Month: December 2022

Zhao, Li published the artcileAu-Pd alloy cooperates with covalent triazine frameworks for the catalytic oxidative cleavage of β-O-4 linkages, SDS of cas: 183303-74-4, the publication is Green Chemistry (2019), 21(24), 6707-6716, database is CAplus.

To design highly efficient catalysts for the cleavage of the C-O/C-C bond is the key task in the depolymerization of lignin. Bimetallic alloy catalysts Au-Pd-CTFs were developed to be effective in the oxidative cleavage of β-O-4 lignin model compounds with O₂. Au-Pd nanoparticles with an Au/Pd molar ratio between 1 : 1 and 1 : 1.5 showed the highest cleavage efficiency. The kinetics of the reaction process revealed that a synergistic effect between Au and Pd played a crucial role in the oxidation of C_α-OH into C_α-O, which was the rate-determining step for the whole oxidative cleavage process. Further insight revealed that the cooperative effect between Au-Pd nanoparticles and the support covalent triazine frameworks (CTFs) facilitated the cleavage of the formed β-O-4 ketone compound to the corresponding aromatics In addition, Au-Pd-CTF catalysts also showed efficiency in the oxidative transformation of the organosolv lignin. This catalytic system will provide guidance in the oxidative cleavage of β-O-4 linkages in lignin.

Green Chemistry published new progress about 183303-74-4. 183303-74-4 belongs to ethers-buliding-blocks, auxiliary class Benzene,Alcohol,Ether, name is 1-(3,4-Dimethoxyphenyl)-2-phenoxyethanol, and the molecular formula is C28H18O4, SDS of cas: 183303-74-4.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Li, Lei published the artcileOne-step synthesis of dimethyl carbonate from carbon dioxide, propylene oxide and methanol over alkali halides promoted by crown ethers, SDS of cas: 1589-47-5, the publication is Journal of Organometallic Chemistry (2015), 231-236, database is CAplus.

Crown ethers (i.e. [2,4]-dibenzo-18-crown-6 (DBC), 18-crown-6, 15-crown-5 and 12-crown-4) show obvious co-catalytic effect for alkali halides catalyzing one-step synthesis of di-Me carbonate (DMC) from CO₂, propylene oxide and methanol. Especially, the DMC yield of KCl catalyst promoted by DBC can increase by more than five times and reach about 40% under mild reaction conditions (i.e., low mole ratio of methanol and epoxides: 7:3, low initial pressure of CO₂: 1.5 MPa, reaction temperature: 140°, time: 10 h). The optimized molar ratio of KCl to DBC is 2: 1. Due to the good complexing ability between DBC and K⁺, KCl and DBC formed an organometallic complex. Actually, DBC can not only promote the reaction rate and equilibrium of cycloaddition and transesterification reactions, but also prevent side reaction. Importantly, DBC can conveniently achieve high recovery ratio and show excellent reusability.

Journal of Organometallic Chemistry published new progress about 1589-47-5. 1589-47-5 belongs to ethers-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ether, name is 2-Methoxypropan-1-ol, and the molecular formula is C4H10O2, SDS of cas: 1589-47-5.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Wang, Jiatong published the artcileInsights into crucial odourants dominating the characteristic flavour of citrus-white teas prepared from citrus reticulata Blanco ‘Chachiensis’ and Camellia sinensis ‘Fudingdabai’, Synthetic Route of 91-16-7, the publication is Food Chemistry (2022), 132048, database is CAplus and MEDLINE.

Citrus-white teas (CWs), which possess a balanced flavor of tea and citrus, are becoming more popular worldwide; however, their characteristic flavor and odourants received limited research. Volatile components of two types of CWs prepared from Citrus reticulata Blanco’Chachiensis’ and Camellia sinensis ‘Fudingdabai’ were comprehensively investigated using a combination of stir bar sorptive extraction and gas chromatog.-mass spectrometry (GC-MS). Ninety-nine crucial odourants in the CWs were quantified by applying GC-olfactometry/MS, significant differences were compared, and their odor activity values (OAVs) were calculated Twenty-two odourants (in total 2628.09 and 1131.18 mg/kg resp.) were further confirmed as traditional CW (CW-A) and innovated CW (CW-B) characteristic flavor crucial contributors which all possessed > 1 OAVs, particularly limonene (72919 in CW-A) and trans-β-ionone (138953 in CW-B). The unravelling of CWs aroma composition will greatly expanding our understanding of tea aroma chem. and the potential aroma interactions will offer insights into tea blending technologies.

Food Chemistry published new progress about 91-16-7. 91-16-7 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether,Inhibitor,Inhibitor,Inhibitor, name is 1,2-Dimethoxybenzene, and the molecular formula is C8H6ClN, Synthetic Route of 91-16-7.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Wu, Xufeng published the artcileNew route to poly(2-methoxy-3-(2′-ethyl-hexyloxy)-p-phenylene), Synthetic Route of 146370-51-6, the publication is Gaofenzi Xuebao (2003), 147-149, database is CAplus.

Poly(2-methoxy-5-(2′-ethylhexyloxy)-p-phenylenevinylene) (MEH-PPV) has been prepared by a liquid/solid two-phase reaction. The liquid phase is THF containing 1 ,4-bis(chloromethyl)-2-methoxyl-5-(2′-ethylhexyloxy) benzene as the monomer and a certain amount of tetrabutylanunmmonium bromide (TBAB) as phase transfer catalyst (PTC). The solid phase is potassium hydroxide particles with diameters <0.5 mm. Gelation was found in the polymerization processes. MEH-PPV is partially soluble because of its large molar mass. Soluble MEH-PPV was obtained by using bromomethylbenzene as retardant reagent. The molar mass of soluble MEH-PPV was measured to be 6.4 × 10⁴ g/mol. The Structure of polymer was identified by IR, Raman, UV/vis and PL spectra. A thin compact film of MEH-PPV can be formed by spin-coating and it emit a yellow light.

Gaofenzi Xuebao published new progress about 146370-51-6. 146370-51-6 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 1-((2-Ethylhexyl)oxy)-4-methoxybenzene, and the molecular formula is C7H13NO2, Synthetic Route of 146370-51-6.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Sun, Kai published the artcileA general electron donor-acceptor complex for photoactivation of arenes via thianthrenation, SDS of cas: 91-16-7, the publication is Chemical Science (2022), 13(19), 5659-5666, database is CAplus and MEDLINE.

General photoactivation of electron donor-acceptor (EDA) complexes between arylsulfonium salts and 1,4-diazabicyclo[2.2.2]octane with visible light or natural sunlight was discovered. This practical and efficient mode enabled the production of aryl radicals under mild conditions, providing an unrealized opportunity for two-step para-selective C-H functionalization of complex arenes. The novel mode for generating aryl radicals via an EDA complex was well supported by UV-vis absorbance measurements, NMR titration experiments, and d. functional theory (DFT) calculations The method was applied to the regio- and stereo-selective arylation of various N-heterocycles under mild conditions, yielding an assembly of challengingly linked heteroaryl-(hetero)aryl products.

Chemical Science published new progress about 91-16-7. 91-16-7 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether,Inhibitor,Inhibitor,Inhibitor, name is 1,2-Dimethoxybenzene, and the molecular formula is C12H14BNO2, SDS of cas: 91-16-7.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Gohil, Vishal M. published the artcileNutrient-sensitized screening for drugs that shift energy metabolism from mitochondrial respiration to glycolysis, Related Products of ethers-buliding-blocks, the publication is Nature Biotechnology (2010), 28(3), 249-255, database is CAplus and MEDLINE.

Most cells have the inherent capacity to shift their reliance on glycolysis relative to oxidative metabolism, and studies in model systems have shown that targeting such shifts may be useful in treating or preventing a variety of diseases ranging from cancer to ischemic injury. However, we currently have a limited number of mechanistically distinct classes of drugs that alter the relative activities of these two pathways. We screen for such compounds by scoring the ability of >3500 small mols. to selectively impair growth and viability of human fibroblasts in media containing either galactose or glucose as the sole sugar source. We identify several clin. used drugs never linked to energy metabolism, including the antiemetic meclizine, which attenuates mitochondrial respiration through a mechanism distinct from that of canonical inhibitors. We further show that meclizine pretreatment confers cardioprotection and neuroprotection against ischemia-reperfusion injury in murine models. Nutrient-sensitized screening may provide a useful framework for understanding gene function and drug action within the context of energy metabolism

Nature Biotechnology published new progress about 637-58-1. 637-58-1 belongs to ethers-buliding-blocks, auxiliary class Inhibitor, name is 4-(3-(4-Butoxyphenoxy)propyl)morpholine hydrochloride, and the molecular formula is C17H28ClNO3, Related Products of ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Knapp, Spring Melody M. published the artcileCatalytic Nitrile Hydration with [Ru(η⁶-p-cymene)Cl₂(PR₂R’)] Complexes: Secondary Coordination Sphere Effects with Phosphine Oxide and Phosphinite Ligands, HPLC of Formula: 16332-06-2, the publication is Organometallics (2013), 32(13), 3744-3752, database is CAplus.

The rates of nitrile hydration reactions were investigated using [Ru(η⁶-p-cymene)Cl₂(PR₂R’)] complexes as homogeneous catalysts, where PR₂R’ = PMe₂(CH₂P(O)Me₂), PMe₂(CH₂CH₂P(O)Me₂), PPh₂(CH₂P(O)Ph₂), PPh₂(CH₂CH₂P(O)Ph₂), PMe₂OH, P(OEt)₂OH. These catalysts were studied because the rate of the nitrile-to-amide hydration reaction was hypothesized to be affected by the position of the hydrogen bond accepting group in the secondary coordination sphere of the catalyst. Experiments showed that the rate of nitrile hydration was fastest when using [Ru(η⁶-p-cymene)Cl₂PMe₂OH]: i.e., the catalyst with the hydrogen bond accepting group capable of forming the most stable ring in the transition state of the rate-limiting step. This catalyst is also active at pH 3.5 and at low temperatures-conditions where α-hydroxynitriles (cyanohydrins) produce less cyanide, a known poison for organometallic nitrile hydration catalysts. The [Ru(η⁶-p-cymene)Cl₂PMe₂OH] catalyst completely converts the cyanohydrins glycolonitrile and lactonitrile to their corresponding α-hydroxyamides faster than previously investigated catalysts. [Ru(η⁶-p-cymene)Cl₂PMe₂OH] is not, however, a good catalyst for acetone cyanohydrin hydration, because it is susceptible to cyanide poisoning. Protecting the -OH group of acetone cyanohydrin was an effective way to prevent cyanide poisoning, resulting in quant. hydration of acetone cyanohydrin acetate.

Organometallics published new progress about 16332-06-2. 16332-06-2 belongs to ethers-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Amide,Ether, name is 2-Methoxyacetamide, and the molecular formula is C3H7NO2, HPLC of Formula: 16332-06-2.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Xu, Ming-xian published the artcileOne-pot synthesis of dimethyl carbonate in supercritical CO₂, COA of Formula: C4H10O2, the publication is Gaoxiao Huaxue Gongcheng Xuebao (2014), 28(6), 1334-1339, database is CAplus.

The synthesis of di-Me carbonate (DMC) was studied with carbon dioxide, propylene oxide (PO) and methanol as raw material, potassium methoxide (CH₃OK) as catalyst, calcium chloride (CaCl₂) as dehydration agent. The effects of factors such as the volume ratio of methanol and PO (1-12), stirring speed (0-500 r·min^-1), pressure (5.0-10.0 MPa), temperature (110-190°) and reaction time (0.25-3.0 h) on the synthesis of DMC were investigated. A possible reaction mechanism of one-pot synthesis of di-Me carbonate on CH₃OK was proposed. The results show that the conversion of methanol and the yield of DMC could reach 22.0% and 45.5% resp. under optimized reaction conditions (V_CH3OH : V_PO = 10 : 1, stirring speed 300 r·min^-1, pressure 7.0 MPa, temperature 140°, reaction time 1 h).

Gaoxiao Huaxue Gongcheng Xuebao published new progress about 1589-47-5. 1589-47-5 belongs to ethers-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ether, name is 2-Methoxypropan-1-ol, and the molecular formula is C4H6F3NOS, COA of Formula: C4H10O2.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Kapadia, Akshay published the artcileStructural and mechanistic insights into the inhibition of amyloid-β aggregation by Aβ_39-42 fragment derived synthetic peptides, Safety of (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)-3-phenylpropanoic acid, the publication is European Journal of Medicinal Chemistry (2021), 113126, database is CAplus and MEDLINE.

The inhibition of amyloid-β (Aβ) aggregation is a promising approach towards therapeutic intervention for Alzheimers disease (AD). Thirty eight tetrapeptides based upon Aβ39-42C-terminus fragment of the parent Aβ peptide were synthesized. The sequential replacement/modification employing unnatural amino acids imparted scaffold diversity, augmented activity, enhanced blood brain barrier permeability and offered proteolytic stability to the synthetic peptides. Several peptides exhibited promising protection against Aβ aggregation-mediated-neurotoxicity in PC-12 cells at doses ranged between 10μM and 0.1μM, further confirmed by the thioflavin-T fluorescence assay. CD study illustrate that these peptides restrict the β-sheet formation, and the non-appearance of Aβ42 fibrillar structures in the electron microscopy confirm the inhibition of Aβ42 aggregation. HRMS and ANS fluorescence spectroscopic anal. provided addnl. mechanistic insights. Two selected lead peptides 5 and 16 depicted enhanced blood-brain penetration and stability against serum and proteolytic enzyme. Structural insights into ligand-Aβ interactions on the monomeric and proto-fibrillar units of Aβ were computationally studied. Promising inhibitory potential and short sequence of the lead peptides offers new avenues for the advancement of peptide-derived therapeutics for AD.

European Journal of Medicinal Chemistry published new progress about 77128-73-5. 77128-73-5 belongs to ethers-buliding-blocks, auxiliary class Inhibitor, name is (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)-3-phenylpropanoic acid, and the molecular formula is C25H23NO4, Safety of (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)-3-phenylpropanoic acid.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Panigrahi, Ahwan published the artcileZnBr₂ Mediated C-N Bond Formation using Cinnamyl Alcohol and 2-Amino Pyridines, Application of N-(4-Methoxybenzyl)pyridin-2-amine, the publication is European Journal of Organic Chemistry (2021), 2021(21), 3054-3058, database is CAplus.

A simple method for C-N bond formation is disclosed by using cinnamyl alcs. and 2-amino pyridine derivatives in the presence of stoichiometric amount of zinc bromide. This reaction works with a wide range of substrates, and is compatible with primary, secondary, and homoallylic alcs. To the best of our knowledge, this is the first report for C-N bond formation using cinnamyl alc. and 2-amino pyridines using zinc bromide as a Lewis acid.

European Journal of Organic Chemistry published new progress about 52818-63-0. 52818-63-0 belongs to ethers-buliding-blocks, auxiliary class Pyridine,Amine,Benzene,Ether, name is N-(4-Methoxybenzyl)pyridin-2-amine, and the molecular formula is C13H14N2O, Application of N-(4-Methoxybenzyl)pyridin-2-amine.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem