Month: November 2022

Discovery of Reversible Inhibitors of KDM1A Efficacious in Acute Myeloid Leukemia Models was written by Romussi, Alessia;Cappa, Anna;Vianello, Paola;Brambillasca, Silvia;Cera, Maria Rosaria;Dal Zuffo, Roberto;Faga, Giovanni;Fattori, Raimondo;Moretti, Loris;Trifiro, Paolo;Villa, Manuela;Vultaggio, Stefania;Cecatiello, Valentina;Pasqualato, Sebastiano;Dondio, Giulio;So, Chi Wai Eric;Minucci, Saverio;Sartori, Luca;Varasi, Mario;Mercurio, Ciro. And the article was included in ACS Medicinal Chemistry Letters in 2020.SDS of cas: 103-16-2 The following contents are mentioned in the article:

Lysine-specific demethylase 1 (LSD1 or KDM1A) is a FAD-dependent enzyme that acts as a transcription corepressor or coactivator by regulating the methylation status of histone H3 lysines K4 and K9, resp. KDM1A represents an attractive target for cancer therapy. While, in the past, the main medicinal chem. strategy toward KDM1A inhibition was based on the optimization of ligands that irreversibly bind the FAD cofactor within the enzyme catalytic site, we and others have also identified reversible inhibitors. Herein we reported the discovery of 5-imidazolylthieno[3,2-b]pyrroles, a new series of KDM1A inhibitors endowed with picomolar inhibitory potency, active in cells and efficacious after oral administration in murine leukemia models. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2SDS of cas: 103-16-2).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.SDS of cas: 103-16-2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Study of the reactive excited-state dynamics of delipidated bacteriorhodopsin upon surfactant treatments was written by Cheng, Chi-Wen;Lee, Yuan-Pern;Chu, Li-Kang. And the article was included in Chemical Physics Letters in 2012.Related Products of 112-59-4 The following contents are mentioned in the article:

The dynamics of the reactive excited-state of bacteriorhodopsin treated with various surfactants have been investigated through the measurement of pump-probe absorption spectra. Upon excitation of bR at 570 nm in the presence of ionic surfactants CTAB and SDS, the lifetime of the reactive excited-state of the all-trans protonated Schiff base, probed at 460 nm, was observed to increase up to 20%, whereas an insignificant change was observed upon addition of neutral surfactant C6E2. Measurements of steady-state absorption spectra, fluorescence, and CD indicated that the bR suspensions retain their trimeric configuration with partial delipidation. This removal of lipids causes a structural alteration and the varied excited-state dynamics. This study involved multiple reactions and reactants, such as 2-(2-(Hexyloxy)ethoxy)ethanol (cas: 112-59-4Related Products of 112-59-4).

2-(2-(Hexyloxy)ethoxy)ethanol (cas: 112-59-4) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Related Products of 112-59-4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Manganese-Catalyzed Selective Hydrogenative Cross-Coupling of Nitriles and Amines to Form Secondary Imines was written by Li, Xiao-Gen;Zhou, Qi-Lin. And the article was included in Advanced Synthesis & Catalysis in 2021.Recommanded Product: 2-Methoxyethylamine The following contents are mentioned in the article:

Manganese complexes with tridentate PNN ligands I (Ar = Ph, 3,5-dimethylphenyl; R = H, Cl, OMe, t-Bu, NMe₂, etc.) have been synthesized as catalysts for hydrogenative cross-coupling reaction of nitriles R¹CN (R¹ = t-Bu, cyclohexyl, Ph, oxan-4-yl, 2H-1,3-benzodioxol-5-yl, etc.) and amines R²NH₂ (R² = heptyl, cyclohexyl, 4-phenylbutyl, 3-(morpholin-4-yl)propyl, etc.) to form secondary imines R¹CH=NR². This reaction afforded a variety of unsym. secondary imines in good yields with excellent selectivity. Investigation of catalyst intermediates indicated that an amido manganese complex may be the active catalyst species for this reaction. This study involved multiple reactions and reactants, such as 2-Methoxyethylamine (cas: 109-85-3Recommanded Product: 2-Methoxyethylamine).

2-Methoxyethylamine (cas: 109-85-3) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Recommanded Product: 2-Methoxyethylamine

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

X-ray study of oil-microemulsion and oil-water interfaces in ternary amphiphilic systems was written by Mitrinovic, Dragoslav M.;Williams, Scott M.;Schlossman, Mark L.. And the article was included in Physical Review E: Statistical, Nonlinear, and Soft Matter Physics in 2001.Synthetic Route of C10H22O3 The following contents are mentioned in the article:

X-ray reflectivity and diffuse scattering measurements are presented from the interfaces between oil-rich and microemulsion bulk phases and between oil-rich and water-rich phases in three-component microemulsion systems (consisting of water, alkane, and C_iE_j, where the last represents n-alkyl polyglycol ether with i = 4,6,10 and j = 1,2,4). The x-ray measurements are analyzed with a two-parameter fit that determines the interfacial roughness, varying from 25-160 Å, and the interfacial tension, varying from 1.4-0.03 mN/m, for these samples. Although a nonmonotonic profile at the oil-microemulsion interface is not observed, these measurements exclude the presence of oscillating profiles with repeat distances >500 Å. This study involved multiple reactions and reactants, such as 2-(2-(Hexyloxy)ethoxy)ethanol (cas: 112-59-4Synthetic Route of C10H22O3).

2-(2-(Hexyloxy)ethoxy)ethanol (cas: 112-59-4) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Synthetic Route of C10H22O3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Discovery of Tenapanor: A First-in-Class Minimally Systemic Inhibitor of Intestinal Na⁺/H⁺ Exchanger Isoform 3 was written by Jacobs, Jeffrey W.;Leadbetter, Michael R.;Bell, Noah;Koo-McCoy, Samantha;Carreras, Christopher W.;He, Limin;Kohler, Jill;Kozuka, Kenji;Labonte, Eric D.;Navre, Marc;Spencer, Andrew G.;Charmot, Dominique. And the article was included in ACS Medicinal Chemistry Letters in 2022.COA of Formula: C3H9NO The following contents are mentioned in the article:

We present herein the design, synthesis, and optimization of gut-restricted inhibitors of Na⁺/H⁺ exchanger isoform 3 (NHE3). NHE3 is predominantly expressed in the kidney and gastrointestinal tract where it acts as the major absorptive sodium transporter. We desired minimally systemic agents that would block sodium absorption in the gastrointestinal tract but avoid exposure in the kidney. Starting with a relatively low-potency highly bioavailable hit compound (1), potent and minimally absorbed NHE3 inhibitors were designed, culminating with the discovery of tenapanor (28). Tenapanor has been approved by the U.S. Food and Drug Administration (FDA) for the treatment of irritable bowel syndrome with constipation in adults. This study involved multiple reactions and reactants, such as 2-Methoxyethylamine (cas: 109-85-3COA of Formula: C3H9NO).

2-Methoxyethylamine (cas: 109-85-3) belongs to ethers. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.COA of Formula: C3H9NO

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Preparation and properties of wood vinegar from pyrolysis of fir sawdust under different temperatures was written by Lu, Xincheng;Jiang, Jianchun;He, Jing;Sun, Kang;Sun, Yunjuan. And the article was included in Linchan Huaxue Yu Gongye in 2019.Safety of 4-Hydroxy-3-methoxyphenethanol The following contents are mentioned in the article:

The preparation and properties of wood vinegar obtained by pyrolysis of fir sawdust under different temperatures were studied. The results showed that the most important pyrolysis phase of fir sawdust was 150-250°C, which obtained the most of wood vinegar and organic compounds Under this pyrolysis phase, the highest yield of organic compound was phenols, and followed with acids. The relative content of organic compounds in wood vinegar was increased with the increasing of pyrolysis temperature, which is up to 48% after 150°C. The relative content for each kind of organic compounds was different under various temperature range, the highest relative content of acids was in 0-150°C, while phenols and ketones in 250-350°C, and aldehydes in 150-250°C. This study involved multiple reactions and reactants, such as 4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1Safety of 4-Hydroxy-3-methoxyphenethanol).

4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1) belongs to ethers. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Safety of 4-Hydroxy-3-methoxyphenethanol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Electroselective and Controlled Reduction of Cyclic Imides to Hydroxylactams and Lactams was written by Bai, Ya;Shi, Lingling;Zheng, Lianyou;Ning, Shulin;Che, Xin;Zhang, Zhuoqi;Xiang, Jinbao. And the article was included in Organic Letters in 2021.HPLC of Formula: 109-85-3 The following contents are mentioned in the article:

An efficient and practical electrochem. method for selective reduction of cyclic imides has been developed using a simple undivided cell with carbon electrodes at room temperature The reaction provides a useful strategy for the rapid synthesis of hydroxylactams and lactams in a controllable manner, which is tuned by elec. current and reaction time, and exhibits broad substrate scope and high functional group tolerance even to reduction-sensitive moieties. Initial mechanistic studies suggest that the approach heavily relies on the utilization of amines (e.g., i-Pr₂NH), which are able to generate α-aminoalkyl radicals. This protocol provides an efficient route for the cleavage of C-O bonds under mild conditions with high chemoselectivity. This study involved multiple reactions and reactants, such as 2-Methoxyethylamine (cas: 109-85-3HPLC of Formula: 109-85-3).

2-Methoxyethylamine (cas: 109-85-3) belongs to ethers. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. HPLC of Formula: 109-85-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Highly convergent modular access to poly-carbon substituted cyclopropanes via Cu(I)-catalyzed three-component cyclopropene carboallylation was written by Li, Hexin;Zhang, Mengru;Mehfooz, Haroon;Zhu, Dongxia;Zhao, Jinbo;Zhang, Qian. And the article was included in Organic Chemistry Frontiers in 2019.Category: ethers-buliding-blocks The following contents are mentioned in the article:

A conjunctive C-C cross-coupling of cyclopropenes enabled by a Cu-catalyzed three-component reaction of organoboron, cyclopropene and allylic bromide, which featured a modular, stereoselective assembly of poly-carbon substituted cyclopropanes I [R¹ = Ph, 4-MeC₆H₄, 2-naphthyl, etc.; R² = Me, Ph, 4-MeC₆H₄, etc.; R³ = Ph, 4-MeC₆H₄, 3-thienyl, etc.; R⁴ = H, Me, Br, etc.; R⁵ = H, F, CH₂CH₂CH:C(Me)₂, etc.; R⁶ = H, F, Me, etc.] was reported. Preliminary studies showed that the reaction could be extended to benzylation and made enantioselective with C2-sym. bisphosphine ligands. This study involved multiple reactions and reactants, such as 2-(3-Methoxyphenyl)-5,5-dimethyl-1,3,2-dioxaborinane (cas: 1003858-50-1Category: ethers-buliding-blocks).

2-(3-Methoxyphenyl)-5,5-dimethyl-1,3,2-dioxaborinane (cas: 1003858-50-1) belongs to ethers. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Category: ethers-buliding-blocks

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Multicomponent Cyclopropane Synthesis Enabled by Cu-Catalyzed Cyclopropene Carbometalation with Organoboron Reagent: Enantioselective Modular Access to Polysubstituted 2-Arylcyclopropylamines was written by Li, Zhanyu;Zhang, Mengru;Zhang, Yu;Liu, Shuang;Zhao, Jinbo;Zhang, Qian. And the article was included in Organic Letters in 2019.Product Details of 1003858-50-1 The following contents are mentioned in the article:

The use of functional-group-tolerant organoboron in lieu of basic organometallic reagents in base-metal-catalyzed cyclopropene carbometalation opens three-component cyclopropane synthesis, as exemplified by the modular assembly of the highly medicinally relevant 2-arylcyclopropylamine (ACPA) framework via stereoselective carboamination. The highly enantioselective version has been realized to afford enantioenriched ACPAs with up to all three cyclopropyl carbons as stereogenic centers in one operation, representing the first example of enantioselective multicomponent cyclopropane synthesis. The reaction significantly improves the efficiency of ACPA synthesis and may inspire the development of other multicomponent cyclopropane syntheses beyond amination. This study involved multiple reactions and reactants, such as 2-(3-Methoxyphenyl)-5,5-dimethyl-1,3,2-dioxaborinane (cas: 1003858-50-1Product Details of 1003858-50-1).

2-(3-Methoxyphenyl)-5,5-dimethyl-1,3,2-dioxaborinane (cas: 1003858-50-1) belongs to ethers. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Product Details of 1003858-50-1

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthesis, biophysical characterization, and anti-HIV-1 fusion activity of DNA helix-based inhibitors with a p-benzyloxyphenyl substituent at the 5′-nucleobase site was written by Tang, Yongjia;Han, Zeye;Guo, Jiamei;Tian, Yangli;Liu, Keliang;Xu, Liang. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2018.Computed Properties of C13H12O2 The following contents are mentioned in the article:

DNA helix-based HIV-1 fusion inhibitors have been discovered as potent drug candidates. Introduction of hydrophobic groups to a nucleobase provides an opportunity to design inhibitors with novel structures and mechanisms of action. In this work, two novel nucleoside analogs (1 and 2) were synthesized and incorporated into four DNA duplex- and quadruplex-based inhibitors. All the mols. showed anti-HIV-1 fusion activity. The effect of the p-benzyloxyphenyl group and the attached linker on the helix formation and thermal stability were fully compared and discussed. Surface plasmon resonance anal. further indicated that inhibitors with the same DNA helix may still have variable reaction targets, mainly attributed to the different hydrophobic modifications. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Computed Properties of C13H12O2).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Computed Properties of C13H12O2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem