Month: February 2023

Leong, Sze Wei et al. published their research in Bioorganic & Medicinal Chemistry Letters in 2018 | CAS: 6972-61-8

3-(2,4-Dimethoxyphenyl)acrylic acid (cas: 6972-61-8) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. At room temperature, ethers are pleasant-smelling colourless liquids. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil.Application In Synthesis of 3-(2,4-Dimethoxyphenyl)acrylic acid

In vitro and in silico evaluations of diarylpentanoid series as α-glucosidase inhibitor was written by Leong, Sze Wei;Abas, Faridah;Lam, Kok Wai;Yusoff, Khatijah. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2018.Application In Synthesis of 3-(2,4-Dimethoxyphenyl)acrylic acid This article mentions the following:

A series of thirty-four diarylpentanoids derivatives were synthesized and evaluated for their α-glucosidase inhibitory activity. Eleven compounds were found to significantly inhibit α-glucosidase in which some compounds demonstrated the highest activity with IC50 values ranging from 14.1 to 15.1 μM. Structure-activity comparison shows that multiple hydroxy groups are essential for α-glucosidase inhibitory activity. Meanwhile, 3,4-dihydroxyphenyl and furanyl moieties were found to be crucial in improving α-glucosidase inhibition. Mol. docking analyses further confirmed the critical role of both 3,4-dihydroxyphenyl and furanyl moieties as they bound to α-glucosidase active site in different mode. Overall result suggests that diarylpentanoids with both five membered heterocyclic ring and polyhydroxyphenyl moiety could be a new lead design in the search of novel α-glucosidase inhibitor. In the experiment, the researchers used many compounds, for example, 3-(2,4-Dimethoxyphenyl)acrylic acid (cas: 6972-61-8Application In Synthesis of 3-(2,4-Dimethoxyphenyl)acrylic acid).

3-(2,4-Dimethoxyphenyl)acrylic acid (cas: 6972-61-8) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. At room temperature, ethers are pleasant-smelling colourless liquids. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil.Application In Synthesis of 3-(2,4-Dimethoxyphenyl)acrylic acid

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Deli, Dario et al. published their research in Reactive & Functional Polymers in 2012 | CAS: 66943-05-3

1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. But on the other hand, ethers undergo cleavage by reaction with acids. Ethyl ether is an excellent solvent for extractions and for a wide variety of chemical reactions. It is also used as a volatile starting fluid for diesel engines and gasoline engines in cold weather. Dimethyl ether is used as a spray propellant and refrigerant. Methyl t-butyl ether (MTBE) is a gasoline additive that boosts the octane number and reduces the amount of nitrogen-oxide pollutants in the exhaust. The ethers of ethylene glycol are used as solvents and plasticizers.Name: 1,4,7,10-Tetraoxa-13-azacyclopentadecane

Selective removal of 90Sr and 60Co from aqueous solution using N-aza-crown ether functional poly(NIPAM) hydrogels was written by Deli, Dario;Law, Kathleen;Liu, Zuguang;Crouch, David J.;Livens, Francis R.;Yeates, Stephen G.. And the article was included in Reactive & Functional Polymers in 2012.Name: 1,4,7,10-Tetraoxa-13-azacyclopentadecane This article mentions the following:

The ability of temperature and pH responsive cross-linked poly(NIPAM-co-AAc) hydrogel beads containing covalently bound N-aza-crown ethers to selectively complex 90Sr and 60Co under competitive and non-competitive conditions is demonstrated using a combination of autoradiog. and scintillation measurements. Due to the presence of copolymerized acrylic acid, which is incorporated to introduce pH responsive behavior as well as acting as the site of covalent attachment of the N-aza-crown ether, the decrease in particle diameter as a function of increasing temperature on going through the LCST of PNIPAM is reduced in the presence of electrolyte. At pH 2 no complexation of either 90Sr or 60Co was observed At pH 7 the incorporation of acrylic acid under non-competitive conditions results in the ability to complex ca. 90% 90Sr and 60Co which increases to between 94% and 96% on inclusion of N-aza-crown ether. Under competitive conditions the hydrogels lose the ability to selectively complex 90Sr, although the selectivity for 60Co was enhanced in the presence of N-aza-crown ether. Subsequent recovery of bound 60Co from the hydrogel on lowering to pH 2 was only partially successful, and lead to a decrease in the swelling behavior on readjustment to pH 7. In the experiment, the researchers used many compounds, for example, 1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3Name: 1,4,7,10-Tetraoxa-13-azacyclopentadecane).

1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. But on the other hand, ethers undergo cleavage by reaction with acids. Ethyl ether is an excellent solvent for extractions and for a wide variety of chemical reactions. It is also used as a volatile starting fluid for diesel engines and gasoline engines in cold weather. Dimethyl ether is used as a spray propellant and refrigerant. Methyl t-butyl ether (MTBE) is a gasoline additive that boosts the octane number and reduces the amount of nitrogen-oxide pollutants in the exhaust. The ethers of ethylene glycol are used as solvents and plasticizers.Name: 1,4,7,10-Tetraoxa-13-azacyclopentadecane

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Yang, Shang-Han et al. published their research in Biochemical Engineering Journal in 2017 | CAS: 605-94-7

2,3-Dimethoxy-5-methylcyclohexa-2,5-diene-1,4-dione (cas: 605-94-7) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil. Ethyl ether is an excellent solvent for extractions and for a wide variety of chemical reactions. It is also used as a volatile starting fluid for diesel engines and gasoline engines in cold weather. Dimethyl ether is used as a spray propellant and refrigerant. Methyl t-butyl ether (MTBE) is a gasoline additive that boosts the octane number and reduces the amount of nitrogen-oxide pollutants in the exhaust. The ethers of ethylene glycol are used as solvents and plasticizers.Formula: C9H10O4

Biosynthesis of 4-acetylantroquinonol B in Antrodia cinnamomea via a pathway related to coenzyme Q synthesis was written by Yang, Shang-Han;Lin, Yu-Wei;Chiang, Been-Huang. And the article was included in Biochemical Engineering Journal in 2017.Formula: C9H10O4 This article mentions the following:

The biosynthesis pathway for production of 4-acetylantroquinonol B (4-AAQB) by Antrodia cinnamomea was investigated by adding various precursors to the culture medium. Adding 4-hydroxybenzoic acid (4-HBA) significantly increased the production of 4-AAQB. Since 4-HBA is an intermediate of the shikimate pathway and 4-AAQB and coenzyme Q (CoQ) are similar in structure, we suspected that the pathway for producing 4-AAQB was closely related to the biosynthesis of CoQ. Since the isoprenoid chain of CoQ is synthesized via the mevalonate pathway, we added oleic acid to the culture medium and confirmed that the addition significantly increased the production of 4-AAQB. Furthermore, adding coenzyme Q0 into the fermentation broth was found to be the most effective way to increase the production of 4-AAQB. We suspect that coenzyme Q0 forms CoQ, after which CoQ is converted to 4-AAQB via unknown steps. The increase in 4-AAQB production due to the addition of CoQ10 further demonstrated that the biosynthesis pathway of 4-AAQB from A. cinnamomea is closely related to CoQ. In the experiment, the researchers used many compounds, for example, 2,3-Dimethoxy-5-methylcyclohexa-2,5-diene-1,4-dione (cas: 605-94-7Formula: C9H10O4).

2,3-Dimethoxy-5-methylcyclohexa-2,5-diene-1,4-dione (cas: 605-94-7) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil. Ethyl ether is an excellent solvent for extractions and for a wide variety of chemical reactions. It is also used as a volatile starting fluid for diesel engines and gasoline engines in cold weather. Dimethyl ether is used as a spray propellant and refrigerant. Methyl t-butyl ether (MTBE) is a gasoline additive that boosts the octane number and reduces the amount of nitrogen-oxide pollutants in the exhaust. The ethers of ethylene glycol are used as solvents and plasticizers.Formula: C9H10O4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Iwao, Masatomo et al. published their research in Heterocycles in 1994 | CAS: 56619-93-3

N-(3-Methoxyphenyl)pivalamide (cas: 56619-93-3) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. But on the other hand, ethers undergo cleavage by reaction with acids. Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. The barrier to rotation about the C–O bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.Recommanded Product: N-(3-Methoxyphenyl)pivalamide

A new method for the construction of indole nucleus was written by Iwao, Masatomo. And the article was included in Heterocycles in 1994.Recommanded Product: N-(3-Methoxyphenyl)pivalamide This article mentions the following:

Directed lithiation of N-tert-butoxycarbonylanilines I (X = H, Y = H, F, MeO; X = Me, CF3, MeO, Cl, F, Y = H) and subsequent reaction with 1-tert-butyldimethylsilyl-1-phenylsulfinylethene gave the conjugate addition products which, without isolation, were cyclized to 1-tert-butoxycarbonyl-2-(phenylthio)indolines II under thermal sila-Pummerer reaction conditions. In the experiment, the researchers used many compounds, for example, N-(3-Methoxyphenyl)pivalamide (cas: 56619-93-3Recommanded Product: N-(3-Methoxyphenyl)pivalamide).

N-(3-Methoxyphenyl)pivalamide (cas: 56619-93-3) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. But on the other hand, ethers undergo cleavage by reaction with acids. Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. The barrier to rotation about the C–O bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.Recommanded Product: N-(3-Methoxyphenyl)pivalamide

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Hao, Mingming et al. published their research in Applied Catalysis, B: Environmental in 2022 | CAS: 105-13-5

(4-Methoxyphenyl)methanol (cas: 105-13-5) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides.Formula: C8H10O2

Efficient visible light initiated one-pot syntheses of secondary amines from nitro aromatics and benzyl alcohols over Pd@NH2-UiO-66(Zr) was written by Hao, Mingming;Li, Zhaohui. And the article was included in Applied Catalysis, B: Environmental in 2022.Formula: C8H10O2 This article mentions the following:

Pd@NH2-UiO-66(Zr), with small-sized Pd nanoparticles encapsulated inside the cavities of NH2-UiO-66(Zr), was obtained via a double-solvent impregnation followed by a photoreduction process, which shows superior activity for the visible light initiated syntheses of secondary amines from nitro compounds and alcs., via a sequential photocatalytic hydrogenation of nitro compounds/dehydrogenation of alcs., condensation of amines and aldehydes to imines, and the hydrogenation of imines. Simultaneous consumption of photogenerated electrons/holes in the photocatalytic hydrogenation of nitro compounds to amines and dehydrogenation of alcs. to aldehydes promotes the whole reaction. Due to the confinement effect of the cavity and the small-sized Pd nanoparticles, Pd@NH2-UiO-66(Zr) shows significantly superior performance as compared with Pd/NH2-UiO-66(Zr), in which larger Pd nanoparticles are deposited on the surface. This study provides an efficient and green strategy for the production of secondary amines and highlights the great potential of using M/MOFs nanocomposites as multifunctional catalysts for light induced one-pot tandem reactions. In the experiment, the researchers used many compounds, for example, (4-Methoxyphenyl)methanol (cas: 105-13-5Formula: C8H10O2).

(4-Methoxyphenyl)methanol (cas: 105-13-5) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides.Formula: C8H10O2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Zhou, Yan et al. published their research in Molecules in 2021 | CAS: 57179-35-8

3-Hydroxy-5-methoxybenzaldehyde (cas: 57179-35-8) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive. Electron-deficient reagents are also stabilized by ethers. For example, borane (BH3) is a useful reagent for making alcohols. Pure borane exists as its dimer, diborane (B2H6), a toxic gas that is inconvenient and hazardous to use. Borane forms stable complexes with ethers, however, and it is often supplied and used as its liquid complex with tetrahydrofuran (THF).Reference of 57179-35-8

Design, synthesis, and evaluation of dihydropyranopyrazole derivatives as novel PDE2 inhibitors for the treatment of Alzheimer’s disease was written by Zhou, Yan;Li, Jinjian;Yuan, Han;Su, Rui;Huang, Yue;Huang, Yiyou;Li, Zhe;Wu, Yinuo;Luo, Haibin;Zhang, Chen;Huang, Ling. And the article was included in Molecules in 2021.Reference of 57179-35-8 This article mentions the following:

In this study, (R)-LZ77 was obtained as a hit compound with moderate PDE2 inhibitory activity (IC50 = 261.3 nM) using a high-throughput virtual screening method based on mol. dynamics. Then, 28 dihydropyranopyrazole derivatives I [R1 = H, CH3O, Cl; R2 = H, CH3, CH3O, etc.; R3 = H, CH3, C6H5; R4 = H, CH3O, Cl, etc; R5 = NH2, (CH3)2N; n = 1, 2, 3] and II [R6 = Cl, CF3; n = 0, 2, 3] were designed and synthesized as PDE2 inhibitors. Among them, compound (+)-I [R1 = H; R2 = CH3O; R3 = CH3; R4 = CF3; R5 = NH2; n = 1] was the most potent PDE2 inhibitor, with an IC50 value of 41.5 nM. The mol. docking of PDE2-(+)-I [R1 = H; R2 = CH3O; R3 = CH3; R4 = CF3; R5 = NH2; n = 1] revealed that the 4-(trifluoromethyl)benzyloxyl side chain of the compound enters the H-pocket and forms strong hydrophobic interactions with L770/L809/F862, which improves inhibitory activity. The above results may provide insight for further structural optimization of highly potent PDE2 inhibitors and may lay the foundation for their use in the treatment of AD. In the experiment, the researchers used many compounds, for example, 3-Hydroxy-5-methoxybenzaldehyde (cas: 57179-35-8Reference of 57179-35-8).

3-Hydroxy-5-methoxybenzaldehyde (cas: 57179-35-8) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive. Electron-deficient reagents are also stabilized by ethers. For example, borane (BH3) is a useful reagent for making alcohols. Pure borane exists as its dimer, diborane (B2H6), a toxic gas that is inconvenient and hazardous to use. Borane forms stable complexes with ethers, however, and it is often supplied and used as its liquid complex with tetrahydrofuran (THF).Reference of 57179-35-8

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ikeda, Taichi et al. published their research in Polymer Chemistry in 2021 | CAS: 60221-37-6

2-(2-(2-((Tetrahydro-2H-pyran-2-yl)oxy)ethoxy)ethoxy)ethan-1-ol (cas: 60221-37-6) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides.Application In Synthesis of 2-(2-(2-((Tetrahydro-2H-pyran-2-yl)oxy)ethoxy)ethoxy)ethan-1-ol

Poly(ionic liquid)s with branched side chains: polymer design for breaking the conventional record of ionic conductivity was written by Ikeda, Taichi. And the article was included in Polymer Chemistry in 2021.Application In Synthesis of 2-(2-(2-((Tetrahydro-2H-pyran-2-yl)oxy)ethoxy)ethoxy)ethan-1-ol This article mentions the following:

Poly(ionic liquid)s with non-branched, di-branched, and tri-branched side chains were synthesized using cationic glycidyl triazolyl polymers (GTPs). Based on the analyses of these cationic GTPs, the effects of side-chain branching on phys. properties, such as glass transition temperature and ionic conductivity, were discussed. It was confirmed that the ionic conductivity increased with the degree of side-chain branching. Despite being a high-mol.-weight polymer (1.9 x 106 Da), GTP with tri-branched side chains exhibited a high ionic conductivity of 3.6 x 10-5 M at 25°C under dry conditions, which is higher than the benchmark value of the conventional poly(ionic liquid)s proposed by Shaplov, Marcilla, and Mecerreyes (3.0 x 10-5 M at 25°C, dry conditions, mol. weight >105 Da). From the anal. based on the electrode polarization model, the higher ionic conductivity of cationic GTPs with branched side chains can be attributed to their higher conducting ion mobility in the polymer matrix. These results indicate that side-chain branching is effective in breaking the conventional limit of ionic conductivity of poly(ionic liquid)s. In the experiment, the researchers used many compounds, for example, 2-(2-(2-((Tetrahydro-2H-pyran-2-yl)oxy)ethoxy)ethoxy)ethan-1-ol (cas: 60221-37-6Application In Synthesis of 2-(2-(2-((Tetrahydro-2H-pyran-2-yl)oxy)ethoxy)ethoxy)ethan-1-ol).

2-(2-(2-((Tetrahydro-2H-pyran-2-yl)oxy)ethoxy)ethoxy)ethan-1-ol (cas: 60221-37-6) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides.Application In Synthesis of 2-(2-(2-((Tetrahydro-2H-pyran-2-yl)oxy)ethoxy)ethoxy)ethan-1-ol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Oh, Young-Ho et al. published their research in Molecules in 2021 | CAS: 3929-47-3

3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. But ether is more polar than alkenes. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides.Reference of 3929-47-3

Inter- and intra-molecular organocatalysis of SN2 fluorination by crown ether: kinetics and quantum chemical analysis was written by Oh, Young-Ho;Yun, Wonhyuck;Kim, Chul-Hee;Jang, Sung-Woo;Lee, Sung-Sik;Lee, Sungyul;Kim, Dong-Wook. And the article was included in Molecules in 2021.Reference of 3929-47-3 This article mentions the following:

We present the intra- and inter-mol. organocatalysis of SN2 fluorination using CsF by crown ether to estimate the efficacy of the promoter and to elucidate the reaction mechanism. The yields of intramol. SN2 fluorination of the veratrole substrates are measured to be very small (<1% in 12 h) in the absence of crown ether promoters, whereas the SN2 fluorination of the substrate possessing a crown ether unit proceeds to near completion (~99%) in 12 h. We also studied the efficacy of intermol. rate acceleration by an independent promoter 18-crown-6 for comparison. We find that the fluorinating yield of a veratrole substrate (leaving group = -OMs) in the presence of 18-crown-6 follows the almost identical kinetic course as that of intramol. SN2 fluorination, indicating the mechanistic similarity of intra- and inter-mol. organocatalysis of the crown ether for SN2 fluorination. The calculated relative Gibbs free energies of activation for these reactions, in which the crown ether units act as Lewis base promoters for SN2 fluorination, are in excellent agreement with the exptl. measured yields of fluorination. The role of the metal salt CsF is briefly discussed in terms of whether it reacts as a contact ion pair or as a “free” nucleophile F–. In the experiment, the researchers used many compounds, for example, 3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3Reference of 3929-47-3).

3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. But ether is more polar than alkenes. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides.Reference of 3929-47-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Fujihira, Yamato et al. published their research in Journal of Organic Chemistry in 2021 | CAS: 112-49-2

2,5,8,11-Tetraoxadodecane (cas: 112-49-2) belongs to ethers. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides. At room temperature, ethers are pleasant-smelling colourless liquids. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil.Product Details of 112-49-2

Pentafluoroethylation of Carbonyl Compounds by HFC-125 via the Encapsulation of the K Cation with Glymes was written by Fujihira, Yamato;Hirano, Kazuki;Ono, Makoto;Mimura, Hideyuki;Kagawa, Takumi;Sedgwick, Daniel M.;Fustero, Santos;Shibata, Norio. And the article was included in Journal of Organic Chemistry in 2021.Product Details of 112-49-2 This article mentions the following:

A simple protocol to overcome the explosive pentafluoroethylation of carbonyl compounds by HFC-125 is described. The use of potassium (K) bases with triglyme or tetraglyme as a solvent safely yields the pentafluoroethylation products in good to high yields. The exptl. results suggest that an encapsulation of the K cation by glymes as K(glyme)2 inhibits the contact between the K cation and the reactive anionic pentafluoroethyl counterion, preventing their transformation into KF and explosive tetrafluoroethylene (TFE). The generation of sterically demanding [K(G3)2]+ and [K(G4)2]+ is an effective way as an unstable pentafluoroethyl anion reservoir. In the experiment, the researchers used many compounds, for example, 2,5,8,11-Tetraoxadodecane (cas: 112-49-2Product Details of 112-49-2).

2,5,8,11-Tetraoxadodecane (cas: 112-49-2) belongs to ethers. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides. At room temperature, ethers are pleasant-smelling colourless liquids. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil.Product Details of 112-49-2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Zhang, Ning et al. published their research in European Journal of Medicinal Chemistry in 2018 | CAS: 365564-07-4

2-(3,5-Dimethoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 365564-07-4) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. Ethyl ether is an excellent solvent for extractions and for a wide variety of chemical reactions. It is also used as a volatile starting fluid for diesel engines and gasoline engines in cold weather. Dimethyl ether is used as a spray propellant and refrigerant. Methyl t-butyl ether (MTBE) is a gasoline additive that boosts the octane number and reduces the amount of nitrogen-oxide pollutants in the exhaust. The ethers of ethylene glycol are used as solvents and plasticizers.Recommanded Product: 365564-07-4

Difuran-substituted quinoxalines as a novel class of PI3Kα H1047R mutant inhibitors: Synthesis, biological evaluation and structure-activity relationship was written by Zhang, Ning;Yu, Zhimei;Yang, Xiaohong;Zhou, Yan;Tang, Qing;Hu, Ping;Wang, Jia;Zhang, Shao-Lin;Wang, Ming-Wei;He, Yun. And the article was included in European Journal of Medicinal Chemistry in 2018.Recommanded Product: 365564-07-4 This article mentions the following:

Phosphatidylinositol 3-kinase α (PI3Kα) is the most frequently mutated kinase in human cancers, making it an attractive therapeutic target for cancer treatment. The authors identified a structurally novel PI3Kα H1047R mutant inhibitor Hit-01 (5,7-dichloro-2,3-di(furan-2-yl)quinoxaline) (EC50 = 76.0 μM) through a high-throughput screening campaign. Chem. optimizations enabled the authors to discover compound 7b (6-bromo-7-(2-fluorophenyl)-2,3-di(furan-2-yl)quinoxaline), which strongly inhibited PI3Kα H1047R mutant with an EC50 value of 0.137 μM, over 500-fold more potent than Hit-01. Western blotting anal. suggested that 7b could decrease the phosphorylation level of p-AKT, another proof that 7b inhibited PI3Kα H1047R function. Cell viability assay revealed that 7b inhibited HCT116 cancer cell growth with an IC50 value of 11.23 μM. In addition, 7b was found to arrest cell cycle at G1 phase and induce cell apoptosis via up-regulation of caspase-3, caspase-8 and caspase-9 protein expressions. Collectively, all these data demonstrated that 7b could be a promising lead for the development of structurally novel PI3Kα inhibitors. In the experiment, the researchers used many compounds, for example, 2-(3,5-Dimethoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 365564-07-4Recommanded Product: 365564-07-4).

2-(3,5-Dimethoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 365564-07-4) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. Ethyl ether is an excellent solvent for extractions and for a wide variety of chemical reactions. It is also used as a volatile starting fluid for diesel engines and gasoline engines in cold weather. Dimethyl ether is used as a spray propellant and refrigerant. Methyl t-butyl ether (MTBE) is a gasoline additive that boosts the octane number and reduces the amount of nitrogen-oxide pollutants in the exhaust. The ethers of ethylene glycol are used as solvents and plasticizers.Recommanded Product: 365564-07-4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem