Month: November 2022

Ester-directed Ru-catalyzed C-O activation/C-C coupling reaction of ortho-methoxy naphthoates with organoboroneopentylates was written by Zhao, Yigang;Snieckus, Victor. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2016.COA of Formula: C12H17BO3 The following contents are mentioned in the article:

A new, catalytic and general synthetic methodol. for the construction of biaryls and heterobiaryls by the cross-coupling of ortho-methoxy naphthoates with organoboroneopentylates is disclosed. The reaction proceeds under RuH₂(CO)(PPh₃)₃-catalyzed conditions driven by unreactive C-O bond activation of a proximate ester directing group (DG)-catalyst chelation. This one-step synthesis of 2-aryl and -heteroaryl-1-naphthoates has the features of operational simplicity, min. waste and convenient scale-up. The hierarchy of C(O)Me > CONEt₂ > CO₂Me coordination-assisted reactivity, of potential value in chemoselective synthesis, is also established. This study involved multiple reactions and reactants, such as 2-(3-Methoxyphenyl)-5,5-dimethyl-1,3,2-dioxaborinane (cas: 1003858-50-1COA of Formula: C12H17BO3).

2-(3-Methoxyphenyl)-5,5-dimethyl-1,3,2-dioxaborinane (cas: 1003858-50-1) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.COA of Formula: C12H17BO3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Cobalt-catalyzed chemoselective dehydrogenation through radical translocation under visible light was written by Yu, Wan-Lei;Ren, Zi-Gang;Ma, Ke-Xing;Yang, Hui-Qing;Yang, Jun-Jie;Zheng, Haixue;Wu, Wangsuo;Xu, Peng-Fei. And the article was included in Chemical Science in 2022.COA of Formula: C3H9NO The following contents are mentioned in the article:

In this report, a straightforward and robust cobaloxime-catalyzed photochem. dehydrogenation strategy via intramol. HAT was described for the first time. The reaction proceeded through an intramol. radical translocation followed by the cobalt assisted dehydrogenation without needing any other external photosensitizers, noble-metals or oxidants. With this approach, a series of valuable unsaturated compounds such as α,β-unsaturated amides, enamides and allylic and homoallylic sulfonamides were obtained in moderate to excellent yields with good chemo- and regioselectivities, and the synthetic versatility was demonstrated by a range of transformations. And mechanistic studies of the method were discussed. This study involved multiple reactions and reactants, such as 2-Methoxyethylamine (cas: 109-85-3COA of Formula: C3H9NO).

2-Methoxyethylamine (cas: 109-85-3) belongs to ethers. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.COA of Formula: C3H9NO

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

The application of derivatization and retention indices system for identification of alkyl polyethylene glycol ethers by capillary gas chromatography was written by Komarek, Karel;Richter, Pavel. And the article was included in Scientific Papers of the University of Pardubice, Series A: Faculty of Chemical Technology in 1999.Computed Properties of C10H22O3 The following contents are mentioned in the article:

This study deals with the possibility of GC anal. of individual alkylpolyethylene glycol ethers (APEGEs) C₄ – C₁₀. The possibilities of derivatization reactions of these substances and the advantages of the derivative preparation are discussed. APEGEs were converted into three types of derivatives: acetates, trifluoroacetates and trimethylsilyl ethers. The retention indexes of individual oligomers of APEGEs and their derivatives for the column temperature programmed linearly were measured. The influence of an increase in the length of the chain in the alkyl or polyoxyethylene glycol part of mol. of non-derivatized APEGEs and their derivatives on the retention indexes was studied. This study involved multiple reactions and reactants, such as 2-(2-(Hexyloxy)ethoxy)ethanol (cas: 112-59-4Computed Properties of C10H22O3).

2-(2-(Hexyloxy)ethoxy)ethanol (cas: 112-59-4) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Computed Properties of C10H22O3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

[4 + 1] Annulation of in-situ generated azoalkenes with amines: A powerful approach to access 1-substituted 1,2,3-triazoles was written by Wang, Hongwei;Ning, Yongquan;Sivaguru, Paramasivam;Zanoni, Giuseppe;Bi, Xihe. And the article was included in Chinese Chemical Letters in 2022.Quality Control of 2-Methoxyethylamine The following contents are mentioned in the article:

Here a base-mediated [4 + 1] annulation of azoalkenes generated in-situ from readily available difluoroacetaldehyde N-tosylhydrazones (DFHZ-Ts) with amines under relatively mild conditions was reported. This azide- and acetylene-free strategy provides facile access to diverse 1-substituted 1,2,3-triazole derivatives in high yield in a regiospecific manner. This transformation was great functional group tolerance and was suit a broad substrate scope. Furthermore, the application of this novel methodol. in the gram-scale synthesis of an antibiotic drug PH-027 and in the late-stage derivatization of several bioactive small mols. and clin. drugs demonstrated its generality, practicability and applicability. This study involved multiple reactions and reactants, such as 2-Methoxyethylamine (cas: 109-85-3Quality Control of 2-Methoxyethylamine).

2-Methoxyethylamine (cas: 109-85-3) belongs to ethers. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Quality Control of 2-Methoxyethylamine

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

A review on demelanizing agents was written by Narkhede, Rohan;Bonde, Prajkta;Mapari, Mangesh. And the article was included in World Journal of Pharmacy and Pharmaceutical Sciences in 2020.Product Details of 103-16-2 The following contents are mentioned in the article:

A review. Demalanizing agent are the agents which causes inhibition of synthesis of melanin and thus prevent hyperpigmentation on skin. They lighten the skin. They are used as single component or along with combinations of demalanizing agent also known as skin whitening agents. Commonly used examples are hydroquinone mequinol, Azelaic acid, monobenzone, tretinoin, ascorbic acid,etc. These agents are used in light induced pigmentations, heperimentations due to sun burn and melisma and chloasma of pregnancy. Certain agents are used in cosmetics, generally plant extracts which has less irritancy are used. The hyperpigmentation caused by skin whitening agents is not ‘curable’ and will persist for a lifetime. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Product Details of 103-16-2).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Product Details of 103-16-2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

A review on demelanizing agents was written by Narkhede, Rohan;Bonde, Prajkta;Mapari, Mangesh. And the article was included in World Journal of Pharmacy and Pharmaceutical Sciences in 2020.Reference of 103-16-2 The following contents are mentioned in the article:

A review. Demalanizing agent are the agents which causes inhibition of synthesis of melanin and thus prevent hyperpigmentation on skin. They lighten the skin. They are used as single component or along with combinations of demalanizing agent also known as skin whitening agents. Commonly used examples are hydroquinone mequinol, Azelaic acid, monobenzone, tretinoin, ascorbic acid,etc. These agents are used in light induced pigmentations, heperimentations due to sun burn and melisma and chloasma of pregnancy. Certain agents are used in cosmetics, generally plant extracts which has less irritancy are used. The hyperpigmentation caused by skin whitening agents is not ‘curable’ and will persist for a lifetime. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Reference of 103-16-2).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Reference of 103-16-2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthesis and properties of monoalkyl ethers of diethylene glycol was written by Ban, Qing;Zhang, Ji;Chen, Yue-mei. And the article was included in Shangqiu Shifan Xueyuan Xuebao in 2000.Computed Properties of C10H22O3 The following contents are mentioned in the article:

Seven title compounds R(OCH₂CH₂)₂OH (R = CH₃(CH₂)₃, CH₃(CH₂)₅, CH₃(CH₂)₇, CH₃(CH₂)₉, CH₃(CH₂)₁₁, CH₃(CH₂)₁₃, CH₃(CH₂)₁₅) were prepared via phase-transfer catalyzed Williamson ether reaction of alkyl halide RX (X = Br, Cl) and diethylene glycol. The reaction mechanism and the phys. constant were discussed. The properties of the surfactants (surface tension, foam as well as critical micellization concentration in aqueous solution) were also discussed. This study involved multiple reactions and reactants, such as 2-(2-(Hexyloxy)ethoxy)ethanol (cas: 112-59-4Computed Properties of C10H22O3).

2-(2-(Hexyloxy)ethoxy)ethanol (cas: 112-59-4) belongs to ethers. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Computed Properties of C10H22O3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Thiols Act as Methyl Traps in the Biocatalytic Demethylation of Guaiacol Derivatives was written by Pompei, Simona;Grimm, Christopher;Schiller, Christine;Schober, Lukas;Kroutil, Wolfgang. And the article was included in Angewandte Chemie, International Edition in 2021.Product Details of 2380-78-1 The following contents are mentioned in the article:

Demethylating Me Ph ethers is challenging, especially when the products are catechol derivatives prone to follow-up reactions. For biocatalytic demethylation, monooxygenases have previously been described requiring mol. oxygen which may cause oxidative side reactions. Here we show that such compounds can be demethylated anaerobically by using cobalamin-dependent methyltransferases exploiting thiols like Et 3-mercaptopropionate as a Me trap. Using just two equivalent of this reagent, a broad spectrum of substituted guaiacol derivatives were demethylated, with conversions mostly above 90%. This strategy was used to prepare the highly valuable antioxidant hydroxytyrosol on a one-gram scale in 97% isolated yield. This study involved multiple reactions and reactants, such as 4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1Product Details of 2380-78-1).

4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Product Details of 2380-78-1

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Cu-Catalyzed cis-selective ring-opening cross-coupling of an oxabicyclic olefin with an organoboron reagent was written by Liu, Bowen;Peng, Guochun;Zhang, Yu;Liu, Chunhui;Zhao, Jinbo. And the article was included in Organic & Biomolecular Chemistry in 2021.Product Details of 1003858-50-1 The following contents are mentioned in the article:

The Cu(I)-catalyzed ring-opening cross-coupling of oxabicyclic olefins I (R = H, 6,7-di-Me, 5,8-dimethoxy, 6,7-dibromo, etc.) with organoboron reagents ArB(-OCH₂C(Me)₂CH₂O-) (Ar = 4-chlorophenyl, 1-methyl-1H-indol-5-yl, naphthalen-2-yl, etc.) and phenylboronic acid pinacol ester provides access to cis-2-aryl-1,2-dihydronaphthalen-1-ol derivatives II, in contrast to the exclusive trans-selectivity in related Cu-catalyzed reactions with Grignard reagents. DFT calculations suggest that the reaction possibly proceeds via boronic ester byproduct assisted ring-opening as an alternative pathway to the canonical β-oxygen elimination as the rate-determining step. This study involved multiple reactions and reactants, such as 2-(3-Methoxyphenyl)-5,5-dimethyl-1,3,2-dioxaborinane (cas: 1003858-50-1Product Details of 1003858-50-1).

2-(3-Methoxyphenyl)-5,5-dimethyl-1,3,2-dioxaborinane (cas: 1003858-50-1) belongs to ethers. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Product Details of 1003858-50-1

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Discovery and Optimization of Pyrrolopyrimidine Derivatives as Selective Disruptors of the Perinucleolar Compartment, a Marker of Tumor Progression toward Metastasis was written by Frankowski, Kevin J.;Patnaik, Samarjit;Wang, Chen;Southall, Noel;Dutta, Dipannita;De, Soumitta;Li, Dandan;Dextras, Christopher;Lin, Yi-Han;Bryant-Connah, Marthe;Davis, Danielle;Wang, Feijun;Wachsmuth, Leah M.;Shah, Pranav;Williams, Jordan;Kabir, Md;Zhu, Edward;Baljinnyam, Bolormaa;Wang, Amy;Xu, Xin;Norton, John;Ferrer, Marc;Titus, Steve;Simeonov, Anton;Zheng, Wei;Mathews Griner, Lesley A.;Jadhav, Ajit;Aube, Jeffrey;Henderson, Mark J.;Rudloff, Udo;Schoenen, Frank J.;Huang, Sui;Marugan, Juan J.. And the article was included in Journal of Medicinal Chemistry in 2022.Computed Properties of C3H9NO The following contents are mentioned in the article:

A high-throughput, high-content assay was developed to identify novel small mols. that selectively reduce PNC prevalence in cancer cells. The pyrrolopyrimidine series able to reduce PNC prevalence in PC3M cancer cells at submicromolar concentrations without affecting cell viability was identified and further optimized. Structure-activity relationship exploration of the structural elements necessary for activity resulted in the discovery of several potent compounds Anal. of in vitro drug-like properties led to the discovery of the bioavailable analog, metarrestin, which has shown potent antimetastatic activity with improved survival in rodent models and is currently being evaluated in a first-in-human phase 1 clin. trial. This study involved multiple reactions and reactants, such as 2-Methoxyethylamine (cas: 109-85-3Computed Properties of C3H9NO).

2-Methoxyethylamine (cas: 109-85-3) belongs to ethers. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Computed Properties of C3H9NO

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem