Month: November 2022

Surface structure and volatile characteristic of peanut proteins obtained through AOT reverse micelles was written by Zhao, Xiaoyan;Liu, Hongkai;Zhang, Xiaowei;Zhu, Haitao;Ao, Qiang. And the article was included in Colloids and Surfaces, B: Biointerfaces in 2019.Quality Control of 2-(2-(Hexyloxy)ethoxy)ethanol The following contents are mentioned in the article:

This study provided the investigation of the surface structure and volatile compounds of peanut proteins obtained through aqueous buffer (AB) and reverse micelles (RMs) by X-ray diffraction (XRD), SEM (SEM), XPS and gas chromatog.-mass spectrometry (GC-MS). The results showed that RMs could modify the amorphous structure of peanut proteins and change the original structure. Significant differences were between the C, O, and N content in two type protein surfaces (P < 0.05). The O/C ratio from AB was higher than from RMs, but the N/C ratio was lower. These changes suggested that RMs could modify the surface morphol. and composition of peanut proteins. Untargeted profiling of volatile compounds showed that the volatile compounds of peanut proteins obtained by AB and RMs were major differences. Such finding suggested that RMs could contribute to improve the flavor properties of peanut protein. This study involved multiple reactions and reactants, such as 2-(2-(Hexyloxy)ethoxy)ethanol (cas: 112-59-4Quality Control of 2-(2-(Hexyloxy)ethoxy)ethanol).

2-(2-(Hexyloxy)ethoxy)ethanol (cas: 112-59-4) belongs to ethers. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Quality Control of 2-(2-(Hexyloxy)ethoxy)ethanol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Bicyclic Diazepinones as Dual Ligands of the α2δ-1 Subunit of Voltage-Gated Calcium Channels and the Norepinephrine Transporter was written by Diaz, Jose Luis;Cuevas, Felix;Pazos, Gonzalo;Alvarez-Bercedo, Paula;Oliva, Ana I.;Sarmentero, M. Angeles;Font, Daniel;Jimenez-Aquino, Agustin;Moron, Maria;Port, Adriana;Pascual, Rosalia;Dordal, Albert;Portillo-Salido, Enrique;Reinoso, Raquel F.;Vela, Jose Miguel;Almansa, Carmen. And the article was included in Journal of Medicinal Chemistry in 2021.Application of 109-85-3 The following contents are mentioned in the article:

The synthesis and pharmacol. activity of a new series of bicyclic diazepinones with dual activity toward the α2δ-1 subunit of voltage-gated calcium channels (Ca_vα2δ-1) and the norepinephrine transporter (NET) are reported. Exploration of the positions amenable for substitution on a nonaminoacidic Ca_vα2δ-1 scaffold allowed the identification of favorable positions for the attachment of NET pharmacophores. Among the patterns explored, attachment of the 2-ethylamino-9-methyl-6-phenyl-6,7,8,9-tetrahydro-5H-pyrimido[4,5-e][1,4]diazepin-5-one framework to the meta-position of the Ph ring of the 3-methylamino-1-phenylpropoxy and 3-methylamino-1-thienylpropoxy moieties provided dual compounds with excellent NET functionality. Alternative bicyclic frameworks were also explored, and some lead mols. were identified, which showed a balanced dual profile and exhibited good ADMET properties. This study involved multiple reactions and reactants, such as 2-Methoxyethylamine (cas: 109-85-3Application of 109-85-3).

2-Methoxyethylamine (cas: 109-85-3) belongs to ethers. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Application of 109-85-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

C-H Activation by Amide Chelation Control: Ruthenium-Catalyzed Direct Synthesis of 2-Aryl-3-furanamides was written by Zhao, Yigang;Snieckus, Victor. And the article was included in Advanced Synthesis & Catalysis in 2014.Application In Synthesis of 2-(3-Methoxyphenyl)-5,5-dimethyl-1,3,2-dioxaborinane The following contents are mentioned in the article:

A new, catalytic methodol. for the synthesis of heterobiaryls by the ruthenium-catalyzed C-H activation/cross-coupling of heterocyclic amides with 2-aryl-1,3,2-dioxaborinanes is surveyed. From this survey, the highly regioselective reaction of furan-3-carboxamide to give 2-aryl-3-furanamides is optimized and generalized in scope with respect to the 2-aryl-1,3,2-dioxaborinane partners. E.g., in presence of RuH₂(CO)(PPh₃)₃ in toluene, reaction of N,N-diethylfuran-3-carboxamide with 2-aryl-1,3,2-dioxaborinane derivative (I) gave 92% heterobiaryl (II). Established thereby is a one-step synthetic method which may supercede the broadly applied two-step directed ortho metalation (DoM)-cross coupling reaction involving cryogenic and strong base conditions and which has potential for further ortho and remote metalation chem. This study involved multiple reactions and reactants, such as 2-(3-Methoxyphenyl)-5,5-dimethyl-1,3,2-dioxaborinane (cas: 1003858-50-1Application In Synthesis of 2-(3-Methoxyphenyl)-5,5-dimethyl-1,3,2-dioxaborinane).

2-(3-Methoxyphenyl)-5,5-dimethyl-1,3,2-dioxaborinane (cas: 1003858-50-1) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Application In Synthesis of 2-(3-Methoxyphenyl)-5,5-dimethyl-1,3,2-dioxaborinane

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Comparative study of the fast pyrolysis behavior of ginkgo, poplar, and wheat straw lignin at different temperatures was written by Wang, Lei;Zhang, Ran;Li, Jian;Guo, Li;Yang, Haiping;Ma, Fuying;Yu, Hongbo. And the article was included in Industrial Crops and Products in 2018.SDS of cas: 2380-78-1 The following contents are mentioned in the article:

Fast pyrolysis of milled wood lignin (MWL) isolated from ginkgo (soft wood), wheat straw (herbaceous biomass), and poplar (hardwood) were conducted at various temperatures (400/600/800 °C) and the liquid products were analyzed by GC-MS. Then all MWLs were fully characterized using GPC, TGA, FT-IR, 2D NMR, and elemental analyzes. Ginkgo MWL showed higher selectivity toward guaiacols (92.38%) at low temperature (400 °C), especially a higher selectivity for five useful compounds (67.7%), namely creosol (10.24%), 2-methoxy-4-vinylphenol (17.83%), vanillin (15.65%), isoeugenol (14.84%), and apocynin (9.14%), as compared to MWLs from wheat straw or poplar. Overall, ginkgo lignin exhibits vast potential for volatilization at low temperature-selective pyrolysis, because it retains highly concentrated guaiacol-type structures which are easy to deconstruct and a few β-5′ phenylcoumarans that are hard to crack. This study involved multiple reactions and reactants, such as 4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1SDS of cas: 2380-78-1).

4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.SDS of cas: 2380-78-1

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthesis of new substituted (2H-chromen-2-one)-phenol derivatives: An approach to molecular docking and antimicrobial assession was written by Mangasuli, Sumitra N.;Managutti, Praveen B.;Hosamani, Kallappa M.;Joshi, Shrinivas D.. And the article was included in Chemical Data Collections in 2020.Quality Control of 4-Benzyloxyphenol The following contents are mentioned in the article:

A number of new substituted (2H-chromen-2-one)-phenol derivatives I [R = Me, Cl, Br, etc.] were synthesized by Williamson ether reaction follows an S_N² bimol. nucleophilic substitution mechanism. The titled compounds I was characterized by IR, ¹H NMR, ¹³C NMR and Mass spectral studies. As predicted, the derivatization of benzyloxy phenol with coumarin via ether linkage enhanced the activity of the titled compounds I against four bacterial and four fungal strains. Compound I [R = 1-naphthyloxy] showed significant strong anti-microbial broad spectrum activity against all tested bacterial and fungal strains. Anti-bacterial assay against standard coupled with in-silico mol. docking studies indicated that I [R = 1-naphthyloxy] showed promising activity with higher C-score values. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Quality Control of 4-Benzyloxyphenol).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Quality Control of 4-Benzyloxyphenol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthesis of new substituted (2H-chromen-2-one)-phenol derivatives: An approach to molecular docking and antimicrobial assession was written by Mangasuli, Sumitra N.;Managutti, Praveen B.;Hosamani, Kallappa M.;Joshi, Shrinivas D.. And the article was included in Chemical Data Collections in 2020.Application of 103-16-2 The following contents are mentioned in the article:

A number of new substituted (2H-chromen-2-one)-phenol derivatives I [R = Me, Cl, Br, etc.] were synthesized by Williamson ether reaction follows an S_N² bimol. nucleophilic substitution mechanism. The titled compounds I was characterized by IR, ¹H NMR, ¹³C NMR and Mass spectral studies. As predicted, the derivatization of benzyloxy phenol with coumarin via ether linkage enhanced the activity of the titled compounds I against four bacterial and four fungal strains. Compound I [R = 1-naphthyloxy] showed significant strong anti-microbial broad spectrum activity against all tested bacterial and fungal strains. Anti-bacterial assay against standard coupled with in-silico mol. docking studies indicated that I [R = 1-naphthyloxy] showed promising activity with higher C-score values. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Application of 103-16-2).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Application of 103-16-2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthesis, Neurotropic Activity, and Molecular Docking of New Condensed Thieno[2,3-b]pyridine Derivatives was written by Dabaeva, V. V.;Baghdasaryan, M. R.;Paronikyan, R. G.;Nazaryan, I. M.;Hakobyan, H. G.;Hunanyan, L. S.;Paronikyan, E. G.;Dashyan, Sh. Sh.. And the article was included in Russian Journal of Bioorganic Chemistry in 2022.Application In Synthesis of 2-Methoxyethylamine The following contents are mentioned in the article:

Methods for the preparation of new condensed derivatives of pyrido[3′,2′:4,5]thieno[3,2-d]pyrimidines based on 5,6-dimethyl-2-oxo-1,2-dihydropyridine-3-carbonitrile were developed. Substitution reactions in the 3rd and 4th positions of 7,8-dimethylpyrido[3′,2′:4,5]thieno[3,2-d]pyrimidin-4(3H)-one were conducted. The neurotropic activity of 12 obtained compounds was studied in vivo in rats and mice. Eight compounds were found to have an anticonvulsant effect of antagonism with corazole. Four selected compounds had anxiolytic and behavior activating effects. Mol. docking of the synthesized compounds was performed to predict their interaction with the GABAA receptor. Five compounds were identified, the complexation of which with the GABAA receptor occurs in two places: the benzamidine site of subsite 1 and subsite 3 of the ECD interface, which indicates the inhibitory effect of the compounds on the target. This study involved multiple reactions and reactants, such as 2-Methoxyethylamine (cas: 109-85-3Application In Synthesis of 2-Methoxyethylamine).

2-Methoxyethylamine (cas: 109-85-3) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Application In Synthesis of 2-Methoxyethylamine

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Gold-Catalyzed Oxidative Biaryl Cross-Coupling of Organometallics was written by Liu, Kai;Li, Nian;Ning, Yunyun;Zhu, Chengjian;Xie, Jin. And the article was included in Chem in 2019.Application In Synthesis of 2-(3-Methoxyphenyl)-5,5-dimethyl-1,3,2-dioxaborinane The following contents are mentioned in the article:

A general dimeric gold-catalyzed oxidative cross-coupling of arylboronates ArB(-OCH₂C(CH₃)₂CH₂O-) (Ar = 3-methoxyphenyl, naphthalen-2-yl, 8-thiatricyclo[7.4.0.0(2,7)]trideca-1(13),2(7),3,5,9,11-hexaen-6-yl, etc.) and arylsilanes Ar¹Si(CH₃)₃ (Ar¹ = 4-iodophenyl, 4-(trifluoromethanesulfonyloxy)phenyl, 2,3-dimethylphenyl, etc.) without an external base for the synthesis, with excellent functional-group tolerance of asym. biaryls ArAr¹ was reported. Both coupling partners are readily available, bench-stable, and non-toxic. A broad array of (pseudo)halogenated and borylated coupling partners can be successfully applied to this site-specific biaryl coupling with unprecedented versatility. Its synthetic value has been substantiated by concise preparation of several π-conjugated organic materials and pharmacophores. This study involved multiple reactions and reactants, such as 2-(3-Methoxyphenyl)-5,5-dimethyl-1,3,2-dioxaborinane (cas: 1003858-50-1Application In Synthesis of 2-(3-Methoxyphenyl)-5,5-dimethyl-1,3,2-dioxaborinane).

2-(3-Methoxyphenyl)-5,5-dimethyl-1,3,2-dioxaborinane (cas: 1003858-50-1) belongs to ethers. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Application In Synthesis of 2-(3-Methoxyphenyl)-5,5-dimethyl-1,3,2-dioxaborinane

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Cobalt-Catalyzed C(sp²)-C(sp³) Suzuki-Miyaura Cross-Coupling Enabled by Well-Defined Precatalysts with L,X-Type Ligands was written by Mills, L. Reginald;Gygi, David;Ludwig, Jacob R.;Simmons, Eric M.;Wisniewski, Steven R.;Kim, Junho;Chirik, Paul J.. And the article was included in ACS Catalysis in 2022.Category: ethers-buliding-blocks The following contents are mentioned in the article:

Cobalt(II) halides in combination with phenoxyimine (FI) ligands generated efficient precatalysts in situ for the C(sp²)-C(sp³) Suzuki-Miyaura cross-coupling between alkyl bromides and neopentylglycol (hetero)arylboronic esters. The protocol enabled efficient C-C bond formation with a host of nucleophiles and electrophiles (36 examples, 34-95%) with precatalyst loadings of 5 mol %. Studies with alkyl halide electrophiles that function as radical clocks support the intermediacy of alkyl radicals during the course of the catalytic reaction. The improved performance of the FI-cobalt catalyst was correlated with decreased lifetimes of cage-escaped radicals as compared to those of diamine-type ligands. Studies of the phenoxy(imine)-cobalt coordination chem. validate the L,X interaction leading to the discovery of an optimal, well-defined, air-stable mono-FI-cobalt(II) precatalyst structure. This study involved multiple reactions and reactants, such as 2-(3-Methoxyphenyl)-5,5-dimethyl-1,3,2-dioxaborinane (cas: 1003858-50-1Category: ethers-buliding-blocks).

2-(3-Methoxyphenyl)-5,5-dimethyl-1,3,2-dioxaborinane (cas: 1003858-50-1) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Category: ethers-buliding-blocks

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Tert-Butyl Hydroperoxide Promoted the Reaction of Quinazoline-3-oxides with Primary Amines Affording Quinazolin-4(3H)-ones was written by Luo, Jin;Wan, Juelin;Wu, Lianlian;Yang, Lingyun;Wang, Tao. And the article was included in Journal of Organic Chemistry in 2022.Name: 2-Methoxyethylamine The following contents are mentioned in the article:

An efficient and facile approach for the synthesis of quinazolin-4(3H)-ones I [R¹ = C₆H₅, 2-MeC₆H₄, 4-MeC₆H₄, 2-furyl, n-Pr, etc., R² = R³ = H; R¹ = Ph, R² = H, 7-OMe, 6,7-(OMe)₂, 6-F, etc., R³ = H, Me] via the reaction of quinazoline-3-oxides II with primary amines R¹CH₂Ph is described. This approach was demonstrated to be applicable for a broad range of substrates and proceeds efficiently under metal-free and mild reaction conditions employing easily available tert-Bu hydroperoxide as the oxidant. Remarkably, I [R¹ = 1H-indol-3-ylmethyl], which was conveniently obtained by this process in 70% yield, was an excellent precursor for the synthesis of bioactive evodiamine and rutaecarpine. This study involved multiple reactions and reactants, such as 2-Methoxyethylamine (cas: 109-85-3Name: 2-Methoxyethylamine).

2-Methoxyethylamine (cas: 109-85-3) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Name: 2-Methoxyethylamine

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem