Month: November 2022

Densities, excess molar volumes, speeds of sound, and isothermal compressibilities for 2-(2-hexyloxyethoxy)ethanol + n-alkylamine at temperatures between 288.15 K and 308.15 K was written by Pal, Amalendu;Gaba, Rekha;Sharma, Sanjay. And the article was included in Journal of Chemical & Engineering Data in 2008.Electric Literature of C10H22O3 The following contents are mentioned in the article:

The densities, ρ, and the speeds of sound, u, for binary liquid mixtures containing 2-(2-hexyloxyethoxy)ethanol (C₆E₂) and n-butylamine (BA), dibutylamine (DBA), and tributylamine (TBA) have been measured as a function of composition using a vibrating tube densimeter and sound analyzer Anton-Paar model DSA-5000 at temperatures (288.15, 293.15, 298.15, 303.15, and 308.15) K and atm. pressure. The ρ and u values were used to calculate excess molar volumes, V^E_m, and excess molar isentropic compressibility, K^E_S,m, resp. The V^E_m and K^E_S,m values are shown to be neg. for all the mixtures over the entire composition range. Both V^E_m and K^E_S,m become more neg. for all the mixtures with the rise of temperature The change of V^E_m and K^E_S,m with composition and temperature are discussed with a view to understand mol. interactions present in alkoxyethanol-alkylamine mixtures This study involved multiple reactions and reactants, such as 2-(2-(Hexyloxy)ethoxy)ethanol (cas: 112-59-4Electric Literature of C10H22O3).

2-(2-(Hexyloxy)ethoxy)ethanol (cas: 112-59-4) belongs to ethers. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Electric Literature of C10H22O3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Efficient asymmetric biomimetic aldol reaction of glycinates and trifluoromethyl ketones by carbonyl catalysis was written by Cheng, Aolin;Zhang, Liangliang;Zhou, Qinghai;Liu, Tao;Cao, Jing;Zhao, Guoqing;Zhang, Kun;Song, Guanshui;Zhao, Baoguo. And the article was included in Angewandte Chemie, International Edition in 2021.Related Products of 109-85-3 The following contents are mentioned in the article:

The direct asym. aldol reaction of glycinates represents an intriguing and straightforward strategy to make biol. significant chiral β-hydroxy-α-amino-acid derivatives But it is not easy to realize the transformation due to the disruption of the reactive NH₂ group of glycinates. Inspired by the enzymic aldol reaction of glycine, we successfully developed an asym. aldol reaction of glycinate, NH₂-CH₂ CO-O-tert-Bu, and trifluoromethyl ketones with 0.1-0.0033 mol % of chiral N-Me pyridoxal (I) as the catalyst, producing chiral β-trifluoromethyl-β-hydroxy-α-amino-acid esters 6 in 55-82% yields (for the syn-diastereomers) with up to >20:1 dr and 99% ee under very mild conditions. The reaction proceeds via a catalytic cycle similar to the enzymic aldol reaction of glycine. Pyridoxal catalyst I activates both reactants at the same time and brings them together in a specific spatial orientation, accounting for the high efficiency as well as excellent diastereo- and enantioselectivities. This study involved multiple reactions and reactants, such as 2-Methoxyethylamine (cas: 109-85-3Related Products of 109-85-3).

2-Methoxyethylamine (cas: 109-85-3) belongs to ethers. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Related Products of 109-85-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Catalytic valorization of lignin to liquid fuels over solid acid catalyst assisted by microwave heating was written by Zhou, Minghao;Sharma, Brajendra K.;Li, Jing;Zhao, Jiaping;Xu, Junming;Jiang, Jianchun. And the article was included in Fuel in 2019.Computed Properties of C9H12O3 The following contents are mentioned in the article:

In this study, three types of lignin feedstocks were introduced into the microwave assisted depolymerization process over solid acid catalysts. The effects of lignin structures, solvents and catalysts were investigated to improve bio-oil yields and properties. A common phenomenon was observed that the highest bio-oil yields were all obtained in methanol under optimal conditions with microwave heating. The highest bio-oil yield from alk. lignin, dealkaline lignin and lignosulfonate was 57.4%, 82.9% and 70.9% resp., all obtained in methanol. The promotional effect of methanol over HSZ-640 (or HSZ-660) in the depolymerization process was confirmed due to the higher polarity of methanol, and higher acidity of catalysts. The promotional effect on the elemental composition and HHV of bio-oil was observed, finding that HSZ-640 (or HSZ-660) exhibited to be effective to convert lignin to liquid fuels with higher HHV, and the HHV of obtained bio-oil increased to about 28-32 MJ/kg, confirming that hydrogenation/hydrodeoxygenation took place during the depolymerization This study involved multiple reactions and reactants, such as 4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1Computed Properties of C9H12O3).

4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Computed Properties of C9H12O3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Modulating Aβ aggregation by tyrosol-based ligands: The crucial role of the catechol moiety was written by Romanucci, Valeria;Garcia-Vinuales, Sara;Tempra, Carmelo;Bernini, Roberta;Zarrelli, Armando;Lolicato, Fabio;Milardi, Danilo;Di Fabio, Giovanni. And the article was included in Biophysical Chemistry in 2020.Safety of 4-Hydroxy-3-methoxyphenethanol The following contents are mentioned in the article:

The abnormal deposition of Aβ amyloid deposits in the brain is a hallmark of Alzheimer’s disease (AD). Based on this evidence, many current therapeutic approaches focus on the development of small mols. halting Aβ aggregation. However, due to the temporary and elusive structures of amyloid assemblies, the rational design of aggregation inhibitors remains a challenging task. Here we combine ThT assays and MD simulations to study Aβ aggregation in the presence of the natural compounds tyrosol (TY), 3-hydroxytyrosol (HDT), and 3-methoxytyrosol (homovanillyl alc. HVA). We show that albeit HDT is a potent inhibitor of amyloid growth, TY and HVA catalyze fibril formation. An inspection of MD simulations trajectories revealed that the different effects of these three mols. on Aβ_1-40 aggregation are ascribable to their capacity to arrange H-bonds network between the ligand (position C-3) and the peptide (Glu22). We believe that our results may contribute to the design of more effective and safe small mols. able to contrast pathogenic amyloid aggregation. This study involved multiple reactions and reactants, such as 4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1Safety of 4-Hydroxy-3-methoxyphenethanol).

4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Safety of 4-Hydroxy-3-methoxyphenethanol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Solid-phase synthesis of curcumin mimics and their anticancer activity against human pancreatic, prostate, and colorectal cancer cell lines was written by Romanucci, Valeria;Giordano, Maddalena;Pagano, Rita;Agarwal, Chapla;Agarwal, Rajesh;Zarrelli, Armando;Di Fabio, Giovanni. And the article was included in Bioorganic & Medicinal Chemistry in 2021.Quality Control of 4-Hydroxy-3-methoxyphenethanol The following contents are mentioned in the article:

Curcumin is a bioactive natural compound with a wide range of pharmacol. properties, including antitumor activity; however, its clin. application has been limited because of its low solubility, stability, and bioavailability. In this study, a solid phase approach was proposed for the combinatorial synthesis of a mini library of the mimics of curcumin in good purity and yield. The non-effective findings in pancreatic cancer cells switched to strong growth inhibition and cell death efficacy for PC3 prostate cancer cells, and mimic 9, in which tyrosol (TYR) and homovanillyl alc. (HVA) units were linked by a phosphodiester bond, was quite effective not only in cell growth inhibition but also in causing strong cell death under the study conditions and treatments that were not effective in PANC1 cells. The results got more exciting when we also consider the findings in SW480 human colorectal carcinoma cell line, where the growth inhibitor effects were more in line with that of the PC3 cells, but the lack of cell death effect was more in line with the PANC1 cells. This study involved multiple reactions and reactants, such as 4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1Quality Control of 4-Hydroxy-3-methoxyphenethanol).

4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Quality Control of 4-Hydroxy-3-methoxyphenethanol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Discovery of 4-Arylindolines Containing a Thiazole Moiety as Potential Antitumor Agents Inhibiting the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Interaction was written by Qin, Mingze;Meng, Yangyang;Yang, Haoshen;Liu, Lei;Zhang, Haotian;Wang, Simeng;Liu, Chunyang;Wu, Xia;Wu, Di;Tian, Ye;Hou, Yunlei;Zhao, Yanfang;Liu, Yajing;Xu, Congjun;Wang, Lihui. And the article was included in Journal of Medicinal Chemistry in 2021.Reference of 109-85-3 The following contents are mentioned in the article:

Through specific structural modification of a 4-phenylindoline precursor, new 4-arylindolines containing a thiazole moiety were developed and found to be promising modulators of the programmed cell death-1 (PD-1)/programmed cell death-ligand 1 (PD-L1) axis. Compound A30(I) exhibited outstanding biochem. activity, with an IC₅₀ of 11.2 nM in a homogeneous time-resolved fluorescence assay. In the cell-based assay, A30 significantly promoted IFN-γ secretion and rescued T-cell proliferation, which were inhibited by PD-1 activation. Furthermore, A30 showed favorable in vivo antitumor activity in a mouse 4T1 breast carcinoma model. Moreover, in mouse CT26 colon carcinoma models, A30 potently suppressed the growth of CT26/PD-L1 tumor but did not obviously affect the growth of CT26/vector tumor. The results of flow cytometry anal. indicated that A30 inhibited tumor growth by activating the immune microenvironment. We concluded that A30 is a new starting point for further development of PD-1/PD-L1 interaction inhibitors as antitumor agents. This study involved multiple reactions and reactants, such as 2-Methoxyethylamine (cas: 109-85-3Reference of 109-85-3).

2-Methoxyethylamine (cas: 109-85-3) belongs to ethers. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Reference of 109-85-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Effect of Solvent, Role of Formic Acid and Rh/C Catalyst for the Efficient Liquefaction of Lignin was written by Matsagar, Babasaheb M.;Wang, Zheng-Yen;Sakdaronnarong, Chularat;Chen, Season S.;Tsang, Daniel C. W.;Wu, Kevin C.-W.. And the article was included in ChemCatChem in 2019.Application of 2380-78-1 The following contents are mentioned in the article:

We demonstrate highly efficient liquefaction of alkali lignin with a very high yield of THF-soluble bio-oil (91.5 wt %) using formic acid (FA) and Rh/C catalyst under relatively mild reaction conditions (250 °C, 6 h) in EtOH-H₂O co-solvent system. The monomeric products are identified in which alkyl guaiacols accounts for the main proportion. The role of FA was not only used as a liquid-phase in-situ hydrogen source but also acts as organic acid which can catalyze the hydrolysis reaction of -C-O-C ether bonds of lignin. Moreover, in the present study, the role of Rh/C and FA is demonstrated for the liquefaction of lignin. The replacement of pure H₂ gas by the liquid-phase FA (hydrogen source) can effectively prevent the char formation. The utilization of Rh/C catalyst helps for the conversion of alkenyl guaiacols to alkyl guaiacols suggesting the hydrogenation of phenolic monomers and further cleavage by hydrogenation results in the formation of bio-oil with lower mol. weight (Mn=466 g mol^-1) as well as lower O/C ratio (0.26). This study involved multiple reactions and reactants, such as 4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1Application of 2380-78-1).

4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1) belongs to ethers. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Application of 2380-78-1

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Inhibiting a dynamic viral protease by targeting a non-catalytic cysteine was written by Hulce, Kaitlin R.;Jaishankar, Priyadarshini;Lee, Gregory M.;Bohn, Markus-Frederik;Connelly, Emily J.;Wucherer, Kristin;Ongpipattanakul, Chayanid;Volk, Regan F.;Chuo, Shih-Wei;Arkin, Michelle R.;Renslo, Adam R.;Craik, Charles S.. And the article was included in Cell Chemical Biology in 2022.Recommanded Product: 2-Methoxyethylamine The following contents are mentioned in the article:

Viruses are responsible for some of the most deadly human diseases, yet available vaccines and antivirals address only a fraction of the potential viral human pathogens. Here, we provide a methodol. for managing human herpesvirus (HHV) infection by covalently inactivating the HHV maturational protease via a conserved, non-catalytic cysteine (C161). Using human cytomegalovirus protease (HCMV Pr) as a model, we screened a library of disulfides to identify mols. that tether to C161 and inhibit proteolysis, then elaborated hits into irreversible HCMV Pr inhibitors that exhibit broad-spectrum inhibition of other HHV Pr homologs. We further developed an optimized tool compound targeted toward HCMV Pr and used an integrative structural biol. and biochem. approach to demonstrate inhibitor stabilization of HCMV Pr homodimerization, exploiting a conformational equilibrium to block proteolysis. Irreversible HCMV Pr inhibition disrupts HCMV infectivity in cells, providing proof of principle for targeting proteolysis via a non-catalytic cysteine to manage viral infection. This study involved multiple reactions and reactants, such as 2-Methoxyethylamine (cas: 109-85-3Recommanded Product: 2-Methoxyethylamine).

2-Methoxyethylamine (cas: 109-85-3) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Recommanded Product: 2-Methoxyethylamine

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Pyrazole Agonist of the Apelin Receptor Improves Symptoms of Metabolic Syndrome in Mice was written by Narayanan, Sanju;Wang, Shaobin;Vasukuttan, Vineetha;Vyas Devambatla, Ravi Kumar;Dai, Donghua;Jin, Chunyang;Snyder, Rodney;Laudermilk, Lucas;Runyon, Scott P.;Maitra, Rangan. And the article was included in Journal of Medicinal Chemistry in 2021.Recommanded Product: 2-Methoxyethylamine The following contents are mentioned in the article:

Apelin receptor agonism improves symptoms of metabolic syndrome. However, endogenous apelin peptides have short half-lives, making their utility as potential drugs limited. Previously, we had identified a novel pyrazole-based agonist scaffold. Systematic modification of this scaffold was performed to produce compounds with improved ADME properties. Compound 13 (I) with favorable agonist potency (cAMPi EC₅₀ = 162 nM), human liver microsome stability (T_1/2 = 62 min), and pharmacokinetic profile in rodents was identified. The compound was tested in a mouse model of diet-induced obesity (DIO) and metabolic syndrome for efficacy. Treatment with 13 led to significant weight loss, hypophagia, improved glucose utilization, reduced liver steatosis, and improvement of disease-associated biomarkers. In conclusion, a small-mol. agonist of the apelin receptor has been identified that is suitable for in vivo investigation of the apelinergic system in DIO and perhaps other diseases where this receptor has been implicated to play a role. This study involved multiple reactions and reactants, such as 2-Methoxyethylamine (cas: 109-85-3Recommanded Product: 2-Methoxyethylamine).

2-Methoxyethylamine (cas: 109-85-3) belongs to ethers. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Recommanded Product: 2-Methoxyethylamine

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Electrophilic Sulfur Reagent Design Enables Directed syn-Carbosulfenylation of Unactivated Alkenes was written by Li, Zi-Qi;Cao, Yilin;Kang, Taeho;Engle, Keary M.. And the article was included in Journal of the American Chemical Society in 2022.COA of Formula: C12H17BO3 The following contents are mentioned in the article:

A multi-component approach to structurally complex organosulfur products was described via the nickel-catalyzed 1,2-carbosulfenylation of unactivated alkenes with organoboron nucleophiles and tailored organosulfur electrophiles. The key to the development of this transformation was the identification of a modular N-alkyl-N-(arylsulfenyl)arenesulfonamide family of sulfur electrophiles. Tuning the electronic and steric properties of the leaving group in these reagents controls pathway selectivity, favoring three-component coupling and suppressing side reactions, as examined via computational studies. The unique syn-stereoselectivity differed from traditional electrophilic sulfenyl transfer processes involving a thiiranium ion intermediate and arose from the directed arylnickel(I) migratory insertion mechanism, as elucidated through reaction kinetics and control experiments Reactivity and regioselectivity are facilitated by a collection of monodentate, weakly coordinating native directing groups, including sulfonamides, alcs., amines, amides, and azaheterocycles. This study involved multiple reactions and reactants, such as 2-(3-Methoxyphenyl)-5,5-dimethyl-1,3,2-dioxaborinane (cas: 1003858-50-1COA of Formula: C12H17BO3).

2-(3-Methoxyphenyl)-5,5-dimethyl-1,3,2-dioxaborinane (cas: 1003858-50-1) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.COA of Formula: C12H17BO3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem