Month: November 2022

Electrooxidation-Induced C(sp³)-H/C(sp²)-H Radical-Radical Cross-Coupling between Xanthenes and Electron-Rich Arenes was written by Liang, Yuwei;Niu, Linbin;Liang, Xing-An;Wang, Shengchun;Wang, Pengjie;Lei, Aiwen. And the article was included in Chinese Journal of Chemistry in 2022.Computed Properties of C3H9NO The following contents are mentioned in the article:

Herein, an electrooxidation-induced alkylation of electron-rich arenes, such as anilines, imidazo[1,2-a]pyridines, etc., with xanthenes with H₂ evolution under exogenous oxidant-free conditions, avoiding the utilization of metal catalysts, is reported. This protocol is well performed with various electron-rich aniline derivatives and nitrogen-containing heterocyclic compounds This electro-oxidative C(sp³)-H arylation represents an important expansion for the classic arenes alkylation, thereby proving that an attractive strategy for the developments of radical cross-coupling chem. was anticipated. This study involved multiple reactions and reactants, such as 2-Methoxyethylamine (cas: 109-85-3Computed Properties of C3H9NO).

2-Methoxyethylamine (cas: 109-85-3) belongs to ethers. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Computed Properties of C3H9NO

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthesis and Spectroscopic Properties of 1,2,3-Triazole BOPAHY Dyes and Their Water-Soluble Triazolium Salts was written by Horsten, Tomas;de Jong, Flip;Theunissen, Dries;Van der Auweraer, Mark;Dehaen, Wim. And the article was included in Journal of Organic Chemistry in 2021.Formula: C3H9NO The following contents are mentioned in the article:

Water-soluble BOPAHY fluorophores have not yet been reported. The potential of 1,2,3-triazolium salts for the formation of water-soluble chromophores is explored. 1,2,3-Triazole-substituted pyrroles were synthesized in a metal-free pathway and alkylated to obtain water-soluble 1,2,3-triazolium BOPAHY dyes. High fluorescence quantum yields were observed for triazole-bridged BOPAHY dyes in DCM and moderate fluorescence quantum yields for 1,2,3-triazolium-bridged BOPAHY chromophores in DCM and H₂O. The fluorescence of the freely rotatable 1,2,3-triazolium-linked BOPAHYs is partially quenched in H₂O. This study involved multiple reactions and reactants, such as 2-Methoxyethylamine (cas: 109-85-3Formula: C3H9NO).

2-Methoxyethylamine (cas: 109-85-3) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Formula: C3H9NO

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Catalyst-free photooxidation reaction from 1,4-dihydropyridazine to pyridazine under air was written by Karaki, Fumika;Kiguchi, Takuto;Itoh, Kennosuke;Sato, Noriko;Konishi, Kazuhide;Fujii, Hideaki. And the article was included in Tetrahedron in 2021.Computed Properties of C13H12O2 The following contents are mentioned in the article:

In the inverse electron-demand Diels-Alder (iEDDA) reactions between tetrazines and strained alkenes, a mixture of 1,4-dihydropyridazine isomers are formed first, and they are then oxidized to pyridazines. Although the products of these related oxidation processes converge as pyridazines, the oxidation rate was quite low with some substrates. In this study, 1,4-dihydropyridazines formed in the iEDDA reactions were oxidized to pyridazines by simply irradiating with an UV light under an air atm. Exptl. results implied that singlet oxygen was formed in the course of the reactions to oxidize the 1,4-dihydropyridazine mols. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Computed Properties of C13H12O2).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Computed Properties of C13H12O2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Catalyst-free photooxidation reaction from 1,4-dihydropyridazine to pyridazine under air was written by Karaki, Fumika;Kiguchi, Takuto;Itoh, Kennosuke;Sato, Noriko;Konishi, Kazuhide;Fujii, Hideaki. And the article was included in Tetrahedron in 2021.Reference of 103-16-2 The following contents are mentioned in the article:

In the inverse electron-demand Diels-Alder (iEDDA) reactions between tetrazines and strained alkenes, a mixture of 1,4-dihydropyridazine isomers are formed first, and they are then oxidized to pyridazines. Although the products of these related oxidation processes converge as pyridazines, the oxidation rate was quite low with some substrates. In this study, 1,4-dihydropyridazines formed in the iEDDA reactions were oxidized to pyridazines by simply irradiating with an UV light under an air atm. Exptl. results implied that singlet oxygen was formed in the course of the reactions to oxidize the 1,4-dihydropyridazine mols. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Reference of 103-16-2).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Reference of 103-16-2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Transition-Metal-Free ipso-Trifluoromethylthiolation of Lithium Aryl Boronates was written by Shen, Feng;Zheng, Hanliang;Xue, Xiao-Song;Lu, Long;Shen, Qilong. And the article was included in Organic Letters in 2019.Recommanded Product: 1003858-50-1 The following contents are mentioned in the article:

A transition-metal-free direct trifluoromethylthiolation of the ipso-carbon of lithium aryl boronates with trifluoromethanesulfenate under mild conditions was described. In addition, late-stage site-selective C-H borylation/trifluoromethylation and C-Cl borylation/trifluoromethylthiolation of biol. active mols. was developed. Initial mechanistic study suggested that the Li⁺ cation plays a vital role by coordinating to the oxygen atom of an aryl boronate complex and the oxygen of the reagent, thus allowing the aryl group to directly attack the trifluoromethylthio group of the trifluoromethylthiolating reagent. This study involved multiple reactions and reactants, such as 2-(3-Methoxyphenyl)-5,5-dimethyl-1,3,2-dioxaborinane (cas: 1003858-50-1Recommanded Product: 1003858-50-1).

2-(3-Methoxyphenyl)-5,5-dimethyl-1,3,2-dioxaborinane (cas: 1003858-50-1) belongs to ethers. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Recommanded Product: 1003858-50-1

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Joint Strength and Microstructure for Sn-Ag-(Cu) Soldering on an Electroless Ni-Au Surface Finish by Using a Flux Containing a Cu Compound was written by Kumamoto, Seishi;Sakurai, Hitoshi;Kukimoto, Youichi;Suganuma, Katsuaki. And the article was included in Journal of Electronic Materials in 2008.Synthetic Route of C10H22O3 The following contents are mentioned in the article:

The effect of a flux containing Cu(II) stearate (barrier flux) on the strength of soldered joints between an electroless Ni-Au surface finish and two Pb-free soldering systems, Sn-3Ag-0.5Cu and Sn-3.5Ag (weight%), was examined Pull and shock tests showed that barrier flux gave a higher joint strength for both solder compositions than did a flux containing no Cu compounds Interface anal. revealed that a thin P-rich layer and refined Cu-Ni-Sn intermetallic compounds were formed at the joint interface when barrier flux was used. It is assumed that the supply of Cu from barrier flux suppresses diffusion of Ni into the solder. This study involved multiple reactions and reactants, such as 2-(2-(Hexyloxy)ethoxy)ethanol (cas: 112-59-4Synthetic Route of C10H22O3).

2-(2-(Hexyloxy)ethoxy)ethanol (cas: 112-59-4) belongs to ethers. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Synthetic Route of C10H22O3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Electrooxidative and Regioselective C-H Azolation of Phenol and Aniline Derivatives was written by Feng, Pengju;Ma, Guojian;Chen, Xiaoguang;Wu, Xing;Lin, Ling;Liu, Peng;Chen, Tianfeng. And the article was included in Angewandte Chemie, International Edition in 2019.Synthetic Route of C13H12O2 The following contents are mentioned in the article:

A general and practical protocol was developed for the regioselective C-H azolation of phenol and aniline derivatives by electrooxidative cross-coupling [e.g., 4-methoxyphenol + pyrazole → 4-methoxy-2-(1H-pyrazol-1-yl)phenol (97%)]. The reaction occurs under metal-, oxidant-, and reagent-free conditions, allowing access to a wide variety of synthetically useful heteroarene derivatives The reaction also tolerates a broad range of functional groups and is amenable to gram-scale synthesis. Finally, a preliminary mechanistic study indicated that a radical-radical-combination pathway might be involved in the coupling reaction. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Synthetic Route of C13H12O2).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Synthetic Route of C13H12O2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

One-pot access to 2-amino-3-arylbenzofurans: direct entry to polyheterocyclic chemical space was written by Prasad, Sure Siva;Joshi, Dirgha Raj;Lee, Jeong Hwa;Kim, Ikyon. And the article was included in Organic & Biomolecular Chemistry in 2020.Recommanded Product: 103-16-2 The following contents are mentioned in the article:

Two efficient one-pot sequential coupling routes to 2-amino-3-arylbenzofurans and 2-amino-3-arylnaphtho[2,1-b]furans I (R = Cl, propan-2-yl, Ph, etc.; R¹ = H, OMe, Ph; RR¹ = -OCH₂O-; R² = H, Me; R³ = H, OMe; RR³ = -CH=CH-CH=CH-; Ar = 4-hydroxy-3-methoxyphenyl, thiophen-2-yl, 6-bromo-2H-1,3-benzodioxol-5-yl, etc.) were established. Further ring formation (six- and seven-membered rings) with the resulting amine moiety at the C2 position of benzofurans I were realized, leading to further expansion of benzofuran-based chem. space. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Recommanded Product: 103-16-2).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Recommanded Product: 103-16-2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

One-pot access to 2-amino-3-arylbenzofurans: direct entry to polyheterocyclic chemical space was written by Prasad, Sure Siva;Joshi, Dirgha Raj;Lee, Jeong Hwa;Kim, Ikyon. And the article was included in Organic & Biomolecular Chemistry in 2020.Recommanded Product: 4-Benzyloxyphenol The following contents are mentioned in the article:

Two efficient one-pot sequential coupling routes to 2-amino-3-arylbenzofurans and 2-amino-3-arylnaphtho[2,1-b]furans I (R = Cl, propan-2-yl, Ph, etc.; R¹ = H, OMe, Ph; RR¹ = -OCH₂O-; R² = H, Me; R³ = H, OMe; RR³ = -CH=CH-CH=CH-; Ar = 4-hydroxy-3-methoxyphenyl, thiophen-2-yl, 6-bromo-2H-1,3-benzodioxol-5-yl, etc.) were established. Further ring formation (six- and seven-membered rings) with the resulting amine moiety at the C2 position of benzofurans I were realized, leading to further expansion of benzofuran-based chem. space. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Recommanded Product: 4-Benzyloxyphenol).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Recommanded Product: 4-Benzyloxyphenol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Identification by Inverse Virtual Screening of magnolol-based scaffold as new tankyrase-2 inhibitors was written by Di Micco, Simone;Pulvirenti, Luana;Bruno, Ines;Terracciano, Stefania;Russo, Alessandra;Vaccaro, Maria C.;Ruggiero, Dafne;Muccilli, Vera;Cardullo, Nunzio;Tringali, Corrado;Riccio, Raffaele;Bifulco, Giuseppe. And the article was included in Bioorganic & Medicinal Chemistry in 2018.Computed Properties of C9H12O3 The following contents are mentioned in the article:

The natural product magnolol (1) and a selection of its bioinspired derivatives 2-5, were investigated by Inverse Virtual Screening in order to identify putative biol. targets from a panel of 308 proteins involved in cancer processes. By this in silico anal. we selected tankyrase-2 (TNKS2), casein kinase 2 (CK2) and bromodomain 9 (Brd9) as potential targets for exptl. evaluations. The Surface Plasmon Resonance assay revealed that 3-5 present a good affinity for tankyrase-2, and, in particular, 3 showed an antiproliferative activity on A549 cells higher than the well-known tankyrase-2 inhibitor XAV939 used as reference compound This study involved multiple reactions and reactants, such as 4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1Computed Properties of C9H12O3).

4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Computed Properties of C9H12O3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem