Month: November 2022

Tan, Jihuai published the artcileDirect transformation of fatty acid-derived monomers from dimer acid manufacturing into valuable bio-plasticizers with high plasticization and compatibilization, Category: ethers-buliding-blocks, the main research area is dimer acid nitrile butadiene rubber plasticization compatibilization property.

Direct transformation of monomer fatty acids derived from the dimer acid manufacturing into high value-added green plasticizers represents a sustainable approach for reutilizing industrial wastes. However, this process is challenging due to the few double bonds and long-chain alkyl in monomer fatty acid-based derivatives, resulting in poor compatibility with polymer matrix and inferior plasticization. Herein, we develop a sustainable and low-cost strategy via direct esterification between monomer fatty acids and polyethylene glycol Me ether to produce plasticizers featured by high plasticization and compatibilization. The performances of monomer acid-based ethoxylated esters as resulting plasticizers for nitrile butadiene rubber were highly structure-dependent. Extensive experiments demonstrated that oxethyl unit played critical roles in both improving the compatibility between monomer acid-based ethoxylated esters and nitrile butadiene rubber and in promoting the dispersion of carbon black in nitrile butadiene rubber matrix. Specially, the processing, freezing resistance, oil resistance, thermal and mech. stabilities of nitrile butadiene rubber plasticized by monomer acid-based ethoxylated esters with three or four oxethyl units were comparable or better than those of nitrile butadiene rubber blended with dioctyl phthalate. This study opens a simple, general and industrialized strategy to produce valuable and sustainable plasticizers as alternatives of toxic dioctyl phthalate.

Journal of Cleaner Production published new progress about Carbon black Role: MOA (Modifier or Additive Use), USES (Uses) (N 550, N 770). 23783-42-8 belongs to class ethers-buliding-blocks, name is 2,5,8,11-Tetraoxatridecan-13-ol, and the molecular formula is C9H20O5, Category: ethers-buliding-blocks.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Hielscher, Maximilian published the artcileOptimization Strategies for the Anodic Phenol-Arene Cross-Coupling Reaction, Product Details of C11H16O2, the main research area is phenol bezene regioselective electrochem dehydrogenative cross coupling; hydoxyphenyl benzene preparation.

Dehydrogenative phenol-arene cross-coupling by direct anodic oxidation is a promising alternative to reductive cross-coupling, especially for construction of smaller mols. The reaction pathway via phenoxyl radicals allows for unusual regioselectivity. Nevertheless, the numerous electrolysis parameters pose a challenge for optimization, as they determine the yield and selectivity of the reaction. Using design of experiments, optimization strategies for two example reactions to improve the space-time yield were reported. In particular, coupling reactions with 2,6-dimethoxyphenol (syringol) were found to be very robust in the electrolysis at high current densities of up to 150 mA/cm2. Cyclic voltammetry was used to classify combinations of phenols and arenes, on the basis of which the various clusters were optimized. Based on this classification, various biaryls were synthesized and isolated in yields of up to 85%.

ChemElectroChem published new progress about Benzenoid aromatic compounds Role: RCT (Reactant), RACT (Reactant or Reagent). 121-00-6 belongs to class ethers-buliding-blocks, name is 4-Hydroxy-3-tert-butylanisole, and the molecular formula is C11H16O2, Product Details of C11H16O2.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Xiao, Qiang published the artcileStructural guidelines for stabilization of α-helical coiled coils via PEG stapling, Product Details of C9H20O5, the main research area is guideline helical coiled PEG stapling.

Macrocyclization or stapling is one of the most well-known and generally applicable strategies for enhancing peptide/protein conformational stability and target binding affinity. However, there are limited structure- or sequence-based guidelines for the incorporation of optimal interhelical staples within coiled coils: the location and length of an interhelical staple is either arbitrarily chosen or requires significant optimization. Here we explore the impact of interhelical PEG stapling on the conformational stability and proteolytic resistance of a model disulfide-bound heterodimeric coiled coil. We demonstrate that (1) interhelical PEG staples are more stabilizing when placed farther from an existing disulfide crosslink; (2) e/g ′ staples are more stabilizing than f/b ′ or b/c ′ staples; (3) PEG staples between different positions have different optimal staple lengths; (4) PEG stapling tolerates variation in the structure of the PEG linker and in the mode of conjugation; and (5) the guidelines developed here enable the rational design of a stabilized PEG-stapled HER-2 affibody with enhanced conformational stability and proteolytic resistance.

RSC Chemical Biology published new progress about Disulfides Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 23783-42-8 belongs to class ethers-buliding-blocks, name is 2,5,8,11-Tetraoxatridecan-13-ol, and the molecular formula is C9H20O5, Product Details of C9H20O5.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ouhib, Farid published the artcileInfluence of the Cyclic versus Linear Carbonate Segments in the Properties and Performance of CO2-Sourced Polymer Electrolytes for Lithium Batteries, Related Products of ethers-buliding-blocks, the main research area is cyclic carbonate segment polymer electrolyte lithium battery.

Polycarbonates bearing linear carbonate linkages and polyether segments have demonstrated to be highly attractive solid electrolyte candidates for the design of safe energy storage devices, for example, lithium metal batteries. In this contribution, we are studying the influence of the introduction of some cyclic carbonate linkages within the polymer backbone on the electrolyte properties. We first describe the synthesis of polycarbonates/polyethers containing different contents of both linear and cyclic carbonate linkages within the chain by the copolymerization of a highly reactive CO2-based monomer (bis(α-alkylidene cyclic carbonate)) with poly(ethylene glycol) diol and a dithiol at room temperature We then explore the influence of the content of the cyclic carbonates and the loading of the polymer by lithium bis(trifluoromethane) sulfonimide (LiTFSI) on the electrolyte properties (glass transition and melting temperatures, ion conductivity, and diffusivity). The best electrolyte candidate is characterized by a linear/cyclic carbonate linkage ratio of 82/18 when loaded with 30 weight % LiTFSI. It exhibits an ion conductivity of 5.6 × 10-5 S cm-1 at 25° (7.9 × 10-4 S cm-1 at 60°), which surpasses by 150% (424% at 60°) the conductivity measured for a similar polymer bearing linear carbonate linkages only. It is also characterized by a high oxidation stability up to 5.6 V (vs. Li/Li+). A self-standing membrane is then constructed by impregnating a glass fiber filter by this optimal polymer, LiTFSI, and a small amount of a plasticizer (tetraglyme). Cells are then assembled by sandwiching the membrane between a C-coated LiFePO4 (LFP) as the cathode and lithium as the anode and counter electrode. The cycling performances are evaluated at 0.1 C at 60° and room temperature for 40 cycles. Excellent cycling performances are noted with 100% of the theor. capacity (170 mAh g-1) at 60° and 73.5% of the theor. capacity (125 mAh g-1) at 25°.

ACS Applied Polymer Materials published new progress about Cyclic carbonates Role: TEM (Technical or Engineered Material Use), USES (Uses). 143-24-8 belongs to class ethers-buliding-blocks, name is 2,5,8,11,14-Pentaoxapentadecane, and the molecular formula is C10H22O5, Related Products of ethers-buliding-blocks.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Vershinin, Vlada published the artcileMechanistic Insights into the FeCl3-Catalyzed Oxidative Cross-Coupling of Phenols with 2-Aminonaphthalenes, Application In Synthesis of 121-00-6, the main research area is iron trichloride catalyzed oxidative cross coupling phenol naphthol aminonaphthalene.

The selective FeCl3-catalyzed oxidative cross-coupling reaction between phenols and primary, secondary, and tertiary 2-aminonaphthalene derivatives was investigated. The generality of this scalable method provides a sustainable alternative for preparing N,O-biaryl compounds that are widely used as ligands and catalysts. Based on a comprehensive kinetic investigation, a catalytic cycle involving a ternary complex that binds to both the coupling partners and the oxidant during the key oxidative coupling step is postulated. Furthermore, the studies showed that the reaction is regulated by off-cycle acid-base and ligand exchange processes.

Journal of Organic Chemistry published new progress about Biaryls Role: PRP (Properties), SPN (Synthetic Preparation), PREP (Preparation). 121-00-6 belongs to class ethers-buliding-blocks, name is 4-Hydroxy-3-tert-butylanisole, and the molecular formula is C11H16O2, Application In Synthesis of 121-00-6.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ueda, Mitsuhiro published the artcileTransition-Metal-Catalyst-Free Cross-Coupling Reaction of Secondary Propargylic Acetates with Alkenyl- and Arylboronic Acids, Related Products of ethers-buliding-blocks, the main research area is propargylic acetate alkenylboronic acid cross coupling; enyne stereoselective preparation; arylboronic acid propargylic acetate cross coupling; alkyne arylated preparation.

A cross-coupling reaction between secondary propargylic acetates and alkenylboronic acids proceeded to give 1,4-enynes in good yields without addition of transition metal catalyst and base. This simple protocol was also applicable to arylboronic acids, which gave 3-arylated alkynes in good yields. The observed induction period suggested that the reaction of propargylic acetates and organoboronic acids was affected by the in-situ generated AcOH as a catalyst, which was confirmed by a sep. experiment

European Journal of Organic Chemistry published new progress about Alcohols, propargyl Role: RCT (Reactant), RACT (Reactant or Reagent) (acetates). 127972-00-3 belongs to class ethers-buliding-blocks, name is 2-Methoxy-5-methylphenylboronic acid, and the molecular formula is C8H11BO3, Related Products of ethers-buliding-blocks.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Sun, Tao published the artcileSolvation Effect on the Improved Sodium Storage Performance of N-Heteropentacenequinone for Sodium-Ion Batteries, Recommanded Product: 2,5,8,11,14-Pentaoxapentadecane, the main research area is heteropentacenequinone sodium ion battery solvation effect; electrolytes; organic electrode; sodium-ion batteries; solvation effect.

The performance of electrode material is correlated with the choice of electrolyte, however, how the solvation has significant impact on electrochem. behavior is underdeveloped. Herein, N-heteropentacenequinone (TAPQ) is investigated to reveal the solvation effect on the performance of sodium-ion batteries in different electrolyte environment. TAPQ cycled in diglyme-based electrolyte exhibits superior electrochem. performance, but experiences a rapid capacity fading in carbonate-based electrolyte. The function of solvation effect is mainly embodied in two aspects: one is the stabilization of anion intermediate via the compatibility of electrode and electrolyte, the other is the interfacial electrochem. characteristics influenced by solvation sheath structure. By revealing the failure mechanism, this work presents an avenue for better understanding electrochem. behavior and enhancing performance from the angle of solvation effect.

Angewandte Chemie, International Edition published new progress about Aromatic compounds Role: TEM (Technical or Engineered Material Use), USES (Uses). 143-24-8 belongs to class ethers-buliding-blocks, name is 2,5,8,11,14-Pentaoxapentadecane, and the molecular formula is C10H22O5, Recommanded Product: 2,5,8,11,14-Pentaoxapentadecane.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Friesen, Richard W. published the artcileComparison of the Suzuki cross-coupling reactions of 4,7-dichloroquinoline and 7-chloro-4-iodoquinoline with arylboronic acids using phosphine-free palladium catalysis in water, Synthetic Route of 127972-00-3, the main research area is regioselective Suzuki cross coupling chloroiodoquinoline palladium acetate.

4,7-Dichloroquinoline (1a) and 7-chloro-4-iodoquinoline (1b) undergo Suzuki cross-coupling reactions with arylboronic acids catalyzed by phosphine-free palladium acetate in boiling water. Using phenylboronic acid (2), the reaction of 1a provides 7-chloro-4-phenylquinoline (3) (78%) together with diphenylquinoline (4) (12%), while 1b reacts in a much more regioselective fashion and provides 3 in 98% isolated yield. Although 1b undergoes a more regioselective Suzuki reaction than 1a, addnl. important observations are that the overall reaction of 1b with 2 is three times slower than 1a and that the reaction occurs in the absence of tetrabutylammonium bromide. Using optimized reaction conditions, a variety of aryl and vinylboronic acids undergo regioselective Suzuki cross-coupling with 1b to provide the products in good to excellent yield.

Canadian Journal of Chemistry published new progress about Chemoselectivity (chemoselective oxidative addition of Pd(0) to aryl iodide bond). 127972-00-3 belongs to class ethers-buliding-blocks, name is 2-Methoxy-5-methylphenylboronic acid, and the molecular formula is C8H11BO3, Synthetic Route of 127972-00-3.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Hardcastle, Ian R. published the artcileRationally designed analogs of tamoxifen with improved calmodulin antagonism, HPLC of Formula: 622-86-6, the main research area is tamoxifen analog preparation calmodulin antagonism structure; antiestrogen tamoxifen analog calmodulin antagonism structure; breast tumor inhibition tamoxifen analog structure.

Computerized mol. modeling studies on the interactions of the antiestrogen tamoxifen and its analogs bound to the calcium-binding protein calmodulin have guided the rational design of more potent antagonists. Compounds with either three or four methylene units in the basic side chain or slim lipophilic 4-substituents were expected to be more potent. All compounds were tested for antagonism of the calmodulin-dependent activity of cAMP phosphodiesterase and for binding affinity to the estrogen receptor from rat uteri. Some compounds were assayed for cytotoxicity against MCF-7 breast tumor cells in vitro. Introduction of lipophilic 4-substituents was accomplished by using palladium(0)-catalyzed coupling reactions with a 4-iodinated precursor. Both the 4-ethynyl and 4-Bu compounds were more potent calmodulin antagonists than tamoxifen. Extension of the basic aminoethoxy side chain of 4-iodotamoxifen and idoxifene ((E)-1-[4-[2-(N-pyrrolidino)ethoxy]phenyl]-1-(4-iodophenyl)-2-phenyl-1-butene) by one or two methylene units resulted in modest gains in calmodulin antagonism. All the compounds assayed retained estrogen receptor-binding characteristics. The compound possessing the optimal combination of calmodulin antagonism and estrogen receptor binding was (E)-1-[4-[3-(N-pyrrolidino)propoxy]phenyl]-1-(4-iodophenyl)-2-phenyl-1-butene (IC50 = 1.1 μM, receptor binding affinity = 23). Correlation between calmodulin antagonism and cytotoxicity was demonstrated for selected compounds

Journal of Medicinal Chemistry published new progress about Antiestrogens Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 622-86-6 belongs to class ethers-buliding-blocks, name is (2-Chloroethoxy)benzene, and the molecular formula is C8H9ClO, HPLC of Formula: 622-86-6.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Kim, Yong-Hak published the artcileDegradation of alkyl ethers, aralkyl ethers, and dibenzyl ether by Rhodococcus sp. strain DEE5151, isolated from diethyl ether-containing enrichment cultures, Application In Synthesis of 622-86-6, the main research area is Rhodococcus ether biodegradation.

Twenty strains isolated from sewage sludge were found to degrade various ethers, including alkyl ethers, aralkyl ethers, and dibenzyl ether. In Rhodococcus strain DEE5151, induction of ether degradation needed substrates exhibiting at least one unsubstituted Cα-methylene moiety as the main structural prerequisite. The cleavage reaction observed with anisole, phenetole, and dibenzyl ether indicates that the initial oxidation occurs at such resp. Cα positions. Di-Et ether-induced strain DEE5151 degraded dibenzyl ether via intermediately accumulated benzoic acid. Phenetole seems to be subject also to another ether-cleaving enzyme. Other strains of this group showed different enzymic activities towards the substrate classes investigated.

Applied and Environmental Microbiology published new progress about Aromatic ethers Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 622-86-6 belongs to class ethers-buliding-blocks, name is (2-Chloroethoxy)benzene, and the molecular formula is C8H9ClO, Application In Synthesis of 622-86-6.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem