-sponges to absorb only more retentive non-freezable water, effective for proton conduction. These nano-sponges display efficient water absorption and retention at low RH and elevated temperatures, together with a much faster hydration process than the dehydration process. Furthermore, the TP-aligned PBA channels also enable faster water transport to promote PEM proton conduction beyond any previously reported water-retentive membrane. Consequently, the novel nano-sponge-like PEMs exhibit remarkable performance in both ex situ and in situ evaluations, especially at low RH and elevated temperature, largely prevailing over the com. benchmark Nafion 212. In the part of experimental materials, we found many familiar compounds, such as 1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5Synthetic Route of C10H20O5)

1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5) is a member of crown ether Ligands. Crown-ethers are macrocyclic polyethers capable of forming host-guest complexes, especially with inorganic and organic cations. Crown-ethers can incorporate protonated primary amine compounds by formation of ion-dipole bonds with the oxygen atoms of the chiral selector. Crown-ethers have been widely used for the separation of several pharmaceuticals both in aqueous and non-aqueous media. Synthetic Route of C10H20O5

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Name: 2-MethoxybenzaldehydeIn 2021 ,《Three-Component Efficient Synthesis of 2-Amino-3-cyano-4H-pyrans Catalyzed by Diammonium Hydrogen Phosphate in Aqueous Media》 appeared in Current Organocatalysis. The author of the article were Taghva, Pardis H.; Kabirifard, Hassan. The article conveys some information:

A series of 2-amino-3-cyano-4H-pyrans I [R = 4-MeC6H4, 2-ClC6H4, 3,4-(MeO)2C6H3, etc.] was synthesized by one-pot three-component condensation reactions of aromatic aldehydes RCHO, malononitrile and Me acetoacetate using diammonium hydrogen phosphate (DAHP) in aqueous ethanol at room temperature in excellent yields. All obtained structures were confirmed by their m.ps., IR, 1H NMR, 1C NMR spectroscopy, and also elemental analyses for new derivatives The present method is straightforward, quick, and most efficient green protocol for the synthesis of 2-amino-3-cyano-4H-pyrans using highly inexpensive, easy to handle and nontoxic DAHP as an efficient catalyst in aqueous ethanol medium at room temperature The results came from multiple reactions, including the reaction of 2-Methoxybenzaldehyde(cas: 135-02-4Name: 2-Methoxybenzaldehyde)

2-Methoxybenzaldehyde(cas: 135-02-4) is found in cassia oil, cinnamon bark, and cinnamon bark oil. It is a clear colorless liquid with a strong aroma. It has been used to examine the acaricidal activity of Periploca sepium oil and its active component against Tyrophagus putrescentiae.Name: 2-Methoxybenzaldehyde

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Application In Synthesis of 1,2-DiphenyldisulfaneIn 2020 ,《Rhodium(III)-catalyzed carboxylate-directed ortho-selective thiolation of benzoic acids》 was published in Organic Chemistry Frontiers. The article was written by Wang, Dongjie; Zhou, Kehan; Zhang, Jingyu; Zhao, Yingsheng. The article contains the following contents:

A regioselective rhodium-catalyzed carboxylate-directed thiolation process was developed. Several benzoic-acid derivatives 2-R-3-R1-4-R2-5-R3-C6HC(O)OH (R = H, Me, Et, OMe, Ph, Cl, OPh; R1 = H, Me, Cl, OMe, OEt; R2 = H, Me, OMe, OEt, OBn, pentyl; R3 = H, Me) and disulfides R4SSR4 (R4 = propan-2-yl, cyclohexyl, Ph, etc.) were found to be well-tolerated, and they yielded the corresponding products 2-R-3-R1-4-R2-5-R3-6-S(R4)-C6C(O)OH in moderate to good yields. Compounds such as the key precursor of roflumilast can be obtained via this reaction, thereby highlighting the potential of this synthetic approach. In the experimental materials used by the author, we found 1,2-Diphenyldisulfane(cas: 882-33-7Application In Synthesis of 1,2-Diphenyldisulfane)

1,2-Diphenyldisulfane(cas: 882-33-7) belongs to ethers.Application In Synthesis of 1,2-DiphenyldisulfaneAlthough ethers resist hydrolysis, they are cleaved by hydrobromic acid and hydroiodic acid. Hydrogen chloride cleaves ethers only slowly.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Washable colorimetric nanofiber nonwoven for ammonia gas detection》 was written by Oh, Hyun Ju; Yeang, Byeong Jin; Park, Young Ki; Choi, Hyun Jung; Kim, Jong H.; Kang, Young Sik; Bae, Younghwan; Kim, Jung Yeon; Lim, Seung Ju; Lee, Woosung; Hahm, Wan-Gyu. Synthetic Route of C8H8O3This research focused onwashable colorimetric nanofiber nonwoven ammonia gas detection; ammonia gas; colorimetric nanofiber sensor; gas detection; meta-aramid nanofiber. The article conveys some information:

The colorimetric sensor is a facile, cost-effective, and non-power-operated green energy material for gas detection. In this study, the colorimetric sensing property of a meta-aramid/dye 3 nanofiber sensor for ammonia (NH3) gas detection was investigated. This colorimetric sensor was prepared using various dye 3 concentrations via electrospinning. Morphol., thermal, structural, and mech. analyses of the sensor were carried out by field-emission SEM, thermogravimetric anal., Fourier-transform IR spectroscopy, and a universal testing machine, resp. A homemade computer color matching machine connected with a gas flow device characterized the response of the meta-aramid/dye 3 nanofiber colorimetric sensor to various exposure levels of NH3 gas. From the results, we confirmed that this colorimetric green energy sensor could detect ammonia gas in the concentration of 1-10 ppm with a sensing response time of 10 s at room temperature After washing with laundry detergent for 30 min, the colorimetric sensors still exhibited sensing property and reversibility.2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3Synthetic Route of C8H8O3) was used in this study.

2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is the main component of root bark essential oil of Periploca sepium Bunge. It is a potential tyrosinase inhibitor present in African medicinal plants. 2-Hydroxy-4-methoxybenzaldehyde was used in the synthesis of Schiff base ligand.Synthetic Route of C8H8O3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Recommanded Product: (3-Methoxy-2-methylphenyl)methanolOn March 11, 2000, Peixoto, Christophe; Laurin, Patrick; Klich, Michel; Dupuis-Hamelin, Claudine; Mauvais, Pascale; Lassaigne, Patrice; Bonnefoy, Alain; Musicki, Branislav published an article in Tetrahedron Letters. The article was 《Synthesis of isothiochroman 2,2-dioxide and 1,2-benzoxathiin 2,2-dioxide gyrase B inhibitors》. The article mentions the following:

The design, synthesis, and in-vitro biol. evaluation of isothiochroman 2,2-dioxide and 1,2-benzoxathiin 2,2-dioxide analogs of coumarin inhibitors of gyrase B are described. Compared to coumarin derivatives, compounds of the 1,2-benzoxathiin 2,2-dioxide series display improved inhibitory potency in neg. supercoiling of relaxed DNA gyrase. In the experiment, the researchers used many compounds, for example, (3-Methoxy-2-methylphenyl)methanol(cas: 33797-34-1Recommanded Product: (3-Methoxy-2-methylphenyl)methanol)

(3-Methoxy-2-methylphenyl)methanol(cas: 33797-34-1) belongs to ethers. Ethers lack the hydroxyl groups of alcohols. Without the strongly polarized O―H bond, ether molecules cannot engage in hydrogen bonding with each other. Recommanded Product: (3-Methoxy-2-methylphenyl)methanol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Safety of 1,4-Diethynyl-2,5-dimethoxybenzeneOn May 21, 2013 ,《Conjugated Porous Polymers For TNT Vapor Detection》 appeared in ACS Macro Letters. The author of the article were Novotney, Jennifer L.; Dichtel, William R.. The article conveys some information:

A conjugated porous polymer (CPP) that exhibits fluorescence quenching when exposed to TNT vapor was synthesized via a Sonaogashira cross-coupling reaction. Two polymerization solvents, DMF and PhMe, and two activation procedures, evacuation and lyophilization, were evaluated to optimize the response of the CPP to TNT vapor. Key differences in surface area and absorption were seen as a function of polymerization solvent and activation procedure. The polymer synthesized in DMF and activated by lyophilization had the highest surface area and the strongest response to TNT vapor. This paper demonstrates the importance of growth and activation conditions in optimizing the porosity and sensing performance of CPPs. In the experiment, the researchers used many compounds, for example, 1,4-Diethynyl-2,5-dimethoxybenzene(cas: 74029-40-6Safety of 1,4-Diethynyl-2,5-dimethoxybenzene)

1,4-Diethynyl-2,5-dimethoxybenzene(cas: 74029-40-6) belongs to ethers. Ethers lack the hydroxyl groups of alcohols. Without the strongly polarized O―H bond, ether molecules cannot engage in hydrogen bonding with each other. Safety of 1,4-Diethynyl-2,5-dimethoxybenzene

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2011,Spaeth, Andreas; Gonschor, Janina; Koenig, Burkhard published 《Synthesis and binding properties of guanidinium biscarboxylates》.Monatshefte fuer Chemie published the findings.COA of Formula: C9H19NO4 The information in the text is summarized as follows:

The ammonium ion binding site of the enzyme glutaminase HisF inspired the design of guanidinium biscarboxylates as potential self-organized ionophores in mol. recognition. The syntheses of the title compounds based on aliphatic and aromatic building blocks, along with a general method for the preparation of δ-aminoethoxyacetic acids, are presented. Investigation of the binding properties of the title compounds in DMSO and methanol solution revealed no ammonium ion affinity, but interaction of the guanidinium moiety with acetate ions. In the experimental materials used by the author, we found tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6COA of Formula: C9H19NO4)

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers.Oxygen is more electronegative than carbon, thus the alpha hydrogens of ethers are more acidic than those of simple hydrocarbons. They are far less acidic than alpha hydrogens of carbonyl groups (such as in ketones or aldehydes), however. COA of Formula: C9H19NO4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem