Tamura, Masazumi published the artcileEfficient and Substrate-Specific Hydration of Nitriles to Amides in Water by Using a CeO2 Catalyst, Application In Synthesis of 16332-06-2, the main research area is amide preparation nitrile hydration cerium dioxide catalyst water solvent.
Cerium dioxide (CeO2) is an effective heterogeneous catalyst for the hydration of nitriles that have a heteroatom (N or O) adjacent to the α carbon of the CN group. The substrate specificity is derived from an enormous difference of frequency factor. For the hydration of pyrazinecarbonitrile to pyrazinecarboxamide in water, CeO2 shows higher activity than the state-of-the-art catalysts including enzymes. A Michaelis-Menten-type mechanism is proposed, which involves (1) H2O dissociation on CeO2, (2) adsorption of the nitrile on CeO2, and (3) nucleophilic attack of a hydroxyl species to the adsorbed nitrile.
Chemistry – A European Journal published new progress about Aliphatic nitriles Role: RCT (Reactant), RACT (Reactant or Reagent). 16332-06-2 belongs to class ethers-buliding-blocks, name is 2-Methoxyacetamide, and the molecular formula is C3H7NO2, Application In Synthesis of 16332-06-2.
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem