Month: November 2022

Chemical constituents of the pericarp of Toona sinensis and their chemotaxonomic significance was written by Chen, Ying;Wang, Feng;Ji, Chaoying;Liu, Di;Liu, Xiaoxiao;Wang, Rongshen;Li, Wanzhong. And the article was included in Biochemical Systematics and Ecology in 2022.Reference of 2380-78-1 The following contents are mentioned in the article:

Phytochem. investigation of the pericarp of Toona sinensis (A. Juss.) Roem (Meliaceae) led to the isolation and identification of 33 compounds, namely, 7 apotirucallane-type triterpenoids (1-7), 2 cycloartane-type triterpenoids (8-9), 5 sterols (10-14), 2 sesquiterpenes (15-16), 2 lignans (17-18), 3 flavonoids (19-21), and 12 phenols (22-33). The chem. structures of these compounds were elucidated based on spectroscopic data and comparison with previously reported data. This is the first report of compounds 11-12, 16, 18, 23, and 31 from the family Meliaceae, compounds 13-15, 26, and 30 within the genus Toona, and compound 33 from T. sinensis. The chemotaxonomic significance of the isolated compounds is also described in this study. This study involved multiple reactions and reactants, such as 4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1Reference of 2380-78-1).

4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1) belongs to ethers. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Reference of 2380-78-1

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Recyclable Palladium-Catalyzed Carbonylative Coupling of 2-Iodoanilines, Trimethyl Orthoformate, and Amines: A Practical Synthesis of Quinazolin-4(3H)-ones was written by Li, Jianying;Zhou, Zebiao;Xie, Gang;Cai, Mingzhong. And the article was included in Synthesis in 2022.Recommanded Product: 2-Methoxyethylamine The following contents are mentioned in the article:

An efficient heterogeneous palladium-catalyzed carbonylative annulation of 2-iodoanilines, tri-Me orthoformate, and amines has been developed. The reaction proceeds smoothly in toluene at 110°C using N,N-diisopropylethylamine (DiPEA) as base and 2 mol% of MCM-41-anchored bidentate phosphine palladium complex [MCM-41-2P-Pd(OAc)₂] as catalyst under 10 bar of carbon monoxide and provides a general and practical method for the construction of a wide variety of quinazolin-4(3H)-ones in good to excellent yields from com. easily available starting materials. This heterogenized palladium catalyst can be easily recovered via a simple centrifugation process and reused more than nine times with almost consistent catalytic efficiency. This study involved multiple reactions and reactants, such as 2-Methoxyethylamine (cas: 109-85-3Recommanded Product: 2-Methoxyethylamine).

2-Methoxyethylamine (cas: 109-85-3) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Recommanded Product: 2-Methoxyethylamine

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Effects of 2-phenoxyethanol on N-methyl-D-aspartate (NMDA) receptor-mediated ion currents was written by Muszhoff, Ulrich;Madeja, Michael;Binding, Norbert;Witting, Ute;Speckmann, Erwin-Josef. And the article was included in Archives of Toxicology in 1999.Safety of 2-(2-(Hexyloxy)ethoxy)ethanol The following contents are mentioned in the article:

The actions were examined of 17 frequently used glycol ether compounds on the glutamate receptor-mediated ion currents. The receptors were expressed in Xenopus oocytes by injection of rat brain mRNA. Most of the 17 glycol ethers exerted no effects on the glutamate subreceptors activated by kainate and N-methyl-d-aspartate (NMDA), whereas 2-phenoxyethanol (ethylene glycol monophenyl ether) caused a considerable reduction of NMDA-induced membrane currents in a reversible and concentration-dependent manner. The threshold concentration of the ethylene glycol monophenyl ether effect was <10 μmol/l. The concentration for a 50% inhibition (IC₅₀) was ∼360 μmol/l. The results indicate a neurotoxic potential for 2-phenoxyethanol. This study involved multiple reactions and reactants, such as 2-(2-(Hexyloxy)ethoxy)ethanol (cas: 112-59-4Safety of 2-(2-(Hexyloxy)ethoxy)ethanol).

2-(2-(Hexyloxy)ethoxy)ethanol (cas: 112-59-4) belongs to ethers. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Safety of 2-(2-(Hexyloxy)ethoxy)ethanol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Discovery of Reversible Inhibitors of KDM1A Efficacious in Acute Myeloid Leukemia Models was written by Romussi, Alessia;Cappa, Anna;Vianello, Paola;Brambillasca, Silvia;Cera, Maria Rosaria;Dal Zuffo, Roberto;Faga, Giovanni;Fattori, Raimondo;Moretti, Loris;Trifiro, Paolo;Villa, Manuela;Vultaggio, Stefania;Cecatiello, Valentina;Pasqualato, Sebastiano;Dondio, Giulio;So, Chi Wai Eric;Minucci, Saverio;Sartori, Luca;Varasi, Mario;Mercurio, Ciro. And the article was included in ACS Medicinal Chemistry Letters in 2020.Safety of 4-Benzyloxyphenol The following contents are mentioned in the article:

Lysine-specific demethylase 1 (LSD1 or KDM1A) is a FAD-dependent enzyme that acts as a transcription corepressor or coactivator by regulating the methylation status of histone H3 lysines K4 and K9, resp. KDM1A represents an attractive target for cancer therapy. While, in the past, the main medicinal chem. strategy toward KDM1A inhibition was based on the optimization of ligands that irreversibly bind the FAD cofactor within the enzyme catalytic site, we and others have also identified reversible inhibitors. Herein we reported the discovery of 5-imidazolylthieno[3,2-b]pyrroles, a new series of KDM1A inhibitors endowed with picomolar inhibitory potency, active in cells and efficacious after oral administration in murine leukemia models. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Safety of 4-Benzyloxyphenol).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Safety of 4-Benzyloxyphenol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Discovery of Reversible Inhibitors of KDM1A Efficacious in Acute Myeloid Leukemia Models was written by Romussi, Alessia;Cappa, Anna;Vianello, Paola;Brambillasca, Silvia;Cera, Maria Rosaria;Dal Zuffo, Roberto;Faga, Giovanni;Fattori, Raimondo;Moretti, Loris;Trifiro, Paolo;Villa, Manuela;Vultaggio, Stefania;Cecatiello, Valentina;Pasqualato, Sebastiano;Dondio, Giulio;So, Chi Wai Eric;Minucci, Saverio;Sartori, Luca;Varasi, Mario;Mercurio, Ciro. And the article was included in ACS Medicinal Chemistry Letters in 2020.SDS of cas: 103-16-2 The following contents are mentioned in the article:

Lysine-specific demethylase 1 (LSD1 or KDM1A) is a FAD-dependent enzyme that acts as a transcription corepressor or coactivator by regulating the methylation status of histone H3 lysines K4 and K9, resp. KDM1A represents an attractive target for cancer therapy. While, in the past, the main medicinal chem. strategy toward KDM1A inhibition was based on the optimization of ligands that irreversibly bind the FAD cofactor within the enzyme catalytic site, we and others have also identified reversible inhibitors. Herein we reported the discovery of 5-imidazolylthieno[3,2-b]pyrroles, a new series of KDM1A inhibitors endowed with picomolar inhibitory potency, active in cells and efficacious after oral administration in murine leukemia models. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2SDS of cas: 103-16-2).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.SDS of cas: 103-16-2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Study of the reactive excited-state dynamics of delipidated bacteriorhodopsin upon surfactant treatments was written by Cheng, Chi-Wen;Lee, Yuan-Pern;Chu, Li-Kang. And the article was included in Chemical Physics Letters in 2012.Related Products of 112-59-4 The following contents are mentioned in the article:

The dynamics of the reactive excited-state of bacteriorhodopsin treated with various surfactants have been investigated through the measurement of pump-probe absorption spectra. Upon excitation of bR at 570 nm in the presence of ionic surfactants CTAB and SDS, the lifetime of the reactive excited-state of the all-trans protonated Schiff base, probed at 460 nm, was observed to increase up to 20%, whereas an insignificant change was observed upon addition of neutral surfactant C6E2. Measurements of steady-state absorption spectra, fluorescence, and CD indicated that the bR suspensions retain their trimeric configuration with partial delipidation. This removal of lipids causes a structural alteration and the varied excited-state dynamics. This study involved multiple reactions and reactants, such as 2-(2-(Hexyloxy)ethoxy)ethanol (cas: 112-59-4Related Products of 112-59-4).

2-(2-(Hexyloxy)ethoxy)ethanol (cas: 112-59-4) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Related Products of 112-59-4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Manganese-Catalyzed Selective Hydrogenative Cross-Coupling of Nitriles and Amines to Form Secondary Imines was written by Li, Xiao-Gen;Zhou, Qi-Lin. And the article was included in Advanced Synthesis & Catalysis in 2021.Recommanded Product: 2-Methoxyethylamine The following contents are mentioned in the article:

Manganese complexes with tridentate PNN ligands I (Ar = Ph, 3,5-dimethylphenyl; R = H, Cl, OMe, t-Bu, NMe₂, etc.) have been synthesized as catalysts for hydrogenative cross-coupling reaction of nitriles R¹CN (R¹ = t-Bu, cyclohexyl, Ph, oxan-4-yl, 2H-1,3-benzodioxol-5-yl, etc.) and amines R²NH₂ (R² = heptyl, cyclohexyl, 4-phenylbutyl, 3-(morpholin-4-yl)propyl, etc.) to form secondary imines R¹CH=NR². This reaction afforded a variety of unsym. secondary imines in good yields with excellent selectivity. Investigation of catalyst intermediates indicated that an amido manganese complex may be the active catalyst species for this reaction. This study involved multiple reactions and reactants, such as 2-Methoxyethylamine (cas: 109-85-3Recommanded Product: 2-Methoxyethylamine).

2-Methoxyethylamine (cas: 109-85-3) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Recommanded Product: 2-Methoxyethylamine

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

X-ray study of oil-microemulsion and oil-water interfaces in ternary amphiphilic systems was written by Mitrinovic, Dragoslav M.;Williams, Scott M.;Schlossman, Mark L.. And the article was included in Physical Review E: Statistical, Nonlinear, and Soft Matter Physics in 2001.Synthetic Route of C10H22O3 The following contents are mentioned in the article:

X-ray reflectivity and diffuse scattering measurements are presented from the interfaces between oil-rich and microemulsion bulk phases and between oil-rich and water-rich phases in three-component microemulsion systems (consisting of water, alkane, and C_iE_j, where the last represents n-alkyl polyglycol ether with i = 4,6,10 and j = 1,2,4). The x-ray measurements are analyzed with a two-parameter fit that determines the interfacial roughness, varying from 25-160 Å, and the interfacial tension, varying from 1.4-0.03 mN/m, for these samples. Although a nonmonotonic profile at the oil-microemulsion interface is not observed, these measurements exclude the presence of oscillating profiles with repeat distances >500 Å. This study involved multiple reactions and reactants, such as 2-(2-(Hexyloxy)ethoxy)ethanol (cas: 112-59-4Synthetic Route of C10H22O3).

2-(2-(Hexyloxy)ethoxy)ethanol (cas: 112-59-4) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Synthetic Route of C10H22O3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Discovery of Tenapanor: A First-in-Class Minimally Systemic Inhibitor of Intestinal Na⁺/H⁺ Exchanger Isoform 3 was written by Jacobs, Jeffrey W.;Leadbetter, Michael R.;Bell, Noah;Koo-McCoy, Samantha;Carreras, Christopher W.;He, Limin;Kohler, Jill;Kozuka, Kenji;Labonte, Eric D.;Navre, Marc;Spencer, Andrew G.;Charmot, Dominique. And the article was included in ACS Medicinal Chemistry Letters in 2022.COA of Formula: C3H9NO The following contents are mentioned in the article:

We present herein the design, synthesis, and optimization of gut-restricted inhibitors of Na⁺/H⁺ exchanger isoform 3 (NHE3). NHE3 is predominantly expressed in the kidney and gastrointestinal tract where it acts as the major absorptive sodium transporter. We desired minimally systemic agents that would block sodium absorption in the gastrointestinal tract but avoid exposure in the kidney. Starting with a relatively low-potency highly bioavailable hit compound (1), potent and minimally absorbed NHE3 inhibitors were designed, culminating with the discovery of tenapanor (28). Tenapanor has been approved by the U.S. Food and Drug Administration (FDA) for the treatment of irritable bowel syndrome with constipation in adults. This study involved multiple reactions and reactants, such as 2-Methoxyethylamine (cas: 109-85-3COA of Formula: C3H9NO).

2-Methoxyethylamine (cas: 109-85-3) belongs to ethers. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.COA of Formula: C3H9NO

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Preparation and properties of wood vinegar from pyrolysis of fir sawdust under different temperatures was written by Lu, Xincheng;Jiang, Jianchun;He, Jing;Sun, Kang;Sun, Yunjuan. And the article was included in Linchan Huaxue Yu Gongye in 2019.Safety of 4-Hydroxy-3-methoxyphenethanol The following contents are mentioned in the article:

The preparation and properties of wood vinegar obtained by pyrolysis of fir sawdust under different temperatures were studied. The results showed that the most important pyrolysis phase of fir sawdust was 150-250°C, which obtained the most of wood vinegar and organic compounds Under this pyrolysis phase, the highest yield of organic compound was phenols, and followed with acids. The relative content of organic compounds in wood vinegar was increased with the increasing of pyrolysis temperature, which is up to 48% after 150°C. The relative content for each kind of organic compounds was different under various temperature range, the highest relative content of acids was in 0-150°C, while phenols and ketones in 250-350°C, and aldehydes in 150-250°C. This study involved multiple reactions and reactants, such as 4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1Safety of 4-Hydroxy-3-methoxyphenethanol).

4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1) belongs to ethers. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Safety of 4-Hydroxy-3-methoxyphenethanol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem