Knapp, Spring Melody M. published the artcileCatalytic Nitrile Hydration with [Ru(η6-p-cymene)Cl2(PR2R’)] Complexes: Secondary Coordination Sphere Effects with Phosphine Oxide and Phosphinite Ligands, HPLC of Formula: 16332-06-2, the publication is Organometallics (2013), 32(13), 3744-3752, database is CAplus.
The rates of nitrile hydration reactions were investigated using [Ru(η6-p-cymene)Cl2(PR2R’)] complexes as homogeneous catalysts, where PR2R’ = PMe2(CH2P(O)Me2), PMe2(CH2CH2P(O)Me2), PPh2(CH2P(O)Ph2), PPh2(CH2CH2P(O)Ph2), PMe2OH, P(OEt)2OH. These catalysts were studied because the rate of the nitrile-to-amide hydration reaction was hypothesized to be affected by the position of the hydrogen bond accepting group in the secondary coordination sphere of the catalyst. Experiments showed that the rate of nitrile hydration was fastest when using [Ru(η6-p-cymene)Cl2PMe2OH]: i.e., the catalyst with the hydrogen bond accepting group capable of forming the most stable ring in the transition state of the rate-limiting step. This catalyst is also active at pH 3.5 and at low temperatures-conditions where α-hydroxynitriles (cyanohydrins) produce less cyanide, a known poison for organometallic nitrile hydration catalysts. The [Ru(η6-p-cymene)Cl2PMe2OH] catalyst completely converts the cyanohydrins glycolonitrile and lactonitrile to their corresponding α-hydroxyamides faster than previously investigated catalysts. [Ru(η6-p-cymene)Cl2PMe2OH] is not, however, a good catalyst for acetone cyanohydrin hydration, because it is susceptible to cyanide poisoning. Protecting the -OH group of acetone cyanohydrin was an effective way to prevent cyanide poisoning, resulting in quant. hydration of acetone cyanohydrin acetate.
Organometallics published new progress about 16332-06-2. 16332-06-2 belongs to ethers-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Amide,Ether, name is 2-Methoxyacetamide, and the molecular formula is C3H7NO2, HPLC of Formula: 16332-06-2.
Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem