Month: November 2022

On December 31, 2022, Mutra, Mohana Reddy; Wang, Jeh-Jeng published an article.Synthetic Route of 157869-15-3 The title of the article was Photoinduced ynamide structural reshuffling and functionalization. And the article contained the following:

In this paper, photoinduced radical trigger regio- and chemoselective ynamide bond fission, structural reshuffling and functionalization of 2-alkynyl-ynamides 4-R-2-(CCR1)C6H3N(Ts)CCR2 (R = H, Me, Et, n-bu, Cl, Br; R1 = Ph, n-Bu, cyclopropyl, etc.; R2 = Ph, 2H-1,3-benzodioxol-5-yl, 2-phenylethyl, etc.) to prepare synthetically inaccessible/challenging chalcogen-substituted indole derivatives I [R3 = tosyl, ethanesulfonyl, cyclopropanesulfonyl, etc.; R4 = I, SeC6H5, Se(CH2)4CH3, etc] with excellent step/atom economy were observed The key breakthroughs of this work include, ynamide bond cleavage, divergent radical precursors, broad scope, easy to handle, larger-scale reactions, and generation of multiple bonds (N-C(sp2), C(sp2)-C(sp2), C(sp2)-SO2R/C-SR, and C-I/C-Se/C-H) in a few minutes without photocatalysts, metals, oxidants, additives. Control experiments and 13C-labeling experiments support the conclusion that sulfone radicals contribute to ynamide structural reshuffling processes via a radical pathway. The experimental process involved the reaction of 2-((4-Methoxyphenyl)ethynyl)aniline(cas: 157869-15-3).Synthetic Route of 157869-15-3

The Article related to indole preparation regioselective chemoselective photochem, alkynyl ynamide sulfonyl compound heterocyclization, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Synthetic Route of 157869-15-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On March 17, 2016, Nagamochi, Masatoshi; Gotanda, Kentoku; Noguchi, Tetsuji; Goto, Taiji; Sasaki, Junko; Torihata, Munefumi; Yoshino, Toshiharu; Isobe, Takashi; Ramadass, Venkataramanan published a patent.Recommanded Product: 4-Bromo-5-methoxy-2-methylaniline The title of the patent was Preparation of carboxylic acid derivatives as RORγt (retinoic acid receptor-related orphan receptor γt) inhibitors. And the patent contained the following:

Title compounds I [R1 = alkyl, cycloalkyl or phenyl; R2 = H, halo, alkyl, etc.; R3 = H, carboxy-alkyl or hydroxy; R4 = halo or alkyl; R5 = H or alkyl; R6 = H, halo or alkyl; R7 = H, halo, alkyl, etc.; R8 = hydroxy, alkoxy, monoalkylamino, etc.; L = single bond, methylene or oxygen atom; E = phenylene (optionally substituted with halo, alkyl or alkylsulfonyl), pyridinylene (optionally substituted with halo, alkyl or alkylsulfonyl), thienylene, etc.; Q1 = nitrogen atom or CH; Q2 = nitrogen atom or CH; -U-T- = -CH2CH2- or -CH:CH-; Y = methylene or oxygen atom; V = nitrogen atom or C(R9); R9 = H, alkyl, cycloalkyl, etc.; or pharmaceutically acceptable salts thereof], useful for the treatment of psoriasis, psoriatic arthritis, etc., were prepared For example, EDCI-mediated amidation of II [R = OH] (prepared from 1-bromo-4-iodo-2-methylbenzene in a multi-step process) with methylamine·HCl afforded compound II [R = NHMe]. In IL-17 production inhibition assay, 81-example of I showed IC50 values (nM) ranging from 4.48 to 1110, e.g., IC50 of II [R = NHMe] was 4.48 nM. Pharmaceutical compositions comprising I are disclosed. The experimental process involved the reaction of 4-Bromo-5-methoxy-2-methylaniline(cas: 152626-77-2).Recommanded Product: 4-Bromo-5-methoxy-2-methylaniline

The Article related to carboxylic acid preparation ror gamma t inhibitor, psoriasis psoriatic arthritis treatment ror gamma t inhibition, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Recommanded Product: 4-Bromo-5-methoxy-2-methylaniline

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Yao, Lingyun; Shang, Yan; Wang, Jian-Shu; Pan, Ailin; Ying, Jun; Wu, Xiao-Feng published an article in 2021, the title of the article was Palladium-catalyzed carbonylative cyclization of 2-alkynylanilines and aryl iodides to access N-acyl indoles.Quality Control of 2-((4-Methoxyphenyl)ethynyl)aniline And the article contains the following content:

A palladium-catalyzed carbonylative synthesis of N-acyl indoles I (R = Ph, 2-methylphenyl, 4-chloropenyl, 3,4-dimethylphenyl, etc.; R1 = Ph, 3-methylphenyl, 4-methylphenyl, 4-methoxyphenyl, 4-fluorophenyl; R2 = H, F) from 2-alkynylanilines 2-NH25-R2C6H3CCR1 and aryl iodides RI has been developed. Using benzene-1,3,5-triyl triformate (TFBen) as the CO source, the reaction produced a variety of N-acyl indoles I in a facile manner with high yields. The experimental process involved the reaction of 2-((4-Methoxyphenyl)ethynyl)aniline(cas: 157869-15-3).Quality Control of 2-((4-Methoxyphenyl)ethynyl)aniline

The Article related to acyl indole preparation, alkynylaniline aryl iodide benzenetriyl triformate carbonylative cyclization palladium catalyst, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Quality Control of 2-((4-Methoxyphenyl)ethynyl)aniline

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On February 9, 1995, Achard, Daniel; Grisoni, Serge; James-Surcouf, Evelyne; Malleron, Jean-Iuc; Morgat, Anne; Peyronel, Jean-Francois; Sabuco, Jean-Francois; Tabart, Michel published a patent.Related Products of 81616-80-0 The title of the patent was Preparation of N-acyl-4-hydroxyperhydroisoindoles as substance P antagonists. And the patent contained the following:

Title compounds [I; 1 of R = H, OH, (hydroxy)alkyl and the other = H, (hydroxy)alkyl, Ph; R1 = Ph, alkyl, alkoxy, etc.; R2 = H, halo, OH, alkyl,alkoxy, etc.; R3 = (un)substituted Ph; R4 = OH; R4 = F when R5,R15 = H or alkyl; 1 of R5,R15 = H, OH, alkyl and the other = H or alkyl; R4R5 = bond; R6 = H, OH, (hydroxy)alkyl] were prepared Thus, 5-methylcyclohex-2-en-1-one was cyclocondensed with PhCH2N(CH2OBu)CH2SiMe3 and the product condensed with BuLi-treated PhOMe to give, after deprotection and N-acylation by (S)-2-(MeO)C6H4CHMeCO2H, title compound (3aR*,4R*,6S*,7aS*)-II which had ED50 of 0.07mg/kg i.v. for inhibition of substance P-induced capillary permeability in monkeys. The experimental process involved the reaction of (S)-2-(2-Methoxyphenyl)propanoic acid(cas: 81616-80-0).Related Products of 81616-80-0

The Article related to acylhydroxyperhydroisoindole preparation substance p antagonist, isoindole acylhydroxyperhydro preparation substance p antagonist, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Related Products of 81616-80-0

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On April 21, 2022, Ito, Mamoru; Onoda, Hideaki; Takaki, Asahi; Shibata, Takanori published an article.COA of Formula: C15H13NO The title of the article was Gold-Catalyzed Cascade and Divergent Synthesis of Indolobenzazepines and Indoloquinolines from Nitrogen-Tethered 1,8-Diynes. And the article contained the following:

Authors describe the divergent construction of two nitrogen-containing polycyclic systems by gold-catalyzed cycloisomerizations. The gold-catalyzed cascade hydroamination and 7-endo-dig-selective cycloisomerization of nitrogen-tethered 1,8-diynes yielded indolo[1,7-ab]benzazepines in one pot. In contrast, when Johnphos-coordinated gold catalyst was used, the same 1,8-diynes were transformed into indolo[1,2-a]quinolines by 6-endo-dig-selective cycloisomerization along with rearrangement of the substituent on one of the alkynes. The reaction of a naphthalene-tethered substrate provided a helically chiral aza[6]helicene. The experimental process involved the reaction of 2-((4-Methoxyphenyl)ethynyl)aniline(cas: 157869-15-3).COA of Formula: C15H13NO

The Article related to indolobenzazepine indoloquinoline preparation, nitrogen tethered diyne tandem hydroamination cycloisomerization rearrangement gold, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.COA of Formula: C15H13NO

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Chakrabarty, Indradweep; Inamdar, Suleman M.; Akram, Manjur O.; Gade, Amol B.; Banerjee, Subhrashis; Bera, Saibal; Patil, Nitin T. published an article in 2017, the title of the article was [3+2]-Annulation of platinum-bound azomethine ylides with distal C=C bonds of N-allenamides.Recommanded Product: 2-((4-Methoxyphenyl)ethynyl)aniline And the article contains the following content:

A Pt-catalyzed, highly regioselective reaction between N-allenamides and imino-alkynes leading to pyrrolo[1,2-a]indoles was described. This represented the first example of [3+2]-annulation of Pt-bound azomethine ylides with the distal C=C bond of N-allenamides. The mechanism of the reaction was established by computational studies. The experimental process involved the reaction of 2-((4-Methoxyphenyl)ethynyl)aniline(cas: 157869-15-3).Recommanded Product: 2-((4-Methoxyphenyl)ethynyl)aniline

The Article related to allenamide aryl imino alkyne platinum catalyst regioselective cyclization, aryl tosyl pyrroloindole diastereoselective preparation, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Recommanded Product: 2-((4-Methoxyphenyl)ethynyl)aniline

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Satyanarayana, Gedu; Maier, Martin E. published an article in 2012, the title of the article was Tricyclic isoindolines by Heck cyclization.Product Details of 887581-09-1 And the article contains the following content:

A series of 4-formyl esters, e.g., I, were prepared by Michael addition of an enamine with Et acrylate. A subsequent condensation with 2-bromobenzylamines gave rise to cyclic enamides, e.g., II. In a Heck cyclization reaction tricyclic isoindoles, e.g., III, were formed in good yields. The experimental process involved the reaction of (2-Bromo-5-methoxyphenyl)methanamine(cas: 887581-09-1).Product Details of 887581-09-1

The Article related to tricyclic isoindoline preparation, formyl ester preparation bromobenzylamine condensation, cyclic enamide preparation heck cyclization, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Product Details of 887581-09-1

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On August 6, 2021, Li, Laiqiang; Hou, Zhong-Wei; Li, Pinhua; Wang, Lei published an article.Recommanded Product: 2-Methoxynaphthalene The title of the article was Site-Selective Electrochemical C-H Cyanation of Indoles. And the article contained the following:

An electrochem. approach for the site-selective C-H cyanation of indoles to form indole-carbonitriles I [R1 = CN, Ph; R2 = Me, CN, C(O)OMe, etc.; R3 = H, 4-Me, 5-F, 6-Cl, etc.; R4 = Me, Bn, i-Pr, etc.] employing readily available TMSCN as cyano source has been developed. The electrosynthesis relied on the tris(4-bromophenyl)amine as a redox catalyst, which achieved better yield and regioselectivity. A variety of C2- and C3-cyanated indoles were obtained in satisfactory yields. The reactions were conducted in a simple undivided cell at room temperature and obviated the need for transition-metal reagent and chem. oxidant. The experimental process involved the reaction of 2-Methoxynaphthalene(cas: 93-04-9).Recommanded Product: 2-Methoxynaphthalene

The Article related to carbonitrile indole green regioselective preparation, indole trimethylsilyl cyanide electrochem cyanation tris bromophenyl amine catalyst, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Recommanded Product: 2-Methoxynaphthalene

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Kasama, Kengo; Kanomata, Kyohei; Hinami, Yuya; Mizuno, Karin; Uetake, Yuta; Amaya, Toru; Sako, Makoto; Takizawa, Shinobu; Sasai, Hiroaki; Akai, Shuji published an article in 2021, the title of the article was Chemo- and regioselective cross-dehydrogenative coupling reaction of 3-hydroxycarbazoles with arenols catalyzed by a mesoporous silica-supported oxovanadium.Safety of 2-Methoxynaphthalene And the article contains the following content:

Cross-dehydrogenative coupling between 3-hydroxycarbazoles I(R = H; R1 = H, Br, Me; RR1 = -CH:CH-CH:CH-; R2 = H, Me, Ph, benzyl, acetyl, tolyl) and 2-naphthols II (R3 = 6-MeO, 7-Br, 3-Me, etc.) has been achieved by using a mesoporous silica-supported oxovanadium catalyst. The experimental process involved the reaction of 2-Methoxynaphthalene(cas: 93-04-9).Safety of 2-Methoxynaphthalene

The Article related to hydroxynaphthalenyl carbazole preparation regioselective chemoselective, hydroxycarbazole naphthol coupling reaction oxovanadium catalyst, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Safety of 2-Methoxynaphthalene

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On January 19, 2022, Jacob, Nicolas; Zaid, Yassir; Oliveira, Joao C. A.; Ackermann, Lutz; Wencel-Delord, Joanna published an article.Recommanded Product: 93-04-9 The title of the article was Cobalt-Catalyzed Enantioselective C-H Arylation of Indoles. And the article contained the following:

Herein, the unprecedented earth-abundant 3D-metal-catalyzed atroposelective direct arylation was reported, furnishing rare atropoisomeric C2-arylated indoles. Kinetic studies and DFT computation revealed an uncommon mechanism for this asym. transformation, with the oxidative addition being the rate- and enantio-determining step. Excellent stereoselectivities were reached (up to 96% ee), while using an unusual N-heterocyclic carbene-ligand bearing essential remote substituent. Attractive dispersion interactions along with pos. C-H—π interactions exerted by the ligand were identified as key factors to guarante the excellent enantioselection. The experimental process involved the reaction of 2-Methoxynaphthalene(cas: 93-04-9).Recommanded Product: 93-04-9

The Article related to methoxyphenyl indole methanimine chloronaphthalene cobalt catalyst enantioselective arylation, naphthalenyl indole carbaldehyde preparation, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Recommanded Product: 93-04-9

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem