Month: November 2022

Synthesis and properties of monoalkyl ethers of diethylene glycol was written by Ban, Qing;Zhang, Ji;Chen, Yue-mei. And the article was included in Shangqiu Shifan Xueyuan Xuebao in 2000.Computed Properties of C10H22O3 The following contents are mentioned in the article:

Seven title compounds R(OCH₂CH₂)₂OH (R = CH₃(CH₂)₃, CH₃(CH₂)₅, CH₃(CH₂)₇, CH₃(CH₂)₉, CH₃(CH₂)₁₁, CH₃(CH₂)₁₃, CH₃(CH₂)₁₅) were prepared via phase-transfer catalyzed Williamson ether reaction of alkyl halide RX (X = Br, Cl) and diethylene glycol. The reaction mechanism and the phys. constant were discussed. The properties of the surfactants (surface tension, foam as well as critical micellization concentration in aqueous solution) were also discussed. This study involved multiple reactions and reactants, such as 2-(2-(Hexyloxy)ethoxy)ethanol (cas: 112-59-4Computed Properties of C10H22O3).

2-(2-(Hexyloxy)ethoxy)ethanol (cas: 112-59-4) belongs to ethers. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Computed Properties of C10H22O3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Thiols Act as Methyl Traps in the Biocatalytic Demethylation of Guaiacol Derivatives was written by Pompei, Simona;Grimm, Christopher;Schiller, Christine;Schober, Lukas;Kroutil, Wolfgang. And the article was included in Angewandte Chemie, International Edition in 2021.Product Details of 2380-78-1 The following contents are mentioned in the article:

Demethylating Me Ph ethers is challenging, especially when the products are catechol derivatives prone to follow-up reactions. For biocatalytic demethylation, monooxygenases have previously been described requiring mol. oxygen which may cause oxidative side reactions. Here we show that such compounds can be demethylated anaerobically by using cobalamin-dependent methyltransferases exploiting thiols like Et 3-mercaptopropionate as a Me trap. Using just two equivalent of this reagent, a broad spectrum of substituted guaiacol derivatives were demethylated, with conversions mostly above 90%. This strategy was used to prepare the highly valuable antioxidant hydroxytyrosol on a one-gram scale in 97% isolated yield. This study involved multiple reactions and reactants, such as 4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1Product Details of 2380-78-1).

4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Product Details of 2380-78-1

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Cu-Catalyzed cis-selective ring-opening cross-coupling of an oxabicyclic olefin with an organoboron reagent was written by Liu, Bowen;Peng, Guochun;Zhang, Yu;Liu, Chunhui;Zhao, Jinbo. And the article was included in Organic & Biomolecular Chemistry in 2021.Product Details of 1003858-50-1 The following contents are mentioned in the article:

The Cu(I)-catalyzed ring-opening cross-coupling of oxabicyclic olefins I (R = H, 6,7-di-Me, 5,8-dimethoxy, 6,7-dibromo, etc.) with organoboron reagents ArB(-OCH₂C(Me)₂CH₂O-) (Ar = 4-chlorophenyl, 1-methyl-1H-indol-5-yl, naphthalen-2-yl, etc.) and phenylboronic acid pinacol ester provides access to cis-2-aryl-1,2-dihydronaphthalen-1-ol derivatives II, in contrast to the exclusive trans-selectivity in related Cu-catalyzed reactions with Grignard reagents. DFT calculations suggest that the reaction possibly proceeds via boronic ester byproduct assisted ring-opening as an alternative pathway to the canonical β-oxygen elimination as the rate-determining step. This study involved multiple reactions and reactants, such as 2-(3-Methoxyphenyl)-5,5-dimethyl-1,3,2-dioxaborinane (cas: 1003858-50-1Product Details of 1003858-50-1).

2-(3-Methoxyphenyl)-5,5-dimethyl-1,3,2-dioxaborinane (cas: 1003858-50-1) belongs to ethers. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Product Details of 1003858-50-1

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Discovery and Optimization of Pyrrolopyrimidine Derivatives as Selective Disruptors of the Perinucleolar Compartment, a Marker of Tumor Progression toward Metastasis was written by Frankowski, Kevin J.;Patnaik, Samarjit;Wang, Chen;Southall, Noel;Dutta, Dipannita;De, Soumitta;Li, Dandan;Dextras, Christopher;Lin, Yi-Han;Bryant-Connah, Marthe;Davis, Danielle;Wang, Feijun;Wachsmuth, Leah M.;Shah, Pranav;Williams, Jordan;Kabir, Md;Zhu, Edward;Baljinnyam, Bolormaa;Wang, Amy;Xu, Xin;Norton, John;Ferrer, Marc;Titus, Steve;Simeonov, Anton;Zheng, Wei;Mathews Griner, Lesley A.;Jadhav, Ajit;Aube, Jeffrey;Henderson, Mark J.;Rudloff, Udo;Schoenen, Frank J.;Huang, Sui;Marugan, Juan J.. And the article was included in Journal of Medicinal Chemistry in 2022.Computed Properties of C3H9NO The following contents are mentioned in the article:

A high-throughput, high-content assay was developed to identify novel small mols. that selectively reduce PNC prevalence in cancer cells. The pyrrolopyrimidine series able to reduce PNC prevalence in PC3M cancer cells at submicromolar concentrations without affecting cell viability was identified and further optimized. Structure-activity relationship exploration of the structural elements necessary for activity resulted in the discovery of several potent compounds Anal. of in vitro drug-like properties led to the discovery of the bioavailable analog, metarrestin, which has shown potent antimetastatic activity with improved survival in rodent models and is currently being evaluated in a first-in-human phase 1 clin. trial. This study involved multiple reactions and reactants, such as 2-Methoxyethylamine (cas: 109-85-3Computed Properties of C3H9NO).

2-Methoxyethylamine (cas: 109-85-3) belongs to ethers. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Computed Properties of C3H9NO

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Catalyst-free reductive hydrogenation or deuteration of aryl-heteroatom bonds induced by light was written by Yan, Boyu;Zhou, Yutong;Wu, Jieliang;Ran, Maogang;Li, Huihui;Yao, Qiuli. And the article was included in Organic Chemistry Frontiers in 2021.Application of 103-16-2 The following contents are mentioned in the article:

A simple and catalyst-free photochem. strategy for the direct reduction of aryl trimethylammonium salts ArNMe₃OTf (Ar = biphenyl-4-yl, 2-naphthyl, quinolin-3-yl, etc.), aryl triflates Ar¹OTf (Ar¹ = biphenyl-3-yl, 1,6-dimethylpyridin-4-yl, benzothiazol-5-yl, etc.), and haloarenes Ar²X (Ar² = biphenyl-4-yl, 2-naphthyl, quinolin-4-yl, etc.; X = Cl, Br, I) to arenes ArH/Ar¹H or deuterium-labeled arenes ArD/Ar¹D/Ar²D was described. A broad range of substrate scope was demonstrated with high yields and deuterium incorporations. Radical clock experiments indicate the formation of aryl radical intermediates that can also be trapped by phenols. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Application of 103-16-2).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Application of 103-16-2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Catalyst-free reductive hydrogenation or deuteration of aryl-heteroatom bonds induced by light was written by Yan, Boyu;Zhou, Yutong;Wu, Jieliang;Ran, Maogang;Li, Huihui;Yao, Qiuli. And the article was included in Organic Chemistry Frontiers in 2021.Application of 103-16-2 The following contents are mentioned in the article:

A simple and catalyst-free photochem. strategy for the direct reduction of aryl trimethylammonium salts ArNMe₃OTf (Ar = biphenyl-4-yl, 2-naphthyl, quinolin-3-yl, etc.), aryl triflates Ar¹OTf (Ar¹ = biphenyl-3-yl, 1,6-dimethylpyridin-4-yl, benzothiazol-5-yl, etc.), and haloarenes Ar²X (Ar² = biphenyl-4-yl, 2-naphthyl, quinolin-4-yl, etc.; X = Cl, Br, I) to arenes ArH/Ar¹H or deuterium-labeled arenes ArD/Ar¹D/Ar²D was described. A broad range of substrate scope was demonstrated with high yields and deuterium incorporations. Radical clock experiments indicate the formation of aryl radical intermediates that can also be trapped by phenols. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Application of 103-16-2).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Application of 103-16-2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Structure-Based Design of Highly Potent Toll-like Receptor 7/8 Dual Agonists for Cancer Immunotherapy was written by Wang, Zhisong;Gao, Yan;He, Lei;Sun, Shuhao;Xia, Tingting;Hu, Lu;Yao, Licheng;Wang, Liangliang;Li, Dan;Shi, Hui;Liao, Xuebin. And the article was included in Journal of Medicinal Chemistry in 2021.COA of Formula: C3H9NO The following contents are mentioned in the article:

Design and synthesis of a series of pyrido[3,2-d]pyrimidine-based toll-like receptor 7/8 dual agonists, e.g., I that exhibited potent and near-equivalent agonistic activities toward TLR7 and TLR8. In vitro, compounds significantly induced the secretion of IFN-α, IFN-γ, TNF-α, IL-1β, IL-12p40, and IP-10 in human peripheral blood mononuclear cell assays. In vivo, compounds significantly suppressed tumor growth in CT26 tumor-bearing mice by remodeling the tumor microenvironment. Addnl., compounds markedly improved the antitumor activity of PD-1/PD-L1 blockade. These results demonstrated that TLR7/8 agonists held great potential as single agents or in combination with PD-1/PD-L1 blockade for cancer immunotherapy. This study involved multiple reactions and reactants, such as 2-Methoxyethylamine (cas: 109-85-3COA of Formula: C3H9NO).

2-Methoxyethylamine (cas: 109-85-3) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.COA of Formula: C3H9NO

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Phase Behavior of Microemulsions Made with n-Alkyl Monoglucosides and n-Alkyl Polyglycol Ethers was written by Ryan, Larry D.;Schubert, Kai-V.;Kaler, Eric W.. And the article was included in Langmuir in 1997.COA of Formula: C10H22O3 The following contents are mentioned in the article:

The phase behavior of mixtures of water, octane, n-alkyl polyglycol ethers (C_iE_j), and n-alkyl β-D-glucopyranosides (C_mG₁) is systematically studied as a function of temperature and composition The addition of C_mG₁ to water-octane-C_iE_j mixtures promotes formation of a three-phase region that is nearly independent of temperature in all mixtures studied. The size and extent of this three-phase region are shown as a function of C_mG₁ concentration and hydrophobicity and C_iE_j amphiphilicity. This unique behavior arises from the extremely low oil solubility of the alkyl monoglucosides. This study involved multiple reactions and reactants, such as 2-(2-(Hexyloxy)ethoxy)ethanol (cas: 112-59-4COA of Formula: C10H22O3).

2-(2-(Hexyloxy)ethoxy)ethanol (cas: 112-59-4) belongs to ethers. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.COA of Formula: C10H22O3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Discovery of AS-0141, a Potent and Selective Inhibitor of CDC7 Kinase for the Treatment of Solid Cancers was written by Irie, Takayuki;Asami, Tokiko;Sawa, Ayako;Uno, Yuko;Taniyama, Chika;Funakoshi, Yoko;Masai, Hisao;Sawa, Masaaki. And the article was included in Journal of Medicinal Chemistry in 2021.Formula: C3H9NO The following contents are mentioned in the article:

CDC7, a serine-threonine kinase, plays conserved and important roles in regulation of DNA replication and has been recognized as a potential anticancer target. We report here the optimization of a series of furanone analogs starting from compound 1 with a focus on ADME properties suitable for clin. development. By replacing the 2-chlorobenzene moiety in 1 with various aliphatic groups, we identified compound 24 as a potent CDC7 inhibitor with excellent kinase selectivity and favorable oral bioavailability in multiple species. Oral administration of 24 demonstrated robust in vivo antitumor efficacy in a colorectal cancer xenograft model. Compound 24 (AS-0141) is currently in phase I clin. trials for the treatment of solid cancers. This study involved multiple reactions and reactants, such as 2-Methoxyethylamine (cas: 109-85-3Formula: C3H9NO).

2-Methoxyethylamine (cas: 109-85-3) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Formula: C3H9NO

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Structure-Activity Relationship Studies Reveal New Astemizole Analogues Active against Plasmodium falciparum In Vitro was written by Mambwe, Dickson;Kumar, Malkeet;Ferger, Richard;Taylor, Dale;Njoroge, Mathew;Coertzen, Dina;Reader, Janette;van der Watt, Mariette;Birkholtz, Lyn-Marie;Chibale, Kelly. And the article was included in ACS Medicinal Chemistry Letters in 2021.Recommanded Product: 109-85-3 The following contents are mentioned in the article:

In the context of drug repositioning and expanding the existing structure-activity relationship around astemizole (AST), a new series of analogs were designed, synthesized, and evaluated for their antiplasmodium activity. Among 46 analogs tested, compounds 21, 30, and 33 displayed high activities against asexual blood stage parasites (PfNF54 IC₅₀ = 0.025-0.043μM), whereas amide compound 46 addnl. showed activity against late-stage gametocytes (stage IV/V; PfLG IC₅₀ = 0.6 ± 0.1μM) and 860-fold higher selectivity over hERG (46, SI = 43) compared to AST. Several analogs displaying high solubility (Sol > 100μM) and low cytotoxicity in the Chinese hamster ovary (SI > 148) cell line have also been identified. This study involved multiple reactions and reactants, such as 2-Methoxyethylamine (cas: 109-85-3Recommanded Product: 109-85-3).

2-Methoxyethylamine (cas: 109-85-3) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Recommanded Product: 109-85-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem