Month: November 2022

Pirzer, Anna S.; Alvarez, Eva-Maria; Friedrich, Heike; Heinrich, Markus R. published an article in 2019, the title of the article was Radical Carbofluorination of Alkenes with Arylhydrazines and Selectfluor: Additives, Mechanistic Pathways, and Polar Effects.Formula: C7H7FO And the article contains the following content:

Radical carbofluorination reactions starting from arylhydrazines and nonactivated alkenes, in which the C-F bond is formed through the use of Selectfluor, can be improved through the addition of anisole. Because direct trapping products could be detected only in trace amounts, anisole does primarily act as a reversible scavenger for the highly reactive ammonium radical dication released from Selectfluor in the C-F bond-forming step. As shown for three diverse substitution patterns, the main role of anisole is to prevent, or at least reduce, the undesired addition of the ammonium radical dication to the alkene, which in turn leads to an unfavorable consumption of the arylhydrazine-derived precursors required for carbofluorination. Moreover, besides the remarkable polar effects in radical trapping, this study shows that the Selectfluor-derived nitrogen-centered radical dication may add directly to alkenes, which has not been described so far. The experimental process involved the reaction of 1-Fluoro-2-methoxybenzene(cas: 321-28-8).Formula: C7H7FO

The Article related to radical carbofluorination alkene arylhydrazine selectfluor mechanism polar effect, selectfluor, alkenes, anisole, fluorination, radical reactions, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Hydroxylamines, Hydrazines, Triazenes, Azides, Azines, and Azo and Diazo Compounds and other aspects.Formula: C7H7FO

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Zhu, Runqing; Sun, Qianqian; Li, Jing; Li, Luohao; Gao, Qinghe; Wang, Yakun; Fang, Lizhen published an article in 2021, the title of the article was para-selective hydroxylation of alkyl aryl ethers.Electric Literature of 578-58-5 And the article contains the following content:

Para-Selective hydroxylation of alkyl aryl ethers is established, which proceeds with a ruthenium(II) catalyst, hypervalent iodine(III) and trifluoroacetic anhydride via a radical mechanism. This protocol tolerates a wide scope of substrates and provides a facile and efficient method for preparing clin. drugs monobenzone and pramocaine on a gram scale. The experimental process involved the reaction of 2-Methylanisole(cas: 578-58-5).Electric Literature of 578-58-5

The Article related to alkyl aryl ether para hydroxylation regioselective, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Phenols, Thiophenols, and Derivatives Including Phenol and Thiophenol Ethers and Esters and other aspects.Electric Literature of 578-58-5

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On December 19, 2005, Salvatore, Ralph Nicholas; Smith, Robert A.; Nischwitz, Adam K.; Gavin, Terrence published an article.Computed Properties of 53136-21-3 The title of the article was A mild and highly convenient chemoselective alkylation of thiols using Cs2CO3-TBAI. And the article contained the following:

A mild and improved method for the synthesis of thioethers has been developed. In the presence of cesium carbonate, tetrabutylammonium iodide, and DMF, various alkyl and aryl thiols underwent S-alkylation to afford structurally diverse sulfides in high yield. Unprotected mercapto alcs. and thio amines reacted chemoselectively at the sulfur moiety exclusively. An example of a one-pot, solid-phase synthesis of a thioether is also described. The experimental process involved the reaction of Benzyl(4-bromophenyl)sulfane(cas: 53136-21-3).Computed Properties of 53136-21-3

The Article related to cesium carbonate tetrabutylammonium iodide alkylation thiol, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Phenols, Thiophenols, and Derivatives Including Phenol and Thiophenol Ethers and Esters and other aspects.Computed Properties of 53136-21-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On November 13, 2001, Oba, Tsuyoshi; Mizushima, Hirozumi; Sone, Hajime; Yamamuro, Akira; Hotta, Mitsuyuki published a patent.Name: 1-((2-Ethylhexyl)oxy)-4-methoxybenzene The title of the patent was Preparation of methoxyphenyl alkyl ethers and blood circulation stimulators as external medicines. And the patent contained the following:

The compounds MeOC6H3R1OR2 (R1 = H, MeO; R2 = C1-18 alkyl, C7-24 aralkyl) are prepared 4-Methoxyphenol was reacted with Bu bromide in the presence of NaOH under reflux for 3 h to give 74.9% Bu 4-methoxyphenyl ether showing good stimulating blood circulation in guinea pig skin. The experimental process involved the reaction of 1-((2-Ethylhexyl)oxy)-4-methoxybenzene(cas: 146370-51-6).Name: 1-((2-Ethylhexyl)oxy)-4-methoxybenzene

The Article related to methoxyphenyl alkyl ether preparation blood circulation stimulator, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Phenols, Thiophenols, and Derivatives Including Phenol and Thiophenol Ethers and Esters and other aspects.Name: 1-((2-Ethylhexyl)oxy)-4-methoxybenzene

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On May 5, 2008, Naidu, Ajay B.; Sekar, G. published an article.Application In Synthesis of 1-((2-Ethylhexyl)oxy)-4-methoxybenzene The title of the article was An efficient intermolecular BINAM-copper(I) catalyzed Ullmann-type coupling of aryl iodides/bromides with aliphatic alcohols. And the article contained the following:

A wide range of alkyl aryl ethers are synthesized from the corresponding aryl iodides and aliphatic alcs. through Ullmann-type intermol. coupling reactions in the presence of a catalytic amount of easily available BINAM-CuI complex. Less reactive aryl bromides also reacted with aliphatic alcs. under identical conditions to give good yields of the alkyl aryl ethers without increasing the reaction temperature and time. The experimental process involved the reaction of 1-((2-Ethylhexyl)oxy)-4-methoxybenzene(cas: 146370-51-6).Application In Synthesis of 1-((2-Ethylhexyl)oxy)-4-methoxybenzene

The Article related to aryl halide aliphatic alc ullmann coupling binam copper catalyst, alkyl aryl ether, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Phenols, Thiophenols, and Derivatives Including Phenol and Thiophenol Ethers and Esters and other aspects.Application In Synthesis of 1-((2-Ethylhexyl)oxy)-4-methoxybenzene

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On May 15, 2020, Wang, Jing-Hao; Lei, Tao; Wu, Hao-Lin; Nan, Xiao-Lei; Li, Xu-Bing; Chen, Bin; Tung, Chen-Ho; Wu, Li-Zhu published an article.Computed Properties of 93-04-9 The title of the article was Thiol Activation toward Selective Thiolation of Aromatic C-H Bond. And the article contained the following:

An effective model for regioselective thiolation of the aromatic C-H bond by thiol activation instead of arene activation was disclosed. This method was applied into anisole derivatives that are not available in the arene activation approach to forge a single thioether isomer with high reactivity. The experimental process involved the reaction of 2-Methoxynaphthalene(cas: 93-04-9).Computed Properties of 93-04-9

The Article related to thiophenol aryl ether regioselective electrochem thiolation, diaryl thioether preparation, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Phenols, Thiophenols, and Derivatives Including Phenol and Thiophenol Ethers and Esters and other aspects.Computed Properties of 93-04-9

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On May 15, 2020, Wang, Jing-Hao; Lei, Tao; Wu, Hao-Lin; Nan, Xiao-Lei; Li, Xu-Bing; Chen, Bin; Tung, Chen-Ho; Wu, Li-Zhu published an article.Category: ethers-buliding-blocks The title of the article was Thiol Activation toward Selective Thiolation of Aromatic C-H Bond. And the article contained the following:

An effective model for regioselective thiolation of the aromatic C-H bond by thiol activation instead of arene activation was disclosed. This method was applied into anisole derivatives that are not available in the arene activation approach to forge a single thioether isomer with high reactivity. The experimental process involved the reaction of 2-Methylanisole(cas: 578-58-5).Category: ethers-buliding-blocks

The Article related to thiophenol aryl ether regioselective electrochem thiolation, diaryl thioether preparation, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Phenols, Thiophenols, and Derivatives Including Phenol and Thiophenol Ethers and Esters and other aspects.Category: ethers-buliding-blocks

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Shigeno, Masanori; Hayashi, Kazutoshi; Korenaga, Toshinobu; Nozawa-Kumada, Kanako; Kondo, Yoshinori published an article in 2022, the title of the article was Organic superbase t-Bu-P4-catalyzed demethylations of methoxyarenes.Related Products of 93-04-9 And the article contains the following content:

The organic superbase t-Bu-P4 catalyzes the demethylation reactions of methoxyarenes ROMe [R = 4-cyanophenyl, 1-oxo-2,3-dihydro-1H-inden-5-yl, 1-benzothiophen-5-yl, etc.] in the presence of alkanethiol and hexamethyldisilazane was reported. The system can efficiently convert a variety of substrates, including electron-deficient, -neutral, and -rich substrates and heteroaromatic substrates, and displays excellent functional group tolerance. Computational studies show that the high reactivity achieved by t-Bu-P4 is due to the formation of the nucleophilic naked thiolate species. The experimental process involved the reaction of 2-Methoxynaphthalene(cas: 93-04-9).Related Products of 93-04-9

The Article related to hydroxyarene preparation dft study, methoxyarene demethylation organic superbase catalyst, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Phenols, Thiophenols, and Derivatives Including Phenol and Thiophenol Ethers and Esters and other aspects.Related Products of 93-04-9

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On June 22, 2021, Misal, Balu; Palav, Amey; Ganwir, Prerna; Chaturbhuj, Ganesh published an article.HPLC of Formula: 578-58-5 The title of the article was Sulfated polyborate-H2O assisted tunable activation of N-iodosuccinimide for expeditious mono and diiodination of arenes. And the article contained the following:

Owing to both Lewis and Bronsted acid active sites on sulfated polyborate under homogeneous conditions, iodination protocol of arenes was developed, which can meet the requirement of regioselectivity and higher yield. The sulfated polyborate activated N-iodosuccinimide for mono iodination of highly activated substrates viz. phenols, anilines under anhydrous condition. Water tuned sulfated polyborate to generate more Bronsted acid sites resulting in rapid activation of NIS for diiodination. The protocol was equally applicable to diiodination of 4-hydroxyphenylacetic acid to synthesize 4-hydroxy-3,5-diiodophenylacetic acid, an intermediate of tiratricol, a thyroid treatment drug. This protocol was further integrated via one-pot sequential iodination and Sonogashira coupling to synthesize aryl acetylenes, building blocks for the synthesis of a variety of specialty chems., API and natural products. The experimental process involved the reaction of 2-Methylanisole(cas: 578-58-5).HPLC of Formula: 578-58-5

The Article related to arene iodosuccinimide sulfated polyborate catalyst regioselective iodination, iodoarene preparation, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Phenols, Thiophenols, and Derivatives Including Phenol and Thiophenol Ethers and Esters and other aspects.HPLC of Formula: 578-58-5

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On June 22, 2021, Misal, Balu; Palav, Amey; Ganwir, Prerna; Chaturbhuj, Ganesh published an article.COA of Formula: C11H10O The title of the article was Sulfated polyborate-H2O assisted tunable activation of N-iodosuccinimide for expeditious mono and diiodination of arenes. And the article contained the following:

Owing to both Lewis and Bronsted acid active sites on sulfated polyborate under homogeneous conditions, iodination protocol of arenes was developed, which can meet the requirement of regioselectivity and higher yield. The sulfated polyborate activated N-iodosuccinimide for mono iodination of highly activated substrates viz. phenols, anilines under anhydrous condition. Water tuned sulfated polyborate to generate more Bronsted acid sites resulting in rapid activation of NIS for diiodination. The protocol was equally applicable to diiodination of 4-hydroxyphenylacetic acid to synthesize 4-hydroxy-3,5-diiodophenylacetic acid, an intermediate of tiratricol, a thyroid treatment drug. This protocol was further integrated via one-pot sequential iodination and Sonogashira coupling to synthesize aryl acetylenes, building blocks for the synthesis of a variety of specialty chems., API and natural products. The experimental process involved the reaction of 2-Methoxynaphthalene(cas: 93-04-9).COA of Formula: C11H10O

The Article related to arene iodosuccinimide sulfated polyborate catalyst regioselective iodination, iodoarene preparation, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Phenols, Thiophenols, and Derivatives Including Phenol and Thiophenol Ethers and Esters and other aspects.COA of Formula: C11H10O

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem