Month: November 2022

Zhang, Junhui published the artcileComparative (co-)pyrolytic performances and by-products of textile dyeing sludge and cattle manure: Deeper insights from Py-GC/MS, TG-FTIR, 2D-COS and PCA analyses, Category: ethers-buliding-blocks, the main research area is kinetic copyrolysis gas char textile dyeing sludge cattle manure; Cattle manure; Char functional groups; Gaseous products; Kinetics; Textile dyeing sludge.

Not only does pyrolysis recover energy and value-added byproducts but also reduces waste stream volume The low volatiles and high ash contents of textile dyeing sludge (TDS) limit its mono-pyrolysis performance. This study aimed to conduct an in-depth anal. of its co-pyrolytic performance with cattle manure (CM). The co-pyrolysis enhanced the volatiles emission from the early devolatilization stage whose reaction mechanism shifted from a diffusion model to a reaction-order model. The further cracking of macromol. materials was mainly elucidated by the reaction-order model. The temperature dependency of the co-pyrolytic gases was of the following order: aliphatic hydrocarbons > CO2 > alcs., phenols, ethers, aldehydes, ketones, and carboxylic acids. The main co-pyrolytic volatile products were coumaran and 4-vinylguaiacol. The relative content of guaiacol-type components could be enhanced by co-pyrolysis and lowering the operational temperature to 450°C. The interaction of co-pyrolysis enriched the char aromaticity. Our findings provide practical insights into the control and application opportunities and limitations on the high value-added energy and products from the co-pyrolysis of TDS and CM.

Journal of Hazardous Materials published new progress about Alcohols Role: FMU (Formation, Unclassified), PEP (Physical, Engineering or Chemical Process), FORM (Formation, Nonpreparative), PROC (Process). 121-00-6 belongs to class ethers-buliding-blocks, name is 4-Hydroxy-3-tert-butylanisole, and the molecular formula is C11H16O2, Category: ethers-buliding-blocks.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ren, Muqing published the artcileBioinspired Redox Mediator in Lithium-Oxygen Batteries, SDS of cas: 143-24-8, the main research area is superoxide dismutase biomimetic redox mediator activated charcoal.

LiO2 is an intermediate formed in aprotic Li-O2 and Li-air batteries during an oxygen reduction reaction (ORR). The soluble LiO2 triggers undesirable side reactions, such as a nucleophilic reaction and the formation of the byproduct Li2CO3 upon reaction with the electrolyte and substrate, resulting in irreversible redox reactions and causing a low Coulombic efficiency with poor cycling durability. Inspired by superoxide dismutase (SOD) in biol. systems, we hypothesized that SOD mimetics could likewise be applied in Li-O2 and Li-air batteries, thereby prolonging the battery cycle life. Oxidized activated charcoal (OAC) is known to be one SOD mimetic with fast kinetics and a high turnover. Therefore, OAC was added to a dual polymer gel electrolyte as a redox mediator. The OAC redox mechanism is well illustrated in quasi-solid Li-O2 batteries, and the battery stability was significantly improved in the presence of OAC. Furthermore, the best Li-O2 battery containing OAC demonstrated stable galvanostatic charge/discharge performance for ~300 cycles (3000 h) with a cutoff capacity of 0.4 mAh cm-2. In addition, under a discharge cutoff potential of 2.0 V, the discharge capacity of the best Li-O2 battery is ~37.0 mAh cm-2.

ACS Catalysis published new progress about Biomimetics. 143-24-8 belongs to class ethers-buliding-blocks, name is 2,5,8,11,14-Pentaoxapentadecane, and the molecular formula is C10H22O5, SDS of cas: 143-24-8.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Gupta, Ramesh C. published the artcileNovel N-substituted 4-hydrazino piperidine derivative as a dipeptidyl peptidase IV inhibitor, Category: ethers-buliding-blocks, the main research area is piperidine cyanothiazolidinoylmethyl hydrazino derivative preparation dipeptidyl peptidase inhibition activity; hydrazinopiperidine DPPIV inhibitor structure activity relationship insulin release stimulator.

A novel class of N-substituted 4-hydrazino piperidine derivatives containing chiral cyanothiazolidinoyl moieties were designed, synthesized and evaluated for DPP IV inhibition. The SAR studies on the N-substituted piperidines led to the discovery of compound I as a potent DPP IV inhibitor (IC50 88 nM), which is highly selective over other peptidases. In vivo efficacy indicates that compound I stimulates insulin release in response to glucose load and improves glucose tolerance in n5-STZ and Zucker Diabetic Fatty (ZDF) rats.

Bioorganic & Medicinal Chemistry Letters published new progress about Hydrazines Role: PAC (Pharmacological Activity), RCT (Reactant), SPN (Synthetic Preparation), BIOL (Biological Study), RACT (Reactant or Reagent), PREP (Preparation). 622-86-6 belongs to class ethers-buliding-blocks, name is (2-Chloroethoxy)benzene, and the molecular formula is C8H9ClO, Category: ethers-buliding-blocks.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Klepel, Florian published the artcilePhoto-responsive host-guest complexation directs dynamic covalent condensation of phenyl boronic acid and D-fructose, Application In Synthesis of 23783-42-8, the main research area is photoresponsive host guest complexation directs dynamic covalent condensation; dynamic combinatorial libraries mol recognition; dynamic covalent system responds rapidly conformation change.

Inspired by the way templates have been used to drive dynamic combinatorial libraries by mol. recognition, we exploited the photo-responsive host-guest interaction of an azo-based photoswitch with permethylated cyclodextrin to reversibly manipulate the dynamic covalent interaction of a Ph boronic acid and D-fructose by irradiation with light.

Chemical Communications (Cambridge, United Kingdom) published new progress about Azo compounds, aromatic Role: PEP (Physical, Engineering or Chemical Process), RCT (Reactant), SPN (Synthetic Preparation), PROC (Process), RACT (Reactant or Reagent), PREP (Preparation). 23783-42-8 belongs to class ethers-buliding-blocks, name is 2,5,8,11-Tetraoxatridecan-13-ol, and the molecular formula is C9H20O5, Application In Synthesis of 23783-42-8.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Niederer, Kyle A. published the artcileOxidative photocatalytic homo- and cross-coupling of phenols: Nonenzymatic, catalytic method for coupling tyrosine, Quality Control of 121-00-6, the main research area is phenol homo cross coupling oxidative photocatalytic method safety eyewear; oxidation potential nucleophilicity homo cross coupling reaction mechanism; tyrosine coupling cyclic voltammetry fluorescence quenching crystal structure; Oxidative coupling; cross-coupling; phenol coupling; photocatalysis; tyrosine dimerization.

An oxidative photocatalytic method for phenol-phenol homo- and cross-coupling is described, and isolated yields of 16-97% are obtained. Measured oxidation potentials and computed nucleophilicity parameters support a mechanism of nucleophilic attack of one partner onto the oxidized neutral radical form of the other partner. Our understanding of this model permitted the development of cross-coupling reactions between nucleophilic phenols/arenes and easily oxidized phenols with high selectivity and efficiency. A highlight of this method is that one equivalent of each coupling partner is utilized. Building on these findings, a nonenzymic, catalytic method for coupling tyrosine was also developed. Due to the high intensity of the light source it is highly recommended that impact resistant sunglasses be worn when placing a reaction in the photochem. bay.

ACS Catalysis published new progress about Cross-coupling reaction. 121-00-6 belongs to class ethers-buliding-blocks, name is 4-Hydroxy-3-tert-butylanisole, and the molecular formula is C11H16O2, Quality Control of 121-00-6.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Benkovics, Tamas published the artcileDiverse Catalytic Reactions for the Stereoselective Synthesis of Cyclic Dinucleotide MK-1454, Quality Control of 143-24-8, the main research area is transition metal thiophosphate enzyme catalytic stereoselective synthesis cyclization nucleotide; STING gene agonist cyclic dinucleotide MK1454 stimulator thiophosphate fluorination.

As practitioners of organic chem. strive to deliver efficient syntheses of the most complex natural products and drug candidates, further innovations in synthetic strategies are required to facilitate their efficient construction. These aspirational breakthroughs often go hand-in-hand with considerable reductions in cost and environmental impact. Enzyme-catalyzed reactions have become an impressive and necessary tool that offers benefits such as increased selectivity and waste limitation. These benefits are amplified when enzymic processes are conducted in a cascade in combination with novel bond-forming strategies. In this article, we report a highly diastereoselective synthesis of MK-1454, a potent agonist of the stimulator of interferon gene (STING) signaling pathway. The synthesis begins with the asym. construction of two fluoride-bearing deoxynucleotides. The routes were designed for maximum convergency and selectivity, relying on the same benign electrophilic fluorinating reagent. From these complex subunits, four enzymes are used to construct the two bridging thiophosphates in a highly selective, high yielding cascade process. Critical to the success of this reaction was a thorough understanding of the role transition metals play in bond formation.

Journal of the American Chemical Society published new progress about Cyclization. 143-24-8 belongs to class ethers-buliding-blocks, name is 2,5,8,11,14-Pentaoxapentadecane, and the molecular formula is C10H22O5, Quality Control of 143-24-8.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ting, Pauline C. published the artcileThe synthesis and structure-activity relationship of 4-benzimidazolyl-piperidinylcarbonyl-piperidine analogs as histamine H3 antagonists, Name: (2-Chloroethoxy)benzene, the main research area is benzimidazolyl piperidinylcarbonyl piperidine preparation; H3 receptor antagonist structure activity human.

A structure-activity relationship study of the lead piperazinylcarbonylpiperidine I, resulted in the identification of 4-benzimidazolyl-piperidinylcarbonyl-piperidine II, as a histamine-3 (H3) receptor antagonist. Addnl. optimization of II led to the identification of compounds e.g., III with good in vivo activity.

Bioorganic & Medicinal Chemistry Letters published new progress about Histamine H3 receptor antagonists. 622-86-6 belongs to class ethers-buliding-blocks, name is (2-Chloroethoxy)benzene, and the molecular formula is C8H9ClO, Name: (2-Chloroethoxy)benzene.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Yang, Minjian published the artcileDesign, synthesis, and biological evaluation of pyrrolopyrimidine derivatives as novel Bruton’s tyrosine kinase (BTK) inhibitors, Safety of 3-Phenoxyazetidine hydrochloride, the main research area is pyrrolopyrimidine preparation Brutons tyrosine kinase mol docking antitumor activity; B-Cell lymphomas; BTK inhibitor; Kinase selectivity.

Here, four key regions where inhibitors bind to BTK were identified by analyzing the existing crystal structures of BTK complexes. Then, a scaffold-based mol. design work flow was established by integrating fragment-growing method, deep learning-based framework XGraphBoost and mol. docking, leading to four compounds that showed potency against BTK. Optimization of compounds I and II led to the discovery of the potent BTK inhibitor compound III by using in vitro potency and pharmacokinetic (PK) studies to prioritize the compounds Compound III exhibited great BTK inhibition activity (IC50 = 0.7 nM) along with high oral absorption. Moreover, compound III demonstrated excellent kinase selectivity, especially over EGFR kinase, and low toxicity. In a TMD8 xenograft model, compound III significantly inhibited tumor growth (TGI = 104%) at a dosage of 50 mg/kg, indicating its potential as a novel therapeutic option for B-cell lymphomas.

European Journal of Medicinal Chemistry published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent). 301335-39-7 belongs to class ethers-buliding-blocks, name is 3-Phenoxyazetidine hydrochloride, and the molecular formula is C9H12ClNO, Safety of 3-Phenoxyazetidine hydrochloride.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Erkin, A. V. published the artcileAryl ethers of 4-[(2-hydroxyethyl)sulfanyl]pyrimidine derivatives: Pathways of synthesis and fungicidal activity of their salt forms, Safety of (2-Chloroethoxy)benzene, the main research area is hydroxyethylsulfanyl pyrimidine aryl ether hydrochloride salt preparation fungicidal activity.

2-Amino-4-[(2-aryloxyethyl)sulfanyl]-6-methylpyrimidines were obtained by S-alkylation of 2-amino-6-methylpyrimidin-4(3H)-thione with 2-aryloxyethyl chlorides. Since 2-amino-4-[(2-chloroethyl)sulfanyl]-6-methylpyrimidine is prone to in situ intramol. cyclization it cannot be used in Claisen reaction. The bromination of the target compounds provided 5-bromo derivatives; some of their hydrochlorides exhibited fungicidal activity.

Russian Journal of General Chemistry published new progress about Fungicides. 622-86-6 belongs to class ethers-buliding-blocks, name is (2-Chloroethoxy)benzene, and the molecular formula is C8H9ClO, Safety of (2-Chloroethoxy)benzene.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem