Month: October 2022

In 2016,Chu, Hualei; Song, Yuanqing; Li, Jiehua; Luo, Feng; Tan, Hong; Huang, Guangsu; Fu, Qiang published 《A novel phosphatidylcholine-modified polyisoprene: synthesis and characterization》.Colloid and Polymer Science published the findings.Application In Synthesis of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate The information in the text is summarized as follows:

Polyisoprene (PI) is the main component of natural rubber. To imitate natural rubber and understand the function of phospholipid in natural rubber, a novel phosphatidylcholine (PC)-modified polyisoprene (PI-pc) was synthesized using a PC and a com. PI. The PI is firstly brominated by N-bromosuccinimide, and then, di-Et malonate is introduced as a branch chain of PI. In sequence, the PC is imported into the branch chain of PI via condensation of the activated ester terminals in di-Et malonate and the amino terminals in PC to obtain the desired product PI-pc. The bulk structure of the prepared PI-pc is carefully characterized with NMR spectra (1H and 31P NMR), Fourier transform IR spectroscopy (FT-IR), gel permeation chromatograph (GPC), and differential scanning calorimetry (DSC). The introduction of PC to the branch chain of PI increases the mol. weight and also the glass transition (Tg) of the PI. The increment of Tgs and melting enthalpy for the PI-pcs from both solution and emulsion indicates that the attached PC is beneficial to the self-assembly of PI chains and thus promotes the crystallization Our present work provides a new method for importing PC to PI to imitate natural rubber, and also, the results could be a footstone for us to explore the effect of phospholipid on the property of natural rubber. The results came from multiple reactions, including the reaction of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6Application In Synthesis of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate)

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers.The C-O bonds that comprise simple ethers are strong. Application In Synthesis of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate They are unreactive toward all but the strongest bases. Although generally of low chemical reactivity, they are more reactive than alkanes.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2017,Zhang, Huaiying; Aonbangkhen, Chanat; Tarasovetc, Ekaterina V.; Ballister, Edward R.; Chenoweth, David M.; Lampson, Michael A. published 《Optogenetic control of kinetochore function》.Nature Chemical Biology published the findings.SDS of cas: 139115-91-6 The information in the text is summarized as follows:

Kinetochores act as hubs for multiple activities during cell division, including microtubule interactions and spindle checkpoint signaling. Each kinetochore can act autonomously, and activities change rapidly as proteins are recruited to, or removed from, kinetochores. Understanding this dynamic system requires tools that can manipulate kinetochores on biol. relevant temporal and spatial scales. Optogenetic approaches have the potential to provide temporal and spatial control with mol. specificity. Here we report new chem. inducers of protein dimerization that allow us to both recruit proteins to and release them from kinetochores using light. We use these dimerizers to manipulate checkpoint signaling and mol. motor activity. Our findings demonstrate specialized properties of the CENP-E (kinesin-7) motor for directional chromosome transport to the spindle equator and for maintenance of metaphase alignment. This work establishes a foundation for optogenetic control of kinetochore function, which is broadly applicable to exptl. probing of other dynamic cellular processes. After reading the article, we found that the author used tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6SDS of cas: 139115-91-6)

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers. Ethers lack the hydroxyl groups of alcohols. SDS of cas: 139115-91-6 Without the strongly polarized O―H bond, ether molecules cannot engage in hydrogen bonding with each other.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2019,Russian Chemical Bulletin included an article by Vasil’ev, L. S.; Baranin, S. V.; Dmitrenok, A. S.; Zavarzin, I. V.. Related Products of 4637-24-5. The article was titled 《A new approach to CF3-containing 3,4-dihydroquinazolin-2(1H)-ones》. The information in the text is summarized as follows:

A new approach to CF3-containing 3,4-dihydroquinazolin-2(1H)-ones based on the condensation of 5-acetyl-6-methyl-1-phenyl-4-trifluoromethylpyrimidin-2(1H)-one with DMF di-Me acetal was suggested. After reading the article, we found that the author used N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Related Products of 4637-24-5)

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Reaction with nitrous acid (HNO2), which functions as an acylating agent that is a source of the nitrosyl group (―NO), converts aliphatic primary amines to nitrogen and mixtures of alkenes and alcohols corresponding to the alkyl group in a complex process. This reaction has been used for analytical determination of primary amino groups in a procedure known as the Van Slyke method.Related Products of 4637-24-5

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ren, Huimin; Liu, Chao; Ding, Xu; Fu, Xianzhang; Wang, Hailong; Jiang, Jianzhuang published an article on February 1 ,2022. The article was titled 《High Fluorescence Porous Organic Cage for Sensing Divalent Palladium Ion and Encapsulating Fine Palladium Nanoparticles》, and you may find the article in Chinese Journal of Chemistry.Electric Literature of C12H10O2 The information in the text is summarized as follows:

Comprehensive Summary : Porous organic cages (POCs) as an innovative type of porous mol. materials enable multifunctional applications. Herein, a fluorescence POC (denoted as 1) has been constructed by means of 5,5′-((2,5-dimethoxy-1,4-phenylene)bis(ethyne-2,1-diyl))diisophthalaldehyde condensing with cyclohexanediamine enantiomer with the aid of trifluoroacetic acid. 1 exhibits the permanent void and prominent fluorescence with relative quantum yield of 73% confirmed by gas sorption and emission experiments, resp. Moreover, this organic cage is capable of sensing diavalent Pd2+ according to the fluorescence response to the addition of various metal ions. The dispersion of 1 in methanol containing palladium acetate was stirred at 25 °C and then 80 °C to reduce Pd2+ ions into nanoparticles (NPs), leading to the composite (Pd@1) composed of fine Pd NPs with the size of ca. 1.8 nm. The catalytic nature of Pd@1 over NaBH4 promoted the degeneration of nitrobenzene and congo red. This work introduces one new case of POCs with versatile properties and functions, including ion fluorescence recognition, fine Pd NPs stabilizer, and gas adsorption, enriching the family of POC-based materials. In the experiment, the researchers used 1,4-Diethynyl-2,5-dimethoxybenzene(cas: 74029-40-6Electric Literature of C12H10O2)

1,4-Diethynyl-2,5-dimethoxybenzene(cas: 74029-40-6) belongs to ethers.Oxygen is more electronegative than carbon, thus the alpha hydrogens of ethers are more acidic than those of simple hydrocarbons. Electric Literature of C12H10O2 They are far less acidic than alpha hydrogens of carbonyl groups (such as in ketones or aldehydes), however.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

The author of 《The experimental study on the influence of crown ethers and glycols on the mutual solubility of lithium bromide in water》 were Krolikowska, Marta; Romanska, Katarzyna. And the article was published in Fluid Phase Equilibria in 2019. Reference of 1,4,7,10,13-Pentaoxacyclopentadecane The author mentioned the following in the article:

In this paper the continuation of our work on searching for anti crystallization additives to the aqueous solution of lithium bromide is presented. This type of research is important from the viewpoint of absorption refrigeration technol. to improve the performance of the efficiency of refrigeration equipment. In this study three crown ethers 12-crown-4 15-crown-5 and 18-crown-6 as well as the glycols ethylene glycol diethylene glycol triethylene glycol and glycerol were investigated as anti crystallization additives for lithiumbromide in water system, conventionally used as a working pair in absorption refrigeration technol. For this purpose the solubility of lithium bromide in water has been detected in the presence of the organic additive. The solubility measurements have been carried out using a dynamic method at a wide temperature and comparision range for different additive to LiBr initial mass fraction from 0.1 0.2 and 0.3. From exptl. SLE data the comparison range of the liquid state for tested systems at the absorbers working temperature was detected and compared to those from conventional LiBr in water system. Further measurements of vapor liquid equillibrium will be performed to select the best anti crystalization additive. In the part of experimental materials, we found many familiar compounds, such as 1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5Reference of 1,4,7,10,13-Pentaoxacyclopentadecane)

1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5) is a member of crown ether Ligands. Crown-ethers are macrocyclic polyethers capable of forming host-guest complexes, especially with inorganic and organic cations. Crown-ethers can incorporate protonated primary amine compounds by formation of ion-dipole bonds with the oxygen atoms of the chiral selector. Crown-ethers have been widely used for the separation of several pharmaceuticals both in aqueous and non-aqueous media. Reference of 1,4,7,10,13-Pentaoxacyclopentadecane

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

The author of 《Evaluating liver uptake and distribution of different poly(2-methyl-2-oxazoline) modified lysine dendrimers following intravenous administration》 were England, Richard M.; Moss, Jennifer I.; Hill, Kathryn J.; Elvevold, Kjetil; Smedsroed, Bard; Ashford, Marianne B.. And the article was published in Biomaterials Science in 2019. COA of Formula: C28H28O3 The author mentioned the following in the article:

We report on the synthesis of four poly(2-methyl-2-oxazoline) modified lysine dendrimers with different residual groups or modifications on the dendrimer core, including: amino groups (pos. charge), carboxyl groups (neg. charge), and two drug mols., one of which has a high log P. We looked at the in vivo distribution amongst three main liver cell types: hepatocytes, liver sinusoidal endothelial cells (LSECs) and Kupffer cells (KCs) and found differences in cell distribution and uptake concentrations dependent on these residual groups. In particular, the amino-functional polymer showed greater uptake by the hepatocytes while the carboxyl-functionalised polymer exhibited greater uptake by KCs and LSECs. These findings provide insight into which professional scavenger cells of the liver remove these types of nanoparticles from the bloodstream and we describe some of the design criteria to consider when creating novel drug delivery systems. In the experimental materials used by the author, we found 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas: 106685-40-9COA of Formula: C28H28O3)

6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas:106685-40-9) is a third-generation synthetic retinoid and a highly lipophilic compound derived from naphthoic acid. It is widely used in the treatment of acne.COA of Formula: C28H28O3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

The author of 《Synthesis and characterization of a magnetic graphene oxide/Zn-Ni-Fe layered double hydroxide nanocomposite: An efficient mesoporous catalyst for the green preparation of biscoumarins》 were Zeynizadeh, Behzad; Gilanizadeh, Masumeh. And the article was published in New Journal of Chemistry in 2019. Related Products of 135-02-4 The author mentioned the following in the article:

In this study, a nanocomposite of Fe3O4@GO@Zn-Ni-Fe-layered double hydroxide was synthesized as a novel and efficient mesoporous magnetic nanocatalyst. The synthesis was carried out via the immobilization of Fe3O4 MNPs (magnetic nanoparticles) on graphene oxide and then the layering of Zn-Ni-Fe-layered double hydroxide moieties on the constituents of Fe3O4@GO. The magnetic graphene oxide/layered double hydroxide system was then characterized using SEM, EDX, FTIR, XRD, TEM and VSM analyses. The catalytic activity of the prepared composite system was further studied towards one-pot Knoevenagel-Michael reaction of aromatic aldehydes with 4-hydroxycoumarin in water. All reactions were carried out under reflux conditions, giving biscoumarin materials I (R = H, 4-Me, 2-MeO, 2,4-Cl2, 4-CHO, etc.) in 87-95% yields within 3-40 min. This method has noteworthy advantages in terms of mild reaction conditions, short reaction times, utilizing water as an environmental friendly solvent and applying a magnetically separable catalyst system. After reading the article, we found that the author used 2-Methoxybenzaldehyde(cas: 135-02-4Related Products of 135-02-4)

2-Methoxybenzaldehyde(cas: 135-02-4) is used as a flavor agent in foods including nonalcoholic/alcoholic beverages, baked goods, chewing gum, confections, frozen dairy, fruit ices, hard/soft candy, instant coffee, tea, Jams, jellies, and milk products. It also has been used to obtain good enantioselectivities using Cu(OAc)(2)-bis(oxazolines) via hydrogen bonding in asymmetric Henry reaction.Related Products of 135-02-4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

The author of 《A signal-on detection of organophosphorus pesticides by fluorescent probe based on aggregation-induced emission》 were Cai, Yue; Fang, Jingkun; Wang, Bingfeng; Zhang, Fangshuai; Shao, Guang; Liu, Yingju. And the article was published in Sensors and Actuators, B: Chemical in 2019. Reference of Bis(4-methoxyphenyl)amine The author mentioned the following in the article:

Organophosphorus pesticides (OPs) have been broadly used in agriculture because of their high insecticidal efficiency. However, most OPs are highly toxic, since they can irreversibly inhibit acetylcholinesterase (AChE), leading to the neurotransmitter acetylcholine disorder which triggers a series of neurol. diseases, and even death. Therefore, the rapid and sensitive detection of OPs is of great significance to life health and environmental protection. In this work, new derivatives of tetraphenylethene (TPE) with one or two aldehyde groups were synthesized and characterized, showing that they exhibited different aggregation-induced emission (AIE) effects in different pH solutions Especially, the hydrolysis product of acetylthiocholine iodide (ATCh) catalyzed by acetylcholinesterase (AChE) can influence the pH of solution, causing the protonation of TPE-1 and changing its fluorescent intensity. Considering that the AChE activity can be specifically inhibited by OPs, the proposed TPE-1 was used to detect OPs between 0.009 and 22.5 mg/L with a detection limit of 0.008 mg/L. In addition, the selectivity was acceptable, providing a possible application for the detection of OPs. After reading the article, we found that the author used Bis(4-methoxyphenyl)amine(cas: 101-70-2Reference of Bis(4-methoxyphenyl)amine)

Bis(4-methoxyphenyl)amine(cas: 101-70-2) is a diphenylamine derivative used as a chemical additive for cured rubber.Bis(4-methoxyphenyl)amine is highly toxic and may potentially induce chromosome abberation.Reference of Bis(4-methoxyphenyl)amine

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Compatibility study of four binary combinations of active ingredients for dermal film forming systems》 was published in Farmacia (Bucharest, Romania) in 2020. These research results belong to Rusu, Aura; Ciurba, Adriana; Birsan, Magdalena; Antonoaea, Paula; Szekely-Szentmiklosi, Blanka; Fulop, Ibolya; Pascu, Giorgiana-Andreea; Todoran, Nicoleta. Safety of 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid The article mentions the following:

Adapalene (ADA), levofloxacin (LEV), meloxicam (MEL) and miconazole nitrate (MIC) were selected as potential active ingredients for film systems with dermal or transdermal delivery. This study aimed to evaluate the compatibility of four binary mixtures – ADA and LEV (M1), ADA and MIC (M2), LEV and MEL (M3), and LEV and MIC (M4) – combinations for new bioadhesive polymeric matrix dermal systems produced by the casting solvent evaporation technique. The Fourier-transform IR spectroscopy (FTIR), differential scanning calorimetry (DSC) and mol. modeling (MM) were used to characterize and evaluate the compatibility between the selected active substances. In the FTIR data, M1, M2, and M4 mixtures presented a good compatibility. DSC revealed different chem. interactions as the temperature rose above 160°C, especially for M3 and M4. Through MM technique, interactions were found on the M2 and M3 mixtures Following the correlation of all obtained results, the best compatibility was found to be on M1 and M4 combinations. The experimental part of the paper was very detailed, including the reaction process of 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas: 106685-40-9Safety of 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid)

6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas:106685-40-9) may be used as a pharmaceutical reference standard for the quantification of the analyte in topical gel formulations using high-performance liquid chromatography technique.Safety of 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Cp*Co(III)-Catalyzed o-Amidation of Benzaldehydes with Dioxazolones Using Transient Directing Group Strategy》 was published in Advanced Synthesis & Catalysis in 2020. These research results belong to Khan, Bhuttu; Dwivedi, Vikas; Sundararaju, Basker. Application of 135-02-4 The article mentions the following:

Transition metal-catalyzed ortho-selective C(sp2)-H amidation of weakly coordinating aldehydes remains limited to precious metals such as Ir, Rh, Ru, etc. Herein, a novel report on ortho-amidation of benzaldehydes employing user-friendly dioxazolones under cost-effective and air-stable Cp*Co(III) catalysis. This catalytic transformation involves transient directing group strategy to enhance the ligating capability of weakly chelating aldehydes.2-Methoxybenzaldehyde(cas: 135-02-4Application of 135-02-4) was used in this study.

2-Methoxybenzaldehyde(cas: 135-02-4) is used as a flavor agent in foods including nonalcoholic/alcoholic beverages, baked goods, chewing gum, confections, frozen dairy, fruit ices, hard/soft candy, instant coffee, tea, Jams, jellies, and milk products. It also has been used to obtain good enantioselectivities using Cu(OAc)(2)-bis(oxazolines) via hydrogen bonding in asymmetric Henry reaction.Application of 135-02-4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem