Month: February 2023

Paper-Based Colorimetric Sensor System for High-Throughput Screening of C-H Borylation was written by Kim, Han-Sung;Eom, Min Sik;Han, Min Su;Lee, Sunwoo. And the article was included in Chemistry – A European Journal in 2017.Name: 2-(3,5-Dimethoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane This article mentions the following:

A paper-based colorimetric sensor system (PBCSS) was developed to detect the amount of bis(pinacolato)diboron (B₂Pin₂) and applied as a high-throughput screening protocol in Ir-catalyzed C-H borylation. First, 96 ligands were screened for the borylation of benzene, and then 12 of them were selected and tested for five substrates. These reaction mixtures were spotted in the PBCSS, showing a blue-violet color. The value of the gray scale of each reaction was obtained from these colored spots and converted to the extent of conversion of B₂Pin₂. The extents of conversion of B₂Pin₂ obtained from the PBCSS showed good correlation with those obtained from gas chromatog. anal. The modified conversion using blank data showed good correlation with the yield of products. In the experiment, the researchers used many compounds, for example, 2-(3,5-Dimethoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 365564-07-4Name: 2-(3,5-Dimethoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane).

2-(3,5-Dimethoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 365564-07-4) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil. Ethyl ether is an excellent solvent for extractions and for a wide variety of chemical reactions. It is also used as a volatile starting fluid for diesel engines and gasoline engines in cold weather. Dimethyl ether is used as a spray propellant and refrigerant. Methyl t-butyl ether (MTBE) is a gasoline additive that boosts the octane number and reduces the amount of nitrogen-oxide pollutants in the exhaust. The ethers of ethylene glycol are used as solvents and plasticizers.Name: 2-(3,5-Dimethoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Acceptorless dehydrogenation of primary alcohols to carboxylic acids by self-supported NHC-Ru single-site catalysts was written by Yin, Shenxiang;Zheng, Qingshu;Chen, Jie;Tu, Tao. And the article was included in Journal of Catalysis in 2022.Recommanded Product: 105-13-5 This article mentions the following:

The acceptorless dehydrogenation of diverse aromatic and aliphatic primary alcs. to corresponding carboxylic acids was accomplished by self-supported NHC-Ru single-site catalysts under mild reaction conditions. Besides broad substrates with excellent activity, selectivity and good tolerance to sensitive functional groups, the solid single-site catalyst could be recovered and reused for more than 20 runs without deactivation. Remarkably, up to 1.8 x 10⁴ turnover numbers could be achieved by this newly developed sustainable protocol in gram scale at low catalyst loading, highlighting its potential in industry. In the experiment, the researchers used many compounds, for example, (4-Methoxyphenyl)methanol (cas: 105-13-5Recommanded Product: 105-13-5).

(4-Methoxyphenyl)methanol (cas: 105-13-5) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive. Autoxidation is the spontaneous oxidation of a compound in air. In the presence of oxygen, ethers slowly autoxidize to form hydroperoxides and dialkyl peroxides. If concentrated or heated, these peroxides may explode. To prevent such explosions, ethers should be obtained in small quantities, kept in tightly sealed containers, and used promptly.Recommanded Product: 105-13-5

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ruthenium(II)/N-Heterocyclic Carbene Catalyzed [3+2] Carbocyclization with Aromatic N-H Ketimines and Internal Alkynes was written by Zhang, Jing;Ugrinov, Angel;Zhao, Pinjing. And the article was included in Angewandte Chemie, International Edition in 2013.HPLC of Formula: 16356-02-8 This article mentions the following:

A ruthenium(II)-catalyzed C-H functionalization by tandem imine-directed C-H bond activation and [3+2]-carbocyclization with internal alkynes to give indenamines, e.g., I, was reported. The reaction proceeded in general at room temperature and without the use of either strong oxidants or acid/base additives. In the experiment, the researchers used many compounds, for example, 1,4-Dimethoxy-2-butyne (cas: 16356-02-8HPLC of Formula: 16356-02-8).

1,4-Dimethoxy-2-butyne (cas: 16356-02-8) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. At room temperature, ethers are pleasant-smelling colourless liquids. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil.HPLC of Formula: 16356-02-8

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Efficient acylation of toluene and anisole with aliphatic carboxylic acids catalyzed by heteropoly salt Cs_2.5H_0.5PW₁₂O₄₀ was written by Kaur, Jaspal;Kozhevnikov, Ivan V.. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2002.SDS of cas: 54916-28-8 This article mentions the following:

Heteropoly salt Cs_2.5H_0.5PW₁₂O₄₀ is a highly efficient and reusable solid acid catalyst for the liquid-phase acylation of toluene or anisole with C₂-C₁₂ aliphatic carboxylic acids. In the experiment, the researchers used many compounds, for example, 1-(4-(4-Methoxyphenoxy)phenyl)ethanone (cas: 54916-28-8SDS of cas: 54916-28-8).

1-(4-(4-Methoxyphenoxy)phenyl)ethanone (cas: 54916-28-8) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. But ether is more polar than alkenes. The unique properties of ethers (i.e., that they are strongly polar, with nonbonding electron pairs but no hydroxyl group) enhance the formation and use of many reagents. For example, Grignard reagents cannot form unless an ether is present to share its lone pair of electrons with the magnesium atom. Complexation of the magnesium atom stabilizes the Grignard reagent and helps to keep it in solution.SDS of cas: 54916-28-8

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthesis of 3,3-diarylpropionic acids using phosphoric acid as catalyst was written by Elsworth, J. F.;Lamchen, M.. And the article was included in Journal of the South African Chemical Institute in 1972.Recommanded Product: 3-(2,4-Dimethoxyphenyl)acrylic acid This article mentions the following:

Phenols and their Me ethers, in the presence of 85% H3PO4, readily add to the β-C atom of cinnamic acids bearing a MeO group in either the ortho or para positions on the phenyl group, to give high yields of 3,3-diarylpropionic acids. If an ortho HO group is present on the addend, the propionic acid can lactonize to yield a 4-aryldihydrocoumarin. The product from addition of 2,4-dimethoxycinnamic acid to anisole is capable reacting nucleophilically with more 2,4-dimethoxycinnamic acid to yield a bispropionic acid. A truxillic acid is obtained when 3,4-dimethoxycinnamic acid is either warmed with H3PO4 or shaken with m-xylene in the presence of H3PO4. The methoxycinnamic acid is initially protonated by H3PO4 and the derived quinonoid structure is susceptible to attack by nucleophiles. In the experiment, the researchers used many compounds, for example, 3-(2,4-Dimethoxyphenyl)acrylic acid (cas: 6972-61-8Recommanded Product: 3-(2,4-Dimethoxyphenyl)acrylic acid).

3-(2,4-Dimethoxyphenyl)acrylic acid (cas: 6972-61-8) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. The barrier to rotation about the C–O bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.Recommanded Product: 3-(2,4-Dimethoxyphenyl)acrylic acid

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Visible Light- and Heat-promoted C-O Coupling Reaction of Phenols and Aryl Halides was written by Yang, Qing-Qing;Liu, Na;Yan, Jia-Ying;Ren, Zhi-Lin;Wang, Long. And the article was included in Asian Journal of Organic Chemistry in 2020.SDS of cas: 54916-28-8 This article mentions the following:

A visible light- and heat-promoted C-O coupling reaction of phenols and aryl halides was described to afford diaryl ethers in good to excellent yields without transition-metal, photocatalysts or ligands. Moreover, the reaction had good substrate universality, suitable for substituted phenol, naphthol and heterocyclic phenol derivatives Control experiments revealed that an electron donor-acceptor (EDA) complex formed from the association of an aryl halide and phenol anion. DFT calculation further confirmed the existence of the EDA complex. In the experiment, the researchers used many compounds, for example, 1-(4-(4-Methoxyphenoxy)phenyl)ethanone (cas: 54916-28-8SDS of cas: 54916-28-8).

1-(4-(4-Methoxyphenoxy)phenyl)ethanone (cas: 54916-28-8) belongs to ethers. The oxygen atom in ethers are more electronegative than carbon, thus the hydrogens which are alpha to the ethers are more acidic than the simple hydrocarbons. Ethers can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.SDS of cas: 54916-28-8

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Simulations of dielectric constants and viscosities of organic electrolytes by quantum mechanics and molecular dynamics was written by Yamaguchi, Toru;Yamada, Hidetaka;Fujiwara, Takayuki;Hori, Kenji. And the article was included in Journal of Molecular Liquids in 2020.Recommanded Product: 2,5,8,11-Tetraoxadodecane This article mentions the following:

Dielec. constants and viscosities are important phys. properties of organic electrolytes. Therefore, predicting these properties by practical computer simulations is valuable for developing new batteries. Here, a combination of quantum mech. calculations and mol. dynamics simulations was used to predict these properties for 17 electrolytes. The computed results were assembled using the Kirkwood-Onsager and the Green-Kubo relational equation to obtain the dielec. constants and viscosities, resp. In particular, Kirkwood’s g-factors were derived based on the method developed by Zhang et al. in 2016. The coefficients of determination (R²) for the dielec. constants and viscosities were calculated to be 0.9875 and 0.9230, resp. It was confirmed that both quantum mech. calculations for elec. properties and mol. dynamics simulations for macroscopic effects can well reproduce the abovementioned properties for a wide range of organic electrolytes. In the experiment, the researchers used many compounds, for example, 2,5,8,11-Tetraoxadodecane (cas: 112-49-2Recommanded Product: 2,5,8,11-Tetraoxadodecane).

2,5,8,11-Tetraoxadodecane (cas: 112-49-2) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil. At room temperature, ethers are pleasant-smelling colourless liquids. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil.Recommanded Product: 2,5,8,11-Tetraoxadodecane

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Rhodium(III)-catalyzed synthesis of cinnolinium salts from azobenzenes and alkynes: application to the synthesis of indoles and cinnolines was written by Muralirajan, Krishnamoorthy;Cheng, Chien-Hong. And the article was included in Chemistry – A European Journal in 2013.Electric Literature of C6H10O2 This article mentions the following:

A rhodium-catalyzed C-H activation/annulation of azobenzenes with alkynes to give various substituted cinnolinium salts in good to excellent yields is reported. The reaction is compatible with a wide substrate scope and highly atom- and step-economic. The proposed mechanism is strongly supported by the isolation of a five-membered rhodacycle. This protocol has been successfully applied to the synthesis of indole, indoloindole, and cinnoline derivatives In the experiment, the researchers used many compounds, for example, 1,4-Dimethoxy-2-butyne (cas: 16356-02-8Electric Literature of C6H10O2).

1,4-Dimethoxy-2-butyne (cas: 16356-02-8) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive. Ethers can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.Electric Literature of C6H10O2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

A rapid Hg²⁺ sensor based on aza-15-crown-5 ether functionalized 1,8-naphthalimide was written by Hou, Chen;Urbanec, Alysha M.;Cao, Haishi. And the article was included in Tetrahedron Letters in 2011.HPLC of Formula: 66943-05-3 This article mentions the following:

A new 1,8-naphthalimide derivative bearing an aza-15-crown-5 macrocycle (I) was synthesized as a chemosensor for Hg²⁺ by a two-step reaction. The sensor shows selectivity to Hg²⁺ over 11 other metal cations in aqueous media. Upon addition of Hg²⁺, the fluorescence emission of the sensor at 537 nm is significantly quenched along with 22 nm blue-shift that makes this compound a useful sensor for Hg²⁺ measurement. In the experiment, the researchers used many compounds, for example, 1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3HPLC of Formula: 66943-05-3).

1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. But on the other hand, ethers undergo cleavage by reaction with acids. Autoxidation is the spontaneous oxidation of a compound in air. In the presence of oxygen, ethers slowly autoxidize to form hydroperoxides and dialkyl peroxides. If concentrated or heated, these peroxides may explode. To prevent such explosions, ethers should be obtained in small quantities, kept in tightly sealed containers, and used promptly.HPLC of Formula: 66943-05-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

A new modification of the Friedlander synthesis via ortho-dilithiated N-pivaloylanilines was written by Ubeda, J. Ignacio;Villacampa, Mercedes;Avendano, Carmen. And the article was included in Synlett in 1997.Safety of N-(3-Methoxyphenyl)pivalamide This article mentions the following:

Formylation of ortho-dilithiated N-pivaloylanilines followed by treatment with carbonyl compounds and KHMDS affords 3- or 2,3-substituted quinoline derivatives in a one-pot reaction. In the experiment, the researchers used many compounds, for example, N-(3-Methoxyphenyl)pivalamide (cas: 56619-93-3Safety of N-(3-Methoxyphenyl)pivalamide).

N-(3-Methoxyphenyl)pivalamide (cas: 56619-93-3) belongs to ethers. The oxygen atom in ethers are more electronegative than carbon, thus the hydrogens which are alpha to the ethers are more acidic than the simple hydrocarbons. Ethyl ether is an excellent solvent for extractions and for a wide variety of chemical reactions. It is also used as a volatile starting fluid for diesel engines and gasoline engines in cold weather. Dimethyl ether is used as a spray propellant and refrigerant. Methyl t-butyl ether (MTBE) is a gasoline additive that boosts the octane number and reduces the amount of nitrogen-oxide pollutants in the exhaust. The ethers of ethylene glycol are used as solvents and plasticizers.Safety of N-(3-Methoxyphenyl)pivalamide

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem