Month: February 2023

Wender, Paul A. et al. published their research in Nature Chemistry in 2014 | CAS: 16356-02-8

1,4-Dimethoxy-2-butyne (cas: 16356-02-8) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. But ether is more polar than alkenes. At room temperature, ethers are pleasant-smelling colourless liquids. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil.Safety of 1,4-Dimethoxy-2-butyne

Structural complexity through multicomponent cycloaddition cascades enabled by dual-purpose, reactivity regenerating 1,2,3-triene equivalents was written by Wender, Paul A.;Fournogerakis, Dennis N.;Jeffreys, Matthew S.;Quiroz, Ryan V.;Inagaki, Fuyuhiko;Pfaffenbach, Magnus. And the article was included in Nature Chemistry in 2014.Safety of 1,4-Dimethoxy-2-butyne This article mentions the following:

Multicomponent reactions allow for more bond-forming events per synthetic operation, enabling more step- and time-economical conversion of simple starting materials to complex and thus value-added targets. These processes invariably require that reactivity be relayed from intermediate to intermediate over several mechanistic steps until a termination event produces the final product. Here, the authors report a multicomponent process in which a novel 1,2,3-butatriene equivalent (TMSBO: TMSCH2C CCH2OH) engages chemospecifically as a two-carbon alkyne component in a metal-catalyzed [5 + 2] cycloaddition with a vinylcyclopropane to produce an intermediate cycloadduct. Under the reaction conditions, this intermediate undergoes a remarkably rapid 1,4-Peterson elimination, producing a reactive four-carbon diene intermediate that is readily intercepted in either a metal-catalyzed or thermal [4 + 2] cycloaddition TMSBO thus serves as an yne-to-diene transmissive reagent coupling two powerful and convergent cycloadditions-the homologous Diels-Alder and Diels-Alder cycloadditions-through a vinylogous Peterson elimination, and enabling flexible access to diverse polycycles. In the experiment, the researchers used many compounds, for example, 1,4-Dimethoxy-2-butyne (cas: 16356-02-8Safety of 1,4-Dimethoxy-2-butyne).

1,4-Dimethoxy-2-butyne (cas: 16356-02-8) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. But ether is more polar than alkenes. At room temperature, ethers are pleasant-smelling colourless liquids. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil.Safety of 1,4-Dimethoxy-2-butyne

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Eshghi, Hossein et al. published their research in Chinese Chemical Letters in 2008 | CAS: 60221-37-6

2-(2-(2-((Tetrahydro-2H-pyran-2-yl)oxy)ethoxy)ethoxy)ethan-1-ol (cas: 60221-37-6) belongs to ethers. The oxygen atom in ethers are more electronegative than carbon, thus the hydrogens which are alpha to the ethers are more acidic than the simple hydrocarbons. Ethers can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.SDS of cas: 60221-37-6

Selective monotetrahydropyranylation of symmetrical diols using P2O5/SiO2 under solvent-free conditions and their depyranylation was written by Eshghi, Hossein;Rahimizadeh, Mohammad;Saberi, Sattar. And the article was included in Chinese Chemical Letters in 2008.SDS of cas: 60221-37-6 This article mentions the following:

Selective protection of one of the hydroxyl group in 1,n-sym. diols is achieved by P2O5/SiO2-catalyzed reaction of the diol with dihydropyran under solvent-free conditions at room temperature This selective protection is simple and it occurred under economically cheap conditions in high yield. The deprotected diol is simply obtained by refluxing of this compound in methanol using the same catalyst without any byproduct formation or addnl. purifications. In the experiment, the researchers used many compounds, for example, 2-(2-(2-((Tetrahydro-2H-pyran-2-yl)oxy)ethoxy)ethoxy)ethan-1-ol (cas: 60221-37-6SDS of cas: 60221-37-6).

2-(2-(2-((Tetrahydro-2H-pyran-2-yl)oxy)ethoxy)ethoxy)ethan-1-ol (cas: 60221-37-6) belongs to ethers. The oxygen atom in ethers are more electronegative than carbon, thus the hydrogens which are alpha to the ethers are more acidic than the simple hydrocarbons. Ethers can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.SDS of cas: 60221-37-6

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Nakahara, Yoshio et al. published their research in Chemistry Letters in 2011 | CAS: 66943-05-3

1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3) belongs to ethers. The oxygen atom in ethers are more electronegative than carbon, thus the hydrogens which are alpha to the ethers are more acidic than the simple hydrocarbons. Ethers can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.HPLC of Formula: 66943-05-3

Alkali metal ion sensing using absorbance changes based on aggregation of silica nanoparticles modified chemically with crown ethers was written by Nakahara, Yoshio;Hayashi, Takafumi;Kawa, Haruna;Kimura, Keiichi. And the article was included in Chemistry Letters in 2011.HPLC of Formula: 66943-05-3 This article mentions the following:

Crown-ether-modified SiO2 nanoparticles (Crown-SNPs) were prepared by simple chem. modifications of SiO2 nanoparticles. The organic moiety introduced into SiO2 nanoparticles was characterized by solid-state 13C NMR and elemental anal. No morphol. damage of SiO2 nanoparticles was recognized according to SEM observation. When an alkali metal salt was added to a solution containing crown-SNPs, the absorbance changes, whose extent was dependent on the kind and the concentration of a metal ion, were observed In the experiment, the researchers used many compounds, for example, 1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3HPLC of Formula: 66943-05-3).

1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3) belongs to ethers. The oxygen atom in ethers are more electronegative than carbon, thus the hydrogens which are alpha to the ethers are more acidic than the simple hydrocarbons. Ethers can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.HPLC of Formula: 66943-05-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Fang, Yibo et al. published their research in Journal of Chemical & Engineering Data in 2019 | CAS: 112-49-2

2,5,8,11-Tetraoxadodecane (cas: 112-49-2) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. But on the other hand, ethers undergo cleavage by reaction with acids. At room temperature, ethers are pleasant-smelling colourless liquids. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil.Application In Synthesis of 2,5,8,11-Tetraoxadodecane

Isothermal Vapor-Liquid Equilibrium of the Absorption Working Pairs (HFC-32 + DMETrEG, HFC-32 + NMP) at Temperatures from 293.15 to 343.15 K was written by Fang, Yibo;Gao, Zanjun;Bao, Kangli;Huang, Jiongliang;Ji, Xiaosheng;Han, Xiaohong;Chen, Guangming. And the article was included in Journal of Chemical & Engineering Data in 2019.Application In Synthesis of 2,5,8,11-Tetraoxadodecane This article mentions the following:

The working pairs of HFCs + organic absorption solvents are commonly used in absorption systems. In this work, the vapor-liquid equilibrium (VLE) data of HFC-32 + DMETrEG at (293.15-343.15) K and HFC-32 + NMP at (323.15-343.15) K were measured in a dual cycle apparatus The VLE data were correlated by Antione-type equation, NRTL, and PR + MHV1 + NRTL model, resp. The predicted VLE data showed a good agreement with the exptl. VLE data. NRTL model was recommended to predict the VLE data and characteristic of solution for HFC-32 + DMETrEG and HFC-32 + NMP, compared to PR + MHV1 + NRTL model. The comparison of VLE characteristics for five binary mixtures (HFC-32 + DMETrEG, HFC-32 + NMP, HFC-32 + DMF, HFC-32 + DMAC, and HFC-32 + DMEDEG) was carried out. The system pressures of HFC-32 + DMETrEG and HFC-32 + NMP were lower than other three mixtures, and the neg. deviations from Raoult’s law of HFC-32 + DMETrEG and HFC-32 + NMP were larger than the others, which indicated that the two mixtures were more suitable as the working fluids for absorption system. In the experiment, the researchers used many compounds, for example, 2,5,8,11-Tetraoxadodecane (cas: 112-49-2Application In Synthesis of 2,5,8,11-Tetraoxadodecane).

2,5,8,11-Tetraoxadodecane (cas: 112-49-2) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. But on the other hand, ethers undergo cleavage by reaction with acids. At room temperature, ethers are pleasant-smelling colourless liquids. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil.Application In Synthesis of 2,5,8,11-Tetraoxadodecane

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Yang, Hao et al. published their research in Organic & Biomolecular Chemistry in 2022 | CAS: 111-77-3

2-(2-Methoxyethoxy)ethanol (cas: 111-77-3) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil. Ethers can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.Formula: C5H12O3

Synthesis of symmetrical secondary oligoethylene glycolated amines from diethanolamine was written by Yang, Hao;Li, Yu;Lin, Ruoyun;Ouyang, Zhen;Han, Mingli;Zhu, Lijun;Chen, Shizhen;Zhou, Xin;Jiang, Zhong-Xing. And the article was included in Organic & Biomolecular Chemistry in 2022.Formula: C5H12O3 This article mentions the following:

Monodisperse oligoethylene glycols (M-OEGs)-containing sym. secondary amines are highly valuable synthetic intermediates in drug development and materials sciences. Scalable three-step synthesis of M-OEGs secondary amines with flexible M-OEGs and/or alkyl chains is described herein. Through reduction amination of diethanolamine, Williamson ether synthesis, and subsequent deprotection, a series of M-OEGs secondary amines with diverse and fine-tunable chem. structures were conveniently prepared The presented strategy is attractive with readily available starting materials, simple catalytic systems, scalable synthesis, and avoids the use of explosive sodium azide. In the experiment, the researchers used many compounds, for example, 2-(2-Methoxyethoxy)ethanol (cas: 111-77-3Formula: C5H12O3).

2-(2-Methoxyethoxy)ethanol (cas: 111-77-3) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil. Ethers can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.Formula: C5H12O3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Guerrand, Helene D. S. et al. published their research in Chemistry – A European Journal in 2014 | CAS: 365564-07-4

2-(3,5-Dimethoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 365564-07-4) belongs to ethers. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides.Related Products of 365564-07-4

Borylation of Unactivated Aryl Chlorides under Mild Conditions by Using Diisopropylaminoborane as a Borylating Reagent was written by Guerrand, Helene D. S.;Marciasini, Ludovic D.;Jousseaume, Melissa;Vaultier, Michel;Pucheault, Mathieu. And the article was included in Chemistry – A European Journal in 2014.Related Products of 365564-07-4 This article mentions the following:

The synthesis of arylboronic ester derivatives from aryl chlorides by using aryl(amino)boranes is described. Palladium-catalyzed coupling between aryl chlorides and diisopropylaminoborane leads to the formation of a C-B bond under mild conditions. A wide range of functional groups are tolerated, making this method particularly useful for the borylation of functionalized aromatics In the experiment, the researchers used many compounds, for example, 2-(3,5-Dimethoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 365564-07-4Related Products of 365564-07-4).

2-(3,5-Dimethoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 365564-07-4) belongs to ethers. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides.Related Products of 365564-07-4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Hameed, Nishar et al. published their research in ACS Applied Polymer Materials in 2020 | CAS: 66943-05-3

1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. But ether is more polar than alkenes. Ethers can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.Quality Control of 1,4,7,10-Tetraoxa-13-azacyclopentadecane

Rapid Crosslinking of Epoxy Thermosets Induced by Solvate Ionic Liquids was written by Hameed, Nishar;Eyckens, Daniel J.;Long, Benjamin M.;Salim, Nisa V.;Capricho, Jaworski C.;Servinis, Linden;De Souza, Mandy;Perus, Magenta D.;Varley, Russell J.;Henderson, Luke C.. And the article was included in ACS Applied Polymer Materials in 2020.Quality Control of 1,4,7,10-Tetraoxa-13-azacyclopentadecane This article mentions the following:

The high-volume manufacture of fiber-reinforced composites faces a huge challenge because long resin curing times put a low ceiling on the total output of parts produced per yr. To translate the benefits from using epoxy in large-volume production platforms, cure cycle times of less than 1 min must be achieved. In this work, we report solvate ionic liquids (SILs) as simple and efficient rapid curing catalytic additives in epoxy systems. Ultrafast curing was observed at low levels of 1-5% of SIL in epoxy resin, and the cure rate is enhanced up to 26-fold without compromising the mech. and thermal properties. Further investigations revealed that enhancement in the cure rate is dependent on the type of SILs employed, influenced by the metal center, the ligands around the metal, and the identity of the counter anion. The relative Lewis acidity of each of the active complexes was calculated, and the rapid cure effect was attributed to the activation of the epoxide moiety via the Lewis acidic nature of the SIL. Making epoxy thermosets rapidly processable enables enormous benefits, finding applications in a whole variety of transformation methods that exist for traditional glass and metals. In the experiment, the researchers used many compounds, for example, 1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3Quality Control of 1,4,7,10-Tetraoxa-13-azacyclopentadecane).

1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. But ether is more polar than alkenes. Ethers can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.Quality Control of 1,4,7,10-Tetraoxa-13-azacyclopentadecane

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Csuros, Zoltan et al. published their research in Magyar Chemiai Folyoirat in 1944 | CAS: 5367-32-8

3-Methyl-4-nitroanisole (cas: 5367-32-8) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides.Electric Literature of C8H9NO3

Derivatives of xanthates and aromatic nitro and amino compounds was written by Csuros, Zoltan;Rusznak, Istvan. And the article was included in Magyar Chemiai Folyoirat in 1944.Electric Literature of C8H9NO3 This article mentions the following:

Cellulose xanthate, dry or in solution, can be stabilized by salts of aromatic nitro sulfonic acids, e.g. m-O2NC6H4SO8H (I). The structure of the products was proved by model experiments with simple xanthates which gave crystalline derivatives Alkali salts (except K) of I, m-O2NC6H4NH2, PhNO2, and m-O2NC6H4NHAc, seem to be effective as stabilizers. The products are esters of PhNHCSOH formed according to the equation 4RNO2 + 6R’OCS2Na + 3H2O = 4RNHCSOR’ (II) + 3Na2S2O3 + CO2 + CS2 + 2R’OH. The following II were prepared Thiocarbanilates, PhNHCSOR (R’ given): Me (32.5% from MeOCS2Na in 90% MeOH with PhNO2), m. 97.5° (S 18.93, N 8.27, PhNH2 46.35-7.92%); Et (27.2% from EtOCS2Na in 90% EtOH), m. 70° (S 18.1, N 7.68, PhNH2 45.55-7.00%); iso-Bu (35.7% from iso-BuOCS2Na in 90% EtOH), m. 75° (S 15.0, N 6.6%). m-Sulfothiocarbanilates: Me (67.6% from MeOCS2Na and m-O2NC6H4SO2Na (III) in MeOH), contained S 24.0, N 5.18%; Et (88.1%), m. 270-5° (S 22.10, N 4.85, PhNH2 27.2-8.9%); iso-Bu (58.8%), m. 243-5° (S 19.9, N 4.39%); glyceryl (34.5% from glycerol xanthate and III in aqueous EtOH 4 h. at 35° and 20 mm.), amorphous, m. 153-5° (S 19.31, N 4.31%). Cellulose xanthate (7%) diluted with water and treated with 5-10% AcOH, the liberated H2S removed, and the solution treated with III 10 h. as above, gives a product (S 12.02, N 2.13, PhNH2 12.3-13.9%), identical with that obtained by Lilienfeld; the same compound was obtained by treating 7% cellulose xanthate with NaOH, centrifuging, mixing with III, treating with CS2, again dissolving in NaOH, and precipitating with saturated NaCl solution Me m-acetamidothiocarbanilate, m. 168° (N 12.39, S 14.37%), was obtained in 69.3% yield from MeOCS2Na and m-O2NC6H4NHAc in 60% MeOH and AcOH heated 15 h. at 60°; Et ester (64.6%), m. 154° (N 11.61, S 13.64%). Me m-nitrothiocarbanilate (45% from MeOCS2Na and m-O2NC6H4NH2 in 60% MeOH and a bit of solid KOH heated 50 h. on a water bath), m. 119° (S 15.0, N 13.16%); Et ester, m. 115° (S 14.24, N 12.22%). The methods proposed by Orndorff and Richmond [Am. Chem. J. 22, 458(1899)] and Hofmann [Ber. 2, 120 (1889)] were also tested. In the experiment, the researchers used many compounds, for example, 3-Methyl-4-nitroanisole (cas: 5367-32-8Electric Literature of C8H9NO3).

3-Methyl-4-nitroanisole (cas: 5367-32-8) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides.Electric Literature of C8H9NO3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Gorski, R. J. et al. published their research in Journal of Chromatography in 1991 | CAS: 1132-95-2

1,1-Diisopropoxycyclohexane (cas: 1132-95-2) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive. Ethyl ether is an excellent solvent for extractions and for a wide variety of chemical reactions. It is also used as a volatile starting fluid for diesel engines and gasoline engines in cold weather. Dimethyl ether is used as a spray propellant and refrigerant. Methyl t-butyl ether (MTBE) is a gasoline additive that boosts the octane number and reduces the amount of nitrogen-oxide pollutants in the exhaust. The ethers of ethylene glycol are used as solvents and plasticizers.Reference of 1132-95-2

Estimation and identification of non-polar compounds in clarithromycin bulk drug by high-performance liquid chromatography was written by Gorski, R. J.;Morgan, D. K.;Sarocka, C.;Plasz, A. C.. And the article was included in Journal of Chromatography in 1991.Reference of 1132-95-2 This article mentions the following:

A HPLC method was developed to estimate and identify the non-polar related substances and process impurities that elute after N-dimethyl-N-formyl-6-O-methylerythromycin A in clarithromycin (I) bulk drug. This method separates at least 15 compounds from the I peak. All of the non-polar compounds can be detected at the 0.02% (weight/weight) level. Five bulk drug lots were examined for late-eluting compounds The total related substances ranged from <0.10 to <0.25%. In the experiment, the researchers used many compounds, for example, 1,1-Diisopropoxycyclohexane (cas: 1132-95-2Reference of 1132-95-2).

1,1-Diisopropoxycyclohexane (cas: 1132-95-2) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive. Ethyl ether is an excellent solvent for extractions and for a wide variety of chemical reactions. It is also used as a volatile starting fluid for diesel engines and gasoline engines in cold weather. Dimethyl ether is used as a spray propellant and refrigerant. Methyl t-butyl ether (MTBE) is a gasoline additive that boosts the octane number and reduces the amount of nitrogen-oxide pollutants in the exhaust. The ethers of ethylene glycol are used as solvents and plasticizers.Reference of 1132-95-2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

TenBrink, Ruth E. et al. published their research in Journal of Medicinal Chemistry in 1980 | CAS: 3929-47-3

3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3) belongs to ethers. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides. Autoxidation is the spontaneous oxidation of a compound in air. In the presence of oxygen, ethers slowly autoxidize to form hydroperoxides and dialkyl peroxides. If concentrated or heated, these peroxides may explode. To prevent such explosions, ethers should be obtained in small quantities, kept in tightly sealed containers, and used promptly.Reference of 3929-47-3

1-[(Ethoxyamino)methyl]-1,3,4,5-tetrahydro-7,8-dimethoxy-2-benzoxepins: a new class of antianaphylactic agents was written by TenBrink, Ruth E.;McCall, John M.;Johnson, Herbert G.. And the article was included in Journal of Medicinal Chemistry in 1980.Reference of 3929-47-3 This article mentions the following:

Benzoxepinylethanolamines I [RR1 = (CH2CH2)2NR2, R2 = 2-MeOC6H4, 2-pyridyl, 4-FC6H4, Me; R = H, R1 = CH2CH2OH] were prepared in 62-92% yields. Reduction of 3,4-(MeO)2C6H3CH2CH2CO2H followed by cyclocondensation with BrCH2CH(OEt)2 gave II (R3 = CH2Br, III). Treating III with HOCH2CH2OH in the presence of Et3N gave II (R3 = CH2OCH2CH2OH) which was esterified by 4-O2NC6H4SO2Cl and stirred with IV (R2 = 2-MeOC6H4) in the presence of Et3N at 25° for 24 h to give I [RR1= (CH2CH2)2NC6H4OMe-2]. Heating III with ClCH2CH2OH in the presence of BaCO3 at 90° for 46 h gave II (R3 = CH2OCH2CH2Cl) which was treated with IV (R2 = 2-pyridyl, 4-FC6H4, Me) or HOCH2CH2NH2 to give the corresponding I. The arylpiperazine compounds I [RR1 = (CH2CH2)2NR2, R2 = 2-MeOC6H4, 2-pyridyl 4-FC6H4] had good activity, i.e., 100%, 94% and 52% inhibition resp., in the rat passive cutaneous anaphylaxis test at 50 mg/kg, p.o. I [RR1 = (CH2CH2)2NMe, R1 = H, R1 = CH2CH2OH] were both inactive. In the experiment, the researchers used many compounds, for example, 3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3Reference of 3929-47-3).

3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3) belongs to ethers. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides. Autoxidation is the spontaneous oxidation of a compound in air. In the presence of oxygen, ethers slowly autoxidize to form hydroperoxides and dialkyl peroxides. If concentrated or heated, these peroxides may explode. To prevent such explosions, ethers should be obtained in small quantities, kept in tightly sealed containers, and used promptly.Reference of 3929-47-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem