Month: December 2022

Ramachandran, Rangasamy published the artcileRuthenium(II) carbonyl complexes designed with arsine and PNO/PNS ligands as catalysts for N-alkylation of amines via hydrogen autotransfer process, Application of N-(4-Methoxybenzyl)pyridin-2-amine, the publication is Journal of Organometallic Chemistry (2015), 130-140, database is CAplus.

A series of phosphine-functionalized hydrazone/thiosemicarbazone ligands and their corresponding ruthenium(II) carbonyl complexes of the type [RuCl(CO)(AsPh₃)(L)] [L = 2-(2-(diphenylphosphino)benzylidene)benzoic acid hydrazone (PNO-BHy), 2-(2-(diphenylphosphino)benzylidene)nicotinic acid hydrazone (PNO-NHy), 2-(2-(diphenylphosphino)benzylidene)-2-furoic hydrazone (PNO-FHy), 2-(2-(diphenylphosphino)benzylidene)-4-ethyl-3-thiosemicarbazone (PNS-EtTs), 2-(2-(diphenylphosphino)benzylidene)-4-cyclohexyl-3-thiosemicarbazone (PNS-CyTs)] have been synthesized based on the ligands with different electronic and steric effects. These complexes were characterized by elemental analyses and various spectral methods. The solid-state structure of the ruthenium PNS-EtTs complex was determined by single-crystal X-ray diffraction method. In all of the complexes, the ligand was bound to the Ru(II) center via the PNO/PNS donor atoms. All the ruthenium(II) complexes were demonstrated as highly efficient catalysts for the synthesis of secondary amines/amides by the coupling of primary amines/amides with alcs. at low catalyst loading, and the maximum yield was obtained up to 98%. The N-alkylation reaction can be readily carried out under moderate conditions, and release of water is the sole byproduct. In addition, the effects of substituents on the ligand, solvents, base and catalyst loading on the catalytic activity of the complexes have been investigated. Advantageously, only one equivalent of the alc. was consumed in the process.

Journal of Organometallic Chemistry published new progress about 52818-63-0. 52818-63-0 belongs to ethers-buliding-blocks, auxiliary class Pyridine,Amine,Benzene,Ether, name is N-(4-Methoxybenzyl)pyridin-2-amine, and the molecular formula is C13H14N2O, Application of N-(4-Methoxybenzyl)pyridin-2-amine.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Ramachandran, Rangasamy published the artcileEfficient and versatile catalysis of N-alkylation of heterocyclic amines with alcohols and one-pot synthesis of 2-aryl substituted benzazoles with newly designed ruthenium(II) complexes of PNS thiosemicarbazones, Recommanded Product: N-(4-Methoxybenzyl)pyridin-2-amine, the publication is Dalton Transactions (2014), 43(21), 7889-7902, database is CAplus and MEDLINE.

Ru(II) carbonyl complexes with phosphine-functionalized PNS type thiosemicarbazone ligands [RuCl(CO)(EPh₃)(L)] (1–6) (E = P or As, L = 2-(2-(diphenylphosphino)benzylidene) thiosemicarbazone (PNS-H), 2-(2-(diphenylphosphino)benzylidene)-N-methylthiosemicarbazone (PNS-Me), 2-(2-(diphenylphosphino)benzylidene)-N-phenylthiosemicarbazone (PNS-Ph)) were synthesized and characterized by elemental anal. and spectroscopy (IR, UV-visible, ¹H, ¹³C, ³¹P-NMR) as well as ESI mass spectrometry. The mol. structures of complexes 1, 2 and 6 were identified by single-crystal x-ray diffraction anal. The anal. revealed that all the complexes possess a distorted octahedral geometry with the ligand coordinating in a uni-neg. tridentate PNS fashion. All the Ru complexes (1–6) were tested as catalyst for N-alkylation of heteroaromatic amines with alcs. Notably, complex 2 is a very efficient and versatile catalyst towards N-alkylation of a wide range of heterocyclic amines with alcs. Complex 2 can also catalyze the direct amination of 2-nitropyridine with benzyl alc. to the corresponding secondary amine. Also, a preliminary examination of performance for N,N-dialkylation of diamine showed promising results, giving good conversion and high selectivity. N-alkylation of ortho-substituted anilines (-NH₂, -OH and -SH) led to the 1-pot synthesis of 2-aryl substituted benzimidazoles, benzoxazoles and benzothiazoles, also revealing the catalytic activity of complex 2.

Dalton Transactions published new progress about 52818-63-0. 52818-63-0 belongs to ethers-buliding-blocks, auxiliary class Pyridine,Amine,Benzene,Ether, name is N-(4-Methoxybenzyl)pyridin-2-amine, and the molecular formula is C13H14N2O, Recommanded Product: N-(4-Methoxybenzyl)pyridin-2-amine.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Ramachandran, Rangasamy published the artcileRuthenium(II) complexes containing a phosphine-functionalized thiosemicarbazone ligand: synthesis, structures and catalytic C-N bond formation reactions via N-alkylation, Recommanded Product: N-(4-Methoxybenzyl)pyridin-2-amine, the publication is RSC Advances (2015), 5(15), 11405-11422, database is CAplus.

A series of ruthenium(II) complexes incorporating a thiosemicarbazone chelate tethered with a diphenylphosphine pendant have been studied. Thus, [(PNS-Et)RuCl(CO)(PPh₃)] (1), [N,S-(PNS-Et)RuH(CO)(PPh₃)₂] (2) and [(PNS-Et)RuCl(PPh₃)] (3) were synthesized by reactions of various Ru^II precursors with 2-(2-(diphenylphosphino)benzylidene)-N-ethylthiosemicarbazone (PNS-Et). However, complexation of PNS-Et with an equimolar amount of [RuCl₂(DMSO)₄] resulted in two different entities [(PNS-Et)RuCl(DMSO)₂] (4) and [(PNS-Et)₂Ru] (5) with different structural features in a single reaction. All the Ru^II complexes have been characterized by anal. and various spectroscopic techniques. Compounds 1–5 were recrystallized, and the x-ray crystal structures have been reported for 1, 2 and 5. In the complexes 1 and 3–5 the ligand coordinated in a tridentate monobasic fashion by forming PNS five- and six-membered rings, whereas in 2, the ligand coordinated in a bidentate monobasic fashion by forming a strained NS four-membered ring. Furthermore, compounds 1–5 showed catalytic activity in N-alkylation of heteroaromatic amines. Notably, complexes 1–3 are very efficient catalysts toward N-alkylation of a wide range of heterocyclic amines with alcs. In the presence of a catalytic amount of 2 with 50 mol% of KOH, N₁,C₅-dialkylation of 4-phenylthiazol-2-amine has been investigated. Reaction of in situ generated aldehyde with amine yields the N₁,C₅-dialkylated products through the hydride ion transformation from alc. Complexes 1–3 also catalyzed a variety of coupling reactions of benzyl alcs. and sulfonamides, which were realized often with 99% isolated yields. Advantageously, only one equivalent of the primary alc. was consumed in the process.

RSC Advances published new progress about 52818-63-0. 52818-63-0 belongs to ethers-buliding-blocks, auxiliary class Pyridine,Amine,Benzene,Ether, name is N-(4-Methoxybenzyl)pyridin-2-amine, and the molecular formula is C13H14N2O, Recommanded Product: N-(4-Methoxybenzyl)pyridin-2-amine.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Ramachandran, P. Veeraraghavan published the artcilePreparative-scale synthesis of both antipodes of B-γ,γ-dimethylallyldiisopinocampheylborane: application for the synthesis of C₁-C₆ subunit of epothilone, HPLC of Formula: 99438-28-5, the publication is Tetrahedron Letters (2004), 45(5), 1011-1013, database is CAplus.

A preparative-scale synthesis of B-γ,γ-dimethylallyldiisopinocampheylborane starting from prenyl alc. has been described. This reagent, upon reaction with various aldehydes, provides the corresponding α,α-dimethylhomoallylic alcs. in high enantioselectivities. The application of this reagent has been demonstrated for the synthesis of C₁-C₆ subunit of epothilone.

Tetrahedron Letters published new progress about 99438-28-5. 99438-28-5 belongs to ethers-buliding-blocks, auxiliary class Chiral,Aliphatic cyclic hydrocarbon, name is (+)-B-Methoxydiisopinocampheylborane, and the molecular formula is C21H37BO, HPLC of Formula: 99438-28-5.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Li, Zhe published the artcileFluorinated triphenylenes and a path to short tailed discotic liquid crystals: synthesis, structure and transport properties, Safety of 1,2-Dimethoxybenzene, the publication is Materials Advances (2022), 3(1), 534-546, database is CAplus.

A new synthetic approach for fluorinated alkoxytriphenylene discotic liquid crystals is presented. This methodol. exploits the previously described photocyclodehydrofluorination (PCDHF) reaction for the preparation of fluorinated triphenylene derivatives coupled with a variety of nucleophilic aromatic substitution (S_NAr) reactions. This particular combination of reactions provides a versatile route to discotic materials with carefully controlled core fluorine and alkoxy tail content. In the course of these studies, new discotic materials with minimal tail content have been revealed. The mesogenic properties of these materials are reported, and their charge transport properties are measured using the time of flight technique.

Materials Advances published new progress about 91-16-7. 91-16-7 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether,Inhibitor,Inhibitor,Inhibitor, name is 1,2-Dimethoxybenzene, and the molecular formula is C8H10O2, Safety of 1,2-Dimethoxybenzene.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Sardashti, A. R. published the artcileChemical composition of the essential oil of A. kermanensis from Taftan area by GC/MS technique, Product Details of C10H14O, the publication is International Journal of Agriculture and Crop Sciences (2012), 4(9), 561-563, 3 pp., database is CAplus.

The aerial parts of A. Kermanensis were subjected to hydro distillation by a Clevenger-type apparatus to produce an oil in 1.87% weight/weight yield. It was then analyzed by GC/MS. Identification of the compounds was carried out by comparison of their mass spectra with those of authentic sample together with the relative retention indexes. 37 Components were identified representing 97.04% of the oil. It contained mainly oxygenated monoterpenes (71.68%) with 1,8 cineole (56.55%), Borneol (5.28%) Geranyl perpionate (4.05%), camphor (4.48%), beta Thujone (2.84%), 4-Terpineol (2.77%) and unknown compound (2.94%) as the major constituents. The amount of Sesquiterpenes were representing (1.30% weight/weight) of the total oil. The results clearly showed the richness of oil in monoterpenes, which may be due to the collection of plant material during the flowering period.

International Journal of Agriculture and Crop Sciences published new progress about 2944-47-0. 2944-47-0 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 2-Isopropylanisole, and the molecular formula is C10H14O, Product Details of C10H14O.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Gurram, Venkateshwarlu published the artcileC-C Cross-Coupling Reactions of O⁶-Alkyl-2-Haloinosine Derivatives and a One-Pot Cross-Coupling/O⁶-Deprotection Procedure, Synthetic Route of 947533-23-5, the publication is Chemistry – An Asian Journal (2012), 7(8), 1853-1861, S1853/1-S1853/41, database is CAplus and MEDLINE.

Reaction conditions for the C-C cross-coupling of O⁶-alkyl-2-bromo- and 2-chloroinosine derivatives with aryl-, heteroaryl-, and alkylboronic acids were studied. Optimization experiments with silyl-protected 2-bromo-O⁶-methylinosine led to the identification of [PdCl₂(dcpf)]/K₃PO₄ in 1,4-dioxane as the best conditions for these reactions (dcpf=1,1′-bis(dicyclohexylphosphino)ferrocene). Attempted O⁶-demethylation, as well as the replacement of the C-6 methoxy group by amines, was unsuccessful, which led to the consideration of Pd-cleavable groups such that C-C cross-coupling and O⁶-deprotection could be accomplished in a single step. Thus, inosine 2-chloro-O⁶-allylinosine was chosen as the substrate and, after re-evaluation of the cross-coupling conditions with 2-chloro-O⁶-methylinosine as a model substrate, one-step C-C cross-coupling/deprotection reactions were performed with the O⁶-allyl analog. These reactions are the first such examples of a one-pot procedure for the modification and deprotection of purine nucleosides under C-C cross-coupling conditions.

Chemistry – An Asian Journal published new progress about 947533-23-5. 947533-23-5 belongs to ethers-buliding-blocks, auxiliary class Nitrile,Boronic acid and ester,Benzene,Ether,Boronic Acids,Boronic Acids,Boronic acid and ester,, name is (4-(Cyanomethoxy)phenyl)boronic acid, and the molecular formula is C8H8BNO3, Synthetic Route of 947533-23-5.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Wang, Xiang published the artcileTotal Synthesis of the Salicylate Enamide Macrolide Oximidine II, Synthetic Route of 99438-28-5, the publication is Journal of the American Chemical Society (2003), 125(20), 6040-6041, database is CAplus and MEDLINE.

The asym. synthesis of the salicylate enamide macrolide oximidine II (I) is reported. The synthesis involves a highly regio- and stereoselective ring-closing metathesis of a bis-diene substrate to construct the macrocyclic triene core. Copper(I)-mediated amidation of a (Z)-vinyl iodide was employed to attach the enamide side chain.

Journal of the American Chemical Society published new progress about 99438-28-5. 99438-28-5 belongs to ethers-buliding-blocks, auxiliary class Chiral,Aliphatic cyclic hydrocarbon, name is (+)-B-Methoxydiisopinocampheylborane, and the molecular formula is C5H5F3O2, Synthetic Route of 99438-28-5.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Nikolic, Kosta published the artcileElectro-analytical determination of some compounds from a group of synthetic local anesthetics, SDS of cas: 637-58-1, the publication is Arhiv za Farmaciju (1977), 27(1), 37-43, database is CAplus.

Amylocaine-HCl [532-59-2], butanilcaine-HCl [6027-28-7], dibucaine-HCl [61-12-1], falicaine [1155-49-3], cornecaine [3686-68-8], pramoxine-HCL [637-58-1], and tetracaine-HCl [136-47-0] in DMSO were determined by conductometric titration with KOH. The standard deviations were 0.2, 0.2, 0.1, 0.3, 0.3, 0.1 and 0.2, reps.

Arhiv za Farmaciju published new progress about 637-58-1. 637-58-1 belongs to ethers-buliding-blocks, auxiliary class Inhibitor, name is 4-(3-(4-Butoxyphenoxy)propyl)morpholine hydrochloride, and the molecular formula is C17H28ClNO3, SDS of cas: 637-58-1.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Jin, Kang published the artcileSynthesis and structure-activity relationship of teixobactin analogues via convergent Ser ligation, Formula: C25H23NO4, the publication is Bioorganic & Medicinal Chemistry (2017), 25(18), 4990-4995, database is CAplus and MEDLINE.

Convergent Ser/Thr ligation has been used to prepare a series of teixobactin analogs (28 in total) to establish a structure-activity relationship of teixobactin. anti-bacterial evaluations of these synthetic analogs have revealed the critical amino acid residues and the sites tolerable of modifications. These studies will shed lights on the further development of teixobactin analogs with improved antibacterial activities.

Bioorganic & Medicinal Chemistry published new progress about 77128-73-5. 77128-73-5 belongs to ethers-buliding-blocks, auxiliary class Inhibitor, name is (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)-3-phenylpropanoic acid, and the molecular formula is C25H23NO4, Formula: C25H23NO4.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem