Month: December 2022

Childers, Wayne published the artcileNovel compounds that reverse the disease phenotype in Type 2 Gaucher disease patient-derived cells, Computed Properties of 622-86-6, the main research area is structure preparation compound reversing phenotype Gaucher disease; Diphenylethanono; Gaucher disease; Lysosomal storage disease; Neuronopathic; Phenotypic screening.

Gaucher disease (GD) results from inherited mutations in the lysosomal enzyme β-glucocerobrosidase (GCase). Currently available treatment options for Type 1 GD are not efficacious for treating neuronopathic Type 2 and 3 GD due to their inability to cross the blood-brain barrier. In an effort to identify small mols. which could be optimized for CNS penetration we identified tamoxifen from a high throughput phenotypic screen on Type 2 GD patient-derived fibroblasts which reversed the disease phenotype. Structure activity studies around this scaffold led to novel mols. that displayed improved potency, efficacy and reduced estrogenic/antiestrogenic activity compared to the original hits. Here we present the design, synthesis and structure activity relationships that led to the lead mol. Compound 31.

Bioorganic & Medicinal Chemistry Letters published new progress about Gaucher disease. 622-86-6 belongs to class ethers-buliding-blocks, name is (2-Chloroethoxy)benzene, and the molecular formula is C8H9ClO, Computed Properties of 622-86-6.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Richter, Reinhard published the artcileDimethylformamide-catalyzed decarboxylation of alkyl chloroformates. A synthesis of primary alkyl chlorides, COA of Formula: C8H9ClO, the main research area is alkyl chloroformate decarboxylation DMF catalyst; chloride alkyl.

Chloroformates prepared from primary aliphatic alcs. readily decompose on heating with catalytic amounts of DMF, thereby giving CO2 and ∼90% alkyl chlorides RCl [R = Me(CH2)nCH2 (n = 5, 8, 10), Me(CH2)7CH:CH(CH2)7CH2, PhOCH2CH2, BuCHEtCH2], Cl2Z [Z = (CH2)10, cis- and trans-1,4-cyclohexanediyldimethylene, 1,4-CH2C6H4CH2, CH2CCCH2] and I. Reactions at 3-5° yield formimidate chlorides as labile intermediates which dissociate on heating into DMF and alkyl chlorides. Formimidates II (X = Cl, BF4) were prepared from trans-1,4-bis(hydroxymethyl)cyclohexane.

Journal of Organic Chemistry published new progress about Decarboxylation. 622-86-6 belongs to class ethers-buliding-blocks, name is (2-Chloroethoxy)benzene, and the molecular formula is C8H9ClO, COA of Formula: C8H9ClO.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ue, Makoto published the artcileMaterial balance in the O2 electrode of Li-O2 cells with a porous carbon electrode and TEGDME-based electrolytes, COA of Formula: C10H22O5, the main research area is O2electrode porous carbon electrode TEGDME electrolyte.

This work figures out the material balance of the reactions occurring in the O electrode of a Li-O cell, where a Ketjenblack-based porous carbon electrode comes into contact with a tetraethylene glycol di-Me ether (TEGDME)-based electrolyte under more practical conditions of less electrolyte amount and high areal capacity. The ratio of electrolyte weight to cell capacity (E/C, g A h) is a good parameter to correlate with cycle life. Only 5 cycles were obtained at an areal capacity of 4 mA h cm (E/C = 10) and a discharge/charge c.d. of 0.4 mA cm, which corresponds to the energy d. of 170 W h kg at a complete cell level. When the areal capacity was decreased to half (E/C = 20) by setting a c.d. at 0.2 mA cm, the cycle life was extended to 18 cycles. However, the total elec. charge consumed for parasitic reactions was 35 and 59% at the first and the third cycle, resp. This surprisingly large amount of parasitic reactions was suppressed by half using redox mediators at 0.4 mA cm while keeping a similar cycle life. Based on byproduct distribution, we will propose possible mechanisms of TEGDME decomposition and report a water breathing behavior, where HO is produced during charge and consumed during discharge.

RSC Advances published new progress about Current density. 143-24-8 belongs to class ethers-buliding-blocks, name is 2,5,8,11,14-Pentaoxapentadecane, and the molecular formula is C10H22O5, COA of Formula: C10H22O5.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Zhang, Yi-Peng published the artcileA porous framework infiltrating Li-O2 battery: a low-resistance and high-safety system, Application In Synthesis of 143-24-8, the main research area is lithium oxygen battery porous framework infiltrating.

Li-O2 batteries, which have attracted great attention because of their high energy d., suffer from issues such as flammability of organic liquid electrolytes, corrosion of the Li anode and the shuttling effect of redox mediators. Using inorganic solid-state electrolytes (SSEs) can solve such issues. But high resistance at the SSE-electrode interfaces in these batteries hinders their further development. In this study, a “”porous framework infiltrating (PFI)”” concept is proposed. The framework is created on the surface of a garnet Li6.4La3Zr1.4Ta0.6O12 (LLZTO) ceramic by acid etching. After infiltrating a tiny amount of liquid electrolyte, this framework exhibits nonflammability and is thus ideal for high-safety applications. Moreover, the porous structure increases the contact area between the SSE and cathode, which can lower the interfacial resistance and improve the rate capability. Utilizing a Li-Sn alloy anode, the PFI Li-O2 battery exhibits smooth charging platforms with different rates, a prolonged cycle life and a promising round-trip efficiency. Therefore, the PFI structure provides a new strategy to build safe and high-performance Li-O2 batteries.

Sustainable Energy & Fuels published new progress about Current density. 143-24-8 belongs to class ethers-buliding-blocks, name is 2,5,8,11,14-Pentaoxapentadecane, and the molecular formula is C10H22O5, Application In Synthesis of 143-24-8.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Kim, Yeongsu published the artcileSynergistic nanoarchitecture of mesoporous carbon and carbon nanotubes for lithium-oxygen batteries, Name: 2,5,8,11,14-Pentaoxapentadecane, the main research area is mesoporous carbon lithium oxygen battery elec conductivity; Carbon nanotube; Electrochemistry; Lithium–oxygen battery; Mesoporous carbon.

A rechargeable lithium-oxygen battery (LOB) operates via the electrochem. formation and decomposition of solid-state Li2O2 on the cathode. The rational design of the cathode nanoarchitectures is thus required to realize high-energy-d. and long-cycling LOBs. Here, we propose a cathode nanoarchitecture for LOBs, which is composed of mesoporous carbon (MPC) integrated with carbon nanotubes (CNTs). The proposed design has the advantages of the two components. MPC provides sufficient active sites for the electrochem. reactions and free space for Li2O2storage, while CNT forests serve as conductive pathways for electron and offer addnl. reaction sites. Results show that the synergistic architecture of MPC and CNTs leads to improvements in the capacity ( ~18,400 mAh g- 1), rate capability, and cyclability (~200 cycles) of the CNT-integrated MPC cathode in comparison with MPC.

Nano Convergence published new progress about Current density. 143-24-8 belongs to class ethers-buliding-blocks, name is 2,5,8,11,14-Pentaoxapentadecane, and the molecular formula is C10H22O5, Name: 2,5,8,11,14-Pentaoxapentadecane.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Cronau, Marvin published the artcileThickness-Dependent Impedance of Composite Battery Electrodes Containing Ionic Liquid-Based Electrolytes, COA of Formula: C10H22O5, the main research area is lithium ion battery thickness charge transfer resistance current density.

Lithium-ion battery models often neglect the salt concentration polarization inside the electrolyte-filled pores of the composite electrodes. However, this concentration polarization causes a significant impedance, in particular in the case of electrolytes with low Li+ transference numbers Here, we analyze in detail measured and calculated impedance spectra of composite electrodes containing a solvate ionic liquid-based electrolyte and an ionic liquid-based electrolyte, resp., in comparison to a conventional carbonate-based electrolyte. For calculating spectra, we use a recently published model by Huang and Zhang. We find that the impedance at 10-4 Hz, which is relevant for battery cycling rates around 1 C to 2 C, increases in the order carbonate-based electrolyteCOA of Formula: C10H22O5.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Moser, Maximilian published the artcileSide Chain Redistribution as a Strategy to Boost Organic Electrochemical Transistor Performance and Stability, Safety of 2,5,8,11-Tetraoxatridecan-13-ol, the main research area is organic electrochem transistor performance stability polythiophene side chain redistribution; bioelectronics; ethylene-glycol-functionalized polymers; mixed ionic-electronic conduction; organic electrochemical transistors.

A series of glycolated polythiophenes for use in organic electrochem. transistors (OECTs) is designed and synthesized, differing in the distribution of their ethylene glycol chains that are tethered to the conjugated backbone. While side chain redistribution does not have a significant impact on the optoelectronic properties of the polymers, this mol. engineering strategy strongly impacts the water uptake achieved in the polymers. By careful optimization of the water uptake in the polymer films, OECTs with unprecedented steady-state performances in terms of [μC*] and current retentions up to 98% over 700 electrochem. switching cycles are developed.

Advanced Materials (Weinheim, Germany) published new progress about Current density. 23783-42-8 belongs to class ethers-buliding-blocks, name is 2,5,8,11-Tetraoxatridecan-13-ol, and the molecular formula is C9H20O5, Safety of 2,5,8,11-Tetraoxatridecan-13-ol.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Zhang, Xiao-Ping published the artcileAnode interfacial layer formation via reductive ethyl detaching of organic iodide in lithium-oxygen batteries, COA of Formula: C10H22O5, the main research area is organic iodide ethyl detaching lithium oxygen battery.

As soluble catalysts, redox mediators can reduce the high charging overpotential of lithium-oxygen batteries by providing sufficient liquid-solid interface for lithium peroxide decomposition However, the redox mediators usually introduce undesirable reactions. In particular, the so-called “”shuttle effect”” leads to the loss of both the redox mediators and elec. energy efficiency. In this study, an organic compound, triethylsulfonium iodide, is found to act bifunctionally as both a redox mediator and a solid electrolyte interphase-forming agent for lithium-oxygen batteries. During charging, the organic iodide exhibits comparable lithium peroxide-oxidizing capability with inorganic iodides. Meanwhile, it in situ generates an interfacial layer on lithium anode via reductive Et detaching and the subsequent oxidation This layer prevents the lithium anode from reacting with the redox mediators and allows efficient lithium-ion transfer leading to dendrite-free lithium anode. Significantly improved cycling performance has been achieved by the bifunctional organic iodide redox mediator.

Nature Communications published new progress about Current density. 143-24-8 belongs to class ethers-buliding-blocks, name is 2,5,8,11,14-Pentaoxapentadecane, and the molecular formula is C10H22O5, COA of Formula: C10H22O5.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Cao, Deqing published the artcileImproving the True Cycling of Redox Mediators-assisted Li-O2 Batteries, SDS of cas: 143-24-8, the main research area is gel polymer membrane redox mediator lithium oxide battery electrolysis.

The application of redox mediators has been considered as a promising strategy to boost the performance of aprotic Li-O2 batteries. However, the issues brought with redox mediators, especially on the Li anode side have been overlooked. Here, we propose a facile approach of preparing a gel polymer membrane that not only allow uniform Li plating/stripping with large current densities over extended cycling but also inhibit the diffusion of redox mediators and avoid redox shuttling, self-discharge, and internal short-circuiting. More importantly, the gel polymer membrane prevents the penetration of O2 and superoxide intermediates from the Li anode. Therefore, it ensures the successful application of both lithium anode and redox mediators in Li-O2 batteries to achieve the desired high capacity and rate performance. Meanwhile, it helps understand the benefit and problems of added redox mediators and reactive oxygen species so that the performance of such Li-O2 batteries can be truly evaluated.

Energy & Environmental Materials published new progress about Current density. 143-24-8 belongs to class ethers-buliding-blocks, name is 2,5,8,11,14-Pentaoxapentadecane, and the molecular formula is C10H22O5, SDS of cas: 143-24-8.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Yan, Yang-Yang published the artcileCharacteristics of enriched components from thermal dissolution extracts of Zhaotong lignite using solid phase microextraction, Quality Control of 121-00-6, the main research area is lignite polydimethylsiloxane thermal dissolution solid phase microextraction.

Due to the low concentration of minor compounds and the detection limit of instruments, numerous compounds in the thermal dissolution (TD) extract of coals cannot be detected. Therefore, it is necessary to introduce solid phase microextraction (SPME) for sampling before anal., which can enrich compounds in mixtures with similar mol. structures and exclude interferences from other components. In this work, partial species in the TD extract of Zhaotong lignite were enriched by SPME with a polydimethylsiloxane (PDMS) coating. The enrichment characteristics of the coating on TD extract were examined by gas chromatog.-mass spectrometry (GC-MS). Nitrogen-containing compounds and sulfur-containing compounds were removed from the enriched species, and the content of aliphatic hydrocarbons increased from 30.0% to 93.2% after enrichment. Oxygenated aromatic compounds with structures similar to the long-chain siloxane bonds of PDMS were also enriched. This study establishes a SPME method and provides a basis for the anal. of lignite and its derivatives

Fuel published new progress about Coating process. 121-00-6 belongs to class ethers-buliding-blocks, name is 4-Hydroxy-3-tert-butylanisole, and the molecular formula is C11H16O2, Quality Control of 121-00-6.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem