Month: December 2022

Nishioka, Kiho published the artcileN,N-Dimethylethanesulfonamide as an Electrolyte Solvent Stable for the Positive Electrode Reaction of Aprotic Li-O2 Batteries, Computed Properties of 143-24-8, the main research area is dimethylethanesulfonamide electrolyte solvent pos electrode lithium oxygen battery.

The realization of secondary lithium-oxygen batteries (Li-O2 batteries, LOBs) with large gravimetric energy d. requires the development of an innovative electrolyte with high chem. stability that allows the charge-discharge reaction to proceed with low overvoltage. In this study, we evaluated the potential of an electrolyte solvent, N,N-dimethylethanesulfonamide (DMESA) with a sulfonamide functional group, at a c.d. of 0.4 mA cm-2 and a capacity of 4 mA h cm-2. The voltage at which CO2 was generated during charging was substantially higher than that of a tetraglyme (G4)-based electrolyte with redox mediators, which is one of the standard electrolytes used for LOBs. Experiments using a 13C-containing pos. electrode revealed that CO2 generated during charging mainly originated from the decomposition of the pos. electrode. The analyses of the charging profile in conjunction with differential electrochem. mass spectrometry suggested the formation of highly degradable lithium peroxide (Li2O2) in the DMESA-based electrolyte. The formation of highly degradable Li2O2 enables a reduction of the charging voltage, leading to further suppression of the electrolyte decomposition

ACS Applied Energy Materials published new progress about Battery anodes. 143-24-8 belongs to class ethers-buliding-blocks, name is 2,5,8,11,14-Pentaoxapentadecane, and the molecular formula is C10H22O5, Computed Properties of 143-24-8.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Zhang, Yi-Nan published the artcileSacrificial Co-solvent Electrolyte to Construct a Stable Solid Electrolyte Interphase in Lithium-Oxygen Batteries, HPLC of Formula: 143-24-8, the main research area is cosolvent electrolyte solid interphase lithium oxygen battery; Li-O2 battery; MeIM; co-solvent; sacrificial electrolyte; solid electrolyte interphase.

Lithium-oxygen batteries are vital devices for electrochem. energy storage. The electrolyte is a crucial factor for improving battery performance. The high reactivity of lithium metal induces side reactions with organic electrolytes, thus leading to an unstable interface between the anode and electrolyte and poor performance of batteries. In this work, to compensate for the above shortcomings, 1-methylimidazole (MeIm) is introduced to the tetraethylene glycol di-Me ether (TEGDME) electrolyte to form the TEGDME/MeIm co-solvent electrolyte. Because of the high donor number value of MeIm, the solution-based pathway of discharge products can be triggered. Compared with the single TEGDME electrolyte, the discharge capacity with the TEGDME/MeIm co-solvent electrolyte is increased by more than 2 times. Moreover, the TEGDME/MeIm co-solvent electrolyte can promote the dissociation of Li salt due to the high dielec. constant of MeIm and thus make up for the shortcomings of TEGDME. In addition, due to the lower energy than the LUMO (LUMO) level of TEGDME, MeIm is decomposed preferentially, and a dense solid electrolyte interphase (SEI) layer is constructed. Then, the decomposition of TEGDME is suppressed. Therefore, the cycle performance of the battery with the TEGDME/MeIm co-solvent electrolyte is 18 times compared to that with the single TEGDME electrolyte.

ACS Applied Materials & Interfaces published new progress about Battery anodes. 143-24-8 belongs to class ethers-buliding-blocks, name is 2,5,8,11,14-Pentaoxapentadecane, and the molecular formula is C10H22O5, HPLC of Formula: 143-24-8.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Sultana, Fozia published the artcileAn innovative approach towards the simultaneous enhancement of the oxygen reduction and evolution reactions using a redox mediator in polymer based Li-O2 batteries, Recommanded Product: 2,5,8,11,14-Pentaoxapentadecane, the main research area is lithium oxygen battery cathode redox mediator polymer electrolyte.

For safety concerns, polymer-based Li-O2 batteries have received more attention than traditional non-aqueous Li-O2 batteries. However, poor cycling stability, low round trip efficiency, and over charge potential during cycling are the major shortcomings for their future applications. In this work, a soluble redox mediator integrated into a polymer electrolyte provides immediate access to the solid discharged product, lowering the energy barrier for reversible Li2O2 generation and disintegration. Moreover, introducing a redox mediator to the polymer electrolyte boosts the ORR during discharge and the OER during the recharge process. The synergistic redox mediator pBQ (1,4-benzoquinone) dramatically reduces the over-potential. A small proportion of pBQ in the polymer electrolyte allows Li2O2 to develop in a thin film-like morphol. on the cathode surface, resulting in a high reversible capacity of ∼12 000 mA h g-1 and an extended cycling stability of 100 cycles at 200 mA g-1 with a cut-off capacity of 1000 mA h g-1. The remarkable cell performance is attributed to the fast kinetics of para-benzoquinone for the ORR and OER in Li-O2 batteries. The use of a redox mediator in a polymer electrolyte opens a new avenue for practical Li-O2 battery applications in achieving low charge potential and excellent energy efficiency.

Dalton Transactions published new progress about Battery anodes. 143-24-8 belongs to class ethers-buliding-blocks, name is 2,5,8,11,14-Pentaoxapentadecane, and the molecular formula is C10H22O5, Recommanded Product: 2,5,8,11,14-Pentaoxapentadecane.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ali, Shoukath M. published the artcileEndoxifen is a new potent inhibitor of PKC: A potential therapeutic agent for bipolar disorder, Recommanded Product: (2-Chloroethoxy)benzene, the main research area is endoxifen preparation PKC inhibitor bipolar disorder.

Protein kinase C (PKC) plays a major role in regulation of both pre and postsynaptic neurotransmission. Excessive activation of PKC results in symptoms related to bipolar disorder. Tamoxifen, a widely used breast cancer drug is known to inhibit PKC and demonstrate antimanic properties in human. We describe herein the synthesis of endoxifen, a tamoxifen active metabolite and compared its PKC inhibitory activity with that of tamoxifen. Endoxifen exhibited fourfold higher potency compared to tamoxifen.

Bioorganic & Medicinal Chemistry Letters published new progress about Antipsychotics. 622-86-6 belongs to class ethers-buliding-blocks, name is (2-Chloroethoxy)benzene, and the molecular formula is C8H9ClO, Recommanded Product: (2-Chloroethoxy)benzene.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Aranapakam, Venkatesan published the artcileSynthesis and Structure-Activity Relationship of N-Substituted 4-Arylsulfonylpiperidine-4-hydroxamic Acids as Novel, Orally Active Matrix Metalloproteinase Inhibitors for the Treatment of Osteoarthritis, Category: ethers-buliding-blocks, the main research area is arylsulfonylpiperidinehydroxamic acid preparation matrix metalloproteinase inhibitor structure activity.

A series of novel and orally active N-substituted 4-benzenesulfonylpiperidine-4-carboxylic acid hydroxyamide derivatives have been synthesized and their structure-activity relationships determined Among the several compounds synthesized, I turned out to be a potent, selective, and an orally active MMP inhibitor in the clin. relevant advanced rabbit osteoarthritis model. Pharmacokinetics and metabolism data are reported.

Journal of Medicinal Chemistry published new progress about Antiarthritics. 622-86-6 belongs to class ethers-buliding-blocks, name is (2-Chloroethoxy)benzene, and the molecular formula is C8H9ClO, Category: ethers-buliding-blocks.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Kawashima, Yutaka published the artcileStructure-activity studies of 3-benzoylpropionic acid derivatives suppressing adjuvant arthritis, Application In Synthesis of 622-86-6, the main research area is antiarthritic benzoylpropionate.

3-Benzoylpropionic acid derivatives possess an immunomodulative activity and suppress adjuvant arthritis. To understand how substituents affect the biol. activity, the quant. structure-activity relationships of 30 compounds were analyzed by the adaptive least-squares method. For the suppressing activity in rats, the electronic effects and the structural feature of the substituent on benzene ring were suggested to be important. To reinforce and confirm the correlation, 4 addnl. compounds of phenoxybutyric acid derivatives were synthesized and tested with the rat adjuvant-induced arthritis. These compounds were found to have potent suppressing activity.

Chemical & Pharmaceutical Bulletin published new progress about Antiarthritics. 622-86-6 belongs to class ethers-buliding-blocks, name is (2-Chloroethoxy)benzene, and the molecular formula is C8H9ClO, Application In Synthesis of 622-86-6.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Atchimnaidu, Siriki published the artcilePhototheranostic DNA micelles from the self-assembly of DNA-BODIPY amphiphiles for the thermal ablation of cancer cells, Product Details of C9H20O5, the main research area is phototheranostic DNA micelle BODIPY amphiphile cancer cell thermal ablation.

Design of phototheranostic agents in a single step approach is one of the challenges in cancer therapy. Herein, a one-step strategy based on amphiphilicity-driven self-assembly of DNA-BODIPY amphiphiles for the design of a new class of micelles, which offer all three phototheranostic functions, is reported. These include (i) strong emission at NIR (ϕf = 30%) for imaging, (ii) high photothermal conversion (η = 52%) for PTT and (iii) an ssDNA-based shell for the integration of cell targeting moieties. Selective uptake of DNA micelles into a target cancer cell and its killing by laser irradiation (635 nm) are also demonstrated. Furthermore, the excellent biocompatibility, ultrasmall nanosize and high stability of DNA micelles are promising for in vivo applications.

Nanoscale published new progress about Amphipathicity. 23783-42-8 belongs to class ethers-buliding-blocks, name is 2,5,8,11-Tetraoxatridecan-13-ol, and the molecular formula is C9H20O5, Product Details of C9H20O5.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Liu, Runzeng published the artcileSynthetic phenolic antioxidants: A review of environmental occurrence, fate, human exposure, and toxicity, Computed Properties of 121-00-6, the main research area is review synthetic phenolic antioxidants environmental occurrence human exposure toxicity.

Synthetic phenolic antioxidants (SPAs) are widely used in various industrial and com. products to retard oxidative reactions and lengthen product shelf life. In recent years, numerous studies have been conducted on the environmental occurrence, human exposure, and toxicity of SPAs. Here, we summarize the current understanding of these issues and provide recommendations for future research directions. SPAs have been detected in various environmental matrixes including indoor dust, outdoor air particulates, sea sediment, and river water. Recent studies have also observed the occurrence of SPAs, such as 2,6-di-tert-butyl-4-methylphenol (BHT) and 2,4-di-tert-butyl-phenol (DBP), in humans (fat tissues, serum, urine, breast milk, and fingernails). In addition to these parent compounds, some transformation products have also been detected both in the environment and in humans. Human exposure pathways include food intake, dust ingestion, and use of personal care products. For breastfeeding infants, breast milk may be an important exposure pathway. Toxicity studies suggest some SPAs may cause hepatic toxicity, have endocrine disrupting effects, or even be carcinogenic. The toxicity effects of some transformation products are likely worse than those of the parent compound For example, 2,6-di-tert-butyl-p-benzoquinone (BHT-Q) can cause DNA damage at low concentrations Future studies should investigate the contamination and environmental behaviors of novel high mol. weight SPAs, toxicity effects of coexposure to several SPAs, and toxicity effects on infants. Future studies should also develop novel SPAs with low toxicity and low migration ability, decreasing the potential for environmental pollution.

Environmental Science & Technology published new progress about Adipose tissue. 121-00-6 belongs to class ethers-buliding-blocks, name is 4-Hydroxy-3-tert-butylanisole, and the molecular formula is C11H16O2, Computed Properties of 121-00-6.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Arrieta, Oscar published the artcileClinical Impact of the COVID -19 Pandemic in Mexican Patients with Thoracic Malignancies, Recommanded Product: 4-Hydroxy-3-tert-butylanisole, the main research area is COVID19 pandemic thoracic malignancy Mexico; Coronavirus disease 2019; Lung cancer; Pandemic; Severe acute respiratory syndrome coronavirus 2; Thoracic neoplasms.

Accumulated evidence indicates that patients with lung cancer are a vulnerable population throughout the pandemic. Limited information is available in Latin America regarding the impact of the pandemic on medical care. The goal of this study was to describe the clin. and social effect of COVID-19 on patients with thoracic cancer and to ascertain outcomes in those with a confirmed diagnosis. This cohort study included patients with thoracic neoplasms within a single institution between March 1, 2020, and Feb. 28, 2021. All variables of interest were extracted from electronic medical records. During this period, the Depression Anxiety and Stress Scale 21 (DASS-2) was applied to evaluate and identify more common psychol. disorders. The mean age for the total cohort (n = 548) was 61.5 ± 12.9 years; non-small cell lung cancer was the most frequent neoplasm (86.9%), advanced stages predominated (80%), and most patients were under active therapy (82.8%). Any change in treatment was reported in 23.9% of patients, of which 78.6% were due to the COVID-19 pandemic. Treatment delays (≥7 days) were the most frequent modifications in 41.9% of cases, followed by treatment suspension at 37.4%. Patients without treatment changes had a more prolonged progression-free survival and overall survival (hazard ratio [HR] 0.21, p < .001 and HR 0.28, p < .001, resp.). The mean DASS-21 score was 10.45 in 144 evaluated patients, with women being more affected than men (11.41 vs. 9.08, p < .001). Anxiety was reported in 30.5% of cases, followed by depression and distress in equal proportions (18%). Depressed and stressed patients had higher odds of experiencing delays in treatment than patients without depression (odds ratio [OR] 4.5, 95% confidence interval [CI] 1.53-13.23, p = .006 and OR 3.18, 95% CI 1.2-10.06, p = .006, resp.). Treatment adjustments in patients with thoracic malignancies often occurred to avoid COVID-19 contagion with detrimental effects on survival. Psychol. disorders could have a role in adherence to the original treatment regimen. Oncologist published new progress about Adenocarcinoma. 121-00-6 belongs to class ethers-buliding-blocks, name is 4-Hydroxy-3-tert-butylanisole, and the molecular formula is C11H16O2, Recommanded Product: 4-Hydroxy-3-tert-butylanisole.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Zhang, Ning published the artcileChanges of amygdalin and volatile components of apricot kernels during the ultrasonically-accelerated debitterizing, Related Products of ethers-buliding-blocks, the main research area is amygdalin apricot kernel ultrasonic debitterizing; Amygdalin; Apricot kernels; Debitterizing; Epimerization; Volatile components.

Ultrasound has been regarded as an efficient novel technique for debitterizing of the apricot kernels, but its influence is severely concerned on the possible epimerization of D-amygdalin to the L-amygdalin, a more potentially toxigenic compound Considering this, the experiments were conducted to investigate the epimerization of D-amygdalin and the volatile components in the debitterizing water, which were separated and identified by the high performance liquid chromatog. (HPLC) and gas chromatog. with a mass spectrometer (GC-MS), resp. The results indicate that the ultrasonically-debitterizing did not cause the epimerization of D-amygdalin to the L-amygdalin, while the procedure can be greatly accelerated due to the rapid mass transfer and degradation of D-amygdalin induced by ultrasound irradiation In addition, the water from the ultrasonically-debitterizing of apricot kernels exerted more aromas compared with that of the conventional debitterizing, which might have more applications about this kind of water. In a word, ultrasound can be safely applied in the debitterizing industry of apricot kernels.

Ultrasonics Sonochemistry published new progress about Ultrasonication. 121-00-6 belongs to class ethers-buliding-blocks, name is 4-Hydroxy-3-tert-butylanisole, and the molecular formula is C11H16O2, Related Products of ethers-buliding-blocks.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem