Month: October 2022

Menard, Travis; Laverny, Aragorn; Denmark, Scott E. published their research in Journal of Organic Chemistry in 2021. The article was titled 《Synthesis of Enantioenriched 3,4-Disubstituted Chromans Through Lewis-Base Catalyzed Carbosulfenylation》.COA of Formula: C7H8O2 The article contains the following contents:

A method for the catalytic, enantioselective, carbosulfenylation of alkenes to construct 3,4-disubstituted chromans was described. Alkene activation proceeded through the intermediacy of enantioenriched, configurationally stable, thiiranium ions generated from catalytic Lewis-base activation of an electrophilic sulfenylating agent. The transformation affords difficult to generate enantioenriched 3,4-disubstituted chromans in moderate to high yields and excellent enantioselectivities. A variety of substituents are compatible including electronically diverse functional groups as well as several functional handles such as aryl halides, esters, anilines, and phenols. The resulting thioether moiety was amenable to a number of functional group manipulations and transformations. Notably, the pendant sulfide was successfully cleaved to furnish a free thiol which readily provides access to most sulfur-containing functional groups which are present in natural products and pharmaceuticals. The experimental part of the paper was very detailed, including the reaction process of m-Methoxyphenol(cas: 150-19-6COA of Formula: C7H8O2)

m-Methoxyphenol(cas: 150-19-6) may be used in synthesis of:C(4) symmetric calix[4]resorcinarene, 2-nitroso-5-methoxyphenol, 6-methoxy-2(3H)-benzoxazoloneCOA of Formula: C7H8O2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Kargar, Hadi; Aghaei-Meybodi, Fariba; Behjatmanesh-Ardakani, Reza; Elahifard, Mohammad Reza; Torabi, Vajiheh; Fallah-Mehrjardi, Mehdi; Tahir, Muhammad Nawaz; Ashfaq, Muhammad; Munawar, Khurram Shahzad published their research in Journal of Molecular Structure in 2021. The article was titled 《Synthesis, crystal structure, theoretical calculation, spectroscopic and antibacterial activity studies of copper(II) complexes bearing bidentate Schiff base ligands derived from 4-aminoantipyrine: Influence of substitutions on antibacterial activity》.COA of Formula: C8H8O3 The article contains the following contents:

A novel series of Cu(II) complexes, including: [Cu(L1)2]: C1, [Cu(L2)2]: C2, [Cu(L3)2]: C3, [Cu(L4)2]: C4, with four bis-N,O-bidentate Schiff base ligands (HL1: (E)-4-[(2-hydroxy-3-methoxybenzylidene)amino]-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one; HL2: (E)-4-[(2-hydroxy-4-methoxybenzylidene)amino]-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one; HL3: (E)-4-[(2-hydroxy-5-methoxybenzylidene)amino]-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one; HL4: (E)-4-[(2-hydroxy-6-methoxybenzylidene)amino]-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one) were synthesized and characterized by elemental analyses, FTIR, 1H NMR and 13C NMR spectroscopic techniques. Furthermore, the crystal structures of HL4 and C2 were determined by single crystal x-ray anal. Single crystal x-ray analyses, the structure of C2 confirmed the bidentate coordination mode. The metal center possesses a distorted tetrahedral geometry with bis-N,O donor atoms coordinating from Schiff base ligand. Theor. calculation of the synthesized compounds were carried out by DFT using B3LYP method with employing the Def2-SVPD (for ligands) and Def2-SV(P) (for complexes) basis sets. Calculated data are in good accordance with the exptl. studies. The in vitro biol. activities of the synthesized ligands and their copper(II) complexes were evaluated against Staphylococcus aureus and Escherichia coli. The activity data showed that the metal complexes have a promising biol. potential comparable with the parent Schiff base ligands against bacterial species. In addition to this study using 2-Hydroxy-4-methoxybenzaldehyde, there are many other studies that have used 2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3COA of Formula: C8H8O3) was used in this study.

2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is employed in the synthesis of Schiff base ligand. It is applied as a reactant in the synthesis of LPA1R antagonists used in the inhibition of LPA-induced proliferation and contraction of normal human lung fibroblasts. Also used in the synthesis of tyrosine kinase 6 proteinase inhibitors.COA of Formula: C8H8O3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Cervi, Aymeric; Vo, Yen; Chai, Christina L. L.; Banwell, Martin G.; Lan, Ping; Willis, Anthony C. published their research in Journal of Organic Chemistry in 2021. The article was titled 《Gold(I)-Catalyzed Intramolecular Hydroarylation of Phenol-Derived Propiolates and Certain Related Ethers as a Route to Selectively Functionalized Coumarins and 2H-Chromenes》.Recommanded Product: 150-19-6 The article contains the following contents:

Methods are reported for the efficient assembly of a series of phenol-derived propiolates, including the parent system, and their Au(I)-catalyzed cyclization (intramol. hydroarylation) to give the corresponding coumarins. Simple syntheses of natural products such as ayapin and scoparone have been realized by such means, and the first of these subject to single-crystal X-ray anal. A related process is described for the conversion of propargyl ethers into the isomeric 2H-chromene precocene I, a naturally occurring inhibitor of juvenile hormone biosynthesis. In the part of experimental materials, we found many familiar compounds, such as m-Methoxyphenol(cas: 150-19-6Recommanded Product: 150-19-6)

m-Methoxyphenol(cas: 150-19-6) may be used in synthesis of:C(4) symmetric calix[4]resorcinarene, 2-nitroso-5-methoxyphenol, 6-methoxy-2(3H)-benzoxazoloneRecommanded Product: 150-19-6

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Sezaki, Maiko; Biswas, Subinoy; Nakata, Sayuri; Oshima, Motohiko; Koide, Shuhei; Ho, Nicole Pui Yu; Okamoto, Nobukazu; Miyamoto, Takeshi; Iwama, Atsushi; Takizawa, Hitoshi published an article in 2021. The article was titled 《CD271+CD51+PALLADIN- Human Mesenchymal Stromal Cells Possess Enhanced Ossicle-Forming Potential》, and you may find the article in Stem Cells and Development.Product Details of 106685-40-9 The information in the text is summarized as follows:

Human mesenchymal stem/stromal cells (hMSCs), when engrafted into immunodeficient mice, can form ectopic bone organs with hematopoietic stem cell (HSC) supportive functions. However, the ability to do so, through a cartilage intermediate, appears limited to 30% of donor bone marrow samples. In this study, we characterize the heterogeneous nature of hMSCs and their ability to efficiently form humanized ossicles observed in “”good donors”” to correlate with the frequency and functionality of chondrocyte progenitors. Flow cytometry of putative hMSC markers was enriched in the CD271+CD51+ stromal cell subset, which also possessed enhanced hMSC activity as assessed by single-cell colony-forming unit fibroblast (CFU-F) and undifferentiated mesensphere formation. Transcriptome anal. of CD271+ cells presented upregulation of chondrogenesis-/osteogenesis-related genes and HSC/niche maintenance factors such as C-X-C motif chemokine 12 (CXCL12) and ANGIOPOIETIN 1. Among the candidate genes selected to enrich for subsets with greater chondrogenic ability, cells neg. for the actin cross-linker PALLADIN displayed the greatest CFU-F potential. Our study contributes to a better characterization of ossicle-forming hMSCs and their efficient isolation for the optimized engineering of human bone organs. In the experiment, the researchers used many compounds, for example, 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas: 106685-40-9Product Details of 106685-40-9)

6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas:106685-40-9) is a third-generation synthetic retinoid and a highly lipophilic compound derived from naphthoic acid. It is widely used in the treatment of acne.Product Details of 106685-40-9

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Bilen, Esra; Ozdemir Ozmen, Ummuhan; Cete, Servet; Alyar, Saliha; Yasar, Ahmet published an article in 2022. The article was titled 《Bioactive sulfonyl hydrazones with alkyl derivative: Characterization, ADME properties, molecular docking studies and investigation of inhibition on choline esterase enzymes for the diagnosis of Alzheimers disease》, and you may find the article in Chemico-Biological Interactions.Reference of 2-Hydroxy-4-methoxybenzaldehyde The information in the text is summarized as follows:

In this work, new sulfonylhydrazone compounds with alkyl derivatives (SH1- SH4 series) were synthesized via a green chem. method, and their inhibition effects on acetylcholinesterase and butyrylcholinesterase (AChE, BChE) were determined in vitro. This work was designed in two stages; in the first stage, using compounds that contain both sulfonamide and hydrazine groups which have important pharmacol. properties, a series of sulfonyl hydrazone with alkyl derivatives (SH1- SH4) were synthesized with a method that is less time-consuming and more environmentalist that was by using different substitute groups containing aldehyde and ketone compounds The structures of the synthesized compounds were characterized by elemental analyses, 1H NMR, 13C NMR, FT-IR methods. In the second stage, the effects of the synthesized sulfonyl hydrazones with alkyl derivatives on acetylcholinesterase and butyrylcholinesterase enzymes were examined According to the results, all the synthesized compounds inhibited AChE and BChE enzymes. When the IC50 values were compared, SH2-3 (IC50 = 5.27 ± 0.05 μM) and SH3-3 (IC50 = 12.29 ± 1.47 μM) compounds which are containing the Bu group have the best inhibition effect on the AChE enzyme and BChE enzyme, resp. In addition, the predictive properties of all compounds in terms of drug similarity were scanned using five Lipinski rules and ADME estimations In silico ADME studies play an important role in improving and predicting drug compounds In the ADME study; The absorption, distribution, metabolism, elimination, and properties of the mols. given below were theor. calculated Also, to evaluate the binding interactions between the sulfonylhydrazone compounds and enzymes, mol. docking studies were performed and the compounds with the best inhibition effect SH2-3 (for AChE enzyme) and SH3-3 (for BChE enzyme) were tested. Both in vitro and silico the results showed that two compounds could act as potent inhibitors of AChE, BChE. The results came from multiple reactions, including the reaction of 2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3Reference of 2-Hydroxy-4-methoxybenzaldehyde)

2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is employed in the synthesis of Schiff base ligand. It is applied as a reactant in the synthesis of LPA1R antagonists used in the inhibition of LPA-induced proliferation and contraction of normal human lung fibroblasts. Also used in the synthesis of tyrosine kinase 6 proteinase inhibitors.Reference of 2-Hydroxy-4-methoxybenzaldehyde

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Postupalenko, Viktoriia; Marx, Leo; Viertl, David; Gsponer, Nadege; Gasilova, Natalia; Denoel, Thibaut; Schaefer, Niklaus; Prior, John O.; Hagens, Gerrit; Levy, Frederic; Garrouste, Patrick; Segura, Jean-Manuel; Nyanguile, Origene published an article in 2022. The article was titled 《Template directed synthesis of antibody Fc conjugates with concomitant ligand release》, and you may find the article in Chemical Science.COA of Formula: C9H19NO4 The information in the text is summarized as follows:

Antibodies are an attractive therapeutic modality for cancer treatment as they allow the increase of the treatment response rate and avoid the severe side effects of chemotherapy. Notwithstanding the strong benefit of antibodies, the efficacy of anti-cancer antibodies can dramatically vary among patients and ultimately result in no response to the treatment. Here, we have developed a novel means to regioselectively label the Fc domain of any therapeutic antibody with a radionuclide chelator in a single step chem., with the aim to study by SPECT/CT imaging if the radiolabeled antibody is capable of targeting cancer cells in vivo. A Fc-III peptide was used as bait to bring a carbonate electrophilic site linked to a metal chelator and to a carboxyphenyl leaving group in close proximity with an antibody Fc nucleophile amino acid (K317), thereby triggering the covalent linkage of the chelator to the antibody lysine, with the concomitant release of the carboxyphenyl Fc-III ligand. Using CHX-A′′-DTPA, we radiolabeled trastuzumab with indium-111 and showed in biodistribution and imaging experiments that the antibody accumulated successfully in the SK-OV-3 xenograft tumor implanted in mice. We found that our methodol. leads to homogeneous conjugation of CHX-A′′-DTPA to the antibody, and confirmed that the Fc domain can be selectively labeled at K317, with a minor level of unspecific labeling on the Fab domain. The present method can be developed as a clin. diagnostic tool to predict the success of the therapy. Furthermore, our Fc-III one step chem. concept paves the way to a broad array of other applications in antibody bioengineering. In the part of experimental materials, we found many familiar compounds, such as tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6COA of Formula: C9H19NO4)

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers.The C-O bonds that comprise simple ethers are strong. COA of Formula: C9H19NO4 They are unreactive toward all but the strongest bases. Although generally of low chemical reactivity, they are more reactive than alkanes.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2022,Yi, Bing; Wang, Qiang; Tan, Jian-Ping; Yi, Ziqi; Li, Daiguang; Kang, Shiyuan; Zhang, Wenhui; Tang, Huan; Xie, Yanjun published an article in Asian Journal of Organic Chemistry. The title of the article was 《Visible Light-mediated, Iodine-catalyzed Radical Cascade Sulfonylation/Cyclization for the Synthesis of Sulfone-containing Coumarin under Photocatalyst-free Conditions》.COA of Formula: C7H8O2 The author mentioned the following in the article:

A visible-light mediated, iodine catalyzed radical cascade sulfonylation/cyclization reaction by employing iodine as catalyst without addition of any of photocatalyst and oxidant was presented. A number of sulfone-containing coumarin derivatives with different substituent and functional groups were obtained in moderate to good yields. Besides, the practicality and utility of this protocol were demonstrated by the scale up synthesis. Furthermore, mechanistic investigations including control experiments and light on/off studies indicated that visible-light irradiation and iodine catalyst were the essential elements to fulfill the radical cascade sulfonylation/cyclization process. This protocol featured green, economical and efficient, and opens a new opportunity for accessing to structurally diverse sulfone-containing coumarin derivatives In the experimental materials used by the author, we found m-Methoxyphenol(cas: 150-19-6COA of Formula: C7H8O2)

m-Methoxyphenol(cas: 150-19-6) may be used in synthesis of:C(4) symmetric calix[4]resorcinarene, 2-nitroso-5-methoxyphenol, 6-methoxy-2(3H)-benzoxazoloneCOA of Formula: C7H8O2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2022,Huang, Yunyuan; Xu, Haiyan; Wang, Pei; Gu, Rurong; Li, Xiaokang; Xu, Yixiang; Wang, Jiqun; Qiao, Sicong; Shi, Donglei; Gao, Zhaobing; Li, Jian published an article in ACS Chemical Neuroscience. The title of the article was 《Identification of Guaifenesin-Andrographolide as a Novel Combinatorial Drug Therapy for Epilepsy Using Network Virtual Screening and Experimental Validation》.Application of 106685-40-9 The author mentioned the following in the article:

Combinatorial drug therapy has attracted substantial attention as an emerging strategy for the treatment of diseases with complex pathol. mechanisms. We previously developed a potentially universal computational screening approach for combination drugs and used this approach to successfully identify some beneficial combinations for the treatment of heart failure. Herein, this screening approach was used to identify novel combination drugs for the treatment of epilepsy in an approved drug library. The combination of guaifenesin-andrographolide was first discovered as a promising therapy with synergistic anticonvulsant activities in maximal electroshock (MES)- and s.c. pentylenetetrazol (s.c.-PTZ)-induced epilepsy models in vivo. The studies of network anal., fluorescence imaging, and N-methyl-D-aspartate (NMDA)-induced cytotoxicity further revealed that guaifenesin-andrographolide might synergistically affect NMDA receptors and then alleviate the pathogenesis of epilepsy. Therefore, we report that the combination of guaifenesin-andrographolide exerts effects against epilepsy through a novel synergistic mechanism and is thus a potential treatment for epilepsy, providing a promising mechanism for the design of novel combinatorial drug treatments against epilepsy. The results came from multiple reactions, including the reaction of 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas: 106685-40-9Application of 106685-40-9)

6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas:106685-40-9) is a third-generation synthetic retinoid and a highly lipophilic compound derived from naphthoic acid. It is widely used in the treatment of acne.Application of 106685-40-9

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2022,Kaya, Busra; Kalindemirtas, Ferdane Danisman; Ertik, Onur; Yanardag, Refiye; Kuruca, Serap Erdem; Ulkuseven, Bahri published an article in Chemico-Biological Interactions. The title of the article was 《New thiosemicarbazone-based Zinc(II) complexes. In vitro cytotoxicity competing with cisplatin on malignant melanoma A375 cells and its relation to neuraminidase inhibition》.Recommanded Product: 2-Hydroxy-4-methoxybenzaldehyde The author mentioned the following in the article:

New thiosemicarbazone-based zinc(II) complexes were synthesized to study their cytotoxicity on A375 malignant melanoma cells. The complexes containing salicylidene (Zn1a), 3-methoxy-salicylidene (Zn1b) or 4-methoxy-salicylidene (Zn1c) moiety were characterized by anal. and spectroscopic methods. Anticancer potential of the complexes was determined by MTT test and HUVEC endothelial cells line was used to comprehend the effect on normal cells. Zn1b with an IC50 of 13 μM was found to be highly cytotoxic against A375 cancer cells, more effective than cisplatin (IC50: 37 μM). Zn1a and Zn1c did not have a neg. effect on cell viability in the normal cells and gave the impression that they are more advantageous than cisplatin in this respect. Further, the ability of Zn1a-c to inhibit neuraminidase enzyme and its role in cytotoxicity was discussed. The test revealed that the Zn1b with 3-methoxy substituent exhibited higher inhibition activity against the neuraminidase than the Zn1a and Zn1c as analogical to the cytotoxicity results. In neuraminidase inhibition, IC50 values of Zn1b and Zn1c were 14 and 66 μM, resp. These concentrations were very close to the cytotoxicity concentrations for Zn1b and Zn1c. The findings may indicate the role of neuraminidase enzyme inhibition in cell death for Zn1b and Zn1c. In the experiment, the researchers used many compounds, for example, 2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3Recommanded Product: 2-Hydroxy-4-methoxybenzaldehyde)

2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is the main component of root bark essential oil of Periploca sepium Bunge. It is a potential tyrosinase inhibitor present in African medicinal plants. 2-Hydroxy-4-methoxybenzaldehyde was used in the synthesis of Schiff base ligand.Recommanded Product: 2-Hydroxy-4-methoxybenzaldehyde

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

SDS of cas: 673-22-3In 2020 ,《Visible-light-induced radical cascade cyclization of pyrazoles bearing a coumarin unit》 appeared in New Journal of Chemistry. The author of the article were Sharma, Amit Kumar; Jaiswal, Anjali; Mishra, Anu; Tiwari, Jyoti; Jaiswal, Deepali; Singh, Shailesh; Singh, Jaya; Singh, Jagdamba. The article conveys some information:

Herein, an efficient, eco-friendly, metal free, visible light catalyzed synthesis of coumarin based pyrazoles I (R1 = H, OH, OMe; R2 = H, Cl, Br, NO2; R3 = H, OMe; R4 = H, Br, F; R5 = H, F) under an open atm. involving a photoredox catalyst, which is an inexpensive organic dye have been described. The present strategy is the first example of visible light promoted, aerobic, oxidative cyclization of pyrazoles bearing a coumarin unit via the formation of C-C, C-O and C-N bonds to afford excellent yields of the products I in a simple one-pot operation under mild reaction conditions. The major advantages of the present methodol. include short reaction time, cost effectiveness, easy work-up, broad substrate scope and high atom economy. In the experiment, the researchers used 2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3SDS of cas: 673-22-3)

2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is the main component of root bark essential oil of Periploca sepium Bunge. It is a potential tyrosinase inhibitor present in African medicinal plants. 2-Hydroxy-4-methoxybenzaldehyde was used in the synthesis of Schiff base ligand.SDS of cas: 673-22-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem