Month: November 2022

Schoen, Florian published the artcileCatalytic Aerobic Phenol Homo- and Cross-Coupling Reactions with Copper Complexes Bearing Redox-Active Guanidine Ligands, Recommanded Product: 4-Hydroxy-3-tert-butylanisole, the main research area is copper guanidine complex preparation redox potential UV visible spectra; phenol dioxygen copper catalyst chemoselective cross coupling green chem; biphenol preparation; catalysis; cross-coupling; guanidines; phenols; redox-active ligands.

New copper catalysts for the C-C coupling reaction of phenols using dioxygen as a green oxidizing reagent were reported. By using redox-active guanidine ligands, the activity as well as chemoselectivity in the cross-coupling reaction of non-complementary phenols (between an electron-rich phenol and a less nucleophilic second phenol) was significantly improved. Based on the collected data for several test reactions, a reaction mechanism was proposed.

Chemistry – A European Journal published new progress about Biphenyls Role: SPN (Synthetic Preparation), PREP (Preparation). 121-00-6 belongs to class ethers-buliding-blocks, name is 4-Hydroxy-3-tert-butylanisole, and the molecular formula is C11H16O2, Recommanded Product: 4-Hydroxy-3-tert-butylanisole.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Jang, Doo Ok published the artcileHighly selective catalytic Friedel-Crafts acylation and sulfonylation of activated aromatic compounds using indium metal, Computed Properties of 622-86-6, the main research area is arene catalytic Friedel Crafts acylation acid chloride indium activator; sulfonyl chloride aryl sulfonylation arene indium activator; aryl ketone preparation selective; sulfone aryl preparation selective.

The Friedel-Crafts acylation of activated benzenes with various aromatic and aliphatic acid chlorides was studied in the presence of indium metal. The reaction was accomplished in high isolated yields under solvent or solvent-less conditions. The method is also applicable for preparing diaryl sulfones from aromatic compounds and aryl sulfonyl chlorides.

Tetrahedron Letters published new progress about Acid chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 622-86-6 belongs to class ethers-buliding-blocks, name is (2-Chloroethoxy)benzene, and the molecular formula is C8H9ClO, Computed Properties of 622-86-6.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Kamitanaka, Tohru published the artcile[3+2] Coupling of Quinone Monoacetals with Vinyl Ethers Effected by Tetrabutylammonium Triflate: Regiocontrolled Synthesis of 2-Oxygenated Dihydrobenzofurans, SDS of cas: 121-00-6, the main research area is dihydrobenzofuran preparation diastereoselective regioselective; quinone monoacetal vinyl ether coupling tetrabutylammonium triflate catalyst.

The synthesis of 2-oxygenated dihydrobenzofurans I (R = H, Me, t-Bu, OMe, NHAc; R1 = H, Me, t-Bu; R2 = Me, Et; R3 = H, OMe; X = -CH2-, -O-; n = 0, 1), II (R4 = Et, i-Pr; R5 = H, Me) involving the [3+2] coupling of quinone monoacetals III with vinyl ethers IV has been realized by tetrabutylammonium triflate catalysis. The reaction involves a new activation method of the acetal moiety in quinone monoacetals III under acid-free conditions affording the highly oxygenated dihydrobenzofurans I, II. This new activation mode was achieved by using the triflate anion catalyst for stabilization of the highly reactive cationic intermediate.

Organic Letters published new progress about [3+2] Cycloaddition reaction catalysts (regio-, stereoselective). 121-00-6 belongs to class ethers-buliding-blocks, name is 4-Hydroxy-3-tert-butylanisole, and the molecular formula is C11H16O2, SDS of cas: 121-00-6.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Wang, Yandong published the artcileElectrochemical Cross-Dehydrogenative Coupling between Phenols and β-Dicarbonyl Compounds: Facile Construction of Benzofurans, COA of Formula: C11H16O2, the main research area is benzofuran preparation; phenol beta dicarbonyl electrochem cross dehydrogenative coupling cyclocondensation; benzofurans; cross-dehydrogenative coupling; electrochemistry; phenols; reaction mechanisms.

Preparative electrochem. synthesis is an ideal method for establishing green, sustainable processes. The major benefits of an electro-organic strategy over that of conventional chem. synthesis are the avoidance of reagent waste and mild reaction conditions. Here, an intermol. cross-dehydrogenative coupling between phenols and β-dicarbonyl compounds has been developed to build various benzofurans under undivided electrolytic conditions. Neither transition metals nor external chem. oxidants are required to facilitate the dehydrogenation and dehydration processes. The key factor in success was the use of nBu4NBF4 as the electrolyte and hexafluoroisopropanol as the solvent, which play key roles in the cyclocondensation step. This electrolysis is scalable and can be used as a key step in drug synthesis. On the basis of several exptl. results, the mechanism, particularly of the remarkable anodic oxidation and cyclization process, was illustrated.

Chemistry – A European Journal published new progress about Benzofurans Role: SPN (Synthetic Preparation), PREP (Preparation). 121-00-6 belongs to class ethers-buliding-blocks, name is 4-Hydroxy-3-tert-butylanisole, and the molecular formula is C11H16O2, COA of Formula: C11H16O2.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Kim, Seoyoung published the artcileNickel-Catalyzed Cross-Electrophile Coupling of Aryl Chlorides with Primary Alkyl Chlorides, SDS of cas: 622-86-6, the main research area is chloroarene alkyl chloride nickel pyridine biscyanocarboxamidine cross electrophile coupling; alkylarene preparation.

Alkyl chlorides and aryl chlorides are among the most abundant and stable carbon electrophiles. Although their coupling with carbon nucleophiles is well developed, the cross-electrophile coupling of aryl chlorides with alkyl chlorides has remained a challenge. We report here the first general approach to this transformation. The key to productive, selective cross-coupling is the use of a small amount of iodide or bromide along with a recently reported ligand, pyridine-2,6-bis(N-cyanocarboxamidine) (PyBCamCN). The scope of the reaction is demonstrated with 35 examples (63 ± 16% average yield), and we show that the Br- and I- additives act as cocatalysts, generating a low, steady-state concentration of more-reactive alkyl bromide/iodide.

Journal of the American Chemical Society published new progress about Alkylarenes Role: SPN (Synthetic Preparation), PREP (Preparation). 622-86-6 belongs to class ethers-buliding-blocks, name is (2-Chloroethoxy)benzene, and the molecular formula is C8H9ClO, SDS of cas: 622-86-6.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Sapotta, Meike published the artcileA Water-Soluble Perylene Bisimide Cyclophane as a Molecular Probe for the Recognition of Aromatic Alkaloids, Quality Control of 23783-42-8, the main research area is perylene bisimide cyclophane mol probe aromatic alkaloid; alkaloids; cyclophanes; fluorescence probes; host-guest systems; perylene bisimides.

Herein, we report a water-soluble macrocyclic host based on perylene bisimide (PBI) chromophores that recognizes natural aromatic alkaloids in aqueous media by intercalating them into its hydrophobic cavity. The host-guest binding properties of our newly designed receptor with several alkaloids were studied by UV/Vis and fluorescence titration experiments as the optical properties of the chromophoric host change significantly upon complexation of guests. Structural information on the host-guest complexes was obtained by 1D and 2D NMR spectroscopy and mol. modeling. Our studies reveal a structure-binding property relationship for a series of structurally diverse aromatic alkaloids with the new receptor and higher binding affinity for the class of harmala alkaloids. To our knowledge, this is the first example of a chromophoric macrocyclic host employed as a mol. probe for the recognition of aromatic alkaloids.

Angewandte Chemie, International Edition published new progress about Alkaloids Role: ANT (Analyte), ANST (Analytical Study) (aromatic). 23783-42-8 belongs to class ethers-buliding-blocks, name is 2,5,8,11-Tetraoxatridecan-13-ol, and the molecular formula is C9H20O5, Quality Control of 23783-42-8.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Tian, Qingqiang published the artcileSelective C-F Bond Etherification of Trifluoromethylalkenes with Phenols, Quality Control of 121-00-6, the main research area is phenoxydifluoromethyl alkene preparation chemoselective insecticidal mol docking.

A novel protocol for the C-F bond etherification of trifluoromethylalkenes and phenols was reported. A variety of alkenyl difluoroaryloxy ethers were obtained with good chemoselectivity and functional group tolerance. DFT calculation results and control experiments suggested that metal ion Cs+ might be involved in this defluorooxylation. Furthermore, the desired product exhibited a good insecticidal activity.

Journal of Organic Chemistry published new progress about Aromatic alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 121-00-6 belongs to class ethers-buliding-blocks, name is 4-Hydroxy-3-tert-butylanisole, and the molecular formula is C11H16O2, Quality Control of 121-00-6.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Wu, Kai published the artcileSelective demethoxylation of guaiacol to alkylphenols in supercritical methanol over a HT-MoS2 catalyst, Synthetic Route of 121-00-6, the main research area is demethoxylation guaiacol alkylphenol supercritical methanol HTMoS catalyst.

The high value-added products such as alkyl substituted phenols (A-Ps) are very important from lignin-derived feedstocks. Herein, the selective conversion of guaiacol, an important chem. of lignin-derived bio-oil, to A-Ps over hydrothermally synthesized bulk MoS2 (HT-MoS2) was examined under supercritical methanol conditions without any gaseous hydrogen input. HRTEM confirms the formation of MoS2 with the nanosheet-like structure and XPS anal. exhibited the presence of Mo5+ and S2-2 species which are likely the active species for demethoxylation (DMO) and alkylation of guaiacol. The possible reaction pathways along with their plausible intermediates of guaiacol conversion are proposed. The HT-MoS2 catalyst can be reused up to 4 catalytic runs without loss of its catalytic activity.

Catalysis Today published new progress about Alkylphenols Role: SPN (Synthetic Preparation), PREP (Preparation). 121-00-6 belongs to class ethers-buliding-blocks, name is 4-Hydroxy-3-tert-butylanisole, and the molecular formula is C11H16O2, Synthetic Route of 121-00-6.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Wang, Miaomiao published the artcileSuspect Screening and Chemical Profile Analysis of Storm-Water Runoff Following 2017 Wildfires in Northern California, Application of 2,5,8,11,14-Pentaoxapentadecane, the main research area is storm water wildfire suspect screening California; Emerging contaminants of concern; Nontargeted analysis; Organic contaminants; Storm-water runoff; Wildfire-impacted.

The combustion of structures and household materials as well as firefighting during wildfires lead to releases of potentially hazardous chems. directly into the landscape. Subsequent storm-water runoff events can transport wildfire-related contaminants to downstream receiving waters, where they may pose water quality concerns. To evaluate the environmental hazards of northern California fires on the types of contaminants in storm water discharging to San Francisco Bay and the coastal marine environment, we analyzed storm water collected after the northern California wildfires (Oct. 2017) using a nontargeted anal. (NTA) approach. Liquid chromatog. quadrupole time-of-flight mass spectrometric anal. was completed on storm-water samples (n = 20) collected from Napa County (impacted by the Atlas and Nuns fires), the city of Santa Rosa, and Sonoma County (Nuns and Tubbs fires) during storm events that occurred in Nov. 2017 and Jan. 2018. The NTA approach enabled us to establish profiles of contaminants based on peak intensities and chem. categories found in the storm-water samples and to prioritize significant chems. within these profiles possibly attributed to the wildfire. The results demonstrated the presence of a wide range of contaminants in the storm water, including surfactants, per- and polyfluoroalkyl substances, and chems. from consumer and personal care products. Homologs of polyethylene glycol were found to be the major contributor to the contaminants, followed by other widely used surfactants. Nonylphenol ethoxylates, typically used as surfactants, were detected and were much higher in samples collected after Storm Event 1 relative to Storm Event 2. The present study provides a comprehensive approach for examining wildfire-impacted storm-water contamination of related contaminants, of which we found many with potential ecol. risk.

Environmental Toxicology and Chemistry published new progress about Alcohols, ethoxylated Role: ANT (Analyte), ANST (Analytical Study). 143-24-8 belongs to class ethers-buliding-blocks, name is 2,5,8,11,14-Pentaoxapentadecane, and the molecular formula is C10H22O5, Application of 2,5,8,11,14-Pentaoxapentadecane.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Wang, Miaomiao published the artcileSuspect Screening and Chemical Profile Analysis of Storm-Water Runoff Following 2017 Wildfires in Northern California, SDS of cas: 23783-42-8, the main research area is storm water wildfire suspect screening California; Emerging contaminants of concern; Nontargeted analysis; Organic contaminants; Storm-water runoff; Wildfire-impacted.

The combustion of structures and household materials as well as firefighting during wildfires lead to releases of potentially hazardous chems. directly into the landscape. Subsequent storm-water runoff events can transport wildfire-related contaminants to downstream receiving waters, where they may pose water quality concerns. To evaluate the environmental hazards of northern California fires on the types of contaminants in storm water discharging to San Francisco Bay and the coastal marine environment, we analyzed storm water collected after the northern California wildfires (Oct. 2017) using a nontargeted anal. (NTA) approach. Liquid chromatog. quadrupole time-of-flight mass spectrometric anal. was completed on storm-water samples (n = 20) collected from Napa County (impacted by the Atlas and Nuns fires), the city of Santa Rosa, and Sonoma County (Nuns and Tubbs fires) during storm events that occurred in Nov. 2017 and Jan. 2018. The NTA approach enabled us to establish profiles of contaminants based on peak intensities and chem. categories found in the storm-water samples and to prioritize significant chems. within these profiles possibly attributed to the wildfire. The results demonstrated the presence of a wide range of contaminants in the storm water, including surfactants, per- and polyfluoroalkyl substances, and chems. from consumer and personal care products. Homologs of polyethylene glycol were found to be the major contributor to the contaminants, followed by other widely used surfactants. Nonylphenol ethoxylates, typically used as surfactants, were detected and were much higher in samples collected after Storm Event 1 relative to Storm Event 2. The present study provides a comprehensive approach for examining wildfire-impacted storm-water contamination of related contaminants, of which we found many with potential ecol. risk.

Environmental Toxicology and Chemistry published new progress about Alcohols, ethoxylated Role: ANT (Analyte), ANST (Analytical Study). 23783-42-8 belongs to class ethers-buliding-blocks, name is 2,5,8,11-Tetraoxatridecan-13-ol, and the molecular formula is C9H20O5, SDS of cas: 23783-42-8.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem