Author: Jessica.F

Ruthenium(II)-enabled para-selective C-H difluoromethylation of anilides and their derivatives was written by Yuan, Chunchen;Zhu, Lei;Chen, Changpeng;Chen, Xiaolan;Yang, Yong;Lan, Yu;Zhao, Yingsheng. And the article was included in Nature Communications in 2018.Computed Properties of C12H17NO2 This article mentions the following:

Here the development of a ruthenium-enabled para-selective C-H difluoromethylation of anilides, indolines, and tetrahydroquinolines is described. This reaction tolerates various substituted arenes, affording para-difluoromethylation products in moderate to good yields. Results of a preliminary study of the mechanism indicate that chelation-assisted cycloruthenation might play a role in the selective activation of para-CAr-H bonds. Furthermore, this method provides a direct approach for the synthesis of fluorinated drug derivatives, which has important application for drug discovery and development. In the experiment, the researchers used many compounds, for example, N-(3-Methoxyphenyl)pivalamide (cas: 56619-93-3Computed Properties of C12H17NO2).

N-(3-Methoxyphenyl)pivalamide (cas: 56619-93-3) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil. Ethers can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.Computed Properties of C12H17NO2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

SARS-CoV-2 M^pro inhibitors with antiviral activity in a transgenic mouse model was written by Qiao, Jingxin;Li, Yue-Shan;Zeng, Rui;Liu, Feng-Liang;Luo, Rong-Hua;Huang, Chong;Wang, Yi-Fei;Zhang, Jie;Quan, Baoxue;Shen, Chenjian;Mao, Xin;Liu, Xinlei;Sun, Weining;Yang, Wei;Ni, Xincheng;Wang, Kai;Xu, Ling;Duan, Zi-Lei;Zou, Qing-Cui;Zhang, Hai-Lin;Qu, Wang;Long, Yang-Hao-Peng;Li, Ming-Hua;Yang, Rui-Cheng;Liu, Xiaolong;You, Jing;Zhou, Yangli;Yao, Rui;Li, Wen-Pei;Liu, Jing-Ming;Chen, Pei;Liu, Yang;Lin, Gui-Feng;Yang, Xin;Zou, Jun;Li, Linli;Hu, Yiguo;Lu, Guang-Wen;Li, Wei-Min;Wei, Yu-Quan;Zheng, Yong-Tang;Lei, Jian;Yang, Shengyong. And the article was included in Science (Washington, DC, United States) in 2021.Application In Synthesis of 2-(4-Methoxyphenoxy)acetic acid This article mentions the following:

The COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continually poses serious threats to global public health. The main protease (M^pro) of SARS-CoV-2 plays a central role in viral replication. We designed and synthesized 32 new bicycloproline-containing M^pro inhibitors derived from either boceprevir or telaprevir, both of which are approved antivirals. All compounds inhibited SARS-CoV-2 M^pro activity in vitro, with 50% inhibitory concentration values ranging from 7.6 to 748.5 nM. The cocrystal structure of M^pro in complex with MI-23, one of the most potent compounds, revealed its interaction mode. Two compounds (MI-09 and MI-30) showed excellent antiviral activity in cell-based assays. In a transgenic mouse model of SARS-CoV-2 infection, oral or i.p. treatment with MI-09 or MI-30 significantly reduced lung viral loads and lung lesions. Both also displayed good pharmacokinetic properties and safety in rats. In the experiment, the researchers used many compounds, for example, 2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4Application In Synthesis of 2-(4-Methoxyphenoxy)acetic acid).

2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. Ethers can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.Application In Synthesis of 2-(4-Methoxyphenoxy)acetic acid

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Allelochemicals of barnyardgrass-infested soil and their activities on crops and weeds was written by Khanh, Tran Dang;Xuan, Tran Dang;Chung, Ill Min;Tawata, Shinkichi. And the article was included in Weed Biology and Management in 2008.Computed Properties of C11H12O4 This article mentions the following:

Barnyardgrass is one of the most noxious paddy weeds in the world and causes great trouble to many crops. In a bioassay, the aqueous extract of paddy soil infested with barnyardgrass showed phytotoxic action against the growth of the tested crops and paddy weeds, of which rice was the most suppressed among the crops. In contrast, barnyardgrass was the least affected paddy weed. By the use of a separation resin, 18 compounds belonging to terpenes, derivatives of cinnamic acid and ferulic acid, long-chain fatty acids, and steroids that were potentially involved in the phytotoxic activities in barnyardgrass-infested soil were isolated and identified by gas chromatog.-mass spectrometry anal. Of these, the quantities of linalool, 4-terpinenol, coumaran, Me phenethyl ketone, and Me ester cinnamic acid were 1.42, 0.37, 0.02, 3.12, and 4.59 μg g^-1 of the wet soil, resp. The herbicidal activity was varied among these qualified test compounds, in which Me phenethyl ketone and Me ester cinnamic acid were more herbicidal than coumaran, linalool, and 4-terpinenol. A mixture of these compounds was also the least inhibitive against the growth of barnyardgrass, but exerted strong suppression against that of rice and monochoria. The present study demonstrates that barnyardgrass possesses strong phytotoxic properties and releases plant growth inhibitors into the soil to compete with rice and other paddy weeds in its vicinity by a chem. pathway. In the experiment, the researchers used many compounds, for example, 3-(2,4-Dimethoxyphenyl)acrylic acid (cas: 6972-61-8Computed Properties of C11H12O4).

3-(2,4-Dimethoxyphenyl)acrylic acid (cas: 6972-61-8) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive. Ethyl ether is an excellent solvent for extractions and for a wide variety of chemical reactions. It is also used as a volatile starting fluid for diesel engines and gasoline engines in cold weather. Dimethyl ether is used as a spray propellant and refrigerant. Methyl t-butyl ether (MTBE) is a gasoline additive that boosts the octane number and reduces the amount of nitrogen-oxide pollutants in the exhaust. The ethers of ethylene glycol are used as solvents and plasticizers.Computed Properties of C11H12O4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthesis of Benzofurans from Ketones and 1,4-Benzoquinones was written by Wu, Fengtian;Bai, Rongxian;Gu, Yanlong. And the article was included in Advanced Synthesis & Catalysis in 2016.Product Details of 605-94-7 This article mentions the following:

Benzofuran derivatives can be synthesized through the sequential Michael addition and cyclization of 1,3-dicarbonyl compounds with 1,4-benzoquinones. However, ketones are rarely used in this reaction because of their low nucleophilicities. In this study, this problem was solved by utilizing tri-Et orthoformate, which enabled the formation of a vinyl Et ether as an additive. As a result, the nucleophilicity of ketones increased. Many important 5-hydroxybenzofuran derivatives, which were not readily available by synthesis in the past, were also prepared via these newly established reactions. In the experiment, the researchers used many compounds, for example, 2,3-Dimethoxy-5-methylcyclohexa-2,5-diene-1,4-dione (cas: 605-94-7Product Details of 605-94-7).

2,3-Dimethoxy-5-methylcyclohexa-2,5-diene-1,4-dione (cas: 605-94-7) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil. At room temperature, ethers are pleasant-smelling colourless liquids. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil.Product Details of 605-94-7

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthesis of copper nanoparticles supported on a microporous covalent triazine polymer: an efficient and reusable catalyst for O-arylation reaction was written by Puthiaraj, Pillaiyar;Ahn, Wha-Seung. And the article was included in Catalysis Science & Technology in 2016.Recommanded Product: 1-(4-(4-Methoxyphenoxy)phenyl)ethanone This article mentions the following:

Copper nanoparticles were supported on a microporous covalent triazine polymer prepared by the Friedel-Crafts reaction (Cu@MCTP-1). The resulting material was characterized by powder X-ray diffraction, thermogravimetric anal., N₂ adsorption-desorption isotherms at 77 K, transmission electron microscopy, XPS, and inductively coupled plasma optical emission spectroscopy, and Cu particles with an average size of 3.0 nm and a BET total surface area of ca. 1002 m² g^-1 were obtained. Cu@MCTP-1 was evaluated as a heterogeneous catalyst for the Ullmann coupling of O-arylation over a series of aryl halides and phenols without employing expensive ligands or inert atm., which produced an excellent yield of the corresponding diaryl ethers. The catalyst could be recovered by simple centrifugation and was reusable at least five times with only a slight decrease in catalytic activity. In the experiment, the researchers used many compounds, for example, 1-(4-(4-Methoxyphenoxy)phenyl)ethanone (cas: 54916-28-8Recommanded Product: 1-(4-(4-Methoxyphenoxy)phenyl)ethanone).

1-(4-(4-Methoxyphenoxy)phenyl)ethanone (cas: 54916-28-8) belongs to ethers. The oxygen atom in ethers are more electronegative than carbon, thus the hydrogens which are alpha to the ethers are more acidic than the simple hydrocarbons. The unique properties of ethers (i.e., that they are strongly polar, with nonbonding electron pairs but no hydroxyl group) enhance the formation and use of many reagents. For example, Grignard reagents cannot form unless an ether is present to share its lone pair of electrons with the magnesium atom. Complexation of the magnesium atom stabilizes the Grignard reagent and helps to keep it in solution.Recommanded Product: 1-(4-(4-Methoxyphenoxy)phenyl)ethanone

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthesis, Structure, and Properties of the 2-[5-(Aryloxyacetyl)-Amino-1,3,4-Thiadiazol-2-Ylthio] Propionate Derivatives was written by Hu, Bing;Zhai, Yue-Yuan;Zhang, Ling;Zhang, You-Ming;Wei, Tai-Bao. And the article was included in Phosphorus, Sulfur and Silicon and the Related Elements in 2014.Quality Control of 2-(4-Methoxyphenoxy)acetic acid This article mentions the following:

A series of novel 2-[5-(aryloxyacetyl)-amino-1,3,4-thiadiazol-2-ylthio] propionate derivatives were synthesized in high yield, and their structures were characterized by IR, ¹H NMR, ¹³C NMR, and elemental anal., coupled with one selected single-crystal x-ray structure determination The herbicidal activities of target compounds were assessed. The preliminary bioassay results showed that some compounds exhibited moderate to strong herbicidal symptoms in preemergence and postemergence tests. At 150 g/ha, S. tritici. show tolerance, while E. crus-galli L., E. Dahuricus, A. retroflexus, and C. glaucum L. were killed or severely injured. The activity of some compounds was comparable to the com. herbicide 2,4-D. A suitable electron-withdrawing substituent at the 2- and/or 4-position of the Ph ring was essential for high herbicidal activity. Moreover, the antifungal activities of the compounds were studied. The compounds were found to possess broad-spectrum antifungal activity. In the experiment, the researchers used many compounds, for example, 2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4Quality Control of 2-(4-Methoxyphenoxy)acetic acid).

2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil. At room temperature, ethers are pleasant-smelling colourless liquids. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil.Quality Control of 2-(4-Methoxyphenoxy)acetic acid

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Market surveillance: analysis of perfuming products for presence of allergens and prohibited substances was written by Sevcik, Vaclav;Andrascikova, Maria;Vavrous, Adam;Moulisova, Alena;Vrbik, Karel;Bendova, Hana;Jirova, Dagmar;Kejlova, Kristina;Hlozek, Tomas. And the article was included in Chemical Papers in 2022.Category: ethers-buliding-blocks This article mentions the following:

The market surveillance study was based on chem. anal. of 166 com. available perfuming products in order to identify the presence of 24 regulated allergens and 21 prohibited substances. For this purpose, several GC methods were tested. The anal. approach for determination of 24 regulated allergens was based on GC-MS and GC-MS/MS anal. Analyses were performed on two different GC columns to avoid potentially overestimated results due to matrix component co-elutions. Allergens determined by the chem. analyses were compared with the allergens declared on the product label to verify whether these products comply with the requirements of the Regulation No 1223/2009 of the European Parliament and of the Council. A specific proportion of the tested cosmetic products (43%) was found as non-compliant either due to a missing list of ingredients or due to the presence of undeclared allergens that were found to be present in the product above limits (0.001%) for required labeling. The GC-MS/MS anal. of 21 prohibited substances did not reveal any of the prohibited compounds in a concentration above LOQ except safrole, which was found in 12 out of 166 tested samples. The concentration of safrole did not exceed the concentration limit permitted by legislation for the presence from natural sources in any of these samples. In the experiment, the researchers used many compounds, for example, (4-Methoxyphenyl)methanol (cas: 105-13-5Category: ethers-buliding-blocks).

(4-Methoxyphenyl)methanol (cas: 105-13-5) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. But ether is more polar than alkenes. Autoxidation is the spontaneous oxidation of a compound in air. In the presence of oxygen, ethers slowly autoxidize to form hydroperoxides and dialkyl peroxides. If concentrated or heated, these peroxides may explode. To prevent such explosions, ethers should be obtained in small quantities, kept in tightly sealed containers, and used promptly.Category: ethers-buliding-blocks

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

An Efficient Polymer Supported Palladium Catalyst for ortho Selective C-H Olefination of Anilides was written by Saranya, Thachora Venu;Sruthi, Pambingal Rajan;Ayana, Nambokkil;Anas, Saithalavi. And the article was included in ChemistrySelect in 2021.Application In Synthesis of N-(3-Methoxyphenyl)pivalamide This article mentions the following:

The development of a novel heterogeneous polymer supported palladium catalyst for the oxidative C-H olefination of anilides was described. The catalyst was realized by immobilizing palladium acetate over ethylene diamine modifiedpolyacrylonitrile (PAN) and characterized by means of FTIR, XRD and XPS analyses which evidenced the complexation of Pd(OAc)₂ with the chelating groups in the polymer. The resulting supported complex (en-PAN-Pd) was then explored as an efficient and reusable heterogeneous catalyst for ortho selective C-H activation of anilides on reaction with a number of alkyl acrylates. This reaction protocol served as a useful and greener method for the synthesis of o-alkenyl anilides under mild reaction conditions. The catalyst also exhibited good recyclability and reusability without losing much catalytic activity. In the experiment, the researchers used many compounds, for example, N-(3-Methoxyphenyl)pivalamide (cas: 56619-93-3Application In Synthesis of N-(3-Methoxyphenyl)pivalamide).

N-(3-Methoxyphenyl)pivalamide (cas: 56619-93-3) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. But on the other hand, ethers undergo cleavage by reaction with acids. Ethers can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.Application In Synthesis of N-(3-Methoxyphenyl)pivalamide

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

TiO₂ supported-reduced graphene oxide co-doped with gallium and sulfur as an efficient heterogeneous catalyst for the selective photochemical oxidation of alcohols; DFT and mechanism insights was written by Khavar, Amir Hossein Cheshme;Khazaee, Zeynab;Mahjoub, Ali Reza;Nejat, Razieh. And the article was included in Journal of Photochemistry and Photobiology, A: Chemistry in 2022.Recommanded Product: 105-13-5 This article mentions the following:

Achieving organic transformation reactions using green synthesis methods under mild conditions is always an aspiration of scientists. In this study, Ga, S co-doped TiO₂/reduced graphene oxide (GaxSy@TRG) nanocomposite was synthesized by an innovative surfactant-free ultrasonic-assisted solvothermal method and used to catalyze the selective photocatalytic oxidation of benzyl alc. under visible light irradiation The prepared photocatalyst was analyzed via XRD, FT-IR, Raman, N₂ adsorption-desorption, SEM, TEM, EDX, ICP-MS, UV-Vis absorption, and electrochem. impedance spectroscopy (EIS) measurement. The characterization outcomes indicated the prepared co-doped TiO₂ nanoparticles with anatase crystal structure possessed a mesoporous texture and were uniformly distributed on the RGO surface. The conversion of GO to RGO was confirmed through FT-IR and Raman spectra. The prepared nanocomposites were examined for their ability in artificial photocatalysis and displayed remarkable catalytic activity for the selective oxidation of alcs. into benzaldehyde. The co-doped catalysts showed significantly enhanced photocatalytic ability, due to improved photogenerated electrons transfer, enhanced charge carriers separation and extended optical absorption to the visible light range. Moreover, the synergistic effect of dopants that could act as electron trapping centers and RGO as a powerful acceptor material efficiently reduced photogenerated electron-hole recombination and promoted charge migration. A high conversion rate of 85% was obtained over the Ga_5.0S_10.0@TRG photocatalyst after 110 min under visible light irradiation The results from d. functional theory (DFT) calculations revealed that the hybridization of Ga 4s and S 3p orbitals with valance band can remarkably affect the decreasing of band gap energy. The mechanism of photocatalytic oxidation of benzyl alc. under visible light irradiation was proposed using the combination of exptl. and computational methods. In the experiment, the researchers used many compounds, for example, (4-Methoxyphenyl)methanol (cas: 105-13-5Recommanded Product: 105-13-5).

(4-Methoxyphenyl)methanol (cas: 105-13-5) belongs to ethers. The oxygen atom in ethers are more electronegative than carbon, thus the hydrogens which are alpha to the ethers are more acidic than the simple hydrocarbons. At room temperature, ethers are pleasant-smelling colourless liquids. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil.Recommanded Product: 105-13-5

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Probing Electrochemical Mg-Ion Activity in MgCr_2-xV_xO₄ Spinel Oxides was written by Kwon, Bob Jin;Lau, Ka-Cheong;Park, Haesun;Wu, Yimin A.;Hawthorne, Krista L.;Li, Haifeng;Kim, Soojeong;Bolotin, Igor L.;Fister, Timothy T.;Zapol, Peter;Klie, Robert F.;Cabana, Jordi;Liao, Chen;Lapidus, Saul H.;Key, Baris;Vaughey, John T.. And the article was included in Chemistry of Materials in 2020.Quality Control of 2,5,8,11-Tetraoxadodecane This article mentions the following:

Mg migration in oxide spinels is impeded by strong affinity between divalent Mg and O, suggesting a necessity of exploring new chem. of solid lattices for functional Mg-ion electrode materials. Cationic mobility with a suitable activation energy in Cr spinels is evidenced by theor. and exptl. results, while redox potentials of V are appropriate to operate with currently limited candidates of nonaqueous electrolytes. By controlling the structure, composition, and complexity, a largely solid-solution MgCrVO₄ spinel was synthesized, which, unlike nanocomposites, can bring together the advantages of each transition metal in the lattice. The spinel was successfully synthesized by a simple solid-state reaction with minor inactive Cr- or V-rich components, which was confirmed via ²⁵Mg MASNMR and high-resolution x-ray diffraction analyses. A thermally and anodically stable Mg(TPFA)₂/triglyme electrolyte was used for high-temperature electrochem. and lowering kinetic barriers at and across interfaces so as to observe intercalation behavior of Mg in the designed lattice. Multimodal characterization confirmed an apparent bulk demagnesiation from MgCrVO₄ with partial reversibility by probing evolution of the local and long-range structure as well as V and Cr electronic states within the lattice. Characterization experiments also provided a direct evidence for (de)intercalation reactions that occurred without any major competitive conversion reactions or insertion of protons into the lattice, except for the formation of a surface rock salt phase upon charge. These findings in Mg-ion activity expand opportunities to design Mg spinel oxide materials while highlighting the need to identify the origins of reversibility challenges due to, but not limited to, phase stability, particularly for the charged states, barriers at the interface, electrolyte stabilities, and desolvation phenomena, collectively hindering practical use as cathode materials. In the experiment, the researchers used many compounds, for example, 2,5,8,11-Tetraoxadodecane (cas: 112-49-2Quality Control of 2,5,8,11-Tetraoxadodecane).

2,5,8,11-Tetraoxadodecane (cas: 112-49-2) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. At room temperature, ethers are pleasant-smelling colourless liquids. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil.Quality Control of 2,5,8,11-Tetraoxadodecane

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem