Gurram, Venkateshwarlu published the artcileC-C Cross-Coupling Reactions of O6-Alkyl-2-Haloinosine Derivatives and a One-Pot Cross-Coupling/O6-Deprotection Procedure, Synthetic Route of 947533-23-5, the publication is Chemistry – An Asian Journal (2012), 7(8), 1853-1861, S1853/1-S1853/41, database is CAplus and MEDLINE.
Reaction conditions for the C-C cross-coupling of O6-alkyl-2-bromo- and 2-chloroinosine derivatives with aryl-, heteroaryl-, and alkylboronic acids were studied. Optimization experiments with silyl-protected 2-bromo-O6-methylinosine led to the identification of [PdCl2(dcpf)]/K3PO4 in 1,4-dioxane as the best conditions for these reactions (dcpf=1,1′-bis(dicyclohexylphosphino)ferrocene). Attempted O6-demethylation, as well as the replacement of the C-6 methoxy group by amines, was unsuccessful, which led to the consideration of Pd-cleavable groups such that C-C cross-coupling and O6-deprotection could be accomplished in a single step. Thus, inosine 2-chloro-O6-allylinosine was chosen as the substrate and, after re-evaluation of the cross-coupling conditions with 2-chloro-O6-methylinosine as a model substrate, one-step C-C cross-coupling/deprotection reactions were performed with the O6-allyl analog. These reactions are the first such examples of a one-pot procedure for the modification and deprotection of purine nucleosides under C-C cross-coupling conditions.
Chemistry – An Asian Journal published new progress about 947533-23-5. 947533-23-5 belongs to ethers-buliding-blocks, auxiliary class Nitrile,Boronic acid and ester,Benzene,Ether,Boronic Acids,Boronic Acids,Boronic acid and ester,, name is (4-(Cyanomethoxy)phenyl)boronic acid, and the molecular formula is C8H8BNO3, Synthetic Route of 947533-23-5.
Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem