Category: 16332-06-2

Nirmala, Muthukumaran published the artcileRuthenium(II) complexes incorporating salicylaldiminato-functionalized N-heterocyclic carbene ligands as efficient and versatile catalysts for hydration of organonitriles, Safety of 2-Methoxyacetamide, the main research area is salicylaldiminato imidazolidene heterocyclic carbene ruthenium preparation catalyst hydration organonitrile.

Authors describe a new synthetic procedure for synthesis of ruthenium(II) complexes containing salicylaldiminato functionalized mixed N-heterocyclic carbene (NHC) ligand and phosphine co-ligand. The complexes (3a-3d) have been obtained in good to excellent yields by transmetalation from the corresponding Ag-NHC complexes (2a-2d) as carbene transfer reagents. All the [Ru-NHC] complexes have been characterized by elemental analyses, spectroscopic methods as well as ESI mass spectrometry. The ligands 1a-1d show their versatility by switching to be O,N,C-chelating in these ruthenium(II) complexes. The resulting complexes have been evaluated as potential catalysts for the selective hydration of nitriles to primary amides, and related amide bond forming reactions, in environmentally friendly medium. The reaction tolerated ether, hydroxyl, nitro, bromo, formyl, pyridyl, benzyl and alkyl functional groups. The catalyst was stable for weeks and could be recovered and reused more than six times without significant loss of activity.

Inorganica Chimica Acta published new progress about Amides Role: SPN (Synthetic Preparation), PREP (Preparation). 16332-06-2 belongs to class ethers-buliding-blocks, name is 2-Methoxyacetamide, and the molecular formula is C3H7NO2, Safety of 2-Methoxyacetamide.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Tamura, Masazumi published the artcileEfficient and Substrate-Specific Hydration of Nitriles to Amides in Water by Using a CeO2 Catalyst, Application In Synthesis of 16332-06-2, the main research area is amide preparation nitrile hydration cerium dioxide catalyst water solvent.

Cerium dioxide (CeO2) is an effective heterogeneous catalyst for the hydration of nitriles that have a heteroatom (N or O) adjacent to the α carbon of the CN group. The substrate specificity is derived from an enormous difference of frequency factor. For the hydration of pyrazinecarbonitrile to pyrazinecarboxamide in water, CeO2 shows higher activity than the state-of-the-art catalysts including enzymes. A Michaelis-Menten-type mechanism is proposed, which involves (1) H2O dissociation on CeO2, (2) adsorption of the nitrile on CeO2, and (3) nucleophilic attack of a hydroxyl species to the adsorbed nitrile.

Chemistry – A European Journal published new progress about Aliphatic nitriles Role: RCT (Reactant), RACT (Reactant or Reagent). 16332-06-2 belongs to class ethers-buliding-blocks, name is 2-Methoxyacetamide, and the molecular formula is C3H7NO2, Application In Synthesis of 16332-06-2.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Hansen, Anders Lindhardt published the artcileFast and regioselective Heck couplings with N-acyl-N-vinylamine derivatives, Application In Synthesis of 16332-06-2, the main research area is vinyl amide derivative aryl triflate Heck coupling; aryl methyl ketone preparation; arylvinyl amide preparation; arylethyl amide preparation.

Highly regioselective Heck couplings of aryl triflates with N-acyl-N-vinylamines lacking an N-alkyl substituent were achieved in good yields using catalytic amounts of Pd2(dba)3, DPPF, and diethylisopropylamine in dioxane. The efficiency of these cross-couplings were studied with several N-vinyl amides and an example each of an N-vinyl carbamate and an N-vinyl urea. The Heck coupling products easily underwent acidic hydrolysis to the corresponding aryl Me ketone or in situ hydrogenation in the presence of (Ph3P)3RhCl under a hydrogen atm. to provide the N-acyl derivatives of pharmaceutically relevant benzylic amines. The coupling of a vinyl triflate and more interestingly a vinyl tosylate to N-vinyl acetamide was also studied affording a 2-acylamino-1,3-butadiene with the same high regioselectivity in preference for the α-isomer. This result suggests that Heck couplings of electron-rich alkenes with vinyl tosylates also follow a cationic pathway.

Journal of Organic Chemistry published new progress about Heck reaction. 16332-06-2 belongs to class ethers-buliding-blocks, name is 2-Methoxyacetamide, and the molecular formula is C3H7NO2, Application In Synthesis of 16332-06-2.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Mantel, Mette L. H. published the artcilePd-catalyzed C-N bond formation with heteroaromatic tosylates, Computed Properties of 16332-06-2, the main research area is heteroaryl amide preparation; amide heteroaryl tosylate arylation palladium.

A protocol for the palladium(0)-catalyzed amidation of heteroaromatic tosylates was successfully developed. The methodol. proved to be effective for a variety of heteroaryl tosylates including the pyridine, pyrimidine, quinoline and quinoxaline ring systems. Successful carbon-nitrogen bond formation with these heteroaryl tosylates could be performed with a wide range of primary amides, oxazolidinones, lactams, anilines and indoles, including one cyclic urea. Moreover, this C-N bond forming reaction provided products with high structural diversity. The coupling reaction was also amenable to scale up applications.

Chemistry – A European Journal published new progress about Arylation. 16332-06-2 belongs to class ethers-buliding-blocks, name is 2-Methoxyacetamide, and the molecular formula is C3H7NO2, Computed Properties of 16332-06-2.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Okabe, Hiroyuki published the artcileAcceptor-Controlled Transfer Dehydration of Amides to Nitriles, Product Details of C3H7NO2, the main research area is palladium catalyzed transfer dehydration amide nitrile chloroacetonitrile water acceptor.

Palladium-catalyzed dehydration of primary amides to nitriles efficiently proceeds under mild, aqueous conditions via the use of dichloroacetonitrile as a water acceptor. A key to the design of this transfer dehydration catalysis is the identification of an efficient water acceptor, dichloroacetonitrile, that preferentially reacts with amides over other polar functional groups with the aid of the Pd catalyst and makes the desired scheme exergonic, thereby driving the dehydration.

Organic Letters published new progress about Chemoselectivity (of dehydration of amide group). 16332-06-2 belongs to class ethers-buliding-blocks, name is 2-Methoxyacetamide, and the molecular formula is C3H7NO2, Product Details of C3H7NO2.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Breno, Kerry L. published the artcileOrganometallic Chemistry in Aqueous Solution. Hydration of Nitriles to Amides Catalyzed by a Water-Soluble Molybdocene, (MeCp)2Mo(OH)(H2O)+, Category: ethers-buliding-blocks, the main research area is molybdocene catalyzed hydration nitrile aqueous solution kinetics; amide preparation.

[Cp’2Mo(μ-OH)2MoCp’2]2+ (1) (Cp’ = η5-CH3C5H4) is a precatalyst for the hydration of nitriles in aqueous solution under mild conditions (∼80°). Among the nitriles hydrated were acetonitrile, isobutyronitrile, benzonitrile, 3-hydroxypropionitrile, 3-bromopropioamide, 4-cyanopyridine, succinonitrile, Me cyanoacetate, 2-methoxyacetonitrile, and acrylonitrile. Except in the case of 2-methoxyacetonitrile, hydrolysis of the resulting amide products did not occur. Hydration of the C:C double bond did not occur in acrylonitrile, but hydrolysis of ester and ether linkages did occur in nitriles containing those functional groups. The apparent rate constants and turnover frequencies of the catalytic reactions were determined using an iterative kinetics-fitting program. The rates and turnover frequencies are comparable to those reported for many homogeneous nitrile hydration catalysts described in the literature. In aqueous solution, 1 is in equilibrium with [Cp’2Mo(OH)(H2O)]+ (2), and this monomer is proposed to be the active hydration catalyst. The hydration is proposed to occur by an intramol. attack of a hydroxide ligand on a coordinated nitrile. The hydration reaction is irreversibly inhibited by product and reversibly inhibited by substrate (nitrile).

Organometallics published new progress about Hydration catalysts. 16332-06-2 belongs to class ethers-buliding-blocks, name is 2-Methoxyacetamide, and the molecular formula is C3H7NO2, Category: ethers-buliding-blocks.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem