Month: November 2022

Kermack, Wm. O.; Wight, Thomas W. published an article in 1935, the title of the article was Attempts to find new antimalarials. XIV. Derivatives of 8-methylquinoline.Product Details of 152626-77-2 And the article contains the following content:

cf. C. A. 29, 7332.6. 5,2-MeO(Me)C6H3NH2, FeSO4, As2O5 and 96% H2SO4, refluxed 4 hrs., give 6-methoxy-8-methylquinoline (I), whose HBr salt, light yellow, m. 268°, and picrate, yellow, m. 232-3°. I in CHCl3, saturated with HBr and treated with Br, gives the 5-Br derivative, m. 116-17° (HBr salt, light yellow, m. 230°). 6-Nitro-m-cresol and Br in CHCl3 give the 4-Br derivative, m. 146°; Me2SO4 and K2CO3 in C6H6 give 4-bromo-6-nitro-m-tolyl Me ether, m. 110-11°; reduction with Fe in concentrated HCl in MeOH gives 4-bromo-5-methoxy-o-toluidine (II), light pink, m. 79-80°; the diazo reaction with CuBr yields 4,6-dibromo-m-tolyl Me ether, m. 73-4°. 6-Bromo-4-nitro-m-tolyl Me ether (III) m. 113-15° (90% yield); reduction gives 90% of 2-bromo-5-methoxy-p-toluidine, m. 71-3° (Ac derivative, m. 130-3°); the Sandmeyer reaction gives III. II with the Skraup reaction gives the 5-Br derivative of I; the 7-Br derivative of I m. 134-5°. 6-Nitro-8-methylquinoline yields a 3-Br derivative, light yellow, m. 188-9°. 8-Bromomethylquinoline, refluxed overnight with N H2SO4, gives 8-quinolylmethyl alc., m. 75-6°; 5-NO2 derivative, light brown, m. 148-9°. 5-Nitro-8-bromomethylquinoline and piperidine in Et2O give the 8-piperidinomethyl derivative, whose HBr salt m. 248-9°. o-O2NC6H4CH2NHEt, Et2NCH2CH2Cl.HCl (IV), K2CO3 and a trace of Cu bronze in C6H6, refluxed 4 hrs., give β-(o-nitrobenzylethylamino)triethylamine (V), whose picrate, light yellow, m. 167-8°; o-NH2 derivative, as the picrate, light yellow, m. 134°; β-(benzylethylamino)-triethylamine picrate, yellow, m. 150-2°. The p-NO2 isomer of V, as the picrate, yellow, m. 195-7°. PrNH2 and IV give β-diethylaminoethylpropylamine, whose picrate, yellow, m. 133-5°; butylamine analog, b. 207-12° (70% yield) (dipicrate, yellow, m. 234°); isobutylamine analog, b. 194-200° (70% yield) (dipicrate, yellow, m. 141°); the following piperidino compounds were analogously prepared; the dipicrates form yellow plates; β-piperidinoethylpropylamine, b. 220-30°, 60% yield (dipicrate, m. 169°); -butylamine, b. 230-40°, 70% (dipicrate, m. 191-2°); -isobutylamine, b. 230-40°, 70% (dipicrate, m. 167-8°); -methylamine, b. 190-200°, 45% (dipicrate, m. 174°); β-piperidinodiethylamine, b. 200-10°, 55% (dipicrate, m. 154°). C2H4Br2 and MeNH2 in EtOH give 50% of sym-dimethylethylenediamine, b. 150-60° (picrate, m. 160°). 8-Bromomethylquinoline and Et2NCH2CH2NHMe with K2CO3 in C6H6 give 8-(β-diethylaminoethylmethylaminomethyl)quinoline, the tri-HBr salt of which m. 215-16°; β-diethylaminodiethylaminomethyl derivative (tri-HBr salt, m. 218-19°; picrate, yellow, m. 131-2°); β-diethylaminoethylpropylaminomethyl derivative (picrate, light yellow, m. 113-15°; dipicrate, deep yellow, m. 163-4°); diethylaminoethylbutylaminomethyl derivative (dipicrate, yellow, m. 178-80°); β-diethylaminoethylisobutylaminomethyl derivative (dipicrate, deep yellow, m. 169-71°); β-piperidinoethylpropylaminomethyl derivative (tri-HBr salt, m. 210°); butylamino analog, m. 211-12°; isobutylamino analog (dipicrate, yellow, m. 210-11°); methylamino analog (dipicrate, yellow, m. 205-6°); β-piperidinodiethylaminomethyl derivative (tri-HBr salt, m. 222°); sym-bis(8-quinolylmethyl)dimethylethylenediamine di-HBr, m. 232°. Bis(8-quinolylmethyl)-β-diethylaminoethylamine, m. 97-8°; picrate, yellow, m. 191°; 8-(β-diethylaminoethylaminomethyl)quinoline tri-HBr, m. 223-4°. 1-β-Bis(8′-quinolylmethyl)aminoethylpiperidine, m. 97-8°; picrate, pale yellow, m. 228-9°. 1,4-Bis(8′-quinolylmethyl)piperazine, with 0.5 mol. H2O, m. 153-4°; HBr salt, m. 265-7°. Although inactive in bird malaria, some of these compounds possess marked local anesthetic activity. The experimental process involved the reaction of 4-Bromo-5-methoxy-2-methylaniline(cas: 152626-77-2).Product Details of 152626-77-2

4-Bromo-5-methoxy-2-methylaniline(cas:152626-77-2) belongs to ethers. Oxygen is more electronegative than carbon, thus the alpha hydrogens of ethers are more acidic than those of simple hydrocarbons. They are far less acidic than alpha hydrogens of carbonyl groups (such as in ketones or aldehydes), however. Product Details of 152626-77-2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Degani, Jacopo; Tiecco, Marcello; Tundo, Antonio published an article in 1962, the title of the article was Homolytic reactions. VI. Reactions between diaryl disulfides and benzyl radicals.Electric Literature of 53136-21-3 And the article contains the following content:

cf. ibid. 1204; CA 56, 5870f. The reactions of diaryl disufides, XC6H4SSC6H4X (I), with PhCH2+ (II) are studied, II being prepared by the addition of 29 g. tert-butyl peroxide to a toluene (150 ml.) solution of I and refluxing 24 hrs. Thus, 14.3 g. I (X = Cl) and II yielded (by chromatography on Al2O3, eluting with petroleum ether) traces of p-ClC6H4SMe, identified as its sulfone, m. 96°, and of diphenylethane, m. 52°, 3.3 g. p-ClC6H4SCH2Ph, m. 52-3°, and 0.5 g. oil from which further chromatographic separation yielded α-(p-chlorophenylthio)diphenylethane, m. 46°, (p-ClC6H4S)2CH2, m. 43-4°, (p-ClC6H4S)2CHPh, m. 60-1°, and unreacted I. Elution with ligroine yielded 0.2 g. unknown compound, m. 77°, 0.3 g. (p-ClC6H4SCHPh)2 m. 210-11°. and 0.15 g. of another unknown compound, m. 120°. Elution with 1:1 ligroine-C6H6, followed by C6H6, yielded tars; elution with CHCl3 yielded 0.25 g. p-C6H4SOCH2Ph, m. 135°. The reaction of 10 g. I (X = H) and II yielded traces of Ph2CH2, thioanisole (sulfone m. 80-1°), 5.2 g. benzyl phenyl sulfide, m. 40-1°, little (PhS)2CH2, m. 40°, Ph2CHPh, m. 52° α-phenylthiodiphenylethane, and an unidentified S compound, m. 60-6° later, (PhCHSCPh)2, m. 194° and benzyl phenyl sulfoxide, m. 124°, and another unknown compound m. 101-3° were recovered. With 18.5 g. I (X = Br) and II, the products separated were (PhCH2)2, m. 52°, p-bromothioanisole, m. 37-8°, 4.6 g. p-BrC6H4SCH2Ph, m. 64°, a little α-(p-bromophenylthio)diphenylethane, m. 66° p-BrC6H4SCH2SC6H4Br, m. 77°, (p-BrC6H4S)2CHPh, m. 79-80% an unidentified S compound, m. 135-6°, and p-bromophenyl benzyl sulfoxide, m. 141-2°. Starting with 11.3 g. p-chlorobenzyl phenyl sulfide and II, the reaction products yielded 1.1 g. α-(p-chlorophenylthio)diphenylethane, m. 46°, 0.3 g. (p-ClC6H4SCHPh)2, m. 210-11°, and traces of an identified compound, m. 120% also obtained from I (X = Cl). Refluxing 12 g. p-ClC6H4SMe in 120 ml. ClPh with 21.2 g. tert-butyl peroxide 24 hrs. yielded (p-ClC6H4S)2CH2, m. 43-4°, (p-ClC6H4SCH2)2, m. 94°, an unknown compound, m. 77°, and tars. Also prepared were α-phenylthiodiphenylethane, m. 148° (by refluxing in alc. the Na derivative of PhSH and α-chlorodiphenylethane 1 hr.); α-(p-bromophenylthio)diphenylethane, prisms, m. 66° (ligroine); and α-(p-chlorophenylthio)diphenylethane, prisms, m. 46° (ligroine), by analogous methods. It is concluded that the diaryl disulfides react with the benzyl radicals forming first thioanisoles and benzyl aryl sulfides, which react in turn to form a variety of other sulfur derivatives The experimental process involved the reaction of Benzyl(4-bromophenyl)sulfane(cas: 53136-21-3).Electric Literature of 53136-21-3

Benzyl(4-bromophenyl)sulfane(cas:53136-21-3) belongs to ethers. Oxygen is more electronegative than carbon, thus the alpha hydrogens of ethers are more acidic than those of simple hydrocarbons. They are far less acidic than alpha hydrogens of carbonyl groups (such as in ketones or aldehydes), however. Electric Literature of 53136-21-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Benati, L.; Tiecco, M.; Tundo, A. published an article in 1963, the title of the article was Homolytic reactions. VII. Benzyl aryl sulfides.Synthetic Route of 53136-21-3 And the article contains the following content:

cf. CA 58, 13830c; 59, 6293f. By heating benzyl aryl sulfides and tert-butyl peroxide, meso- and dl-1,2-bis(arylthio)-1,2-diphenylethanes were obtained: their configurations were established through trans elimination of thiophenol and synthesis from erythro and threo-1-chloro-2arylthio-1,2-diphenylethanes and thiophenates, p-XC6H4SCH2Ph (I) (X = Br) (II) (9 g.), and 50 ml. tert-butyl peroxide (III) refluxed 10 hrs. and cooled gave 1.8 g. meso-(p-XC6H4SCHPh)2 (meso-IV) (X = Br) (V), m. 223°; the mother liquor chromatographed on Al2O3 yielded 3.3 g. II, m. 64°, 0.6 g. V, and 1.5 g. dl-IV (X = Br) (VI), m. 125-6° (EtOH). V was also obtained from erythro-1-(p-bromophenylthio)-2-chloro-1,2-diphenylethane and p-BrC6H4SNa (VII), and V. was also obtained from threo-1-(p-bromophenylthio)-2-chloro-1,2-diphenylethane with VII. Similarly, 9 g. I (X = Cl) and 50 ml. III gave 2.4 g. meso-IV (X = Cl), m. 209-10°, and 1.6 g. dl-IV (X = Cl), m. 121-2°. I (X = H) (10 g.) furnished meso-IV (X = H), m. 193-4° (EtOH), and 1.8 g. dl-IV (X = H), m. 119-20°. V (1 g.) in 200 ml. tetrahydrofuran (THF) was treated 15 hrs. with NaNH2 prepared from 0.87 g. Na and 500 ml. NH3, evaporated, diluted with Et2O and H2O to give 0.6 g. V; the Et2O residue dissolved in AcOH, filtered, treated with H2O2 1 hr. on a water bath, cooled, and diluted with H2O gave some cis-1-(p-bromophenylsulfonyl)stilbene, m. 194-6°. VI (0.5 g.) in 100 ml. THF treated 15 hrs. with NaNH2 (prepared from 0.12 g. Na and 250 ml. NH3), evaporated, diluted with Et2O and H2O, Et2O evaporated, and the residue chromatographed on Al2O3 gave 0.2 g. trans-pbromophenylthiostilbene, m. 92-3°, and 0.2 g. VI. transStilbene (10 g.) in 250 ml. anhydrous CHCl3 treated with 10 g. pBrC6H4SCl in 50 ml. CHCl3 gave erythro-1-(p-bromophenylthio)-2-chloro-1,2-diphenylethane (VIII), m. 145-7° (C6H6-ligroine). VIII (8.1 g.) in 300 ml. Et2O treated 10 hrs. with NaNH2 (prepared from 1.4 g. Na and 500 ml. NH3) and worked up furnished 2.6 g. cis-1-(p-bromophenylthio)stilbene (IX), m. 104-5°. IX (1 g.) in Et2O treated with NaNH2 yielded, after treatment with H2O2, trans-1-(p-bromophenylsulfonyl)stilbene, m. 146-7°. Cis-stilbene and p-BrC6H4SCl furnished threo-1(p-bromophenylthio)-2-chloro-1,2-diphenylethane (X), m. 702° (ligroine). X and NaNH2 in NH3 yielded 95% trans-1-(pbromophenylthio)stilbene, m. 92-3°. VIII (1 g.) in 90 ml. 80% EtOH and 75 ml. dioxane treated 4 hrs. at 50° with pBrC6H4SNa (XI) (prepared from 0.5 g. p-BrC6H4SH and 0.06 g. Na in 10 ml. EtOH) gave V. X treated as above with XI furnished VI. The experimental process involved the reaction of Benzyl(4-bromophenyl)sulfane(cas: 53136-21-3).Synthetic Route of 53136-21-3

Benzyl(4-bromophenyl)sulfane(cas:53136-21-3) belongs to ethers. Oxygen is more electronegative than carbon, thus the alpha hydrogens of ethers are more acidic than those of simple hydrocarbons. They are far less acidic than alpha hydrogens of carbonyl groups (such as in ketones or aldehydes), however. Synthetic Route of 53136-21-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On February 5, 1958, Stevenson, Herbert A.; Clark, Nigel B.; Marshall, John R.; Greenwood, Douglas; Cranham, John E.; Higgons, Dennis J.; Brookes, Robert F. published a patent.Category: ethers-buliding-blocks The title of the patent was Benzyl phenyl sulfides and acaricidal compositions therefrom. And the patent contained the following:

Na (1.0 g.) is dissolved in 6.3 g. p-BrC6H4SH and 100 ml. anhydrous EtOH, 6.9 g. p-BrC6H4CH2Cl added, the mixture refluxed 1.5 hrs., cooled, poured into 150 ml. H2O, the precipitate filtered off, and recrystallized to give p-BrC6H4SCH2C6H4Br-p, m. 106-7°. Similarly are prepared the following p,p’-substituted analogs (benzyl substituents, phenyl substituents, and m.p. given): Br, H, 78-9°; Br, F, 48-9°; Br, Cl, 87-8°. NaOH is used instead of Na to prepare the following compounds: Cl, Br, 87-8°; F, F, 56.5-7.5°; Cl, I, 102°; I, Cl, 101°; I, I, 130-1°; H, I, 75-7°; I, F, 54.5-6.0°; I, H, 87-8.5°; F, I, 74-5°; I, Br, 117-18°; Br, I, 115-16°. Na and EtOH are used in preparing the following compounds: MeO, Cl, 80°; MeO, MeO, 89-90°; Cl, Me, 70°; Cl, CH2:CHCH2O, 38°; MeO, H, 86°; Me, Me, 67-8°; Me, H, 69-70°; F, Me, 61.5-2.5°; Me, Cl, 80-1°; Me, F, 44.5-5.5°; MeO, F, 71.5-2.5°; Br, Br, 101°; Cl, Br, 87-8°; Br H, 78°; Br, F, 44-5°; Br, Cl, 83-4°; F, Br, 56.5-7.5°; F, MeO, 57.5-8.5°; I, Cl, 101°; Cl, I, 102°. Other compounds prepared were: 4-Cl, 5,2-ClMe, 65-5.5°; H, 2,5-Cl2, 65° [cf. Brit. 713,-984, 745,360; Brit. 738,170 (C.A. 50, 10334b); Brit. 758,926 (C.A. 51, 11394h and C.A. 51, 1267g)]. The compounds are useful in the control of eggs and active stages of Acari, particularly Tetranychidae. The compounds are useful in aerosols, dusts, emulsion, and dispersions. The experimental process involved the reaction of Benzyl(4-bromophenyl)sulfane(cas: 53136-21-3).Category: ethers-buliding-blocks

Benzyl(4-bromophenyl)sulfane(cas:53136-21-3) belongs to ethers. Oxygen is more electronegative than carbon, thus the alpha hydrogens of ethers are more acidic than those of simple hydrocarbons. They are far less acidic than alpha hydrogens of carbonyl groups (such as in ketones or aldehydes), however. Category: ethers-buliding-blocks

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On January 27, 2011, Schwede, Wolfgang; Klar, Ulrich; Moeller, Carsten; Rotgeri, Andrea; Bone, Wilhelm published a patent.Category: ethers-buliding-blocks The title of the patent was 17-Hydroxy-17-pentafluoroethylestra-4,9(10)-dien-11-aryl derivatives as progesterone receptor antagonists and their preparation and use in the treatment of diseases. And the patent contained the following:

The invention relates to 17-hydroxy-17-pentafluoroethylestra-4,9(10)-dien-11-aryl derivatives of formula I exhibiting progesterone-antagonistic effects and to methods for the production thereof, to the use thereof for the treatment and/or prophylaxis of diseases and to the use thereof for producing medicaments for the treatment and/or prophylaxis of diseases, in particular uterine fibroids (myomas, uterine leiomyomas), endometriosis, menorrhagia, meningiomas, hormone-dependent mammary carcinomas and menopause-associated troubles, or for fertility control and emergency contraception. Compounds of formula I wherein R1 is SH and derivatives, S(O)H and derivatives, SO2H and derivatives, SONH2 and derivatives, (un)substituted aryl, etc.; X is O, NOH and derivatives and NNHSO2H and derivatives; and stereoisomers, salts, solvates, solvated salts, and all crystal modifications thereof, are claimed. Example compound II was prepared by addition of pentafluoroiodoethane to (5’R,8’S,10’R,13’S,14’S)-5,5,13′-trimethyl-1′,2′,6′,7′,8′,12′,13′,14′,15′,16′-decahydro-17’H-spiro[1,3-dioxan-2,3′-[5,10]epoxycyclopenta[a]phenanthren]-17′-one, followed by conjugate addition of 1-bromo-4-methylthiobenzene in the presence of magnesium and copper, and deacetalization. All the invention compounds were evaluated for their progesterone receptor antagonistic activity. From the assay, it was determined that compound II exhibited IC50 values of 0.011 nmol/L and 0.012 nmol/L towards progesterone receptor A and B, resp. The experimental process involved the reaction of Benzyl(4-bromophenyl)sulfane(cas: 53136-21-3).Category: ethers-buliding-blocks

The Article related to estradiene aryl preparation progesterone receptor antagonist, Steroids: Estranes and other aspects.Category: ethers-buliding-blocks

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On January 27, 2011, Schwede, Wolfgang; Klar, Ulrich; Moeller, Carsten; Rotgeri, Andrea; Bone, Wilhelm published a patent.HPLC of Formula: 53136-21-3 The title of the patent was 17-Hydroxy-17-pentafluoroethylestra-4,9(10)-dien-11-aryl derivatives as progesterone receptor antagonists and their preparation and use in the treatment of diseases. And the patent contained the following:

The invention relates to 17-hydroxy-17-pentafluoroethylestra-4,9(10)-dien-11-aryl derivatives of formula I exhibiting progesterone-antagonistic effects and to methods for the production thereof, to the use thereof for the treatment and/or prophylaxis of diseases and to the use thereof for producing medicaments for the treatment and/or prophylaxis of diseases, in particular uterine fibroids (myomas, uterine leiomyomas), endometriosis, menorrhagia, meningiomas, hormone-dependent mammary carcinomas and menopause-associated troubles, or for fertility control and emergency contraception. Compounds of formula I wherein R1 is SH and derivatives, SOH and derivatives, SO2H and derivatives, SONH2 and derivatives, (un)substituted aryl, etc.; X is O, NOH and derivatives and NNHSO2H and derivatives; and stereoisomers, salts, solvates, solvated salts, and all crystal modifications thereof, are claimed. Example compound II was prepared by addition of pentafluoroiodoethane to (5’R,8’S,10’R,14’S)-5,5,13′-trimethyl-1′,2′,6′,7′,12′,13′,14′,15′,16′-decahydro-17’H-spiro[1,3-dioxan-2,3′-[5,10]epoxycyclopenta[a]phenanthren]-17′-one, followed by conjugate addition of 1-bromo-4-methylthiobenzene in the presence of magnesium and copper, and deacetalization. All the invention compounds were evaluated for their progesterone receptor antagonistic activity. From the assay, it was determined that compound II exhibited IC50 values of 0.011 nmol/L and 0.012 nmol/L towards progesterone receptor A and B, resp. The experimental process involved the reaction of Benzyl(4-bromophenyl)sulfane(cas: 53136-21-3).HPLC of Formula: 53136-21-3

The Article related to estradiene aryl derivative preparation progesterone receptor antagonist treatment disease, Steroids: Estranes and other aspects.HPLC of Formula: 53136-21-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On December 31, 2020, Lopez-Arencibia, Atteneri; Bethencourt-Estrella, Carlos J.; Freijo, Monica B.; Reyes-Batlle, Maria; Sifaoui, Ines; Nicolas-Hernandez, Desiree San; McNaughton-Smith, Grant; Lorenzo-Morales, Jacob; Abad-Grillo, Teresa; Pinero, Jose E. published an article.Product Details of 93-04-9 The title of the article was New phenalenone analogues with improved activity against Leishmania species. And the article contained the following:

The in vitro activity against Leishmania spp. of five novel designed compounds, phenalenone derivatives, is described in this study. Previous works have shown that some phenalenones present leishmanicidal activity, some of which could induce programmed cell death events in L. amazonensis parasites. In this research, we focused on the determination of the programmed cell death evidence by detecting the characteristic features of the apoptosis-like process, such as phosphatidylserine exposure and mitochondrial membrane potential, among others. The results showed that the new derivatives have comparable or better activity and selectivity than the commonly prescribed anti-leishmanial drug. This result was obtained by inducing stronger mitochondrial depolarization or more intense phosphatidylserine exposure than miltefosine, highlighting compound 8 with moreover 9-times better selectivity index. In addition, the new five mols. activated the apoptosis-like process in the parasite. All the signals observed were indicative of the death process that the parasites were undergoing. The experimental process involved the reaction of 2-Methoxynaphthalene(cas: 93-04-9).Product Details of 93-04-9

The Article related to leishmania species phenalenone analog phosphatidylserine mitochondrial membrane, leishmania amazonensis, phenalenones, apoptosis-like, chemotherapy, Pharmacology: Methods and other aspects.Product Details of 93-04-9

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On July 15, 2005, Moise, Tamar; Rudich, Yinon; Rousse, Davy; George, Christian published an article.Category: ethers-buliding-blocks The title of the article was Multiphase Decomposition of Novel Oxygenated Organics in Aqueous and Organic Media. And the article contained the following:

Prior to the massive use of new oxygenated solvents, data on their multiphase reactivity must be obtained to assess their environmental fate and impact on water and air quality. For this, the kinetics and mechanisms of the photochem. and photocatalytic degradation of selected oxygenated solvents by common tropospheric oxidants (such as OH and ozone) must be characterized. The authors studied the oxidation kinetics of new oxygenated solvents as pure organic liquids and in an aqueous medium by ozone and by the OH radical, resp. The studied chems. are all unsaturated compounds, having none, one, or two ether groups. The OH reaction proceeds at the diffusion limit by addition to the double bond. The reactive uptake coefficients associated with the reaction initiated by ozone are of the order of 10-3. The reactions of compounds with two double bonds are very fast and probably occur at the surface. This kinetic information demonstrates that organic solvents in an organic medium or in an aqueous droplet will be oxidized rapidly by these oxidation reactions. These reactions, however, are not significant sinks for ozone and OH radicals. The experimental process involved the reaction of 2-(2-(Vinyloxy)ethoxy)ethanol(cas: 929-37-3).Category: ethers-buliding-blocks

The Article related to multiphase decomposition oxygenated organic aqueous media, Water: Water Pollution and other aspects.Category: ethers-buliding-blocks

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Ruzo, Luis O.; Unai, Tadaaki; Casida, John E. published an article in 1978, the title of the article was Decamethrin metabolism in rats.Electric Literature of 66855-92-3 And the article contains the following content:

On oral administration to male rats, the pyrethroid insecticide decamethrin (I) [52918-63-5] and various metabolites derived from its acid and alc. fragments were almost completely eliminated from the body within 2-4 days. Metabolites of the cyano substituent were eliminated more slowly, especially from the skin and stomach, due in the latter case to temporary retention of thiocyanate which was formed from released cyanide. The excreted metabolites included: esters monohydroxylated at the 2′, 4′, and 5 positions of the alc. moiety; 2,2-dimethyl-3-(2,2-dibromovinyl)cyclopropanecarboxylic acid [59952-39-5] and its glucuronide [66855-97-8] and glycine conjugate [66855-98-9] and a hydroxylated derivative [66855-99-0] of this acid, with the hydroxymethyl group trans to the carboxyl, and its glucuronide [66856-00-6]; 3-phenoxybenzoic acid [3739-38-6] and its glucuronide [57991-35-2] and glycine conjugate [57991-36-3], 3-(4-hydroxyphenoxy)benzoic acid [35065-12-4] and its glucuronide [66856-01-7] and sulfate conjugate [58218-91-0], and 3-(2-hydroxyphenoxy)benzoic acid sulfate [61183-26-4]; thiocyanate [302-04-5] and 2-iminothiazolidine-4-carboxylic acid [2150-55-2]. Trans-Decamethrin [64363-96-8] was also rapidly metabolized in rats. The experimental process involved the reaction of 3-(2-Methoxyphenoxy)benzaldehyde(cas: 66855-92-3).Electric Literature of 66855-92-3

The Article related to decamethrin metabolism rat, Toxicology: Agrochemical and other aspects.Electric Literature of 66855-92-3

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Liu, Jianchao; Xiao, Xiao; Han, Puren; Zhou, Huiwen; Yin, Qi-Shuang; Sun, Jian-Song published an article in 2020, the title of the article was Palladium-catalyzed C-glycosylation and annulation of o-alkynylanilines with 1-iodoglycals: convenient access to 3-indolyl-C-glycosides.Name: 2-((4-Methoxyphenyl)ethynyl)aniline And the article contains the following content:

An efficient and practical approach for the synthesis of 3-indolyl-C-Δ1,2-glycosides through a palladium-catalyzed annulation/C-glycosylation sequence of o-alkynylanilines with 1-iodoglycals has been developed. This methodol. has a wide scope of substrates and gives access to 3-indolyl-C-Δ1,2-glycosides in high yields. Furthermore, the product obtained here exhibits a high utility for further transformations. The experimental process involved the reaction of 2-((4-Methoxyphenyl)ethynyl)aniline(cas: 157869-15-3).Name: 2-((4-Methoxyphenyl)ethynyl)aniline

The Article related to c aryl glycoside preparation iodoglycal annulation, alkynylaniline annulation glycosylation palladium catalyzed indolylglycoside, Carbohydrates: Glycosides and other aspects.Name: 2-((4-Methoxyphenyl)ethynyl)aniline

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem