Month: February 2023

Controlled Self-Assembly of Carbohydrate Conjugate Rod-Coil Amphiphiles for Supramolecular Multivalent Ligands was written by Kim, Byung-Sun;Hong, Dong-Je;Bae, Jinyoung;Lee, Myongsoo. And the article was included in Journal of the American Chemical Society in 2005.HPLC of Formula: 60221-37-6 This article mentions the following:

Carbohydrate conjugate rod-coil amphiphiles were synthesized and their self-assembling behavior in aqueous solution was investigated. These amphiphiles were observed to self-assemble into supramol. structures that differ significantly depending on the mol. architecture. The rod-coil amphiphiles based on a short coil (1) self-assemble into a vesicular structure, while the amphiphiles with a long coil (2) show a spherical micellar structure. In contrast, 3, based on a twin-rod segment, was observed to aggregate into cylindrical micelles with twice the diameter of mol. length scale. As a means to determine the binding activity to protein receptors of these supramol. objects, hemagglutination inhibition assay was performed. The experiments showed that the supramol. architecture has a significant effect on the binding activity. In addition, incubation experiments with Escherichia coli showed that mannose-coated objects specifically bind to the bacterial pili of the ORN 178 strain. These results demonstrate that precise control of the nano-objects in shape and size by mol. design can provide control of the biol. activities of the supramol. materials. In the experiment, the researchers used many compounds, for example, 2-(2-(2-((Tetrahydro-2H-pyran-2-yl)oxy)ethoxy)ethoxy)ethan-1-ol (cas: 60221-37-6HPLC of Formula: 60221-37-6).

2-(2-(2-((Tetrahydro-2H-pyran-2-yl)oxy)ethoxy)ethoxy)ethan-1-ol (cas: 60221-37-6) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. The unique properties of ethers (i.e., that they are strongly polar, with nonbonding electron pairs but no hydroxyl group) enhance the formation and use of many reagents. For example, Grignard reagents cannot form unless an ether is present to share its lone pair of electrons with the magnesium atom. Complexation of the magnesium atom stabilizes the Grignard reagent and helps to keep it in solution.HPLC of Formula: 60221-37-6

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Site-Selective Synthesis of N-Benzyl 2,4,6-Collidinium Salts by Electrooxidative C-H Functionalization was written by Motsch, Bill J.;Wengryniuk, Sarah E.. And the article was included in Organic Letters in 2022.Related Products of 105-13-5 This article mentions the following:

The synthesis of benzylic 2,4,6-collidinium salts I (R = Br, 3-chloropropyl, (piperidin-1-yl)carbonyl, etc.; R¹ = Me, Bn, TBS, etc.; R² = R³ = H, Me; R⁴ = Me, Et, propan-2-yl, etc.; R⁴, R³ = -CH₂-CH₂-CH₂-; R⁵ = 2,4,6-trimethyl-pyridin-1-ylium-1-yl-tetrafluoroborate salt, pyridin-1-ylium-1-yl-tetrafluoroborate salt, 2-phenyl-pyridin-1-ylium-1-yl-tetrafluoroborate salt, etc.; X = C, N) via electrooxidative C-H functionalization has been reported . This method provides a complementary approach to traditional strategies relying on substitution and condensation of prefunctionalized substrates. In the experiment, the researchers used many compounds, for example, (4-Methoxyphenyl)methanol (cas: 105-13-5Related Products of 105-13-5).

(4-Methoxyphenyl)methanol (cas: 105-13-5) belongs to ethers. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides. Ethers feature bent C閳ユ彊閳ユ弲 linkages. In dimethyl ether, the bond angle is 111鎺?and C閳ユ彊 distances are 141 pm. The barrier to rotation about the C閳ユ彊 bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.Related Products of 105-13-5

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Heterogeneous vanadium-catalyzed oxidative cleavage of olefins for sustainable synthesis of carboxylic acids was written by Upadhyay, Rahul;Rana, Rohit;Sood, Aakriti;Singh, Vikash;Kumar, Rahul;Srivastava, Vimal Chandra;Maurya, Sushil K.. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2021.Recommanded Product: 3-(2,4-Dimethoxyphenyl)acrylic acid This article mentions the following:

A green and sustainable protocol for the oxidative cleavage of olefins to produce pharmaceutically and biol. valuable carboxylic acids was achieved. The developed protocol involved 70% aqueous TBHP as an oxidant over a heterogeneous vanadium catalyst system. Notably, the synthesis of industrially important azelaic acid from various renewable vegetable oils was accomplished. The catalyst was recycled for up to 5 cycles without significant loss in yield and the protocol was successfully demonstrated at the gram-scale. In the experiment, the researchers used many compounds, for example, 3-(2,4-Dimethoxyphenyl)acrylic acid (cas: 6972-61-8Recommanded Product: 3-(2,4-Dimethoxyphenyl)acrylic acid).

3-(2,4-Dimethoxyphenyl)acrylic acid (cas: 6972-61-8) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. But ether is more polar than alkenes. Electron-deficient reagents are also stabilized by ethers. For example, borane (BH3) is a useful reagent for making alcohols. Pure borane exists as its dimer, diborane (B2H6), a toxic gas that is inconvenient and hazardous to use. Borane forms stable complexes with ethers, however, and it is often supplied and used as its liquid complex with tetrahydrofuran (THF).Recommanded Product: 3-(2,4-Dimethoxyphenyl)acrylic acid

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Selective Reductive Cleavage of Inert Aryl C-O Bonds by an Iron Catalyst was written by Ren, Yunlai;Yan, Mengjie;Wang, Jianji;Zhang, Z. Conrad;Yao, Kaisheng. And the article was included in Angewandte Chemie, International Edition in 2013.Related Products of 75581-11-2 This article mentions the following:

An effective reductive cleavage of inert aryl C-O bonds with an inexpensive Fe catalyst has been developed. During this process, the reduction of the arene rings was not observed This catalytic system also enabled the selective cleavage of the 灏?O-4 linkage of lignin model compounds, thus offering an opportunity for the depolymerization of lignin. Thus, e.g., reductive cleavage of Ph₂O in presence of Fe(acac)₃, LiAlH₄ as reducing agent, and tBuONa at 140鎺?afforded PhOH (81%) and benzene (97%). In the experiment, the researchers used many compounds, for example, 4-Iodo-1-methoxy-2-methylbenzene (cas: 75581-11-2Related Products of 75581-11-2).

4-Iodo-1-methoxy-2-methylbenzene (cas: 75581-11-2) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides.Related Products of 75581-11-2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Nonvolatile and nonflammable sulfolane-based electrolyte achieving effective and safe operation of the Li-O₂ battery in open O₂ environment was written by Li, Zhengang;Song, Cun;Dai, Peng;Wu, Xiaohong;Zhou, Shiyuan;Qiao, Yu;Huang, Ling;Sun, Shi-Gang. And the article was included in Nano Letters in 2022.HPLC of Formula: 112-49-2 This article mentions the following:

The Li-O₂ battery should operate effectively/safely in an open O₂ environment for practical applications, but not trapped in sealed/closed atm. However, the typical use of volatile and flammable electrolyte restricts Li-O₂ battery to be able to be running in open O₂ environment. We report herein, for the first time, a highly electrochem. reversible Li-O₂ battery operated in an open O₂ environment, i.e., under the condition of keeping O₂ flowing continuously based on a nonvolatile and nonflammable sulfolane (TMS) solvent. The electrochem. irreversibility of Li₂O₂/O₂ conversion and incompatibility between Li metal anodes and electrolyte have been addressed via dissolving LiNO₃ in concentrated TMS electrolyte. The tuned electrolyte not only enables a stable solid electrolyte interphase (SEI) with conformal inorganic components (including LiF, LiN_xO_y, and Li₂O) that promotes a uniform Li electro-plating/stripping process but also results in a low charge overpotential, a stable discharge terminal plateau, and reversible O₂ generation of the Li-O₂ battery conducted in an open O₂ environment. In the experiment, the researchers used many compounds, for example, 2,5,8,11-Tetraoxadodecane (cas: 112-49-2HPLC of Formula: 112-49-2).

2,5,8,11-Tetraoxadodecane (cas: 112-49-2) belongs to ethers. The oxygen atom in ethers are more electronegative than carbon, thus the hydrogens which are alpha to the ethers are more acidic than the simple hydrocarbons. Electron-deficient reagents are also stabilized by ethers. For example, borane (BH3) is a useful reagent for making alcohols. Pure borane exists as its dimer, diborane (B2H6), a toxic gas that is inconvenient and hazardous to use. Borane forms stable complexes with ethers, however, and it is often supplied and used as its liquid complex with tetrahydrofuran (THF).HPLC of Formula: 112-49-2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Guided in Situ Polymerization of MEH-PPV in Mesoporous Titania Photoanodes was written by Minar, Norma K.;Docampo, Pablo;Fattakhova-Rohlfing, Dina;Bein, Thomas. And the article was included in ACS Applied Materials & Interfaces in 2015.Recommanded Product: 1877-75-4 This article mentions the following:

Incorporation of conjugated polymers into porous metal oxide networks is a challenging task, which is being pursued via many different approaches. We have developed the guided in situ polymerization of poly(2-methoxy-5-(2′-ethylhexyloxy)-p-phenylenevinylene) (MEH-PPV) in porous titania films by means of surface functionalization. The controlled polymerization via the Gilch route was induced by an alkoxide base and by increasing the temperature The selected and specially designed surface-functionalizing linker mols. mimic the monomer or its activated form, resp. In this way, we drastically enhanced the amount of MEH-PPV incorporated into the porous titania phase compared to nonfunctionalized samples by a factor of 6. Addnl., photovoltaic measurements were performed. The devices show shunting or series resistance limitations, depending on the surface functionalization prior to in situ polymerization of MEH-PPV. We suggest that the reason for this behavior can be found in the orientation of the grown polymer chains with respect to the titania surface. Therefore, the geometry of the anchoring via the linker mols. is relevant for exploiting the full electronic potential of the conjugated polymer in the resulting hybrid composite. This observation will help to design future synthesis methods for new hybrid materials from conjugated polymers and n-type semiconductors to take full advantage of favorable electronic interactions between the two phases. In the experiment, the researchers used many compounds, for example, 2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4Recommanded Product: 1877-75-4).

2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil. Autoxidation is the spontaneous oxidation of a compound in air. In the presence of oxygen, ethers slowly autoxidize to form hydroperoxides and dialkyl peroxides. If concentrated or heated, these peroxides may explode. To prevent such explosions, ethers should be obtained in small quantities, kept in tightly sealed containers, and used promptly.Recommanded Product: 1877-75-4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Aza-crown-ether functionalized graphene oxide for gas sensing and cation trapping applications was written by Valt, M.;Fabbri, B.;Gaiardo, A.;Gherardi, S.;Casotti, D.;Cruciani, G.;Pepponi, G.;Vanzetti, L.;Iacob, E.;Malagu, C.;Bellutti, P.;Guidi, V.. And the article was included in Materials Research Express in 2019.Formula: C10H21NO4 This article mentions the following:

Graphene oxide has been functionalized with 1-aza-15-crown-5 ether via chem. route synthesis. Modification of graphene oxide was achieved via nucleophilic attack where the amine groups of an aza-crown ether mol. can easily react with the epoxy sites of graphene oxide basal plane. Owing to the inherent two-dimensional character of graphene oxide, it resulted in large specific-surface material with strong affinity for charged chem. species. Such property was exploited for reversible and controlled interaction of adsorbed species, envisaging two possible applications of the functionalized graphene oxide. Thus, an easy-to-fabricate and high-sensitivity functionalized graphene oxide-based gas sensor was achieved. The sensing material proved to be highly stable and capable of selectively detecting humidity at room temperature over a wide range of concentrations Moreover, the porous scaffold built by the functionalization, together with the well-known affinity of crown ethers to metal ions, allow the use of aza-crown ether functionalized graphene oxide for cation trapping application, e.g. pre-concentration of trace amount of metals or filter for water. Remarkable results in this field have been obtained with respect to some heavy-metal cations of environmental interest. We also demonstrated significant enhancement in performance vs. pure graphene oxide in both tested applications. More generally, the functionalization approach we pursued appears to be quite flexible in the tested applications. In fact, with an appropriate selection of crown ethers with specific cage-like structure, functionalized graphene oxide allows the capture of any desired guest in order to prepare a wide range of other crown-ether-GO nanocomposites for different applications. In the experiment, the researchers used many compounds, for example, 1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3Formula: C10H21NO4).

1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. Autoxidation is the spontaneous oxidation of a compound in air. In the presence of oxygen, ethers slowly autoxidize to form hydroperoxides and dialkyl peroxides. If concentrated or heated, these peroxides may explode. To prevent such explosions, ethers should be obtained in small quantities, kept in tightly sealed containers, and used promptly.Formula: C10H21NO4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Facile synthesis of N-1,2,4-oxadiazole substituted sulfoximines from N-cyano sulfoximines was written by M. L., Chenna Reddy;Nawaz Khan, Fazlur Rahman;Saravanan, Vadivelu. And the article was included in Organic & Biomolecular Chemistry in 2019.Name: 2-(4-Methoxyphenoxy)acetic acid This article mentions the following:

A divergent approach has been successfully developed for synthesis of N-1,2,4-oxadiazole substituted sulfoximines starting from N-cyano sulfoximines. This method has a wide degree of substrate scope that includes aryl, heteroaryl, alkyl, fluoroalkyl and saturated heterocyclic compounds Excellent functional group tolerability was also observed Extension of this methodol. to nucleosides, amino acids and dipeptides was found to be successful. A gram scale reaction was also established. The major part of this method is metal free and the utility of environmentally friendly solvents such as 2-Me THF and ionic liquids is an added advantage. In the experiment, the researchers used many compounds, for example, 2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4Name: 2-(4-Methoxyphenoxy)acetic acid).

2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4) belongs to ethers. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides. Autoxidation is the spontaneous oxidation of a compound in air. In the presence of oxygen, ethers slowly autoxidize to form hydroperoxides and dialkyl peroxides. If concentrated or heated, these peroxides may explode. To prevent such explosions, ethers should be obtained in small quantities, kept in tightly sealed containers, and used promptly.Name: 2-(4-Methoxyphenoxy)acetic acid

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

A New Benzoquinone from Antrodia camphorata was written by Chen, C. Y.;Wang, J. J.;Kao, C. L.;Li, H. T.;Wu, M. D.;Cheng, M. J.. And the article was included in Chemistry of Natural Compounds in 2022.Synthetic Route of C9H10O4 This article mentions the following:

A new benzoquinone, 2-hydroxy-3-methoxy-5-methyl-p-benzoquinone (1), along with 11 known compounds including three benzoquinones, 2-methoxy-6-methyl-p-benzoquinone (2), 2,3-dimethoxy-5-methyl-pbenzoquinone (3), and 2-hydroxy-5-methoxy-3-methyl-p-benzoquinone (4); three lignans, 4-hydroxysesamin (5), (+)-sesamin (6), and aptosimon (7); five benzenoids, 2,4-dimethoxy-6-methylbenzene-1,3-diol (8), benzocamphorin A (9), benzocamphorin D (10), 2,2閳?5,5閳?tetramethoxy-3,4,3閳?4閳?bi-methylenedioxy-6,6閳?dimethylbiphenyl (11), and 4,7-dimethoxy-5-methyl-1,3-benzodioxole (12), were isolated from the fruiting body of Antrodia camphorata (Polyporaceae). These compounds were characterized and identified by phys. and spectral evidences. In the experiment, the researchers used many compounds, for example, 2,3-Dimethoxy-5-methylcyclohexa-2,5-diene-1,4-dione (cas: 605-94-7Synthetic Route of C9H10O4).

2,3-Dimethoxy-5-methylcyclohexa-2,5-diene-1,4-dione (cas: 605-94-7) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive. Autoxidation is the spontaneous oxidation of a compound in air. In the presence of oxygen, ethers slowly autoxidize to form hydroperoxides and dialkyl peroxides. If concentrated or heated, these peroxides may explode. To prevent such explosions, ethers should be obtained in small quantities, kept in tightly sealed containers, and used promptly.Synthetic Route of C9H10O4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Utiziling a copper-free Sonogashira reaction in the synthesis of the leukotriene a4 hydrolase modulator batatasin IV was written by Petruncio, Greg;Girgis, Michael;Moummi, Sanae;Jayatilake, Meth;Lee, Kyung Hyeon;Paige, Mikell. And the article was included in Tetrahedron Letters in 2020.Synthetic Route of C8H8O3 This article mentions the following:

Batatasin IV is a dihydrostilbenoid isolated from Chinese yams which was shown to have inhibitory activities against plant growth. Later studies showed that this compound may exhibit anti-inflammatory properties by inhibiting the epoxide hydrolase activity of the leukotriene A₄ hydrolase enzyme. To access the dihydrostilbenoid skeleton, a copper-free SPhos-mediated Sonogashira reaction was conceived and the substrate scope was explored. Our results indicate that the reaction can tolerate the presence of free alcs., aldehydes, nitro groups, and anilinyl groups. However, a substituent with an acidic phenol or carboxylic acid group gave significantly lower yields. Next, a total synthesis of batatasin IV was accomplished in 16% overall yield incorporating the reported copper-free Sonogashira reaction. Finally, we show that batatasin IV inhibits the hydrolysis of alanine p-nitroanilide by leukotriene A₄ hydrolase with an IC₅₀ of 91.4娓璏. In the experiment, the researchers used many compounds, for example, 3-Hydroxy-5-methoxybenzaldehyde (cas: 57179-35-8Synthetic Route of C8H8O3).

3-Hydroxy-5-methoxybenzaldehyde (cas: 57179-35-8) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. Electron-deficient reagents are also stabilized by ethers. For example, borane (BH3) is a useful reagent for making alcohols. Pure borane exists as its dimer, diborane (B2H6), a toxic gas that is inconvenient and hazardous to use. Borane forms stable complexes with ethers, however, and it is often supplied and used as its liquid complex with tetrahydrofuran (THF).Synthetic Route of C8H8O3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem