Month: November 2022

On February 10, 2022, Li, Yong; Liu, Yan; Zhu, Zejiang; Yan, Wei; Zhang, Chufeng; Yang, Zhuang; Bai, Peng; Tang, Minghai; Shi, Mingsong; He, Wen; Fu, Suhong; Liu, Jiang; Han, Kai; Li, Jiewen; Xie, Lixin; Ye, Haoyu; Yang, Jianhong; Chen, Lijuan published an article.Electric Literature of 66855-92-3 The title of the article was Structure-Based Design and Synthesis of N-Substituted 3-Amino-β-Carboline Derivatives as Potent αβTubulin Degradation Agents. And the article contained the following:

Compound I, a noncovalent colchicine-site ligand, was capable of promoting αβ-tubulin degradation was found in previous studies. To further improve its antiproliferative activity, derivatives or analogs II [R1 = n-Pr, n-Bu, cyclopentyl, etc.], III [R3 = Et, 2-FC6H4, 3-pyridyl, etc.] of compound I were designed and synthesized based on 2-tubulin cocrystal structure. Among them, compound III [R3 = 1,3-benzodioxol-5-yl] displayed nanomolar potency against a variety of tumor cells, including paclitaxel- and adriamycin-resistant cell lines. Compound III [R3 = 1,3-benzodioxol-5-yl] binds to the colchicine site and promotes αβ-tubulin degradation in a concentration-dependent manner via the ubiquitin-proteasome pathway. The X-ray crystal structure revealed that compound III [R3 = 1,3-benzodioxol-5-yl] binds in a similar manner as compound I, but there was a slight conformation change of the B ring, which resulted in better interaction of compound III [R3 = 1,3-benzodioxol-5-yl] with surrounding residues. Compound III [R3 = 1,3-benzodioxol-5-yl] effectively suppressed tumor growth at an i.v. dose of 40 mg/kg (3 times a week) on both A2780S (paclitaxel-sensitive) and A2780T (paclitaxel-resistant) ovarian xenograft models, with resp. TGIs of 92.42 and 79.75% without obvious side effects, supporting its potential utility as a tumor-therapeutic compound The experimental process involved the reaction of 3-(2-Methoxyphenoxy)benzaldehyde(cas: 66855-92-3).Electric Literature of 66855-92-3

The Article related to amino beta carboline preparation antitumor sar pharmacokinetic human, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Electric Literature of 66855-92-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On February 29, 2020, Liu, Na; Shi, Liangfeng; Han, Xianghao; Qi, Qiao-Yan; Wu, Zong-Quan; Zhao, Xin published an article.Formula: C8H10O2 The title of the article was A heteropore covalent organic framework for adsorptive removal of Cd(II) from aqueous solutions with high efficiency. And the article contained the following:

A heteropore covalent organic framework (COF) integrating tetraphenylethene skeleton and catechol segment is designed and synthesized. It exhibits extremely high stability in water under different pH conditions, which makes it an excellent material for adsorptive removal of Cd(II) from aqueous solutions with very fast adsorption kinetics, high uptake capacity, and good recyclability. The experimental process involved the reaction of 1,2-Dimethoxybenzene(cas: 91-16-7).Formula: C8H10O2

The Article related to covalent organic framework adsorptive cadmium removal aqueous solution, Plastics Fabrication and Uses: Plastic Product Uses and other aspects.Formula: C8H10O2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On November 1, 2018, Biediger, Ronald J.; Benish, Michele A.; Market, Robert V.; Savage, Michael M.; Young, Brandon M. published a patent.Application of 66855-92-3 The title of the patent was Preparation of propionic acid derivatives as α4-integrin inhibitors. And the patent contained the following:

The title compounds I [R1 and R2 = (independently) H, halo, alkyl, cycloalkyl, or arylalkyl; R3 = hydroxy or oxido paired with a pharmaceutically acceptable cation.; R4 = hydroxy, alkoxy, or oxido paired with a pharmaceutically acceptable cation; R5 = (un)substituted Ph, aryl, heteroaryl or arylalkyl; X = CH2, O, or CF2; R6 = (un)substituted alkyl, Ph, aryl, heteroaryl] or pharmaceutically acceptable salts or stereoisomers thereof, useful for antagonizing the action of an α4-integrin to treat various pathophysiol. conditions, were prepared E.g., a multi-step synthesis of sodium 3-[3-(1,5-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido]-3-(3-phenoxyphenyl)propanoate (II), starting from Me propionylacetate and Me formate, was described. Exemplified compounds I were evaluated for their activities as α4-integrin inhibitors (data given for representative compounds I). Pharmaceutical composition comprising compound I was described. The experimental process involved the reaction of 3-(2-Methoxyphenoxy)benzaldehyde(cas: 66855-92-3).Application of 66855-92-3

The Article related to propionic acid derivative propanoate pyridinylureido preparation alpha4 integrin inhibitor, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Application of 66855-92-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On November 15, 2018, Biediger, Ronald J.; Benish, Michele A.; Hardy, Lindsay Bonner; Boyd, Vincent A.; Market, Robert V.; Thrash, Thomas P.; Young, Brandon M. published a patent.HPLC of Formula: 66855-92-3 The title of the patent was Preparation of propionic acid derivatives as α4-integrin inhibitors. And the patent contained the following:

The title compounds I [R1 and R2 = (independently) H, halo, alkyl, cycloalkyl, or arylalkyl; R3 = hydroxy or oxido paired with a pharmaceutically acceptable cation.; R4 = hydroxy, alkoxy, or oxido paired with a pharmaceutically acceptable cation; R5 = (un)substituted Ph, aryl, heteroaryl or arylalkyl; X = CH2, O, or CF2; R6 = (un)substituted alkyl, Ph, aryl, heteroaryl] or pharmaceutically acceptable salts or stereoisomers thereof, useful for antagonizing the action of an α4-integrin to treat various pathophysiol. conditions, were prepared E.g., a multi-step synthesis of sodium 3-[3-(1,5-dimethyl-4-oxido-2-oxo-1,2-dihydropyridin-3-yl)ureido]-3-(3-phenoxyphenyl)propanoate (II), starting from Me propionylacetate and Me formate, was described. Exemplified compounds I were evaluated for their activities as α4-integrin inhibitors (data given for representative compounds I). Pharmaceutical composition comprising compound I was described. The experimental process involved the reaction of 3-(2-Methoxyphenoxy)benzaldehyde(cas: 66855-92-3).HPLC of Formula: 66855-92-3

The Article related to propionic acid derivative propanoate pyridinylureido preparation alpha4 integrin inhibitor, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.HPLC of Formula: 66855-92-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On March 15, 2022, Liu, E.; Liu, Xiaojing; Jin, Zesen; Jian, Fang published an article.Formula: C8H10O2 The title of the article was Study on the relationship between structure and fluorescence properties of anthracene derivatives. And the article contained the following:

Five anthracene derivatives using quinoa perch ether and 2-acetaldehyde pyridine or 4-acetaldehyde pyridine as raw material were designed and synthesized. Their single crystals were obtained and determined by X-ray diffraction anal. and their Hirshfeld surface anal. had also been done. Different compounds with different structures could be obtained from the same raw material by changing the reaction conditions and the concentration of acid. In terms of performance, the hydroanthracene compounds did not produce fluorescence, but the anthracene compounds have strong fluorescence properties. At the same time, Hirschfeld surface anal. was used in this paper to study the interaction between mols. In crystals with visual graphics, which had a certain scientific significance to the identification of close contacts between atoms in neighboring mols. and supramol. forces in mols. The experimental process involved the reaction of 1,2-Dimethoxybenzene(cas: 91-16-7).Formula: C8H10O2

The Article related to anthracene preparation fluorescence uv crystal structure mol, hirshfeld surface analysis anthracene preparation, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Formula: C8H10O2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On January 31, 2021, Gu, Xinzhe; Feng, Li; Zhu, Jingyi; Li, Yue; Tu, Kang; Dong, Qingli; Pan, Leiqing published an article.COA of Formula: C8H10O2 The title of the article was Application of gas sensors for modelling the dynamic growth of Pseudomonas in pork stored at different temperatures. And the article contained the following:

Pseudomonas have a faster growth rate over other bacteria in chilled meat under aerobic conditions. A non-destructive method for modeling the dynamic growth of Pseudomonas in pork stored at different temperatures using gas sensors was presented in our work. Based on selected gas sensor data, the first-order kinetic equations (Gompertz and Logistic Functions) combined with the secondary model (Square-root Function) effectively simulated Pseudomonas growth in pork at different temperatures with R2 and RMSE values of 0.71-0.97 and 0.27-0.84, resp. Addnl., these models showed high accuracy with correlation coefficients greater than 0.90, in addition to several individual accuracy values. Furthermore, HS-SPME/GC-MS results demonstrated the presence of identified key volatiles in samples inoculated with Pseudomonas, including three amine compounds (mercaptamine, 1-octanamine and 1-heptadecanamine), phenol and indole. Our work showed that gas sensors are a rapid, easy and non-destructive method with acceptable feasibility in modeling the dynamic growth of spoilage microorganisms in meat. The experimental process involved the reaction of 1,4-Dimethoxybenzene(cas: 150-78-7).COA of Formula: C8H10O2

The Article related to pork pseudomonas different temperature dynamic growth modeling gas sensor, dynamic growth, gc–ms, gas sensors, model, pseudomonas, Food and Feed Chemistry: Contaminants and Toxicants and other aspects.COA of Formula: C8H10O2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On July 31, 1990, Sugimoto, Hachiro; Tsuchiya, Yutaka; Sugumi, Hiroyuki; Higurashi, Kunizo; Karibe, Norio; Iimura, Yoichi; Sasaki, Atsushi; Kawakami, Yoshiyuki; Nakamura, Takaharu published an article.Recommanded Product: Benzyl(4-bromophenyl)sulfane The title of the article was Novel piperidine derivatives. Synthesis and anti-acetylcholinesterase activity of 1-benzyl-4-[2-(N-benzoylamino)ethyl]piperidine derivatives. And the article contained the following:

The title compound I (R = H, 2-Me, 4-NO2, 4-MeO, 4-CHO, 4-Cl, 4-PhCH2SO2; R1 = Bz, CH2Ph, CH2CH:CHPh, CH2CH2Ph, CH2C6H4Me-4, CH2C6H4NO2-2; R2 = H, Me, Et, Ph) were prepared and evaluated for antiacetylcholinesterase activity. Substituting the benzamide group with a bulky moiety in the para position led to a substantial increase in activity. Introduction of an alkyl or Ph group at the benzamide nitrogen atom dramatically enhanced the activity. The basicity of the piperidine nitrogen atom appears to play an important role in the increased activity, since the N-benzoylpiperidine derivative was almost inactive. I (R = 4-PhCH2SO2, R1 = CH2Ph, R2 = Me, R)(II) were the most potent inhibitors of acetylcholinesterase and produced significant increases in acetylcholine content in the cerebral cortex and hippocampus of rats. II was chosen for development as an antidementia agent. The experimental process involved the reaction of Benzyl(4-bromophenyl)sulfane(cas: 53136-21-3).Recommanded Product: Benzyl(4-bromophenyl)sulfane

The Article related to acetylcholinesterase inhibiting msbar benzylethylpiperidine, antidementia agent benzylethylpiperidine, dementia treatment agent benzylethylpiperidine, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Recommanded Product: Benzyl(4-bromophenyl)sulfane

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On July 22, 2020, Cui, Peng; Svensson Grape, Erik; Spackman, Peter R.; Wu, Yue; Clowes, Rob; Day, Graeme M.; Inge, A. Ken; Little, Marc A.; Cooper, Andrew I. published an article.Reference of 1,2-Dimethoxybenzene The title of the article was An Expandable Hydrogen-Bonded Organic Framework Characterized by Three-Dimensional Electron Diffraction. And the article contained the following:

A mol. crystal of a 2-D hydrogen-bonded organic framework (HOF) undergoes an unusual structural transformation after solvent removal from the crystal pores during activation. The conformationally flexible host mol., ABTPA, adapts its mol. conformation during activation to initiate a framework expansion. The microcrystalline activated phase was characterized by three-dimensional electron diffraction (3D ED), which revealed that ABTPA uses out-of-plane anthracene units as adaptive structural anchors. These units change orientation to generate an expanded, lower d. framework material in the activated structure. The porous HOF, ABTPA-2, has robust dynamic porosity (SABET = 1183 m2 g-1) and exhibits neg. area thermal expansion. We use crystal structure prediction (CSP) to understand the underlying energetics behind the structural transformation and discuss the challenges facing CSP for such flexible mols. The experimental process involved the reaction of 1,2-Dimethoxybenzene(cas: 91-16-7).Reference of 1,2-Dimethoxybenzene

The Article related to hydrogen bond organic framework 3d electron diffraction solvent structure, Surface Chemistry and Colloids: Solid-Liquid Systems and other aspects.Reference of 1,2-Dimethoxybenzene

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On June 30, 2007, Zhang, Zhi-Hong; Feng, Chuan-Liang published an article.Application In Synthesis of 2-(2-(Vinyloxy)ethoxy)ethanol The title of the article was The investigation of protein adsorption behaviors on different functionalized polymers films. And the article contained the following:

The adsorption of BSA and fibrinogen onto plasma-polymerized di-(ethylene glycol) vinyl ether, allylamine, and maleic anhydride films were investigated in detail by surface plasmon resonance spectroscopy (SPR). The chem. properties of the plasma polymers were initially determined by the plasma deposition conditions during the generation procedure. The anal. of the chem. structure of the films and the refractive index of plasma polymers in aqueous solution was carried out using Fourier transform IR spectroscopy and waveguide mode spectroscopy, resp. Using water contact angle measurement, the surface wettability of plasma polymers was also characterized. These properties have a critical influence on the behavior of protein adsorption on the surface of the plasma polymers. Protein adsorption was found to depend not only on the types of functionalized groups, but also on the plasma polymer thickness since the protein mols. penetrate into the plasma polymer network bulk. According to the size of protein mols. in aqueous solution and the amount of adsorbed proteins observed by SPR, the conformational changes of proteins could be deduced. The experimental process involved the reaction of 2-(2-(Vinyloxy)ethoxy)ethanol(cas: 929-37-3).Application In Synthesis of 2-(2-(Vinyloxy)ethoxy)ethanol

The Article related to protein adsorption functionalized polymer film, General Biochemistry: Proteins and Their Constituents and other aspects.Application In Synthesis of 2-(2-(Vinyloxy)ethoxy)ethanol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On August 23, 2022, Zhao, Bowen; Li, Jiajia; Li, Zhuang; Lin, Xia; Pan, Xiangqiang; Zhang, Zhengbiao; Zhu, Jian published an article.COA of Formula: C6H12O3 The title of the article was Photoinduced 3D Printing through a Combination of Cationic and Radical RAFT Polymerization. And the article contained the following:

Photopolymerization-based three-dimensional (3D) printing techniques have been widely utilized to fabricate polymeric materials with complex architectures. The application of reversible deactivation radical polymerization (RDRP) in 3D printing is emerging as a powerful tool to introduce various postprinting abilities but is still at an early stage. Here, a photoinduced free radical-promoted cationic reversible addition-fragmentation chain transfer (RAFT) polymerization method was developed, utilizing the direct photolysis of the RAFT agent as a radical source, which was further combined with photo-iniferter RAFT polymerization to prepare polymer networks. The polymerization mechanism was studied by model polymerization using monofunctional monomers. The effects of each component on the properties of the final materials and polymerization behavior of the crosslinking systems were studied in detail. This method was successfully applied in a digital light processing (DLP) technique-based com. 3D printer. Finally, polymer welding of the printed objects through both cationic and radical RAFT chain extension was realized, expanding avenues of postprinting and future applications in various fields. The experimental process involved the reaction of 2-(2-(Vinyloxy)ethoxy)ethanol(cas: 929-37-3).COA of Formula: C6H12O3

The Article related to photoinduced 3d printing cationic radical raft polymerization, Plastics Fabrication and Uses: Fabricating Techniques and other aspects.COA of Formula: C6H12O3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem