Author: Jessica.F

Mandrelli, Francesca; Blond, Aurelie; James, Thomas; Kim, Hyejin; List, Benjamin published an article in 2019, the title of the article was Deracemizing α-Branched Carboxylic Acids by Catalytic Asymmetric Protonation of Bis-Silyl Ketene Acetals with Water or Methanol.Electric Literature of 81616-80-0 And the article contains the following content:

We report a highly enantioselective catalytic protonation of bis-silyl ketene acetals. Our method delivers α-branched carboxylic acids, including nonsteroidal anti-inflammatory arylpropionic acids such as Ibuprofen, in high enantiomeric purity and high yields. The process can be incorporated in an overall deracemization of α-branched carboxylic acids, involving a double deprotonation and silylation followed by the catalytic asym. protonation. The experimental process involved the reaction of (S)-2-(2-Methoxyphenyl)propanoic acid(cas: 81616-80-0).Electric Literature of 81616-80-0

The Article related to alpha branched carboxylic acid catalytic asym protonation deracemization, enantioselective catalytic protonation bissilyl ketene acetal, brønsted acids, bis-silyl ketene acetals, deracemization, deuteration, disulfonimide, protonation and other aspects.Electric Literature of 81616-80-0

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Xie, Jialin; Guo, Zhonglin; Huang, Yuanqiong; Qu, Yi; Song, Hongjian; Song, Haibin; Liu, Yuxiu; Wang, Qingmin published an article in 2019, the title of the article was One-Pot Copper-Catalyzed Cascade Bicyclization Strategy for Synthesis of 2-(1H-Indol-1-yl)-4,5-dihydrothiazoles and 2-(1H-Indol-1-yl)thiazol-5-yl Aryl Ketones with Molecular Oxygen as an Oxygen Source.Reference of 2-((4-Methoxyphenyl)ethynyl)aniline And the article contains the following content:

An atom-economical method for synthesizing N-heterocyclic indoles from readily available o-alkynylphenyl isothiocyanates and propargylamine derivatives is reported. This method involves a copper-catalyzed cascade bicyclization process consisting of an intramol. 5-exo-dig hydrothiolation reaction and an intramol. hydroamination reaction and, depending on whether or not mol. oxygen is present, selectively affords Z-isomers of 2-(1H-indol-1-yl)-4,5-dihydrothiazoles, e.g., I (X-rays single crystal structure shown), or 2-(1H-indol-1-yl)thiazol-5-yl aryl ketones in satisfactory yields. Mechanistic studies indicate that mol. oxygen acts as the oxygen source for the ketone moiety in the products. The experimental process involved the reaction of 2-((4-Methoxyphenyl)ethynyl)aniline(cas: 157869-15-3).Reference of 2-((4-Methoxyphenyl)ethynyl)aniline

The Article related to alkynylphenyl isothiocyanate propargylamine cascade bicyclization copper, indolyl dihydrothiazole preparation mol crystal structure, aryl ketone indolylthiazolyl preparation mol crystal structure, copper cascade bicyclization catalyst and other aspects.Reference of 2-((4-Methoxyphenyl)ethynyl)aniline

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On March 1, 2022, Dalai, Pallaba Ganjan; Palit, Kuntal; Panda, Niranjan published an article.Synthetic Route of 93-04-9 The title of the article was Generation of Dimethyl Sulfoxide Coordinated Thermally Stable Halogen Cation Pools for C-H Halogenation. And the article contained the following:

A method to generate halogen cation pools from the reaction of 1,2-dihaloethanes (hal=Br, I) and DMSO (DMSO) for C-H halogenation of arenes and heteroarenes was reported. The initial reaction of DMSO and 1,2-dihaloethane generates the sulfur ylide, which undergoes pyrolytic elimination of ethylene by affording halonium ions. These ions were accumulated and stabilized by DMSO through coordination by forming halogen cation pools for the halogenation reaction. This protocol was selective for electrophilic monohalogenation of arenes at room temperature; however, polyhalogenated products were formed by raising the reaction temperature Late-stage halogenation of heteroarenes and some commonly marketed drugs signifies the synthetic utility of this protocol in pharmaceutical chem. Unlike the classical methods, the in-situ generated electrophilic bromonium ion was further exploited for the direct synthesis of α-diketones from the alkenes under base-free conditions. The experimental process involved the reaction of 2-Methoxynaphthalene(cas: 93-04-9).Synthetic Route of 93-04-9

The Article related to arene dmso coordinated halogen halogenation, haloarene preparation, alkene dmso coordinated bromide halogenation, dibromoalkane preparation, diketone preparation, enamide dmso coordinated bromide intramol cyclization, oxazole preparation and other aspects.Synthetic Route of 93-04-9

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Hernandez-Vazquez, Eduardo; Miranda, Luis D. published an article in 2016, the title of the article was Practical synthesis and cytotoxic evaluation of the pyrazino[1,2-b]-isoquinoline ring system.Electric Literature of 887581-09-1 And the article contains the following content:

A practical three-step protocol for the synthesis of pyrazino[1,2-b]isoquinolines I [R1 = H, 4-Me, 5-MeO, 5-F, etc.; R2 = t-Bu, cyclohexyl, 2,6-diMeC6H3, benzyl, etc.] was reported. This approach included a one-pot parallel cyclization/cyclization parallel process followed by a non-common 6-endo Heck cyclization that transformed previously constructed Ugi adducts into diversely decorated tricyclic systems. Compounds bearing a t-Bu or 2,6-dimethylphenyl substituent showed significant cytotoxic activity. The most active analog I (R1 = CH2O2; R2 = 2,6-diMeC6H3) showed significant activity against HCT-15 and K562 (IC50 = 41.8 ± 3.3 and 57.7 ± 2.1 μM, resp.) with no cytotoxicity against human gingival fibroblasts. The experimental process involved the reaction of (2-Bromo-5-methoxyphenyl)methanamine(cas: 887581-09-1).Electric Literature of 887581-09-1

The Article related to benzylamine isocyanide benzoyloxy acetaldehyde chloroacetic acid ugi reaction, bromo chloroacetylamiono oxopropylamino benzoate preparation heck reaction, pyrazinoisoquinoline preparation antitumor activity structure activity relationship and other aspects.Electric Literature of 887581-09-1

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Yu, Liu-Zhu; Wei, Yin; Shi, Min published an article in 2017, the title of the article was Copper-catalyzed trifluoromethylazidation and rearrangement of aniline-linked 1,7-enynes: access to CF3-substituted azaspirocyclic dihydroquinolin-2-ones and furoindolines.Electric Literature of 157869-15-3 And the article contains the following content:

A set of reactions involving copper-catalyzed trifluoromethylazidation and then rearrangement of aniline-linked 1,7-enynes with the relatively poorly reactive Togni reagent and TMSN3 was developed, and provided facile access to structurally diverse and useful CF3-substituted azaspirocyclic dihydroquinolin-2-ones I [R1 = H, 4-Cl, 4-CN, etc.; R2 = Ph, 4-ClC6H4, 2-naphthyl, etc.; R3 = Ms, Bn, Ts, etc.; R4 = Me, Ph] bearing two adjacent quaternary carbon centers. These products were also obtained on a large scale. Moreover, the obtained products were further transformed into a range of synthetically valuable furoindolines bearing three consecutive quaternary carbon centers after reduction by NaBH4. Also, the delivery of multi-functionalized aziridines as a result of alcoholysis and LiAlH4-reduction of corresponding dihydroquinolin-2-ones I [R1 = H, R2 = Ph, R3 = Ts, R4 = Me] demonstrated the synthetic value of this newly developed protocol. The experimental process involved the reaction of 2-((4-Methoxyphenyl)ethynyl)aniline(cas: 157869-15-3).Electric Literature of 157869-15-3

The Article related to arylethynyl phenyl acrylamide copper catalyst regioselective trifluoromethylaziridination rearrangement, trifluromethyl azaspirocyclic dihydroquinolinone diastereoselective preparation sodium borohydride reduction, furoindoline preparation and other aspects.Electric Literature of 157869-15-3

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On March 6, 2020, Ling, Fei; Song, Dingguo; Chen, Linlin; Liu, Tao; Yu, Mengyao; Ma, Yan; Xiao, Lian; Xu, Min; Zhong, Weihui published an article.SDS of cas: 157869-15-3 The title of the article was Syntheses of N-Alkyl 2-Arylindoles from Saturated Ketones and 2-Arylethynylanilines via Cu-Catalyzed Sequential Dehydrogenation/aza-Michael Addition/Annulation Cascade. And the article contained the following:

A Cu-catalyzed and 4-OH-TEMPO-mediated sequential dehydrogenation/aza-Michael addition/annulation cascade reaction for the construction of N-alkyl 2-arylindoles I (R = H, 2-F, 3-OMe, 4-Cl, etc.; R1 = H, F, Cl, OMe, C(O)OCH3; R2 = H; R3 = H, Cl; R2R3 = -CH=CHCH=CH-; R4 = Ph, Me, pyridin-3-yl, thiophen-2-yl, etc.) and from facilely available saturated ketones R4C(O)CH2CH3 and 2-arylethynylanilines 2-RC6H4CC-4-R1-5-R2-6-R3C6HNH2 was described. This reaction shows high regioselectivity and tolerates a variety of functional groups. Moreover, 3-alkyl-substituted indoles II (R5 = Bu, tert-Bu, pentyl, propyl) can also be obtained when using 2-alkylethynylanilines 2-R5CCC6H4NH2 as starting materials. The experimental process involved the reaction of 2-((4-Methoxyphenyl)ethynyl)aniline(cas: 157869-15-3).SDS of cas: 157869-15-3

The Article related to alkyl arylindole preparation regioselective, arylethynylaniline preparation ketone dehydrogenation michael cyclization tandem copper catalyst, alkylethynylaniline preparation ketone dehydrogenation michael cyclization tandem copper catalyst and other aspects.SDS of cas: 157869-15-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On April 27, 2020, Zhang, Dao; Yu, Jueqin published an article.Safety of 2-Methoxynaphthalene The title of the article was Fine Tuning of Chiral Bis(N-heterocyclic carbene) Palladium Catalysts for Asymmetric Suzuki-Miyaura Cross-Coupling Reactions: Exploring the Ligand Modification. And the article contained the following:

Novel chiral N,N’-bisaryl bis(NHC) ligand precursors H2[(S)-2]Cl2 on a spiro scaffold and H2[(S)-3b-g]Cl2 with a binaphthyl linkage were rationally designed and their cyclometalated cis-chelated NHC Pd complexes (S)-5, (S)-6, and (S)-7b-g were synthesized and fully characterized. Complexes 6 and 7b were further confirmed by x-ray single-crystal anal. Both complexes adopted a slightly distorted square planar geometry around the Pd(II) center. The structure of 6 consists of a rare dimeric arrangement incorporating two Pd(II) centers bonded through a short metal-metal bond (2.853(2) Å), indicating a PdII-PdII intramol. interaction (<3.00 Å). These N,N'-bisaryl-bis(NHC)-Pd complexes together with N,N'-bisalkyl analogs {[(S)-1a-d]PdX2} (X = I, (S)-4a; X = Br, (S)-4b-d) were used in the asym. aryl-aryl cross-coupling reactions of arylboronic acids and aryl halides. The enantioselectivity of the biaryl products was greatly improved within 24 h (up to 74% ee) when complexes 7a-g were used as catalysts. For these types of bis(NHC) Pd catalysts the structural characters of the chiral scaffolds play a decisive role in the enantioselectivities of cross-coupling reactions. The experimental process involved the reaction of 2-Methoxynaphthalene(cas: 93-04-9).Safety of 2-Methoxynaphthalene

The Article related to spirobiindenediylbisdiamine palladacycle carbene complex preparation catalyst suzuki reaction, crystal structure spirobiindenediylbisdiamine palladacycle carbene complex, mol structure spirobiindenediylbisdiamine palladacycle carbene complex and other aspects.Safety of 2-Methoxynaphthalene

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On June 30, 2014, Soleiman-Beigi, Mohammad; Kazemi, Mosstafa; Aryan, Reza; Shiri, Lotfi published an article.Quality Control of Benzyl(4-bromophenyl)sulfane The title of the article was TBAOH mediated: An efficient and simple procedure for alkylation of alcohols, phenols and thiols under neat aqueous conditions. And the article contained the following:

Aqueous Bu4NOH (TBAOH) solution was used as a green reaction medium and efficient catalyst for the O-alkylation of alcs. and phenols as well as S-alkylation of thiols under a novel, mild, and convenient procedure. Herein, TBAOH was used as a strong base, medium of reaction, and phase transfer reagent. The experimental process involved the reaction of Benzyl(4-bromophenyl)sulfane(cas: 53136-21-3).Quality Control of Benzyl(4-bromophenyl)sulfane

The Article related to alc alkyl halide alkylation butylammonium hydroxide water, phenol alkyl halide alkylation butylammonium hydroxide water, thiol alkyl halide alkylation butylammonium hydroxide water, ether preparation green chem, thioether preparation green chem and other aspects.Quality Control of Benzyl(4-bromophenyl)sulfane

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On December 31, 2022, Ji, Peng; Davies, Cassondra C.; Gao, Feng; Chen, Jing; Meng, Xiang; Houk, Kendall N.; Chen, Shuming; Wang, Wei published an article.Computed Properties of 93-04-9 The title of the article was Selective skeletal editing of polycyclic arenes using organophotoredox dearomative functionalization. And the article contained the following:

A general organophotoredox approach for the chemo- and regioselective dearomatization of structurally diverse polycyclic aromatics, including quinolines, isoquinolines, quinoxalines, naphthalenes, anthracenes and phenanthrenes was described. The success of the method for chemoselective oxidative rupture of aromatic moieties relies on precise manipulation of the electronic nature of the fused polycyclic arenes. Mechanistic studies show that the addition of a hydrogen atom transfer (HAT) agent helps favor the dearomatization pathway over the more thermodynamically downhill aromatization pathway. This strategy was applied to rapid synthesis of biol. valued targets and late-stage skeletal remodeling en route to complex structures. The experimental process involved the reaction of 2-Methoxynaphthalene(cas: 93-04-9).Computed Properties of 93-04-9

The Article related to arene azole acridinium photocatalyst chemoselective regioselective dearomatization, azolyl dihydroarene preparation, carboxylic acid arene acridinium photocatalyst chemoselective regioselective dearomatization, dihydroaryl alkanoate preparation and other aspects.Computed Properties of 93-04-9

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Zhang, He; Cao, Tongxiang; Luo, Hejiang; Chen, Lianfen; Zhu, Shifa published an article in 2019, the title of the article was Enynone-enabled migratory insertion and Schmittel cyclization cascade for the synthesis of furan-fused fluorenes.Category: ethers-buliding-blocks And the article contains the following content:

A new method for the synthesis of furan-/benzo-fused fluorenes through copper(I)-catalyzed coupling of conjugated enynones or α-diazocarbonyl compounds with dialkynylbenzenes were developed. This process included 5-exo-dig cyclization, carbene migratory insertion, Schmittel cyclization and 1,5-H transfer. The obvious advantages of wide substrate scopes, mild reaction conditions and high atom efficiency make this system highly appealing for the construction of six-substituted benzofuran-embedded fluorenes in a one-pot manner. The experimental process involved the reaction of 2-((4-Methoxyphenyl)ethynyl)aniline(cas: 157869-15-3).Category: ethers-buliding-blocks

The Article related to propynylidene alkane dione dialkynylbenzene preparation copper tandem regioselective cyclization, carbonyl fluorenofuran preparation, diazo phenylacetate dialkynylbenzene preparation copper tandem cyclization, benzofluorene carboxylate preparation and other aspects.Category: ethers-buliding-blocks

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem