Month: November 2022

Synthesis and biological evaluation of novel SIPI-7623 derivatives as farnesoid X receptor (FXR) antagonists was written by Nian, Si-Yun;Wang, Guo-Ping;Jiang, Zheng-Li;Xiao, Ying;Huang, Mo-Han;Zhou, Yi-Huan;Tan, Xiang-Duan. And the article was included in Molecular Diversity in 2019.Related Products of 103-16-2 The following contents are mentioned in the article:

Most of reported steroidal FXR antagonists are restricted due to low potency. We described the design and synthesis of novel nonsteroidal scaffold SIPI-7623 derivatives as FXR antagonists. The most potent compound A-11 (IC₅₀ = 7.8 ± 1.1 μM) showed better activity compared to SIPI-7623 (IC₅₀ = 40.8 ± 1.7 μM) and guggulsterone (IC₅₀ = 45.9 ± 1.1 μM). Docking of A-11 in FXR′s ligand-binding domain was also studied. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Related Products of 103-16-2).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Related Products of 103-16-2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Power Law Expressions for Predicting Lower and Upper Flammability Limit Temperatures was written by Mathieu, Didier. And the article was included in Industrial & Engineering Chemistry Research in 2013.COA of Formula: C10H22O3 The following contents are mentioned in the article:

By analogy with recent models for flash point, the lower and upper flammability limit temperatures of organic compounds are represented as power law expressions in terms of fragment contributions. The predictive value of the resulting models compares well with recently published methods. A major advantage of the present approach is the fact it provides better insight into the relations between flammability limit temperatures and mol. structure. This study involved multiple reactions and reactants, such as 2-(2-(Hexyloxy)ethoxy)ethanol (cas: 112-59-4COA of Formula: C10H22O3).

2-(2-(Hexyloxy)ethoxy)ethanol (cas: 112-59-4) belongs to ethers. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.COA of Formula: C10H22O3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Exploring the regioselectivity of the cyanoalkylation of 3-aza-1,5-dienes: photoinduced synthesis of 3-cyanoalkyl-4-pyrrolin-2-ones was written by He, Jia-Qin;Yang, Zhi-Xian;Zhou, Xue-Lu;Li, Yanni;Gao, Shulin;Shi, Lou;Liang, Deqiang. And the article was included in Organic Chemistry Frontiers in 2022.COA of Formula: C3H9NO The following contents are mentioned in the article:

A visible-light-induced regioselective cyanoalkylalkenylation of 1,5-dienes with oxime esters as the alkyl radical precursors was reported. Such a radical cascade proceeds with high yields and a broad substrate scope under mild conditions to provide 3-cyanoalkyl-4-pyrrolin-2-ones in one step from readily available N-vinylacrylamides. It was readily scalable to the gram scale, and could be induced by natural sunlight as a sustainable light source. This study involved multiple reactions and reactants, such as 2-Methoxyethylamine (cas: 109-85-3COA of Formula: C3H9NO).

2-Methoxyethylamine (cas: 109-85-3) belongs to ethers. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.COA of Formula: C3H9NO

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Novel Pd-N-heterocyclic carbene complexes: design, synthesis and application in Buchwald-Hartwig cross coupling reaction was written by Wang, Fan;Hu, Yucai;Shen, An;Cao, Yucai. And the article was included in Youji Huaxue in 2017.Reference of 562085-85-2 The following contents are mentioned in the article:

N-Heterocyclic carbene (NHC) palladium complexes with different imine ligands had been developed and applied in Buchwald-Hartwig cross coupling reaction. The structure of imine ligand would influence the catalytic activity apparently. Especially, the imine ligand with electron withdrawing group performed best. Low to 0.5 mol% catalyst loading could realize effective Buchwald-Hartwig cross coupling reaction between various aryl chlorides and amines. This study involved multiple reactions and reactants, such as N-(4-Methoxyphenyl)pyridin-3-amine (cas: 562085-85-2Reference of 562085-85-2).

N-(4-Methoxyphenyl)pyridin-3-amine (cas: 562085-85-2) belongs to ethers. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Reference of 562085-85-2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthesis of 3-Amino-5-fluoroalkylfurans by Intramolecular Cyclization was written by Placais, Clotilde;Donnard, Morgan;Panossian, Armen;Vors, Jean-Pierre;Bernier, David;Pazenok, Sergii;Leroux, Frederic R.. And the article was included in Organic Letters in 2021.Recommanded Product: 109-85-3 The following contents are mentioned in the article:

A synthesis to access rarely described 3-amino-5-fluoroalkylfurans has been developed by cyclization of easily accessible fluorovinamides. This method is rapid and simple and affords the desired furans as hydrochloride salts in quant. or nearly quant. yields. It is compatible with four different fluorinated groups (-CF₃, -CF₂CF₃, -CHF₂, and -CF₂Cl) and a wide range of substituents on the amine. This study involved multiple reactions and reactants, such as 2-Methoxyethylamine (cas: 109-85-3Recommanded Product: 109-85-3).

2-Methoxyethylamine (cas: 109-85-3) belongs to ethers. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Recommanded Product: 109-85-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Photoinduced hydroxylation of arylboronic acids with molecular oxygen under photocatalyst-free conditions was written by Xu, Yu-Ting;Li, Chen-Yuan;Huang, Xiao-Bo;Gao, Wen-Xia;Zhou, Yun-Bing;Liu, Miao-Chang;Wu, Hua-Yue. And the article was included in Green Chemistry in 2019.Application of 103-16-2 The following contents are mentioned in the article:

Photoinduced hydroxylation of boronic acids RB(OH)₂ (R = octyl, 1-naphthyl, thianthren-1-yl, benzo[d][1,3]dioxol-5-yl, 9-phenyl-9H-carbazol-2-yl, etc.) with mol. oxygen under photocatalyst-free conditions is reported, providing a green entry to a variety of phenols and aliphatic alcs. ROH in a highly concise fashion. This new protocol features photocatalyst-free conditions, wide substrate scope and excellent functional group compatibility. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Application of 103-16-2).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Application of 103-16-2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Heat capacity of aqueous 2-(2-hexyloxyethoxy)ethanol solutions by DSC. Application of two-point scaling to pseudophases coexistence was written by Piekarski, H.;Tkaczyk, M.;Wasiak, M.. And the article was included in Journal of Thermal Analysis and Calorimetry in 2005.Electric Literature of C10H22O3 The following contents are mentioned in the article:

The sp. heat capacities of aqueous solutions of 2-(hexyloxyethoxy)ethanol have been measured from 2 to 55°C within the whole available composition range by DSC. Changes of specific, partial, and apparent molar heat capacities of investigated system were analyzed and considered as an effect of structural transformations. The two-point scaling theory was applied to the description of the binary mixtures properties in the pseudo-phase coexistence region. This study involved multiple reactions and reactants, such as 2-(2-(Hexyloxy)ethoxy)ethanol (cas: 112-59-4Electric Literature of C10H22O3).

2-(2-(Hexyloxy)ethoxy)ethanol (cas: 112-59-4) belongs to ethers. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Electric Literature of C10H22O3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Copper-Catalyzed Substrate-Controlled Carbonylative Synthesis of α-Keto Amides and Amides from Alkyl Halides was written by Zhao, Fengqian;Ai, Han-Jun;Wu, Xiao-Feng. And the article was included in Angewandte Chemie, International Edition in 2022.COA of Formula: C3H9NO The following contents are mentioned in the article:

Controllable production of α-keto amides and amides from the same substrates is an attractive goal in the field of transition-metal-catalyzed (double-)carbonylation. A novel copper-catalyzed highly selective double carbonylation of alkyl bromides was developed. Moderate to good yields of α-keto amides were obtained as the only products. In the case of alkyl iodides, double- and mono-carbonylation can be achieved controllably under different conditions. This study involved multiple reactions and reactants, such as 2-Methoxyethylamine (cas: 109-85-3COA of Formula: C3H9NO).

2-Methoxyethylamine (cas: 109-85-3) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. COA of Formula: C3H9NO

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Borylation of organo halides and triflates using tetrakis(dimethylamino)diboron was written by Bello, Charles S.;Schmidt-Leithoff, Joachim. And the article was included in Tetrahedron Letters in 2012.Related Products of 1003858-50-1 The following contents are mentioned in the article:

We report a new in situ borylation method using tetrakis(dimethylamino)diboron, DMA₄B₂, in the presence of a diol. Our method uses standard borylation conditions and readily available Pd-catalysts. The scope of this method includes aryl halides and triflates as well as vinyl halides and triflates. The method successfully works with a broad range of diols, enabling the selection of the best boronic ester for subsequent Suzuki coupling. This study involved multiple reactions and reactants, such as 2-(3-Methoxyphenyl)-5,5-dimethyl-1,3,2-dioxaborinane (cas: 1003858-50-1Related Products of 1003858-50-1).

2-(3-Methoxyphenyl)-5,5-dimethyl-1,3,2-dioxaborinane (cas: 1003858-50-1) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Related Products of 1003858-50-1

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Copper-Catalyzed Chan-Lam Cyclopropylation of Phenols and Azaheterocycles was written by Derosa, Joseph;O’Duill, Miriam L.;Holcomb, Matthew;Boulous, Mark N.;Patman, Ryan L.;Wang, Fen;Tran-Dube, Michelle;McAlpine, Indrawan;Engle, Keary M.. And the article was included in Journal of Organic Chemistry in 2018.Recommanded Product: 4-Benzyloxyphenol The following contents are mentioned in the article:

Aryl cyclopropyl ethers and N-cyclopropyl benzimidazolones, (fused) N-cyclopropylpyridinones, and N-cyclopropyl heteroaryl amides and an N-cyclopropyl pyrazinamine were prepared by chemoselective Cham-Lam cyclopropylation of phenols, 2-hydroxybenzimidazoles, hydroxypyridines, and heteroaryl amines or amides with potassium cyclopropyltrifluoroborate in the presence of Cu(OAc)₂ and 1,10-phenanthroline under 1 atm. oxygen in toluene/H₂O. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Recommanded Product: 4-Benzyloxyphenol).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Recommanded Product: 4-Benzyloxyphenol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem