Month: November 2022

Liao, Yang et al. published their research in Organic Letters in 2021 | CAS: 103-16-2

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Name: 4-Benzyloxyphenol

Intramolecular Oxidative Coupling between Unactivated Aliphatic C-H and Aryl C-H Bonds was written by Liao, Yang;Zhou, Yi;Zhang, Zhen;Fan, Junzhen;Liu, Feng;Shi, Zhangjie. And the article was included in Organic Letters in 2021.Name: 4-Benzyloxyphenol The following contents are mentioned in the article:

In this article, a Pd-catalyzed intramol. oxidative coupling between unactivated aliphatic and aryl C-H compounds ROCH2C(CH3)2CO2H (R = C6H5, 4-ClC6H4, 2-naphthyl, etc.) has been described. This chem. showed great potential to build up fused cyclic scaffolds I (R1 = H, Me, OMe; R2 = Me, Ph, F, etc.; R3 = H, Me; R4 = H, Me; R1R2 = R3R4 = -CH=CHCH=CH-) and 3-methyl-3,4-dihydro-2H-benzofuro[2,3-h]chromene-3-carboxylic acid from linear substrates through oxidative couplings. Privileged chromane and tetralin scaffolds were constructed from readily available linear starting materials in the absence of any organohalides and organometallic partners. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Name: 4-Benzyloxyphenol).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Name: 4-Benzyloxyphenol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Song, Peilu et al. published their research in Acta Pharmaceutica Sinica B in 2022 | CAS: 109-85-3

2-Methoxyethylamine (cas: 109-85-3) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Product Details of 109-85-3

Synthesis of selective PAK4 inhibitors for lung metastasis of lung cancer and melanoma cells was written by Song, Peilu;Zhao, Fan;Li, Dahong;Qu, Jiqiang;Yao, Miao;Su, Yuan;Wang, Hanxun;Zhou, Miaomiao;Wang, Yujie;Gao, Yinli;Li, Feng;Zhao, Dongmei;Zhang, Fengjiao;Rao, Yu;Xia, Mingyu;Li, Haitao;Wang, Jian;Cheng, Maosheng. And the article was included in Acta Pharmaceutica Sinica B in 2022.Product Details of 109-85-3 The following contents are mentioned in the article:

The p21 activated kinase 4 (PAK4) is serine/threonine protein kinase that is critical for cancer progression. Guided by X-ray crystallog. and structure-based optimization, we report a novel subseries of C-3-substituted 6-ethynyl-1H-indole derivatives that display high potential and specificity towards group II PAKs. Among these inhibitors, compound 55 exhibited excellent inhibitory activity and kinase selectivity, displayed superior anti-migratory and anti-invasive properties against the lung cancer cell line A549 and the melanoma cell line B16. Compound 55 exhibited potent in vivo antitumor metastatic efficacy, with over 80% and 90% inhibition of lung metastasis in A549 or B16-BL6 lung metastasis models, resp. Further mechanistic studies demonstrated that compound 55 mitigated TGF-β1-induced epithelial-mesenchymal transition (EMT). This study involved multiple reactions and reactants, such as 2-Methoxyethylamine (cas: 109-85-3Product Details of 109-85-3).

2-Methoxyethylamine (cas: 109-85-3) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Product Details of 109-85-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ambrosone, L. et al. published their research in Journal of Solution Chemistry in 1997 | CAS: 112-59-4

2-(2-(Hexyloxy)ethoxy)ethanol (cas: 112-59-4) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Synthetic Route of C10H22O3

A self-diffusion study of poly(ethylene-oxide) alkyl alcohols was written by Ambrosone, L.;Costantino, L.;D’Errico, G.;Vitagliano, V.. And the article was included in Journal of Solution Chemistry in 1997.Synthetic Route of C10H22O3 The following contents are mentioned in the article:

The self-diffusion coefficients of HDO and some surfactants in aqueous mixtures at different concentrations, below the critical micelle concentration, have been determined by means of the NMR, spin-echo pulsed field gradient method. The surfactant solutes chosen were ethylene glycol-pentyl alc., diethylene glycol-pentyl alc., ethylene glycol-hexyl alc., diethylene glycol-hexyl alc., triethylene glycol-hexyl alc., tetraethylene glycol-hexyl alc., pentaethylene glycol-hexyl alc. The interactions in solution are studied by analyzing the solute self-diffusion coefficients extrapolated to infinite dilution These values are compared with those of 1-alkanols. The slope of the self diffusion coefficients vs. the solute concentration are correlated with the microscopic friction coefficients A model for interpreting the exptl. data is suggested. This study involved multiple reactions and reactants, such as 2-(2-(Hexyloxy)ethoxy)ethanol (cas: 112-59-4Synthetic Route of C10H22O3).

2-(2-(Hexyloxy)ethoxy)ethanol (cas: 112-59-4) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Synthetic Route of C10H22O3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Hamaguchi, Kazuma et al. published their research in ACS Macro Letters in 2019 | CAS: 103-16-2

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Formula: C13H12O2

Nanostructured Virus Filtration Membranes Based on Two-Component Columnar Liquid Crystals was written by Hamaguchi, Kazuma;Kuo, Daniel;Liu, Miaomiao;Sakamoto, Takeshi;Yoshio, Masafumi;Katayama, Hiroyuki;Kato, Takashi. And the article was included in ACS Macro Letters in 2019.Formula: C13H12O2 The following contents are mentioned in the article:

Here we report columnar liquid-crystalline (LC) nanostructured membranes that highly remove viruses and show sufficient water permeation. These membranes were prepared by employing two-component liquid crystals that exhibit tetragonal columnar phases. The membranes exhibited virus rejection values of >99.99% (log10 reduction value (LRV) > 4) and water flux ranging from 19 to 61 L m-2 h-1 (operation pressure: 0.3 MPa). These membranes were fabricated by photopolymerization of a fan-shaped diol mol. and imidazolium ionic liquid mixture, followed by subsequent removal of the ionic liquid The rejection values and water flux depend on the fraction of ionic liquid These results show new design strategies of materials for the water treatment nanostructured membranes that remove pathogens and contaminants. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Formula: C13H12O2).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Formula: C13H12O2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Zhang, Yan et al. published their research in Chemistry – A European Journal in 2021 | CAS: 109-85-3

2-Methoxyethylamine (cas: 109-85-3) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Application of 109-85-3

Electrochemical C-H Amidation of Heteroarenes with N-Alkyl Sulfonamides in Aqueous Medium was written by Zhang, Yan;Lin, Zhipeng;Ackermann, Lutz. And the article was included in Chemistry – A European Journal in 2021.Application of 109-85-3 The following contents are mentioned in the article:

The construction of C-N bonds by free radical reactions represents a powerful synthetic approach for direct C-H amidations of arenes or heteroarenes. Developing efficient and more environmentally friendly synthetic methods for C-H amidation reactions remains highly desirable. Herein, metal-free electrochem. oxidative dehydrogenative C-H amidations of heteroarenes with N-alkylsulfonamides have been accomplished. The catalyst- and chem.-oxidant-free C-H amidation features an ample scope and employs electricity as the green and sole oxidant. A variety of heteroarenes, including indoles, pyrroles, benzofuran and benzothiophene, thereby underwent this C(sp2)-H nitrogenation. Cyclic voltammetry studies and control experiments provided evidence for nitrogen-centered radicals being directly generated under metal-free electrocatalysis. This study involved multiple reactions and reactants, such as 2-Methoxyethylamine (cas: 109-85-3Application of 109-85-3).

2-Methoxyethylamine (cas: 109-85-3) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Application of 109-85-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Chen, Yang et al. published their research in Synthesis in 2021 | CAS: 109-85-3

2-Methoxyethylamine (cas: 109-85-3) belongs to ethers. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Reference of 109-85-3

Proton-Mediated Practical Synthesis of McGeachin-Type Bisaminals was written by Chen, Yang;Wang, Tingting;Du, Hongguang;Xu, Jiaxi;Yang, Zhanhui. And the article was included in Synthesis in 2021.Reference of 109-85-3 The following contents are mentioned in the article:

A proton-mediated practical synthesis of McGeachin-type bisaminals I (R = R1 = H, Br, OMe; R2 = t-Bu, prop-2-en-1-yl, cyclohexyl, naphthalen-1-yl, furan-2-ylmethyl, etc.) from 2-(alkylamino)arenecarbaldehydes 2-(NHCH3)-5-RC6H3CHO and primary amines R2NH2 is achieved, with trifluoroacetic acid as the proton donor. The use of a proton, a smallest electrophilic activator, allows previously inviable ortho-substituted anilines and linear and branched aliphatic amines R2NH2 to be viable substrates for McGeachin bisaminal synthesis I. Overcoming the steric and electronic limitations provides a practical synthetic method. The applications in product derivation and pharmaceutical mol. modification are also demonstrated. This study involved multiple reactions and reactants, such as 2-Methoxyethylamine (cas: 109-85-3Reference of 109-85-3).

2-Methoxyethylamine (cas: 109-85-3) belongs to ethers. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Reference of 109-85-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Xie, Jizhao et al. published their research in Bioorganic & Medicinal Chemistry Letters in 2021 | CAS: 109-85-3

2-Methoxyethylamine (cas: 109-85-3) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Name: 2-Methoxyethylamine

Design, synthesis and anti-TNBC activity of Azeliragon triazole analogues was written by Xie, Jizhao;Xu, Huanji;Wu, Xinduo;Xie, Yunfeng;Lu, Xiuhong;Wang, Lisheng. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2021.Name: 2-Methoxyethylamine The following contents are mentioned in the article:

Triple-neg. breast cancer (TNBC) is the most aggressive subtype of breast cancer. Many studies have shown a significant increase in the marker signal of the receptor for advanced glycation end-products (RAGE) with the malignant progression of tumor growth, metastasis and recurrence of breast cancer, including TNBC of primary tumors and lymph node metastases. Azeliragon is a RAGE inhibitor and it has been shown to actively inhibit the TNBC cell line, SUM149 (IC50 = 5.292 ± 0.310 μM). In order to develop a new anti-TNBC agent, we designed, synthesized and screened 26 Azeliragon triazole analogs to determine their anti-TNBC activities in vitro. The most active compound was KC-10 (3-(4-(5-butyl-1-(4′-chloro-[1,1′-biphenyl]-4-yl)-1H-1,2,4-triazol-3-yl)phenoxy)-N, N-diethylpropan-1-amine) with an IC50 value of 0.220 ± 0.034 μM. This study involved multiple reactions and reactants, such as 2-Methoxyethylamine (cas: 109-85-3Name: 2-Methoxyethylamine).

2-Methoxyethylamine (cas: 109-85-3) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Name: 2-Methoxyethylamine

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Xiao, Pan et al. published their research in Journal of Organic Chemistry in 2019 | CAS: 103-16-2

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Reference of 103-16-2

Fluoroalkylation of Various Nucleophiles with Fluoroalkyl Sulfones through a Single Electron Transfer Process was written by Xiao, Pan;Ni, Chuanfa;Miao, Wenjun;Zhou, Min;Hu, Jingyu;Chen, Dingben;Hu, Jinbo. And the article was included in Journal of Organic Chemistry in 2019.Reference of 103-16-2 The following contents are mentioned in the article:

The fluoroalkylation of various nucleophilic reagents with (phenylsulfonyl)difluoromethyl (PhSO2CF2)-substituted phenanthridines was achieved to give fluorinated phenanthridine derivatives, which enables the construction of both carbon-heteroatom and carbon-carbon bonds via the substitution of the phenylsulfonyl group. Mechanistic studies indicated that these reactions proceed through a unimol. radical nucleophilic substitution (SRN1) mechanism. It is worthwhile noting that in the cases of O-nucleophiles (t-BuO– and PhO–), the addition of t-BuOK/PhCHO could significantly promote the reactions, due to the in situ formation of a highly reactive electron donor species through the interaction of t-BuOK, PhCHO, and the solvent DMF, which can effectively initiate the single electron transfer process. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Reference of 103-16-2).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Reference of 103-16-2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ocak, Hale et al. published their research in Journal of Molecular Structure in 2021 | CAS: 103-16-2

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Electric Literature of C13H12O2

Synthesis, mesomorphic and dielectric properties of new bent-core liquid crystal with a terminal lactate group was written by Ocak, Hale;Canli, Nimet Yilmaz;Bilgin Eran, Belkiz. And the article was included in Journal of Molecular Structure in 2021.Electric Literature of C13H12O2 The following contents are mentioned in the article:

The synthesis, liquid crystalline properties and dielec. properties of a new bent-core compound (DBOB) composed of terephthalate based rod-like units with a O-dodecyl lactate group substituted at one side as well as n-octyloxy located at other terminal are presented. The liquid crystalline properties have been investigated by polarizing optical microscopy, differential scanning calorimetry and electro-optical studies. The dielec. parameters and phase regions of DBOB, which exhibits an enantiotropic non-polar SmA phase between 156 and 100° as well as SmA phase with a ferroelec. polar response at lower temperatures than 100°, have been carried out by impedance spectroscopy at different temperatures The dielec. relaxation mechanisms have been analyzed by Cole-Cole plots. The Debye distribution parameters and activation energies have also been determined This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Electric Literature of C13H12O2).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Electric Literature of C13H12O2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ocak, Hale et al. published their research in Journal of Molecular Structure in 2021 | CAS: 103-16-2

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Computed Properties of C13H12O2

Synthesis, mesomorphic and dielectric properties of new bent-core liquid crystal with a terminal lactate group was written by Ocak, Hale;Canli, Nimet Yilmaz;Bilgin Eran, Belkiz. And the article was included in Journal of Molecular Structure in 2021.Computed Properties of C13H12O2 The following contents are mentioned in the article:

The synthesis, liquid crystalline properties and dielec. properties of a new bent-core compound (DBOB) composed of terephthalate based rod-like units with a O-dodecyl lactate group substituted at one side as well as n-octyloxy located at other terminal are presented. The liquid crystalline properties have been investigated by polarizing optical microscopy, differential scanning calorimetry and electro-optical studies. The dielec. parameters and phase regions of DBOB, which exhibits an enantiotropic non-polar SmA phase between 156 and 100° as well as SmA phase with a ferroelec. polar response at lower temperatures than 100°, have been carried out by impedance spectroscopy at different temperatures The dielec. relaxation mechanisms have been analyzed by Cole-Cole plots. The Debye distribution parameters and activation energies have also been determined This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Computed Properties of C13H12O2).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Computed Properties of C13H12O2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem