Category: 171290-52-1

These common heterocyclic compound, 171290-52-1, name is 3,5-Dimethoxyphenylacetylene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C10H10O2

General procedure: Glass reactor (3 mL) equipped with a condenser and a stirringbar was charged under argon with arylacetylene (9.11 104 mol),EtOH (99.8%) (2 mL) and catalyst 8 (0.25-2.0 mol% in relation toacetylene). The reaction mixture was stirred at 22 C for 24 h. Thenthe solventwas evaporated under reduced pressure and the residuewas purified by column chromatography (silica gel, hexane/CH2Cl2 = 4/1). Evaporation of the solvent gave an analytically pureproduct.

The synthetic route of 3,5-Dimethoxyphenylacetylene has been constantly updated, and we look forward to future research findings.

Reference:
Article; Ostrowska, Sylwia; Szymaszek, Natalia; Pietraszuk, Cezary; Journal of Organometallic Chemistry; vol. 856; (2018); p. 63 – 69;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 171290-52-1, name is 3,5-Dimethoxyphenylacetylene, This compound has unique chemical properties. The synthetic route is as follows., SDS of cas: 171290-52-1

General procedure: 2-Iodo-N-phenyl-N-(trimethylsilylethynyl)benzenesulfonamide 18 (100 mg, 0.22 mmol), CuI (4.2 mg, 0.022 mmol), and PdCl2(PPh3)2 (7.7 mg, 0.011 mmol) were placed successively in a two-necked 100 mL flask containing a bar magnet and capped by a three-way stopcock. The reactor was purged of air (three vacuum-nitrogen cycles) before 5 mL of dry and degassed triethylamine and 3 mL of dry and degassed THF were added. 0.5 h later, the desired alkyne 19 (0.24 mmol) was added. The resulting mixture was stirred at room temperature and the reaction was followed by thin layer chromatography. When the reaction was complete, the solvents were removed under reduced pressure and the crude product was purified by column chromatography.

According to the analysis of related databases, 171290-52-1, the application of this compound in the production field has become more and more popular.

Reference:
Article; Etse, Koffi Senam; Dassonneville, Benjamin; Zaragoza, Guillermo; Demonceau, Albert; Tetrahedron Letters; vol. 58; 8; (2017); p. 789 – 793;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

171290-52-1, name is 3,5-Dimethoxyphenylacetylene, belongs to ethers-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Product Details of 171290-52-1

General procedure: A 10 mL reaction vial was charged with a terminal acetylenes 1a-p (1.0 mmol), piperidine (3.0 mmol), H2O (1 mL) and 30 mol% molecular iodine. The reaction vial was then heated at 100 C for 12 h. After completion of the reaction (progress was monitored by TLC; SiO2, Hexane/EtOAc = 9.5:0.5), the mixture was diluted with ethyl acetate (15 mL) and water (20 mL) and extracted with ethyl acetate (3 × 10 mL). The combined organic layer was washed with brine (3 × 10 mL) and dried over anhydrous Na2SO4. Solvent was removed under reduced pressure and the remaining residue was purified by column chromatography over silica gel using hexane / ethyl acetate (9.5:0.5) as an eluent to obtain the desired products 2a-p in high yields.

The synthetic route of 171290-52-1 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Kaldhi, Dhananjaya; Vodnala, Nagaraju; Gujjarappa, Raghuram; Kabi, Arup K.; Nayak, Subhashree; Malakar, Chandi C.; Tetrahedron Letters; vol. 61; 16; (2020);,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 171290-52-1, name is 3,5-Dimethoxyphenylacetylene, This compound has unique chemical properties. The synthetic route is as follows., Application In Synthesis of 3,5-Dimethoxyphenylacetylene

Compound 3-iodo-1-((2- (trimethylsilyl) ethoxy) methyl) -1H-pyrazole 4-formamidine 2c (2.7 g, 7.3 mmol), 1-ethynyl-3,5-dimethoxybenzene (1.78 g, 11 mmol), triethylamine (2.2 g, 21.9 mmol), bis (triphenylphosphonium) palladium chloride (512 mg, 0.73 mmol) and anhydrous tetrahydrofuran (70 mL) were mixed, deoxygenated, and stirred at room temperature under an argon atmosphere for 15 hours.The solvent was removed under reduced pressure, and the residue was purified by silica gel column chromatography (ethyl acetate / petroleum ether = 10/1 to 2/1) to give the target product 3-((3,5-dimethoxyphenyl) acetylene Yl) -1-((2- (trimethylsilyl) ethoxy) methyl) -1H-pyrazole-4-carboxamide 2d (1.5 g, yellow solid), yield: 51%.

According to the analysis of related databases, 171290-52-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BEIJING TIANCHENG PHARMA CO., LTD.; CHEN, XIANGYANG; GAO, YINGXIANG; KONG, NORMAN XIANGLONG; (118 pag.)TW2019/38538; (2019); A;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 171290-52-1, name is 3,5-Dimethoxyphenylacetylene, A new synthetic method of this compound is introduced below., COA of Formula: C10H10O2

Formula 7 of the azide compound (300 mumol), alkynyl (750 mumol), CuSO4 (9.6 mg, 60 mumol) and Na. An ascorbate (60.0 mg, 300 mumol) 1: was dissolved in 1 t-BuOH / H2O (3 mL). The mixture was stirred at room temperature for 2 hours. After the reaction was completed, the mixture was filtered of and washed using H2O (70 mL) (solid A). The filtrate was extracted with EtOAc (3 × 70 mL). The combined organic extracts were then dried using anhydrous MgSO4, filtered and concentrated by rotaryevaporation (residue B). It was combined and the solid residue A and B, was purified by column chromatography to give the compound of formula 2 and 3. Following the general method for the general formula 2, 1: 1 t-BuOH / H2O (1 mL) Compound 7g (31.2 mg, 100 mumol), in a 1-Ethynyl -3,5-dimethoxy-benzene (40.5 mg, 250 mumol), CuSO4 (3.2 mg, 20 mumol) and Na. Using ascorbate (20.0 mg, 100mumol) was prepared the desired compound. After stirring at 60 the reaction mixture for 5 hours, was purified by column chromatography (5: 1 hexane / EtOAc ? 20: 1 CH2Cl2 / MeOH) using afford 2g as a brown solid (33,6mg, 71% ).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; EWHA UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION; YOO, JAE SANG; SONG, DOO HUI; (33 pag.)KR2015/134731; (2015); A;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Reference of 171290-52-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 171290-52-1 name is 3,5-Dimethoxyphenylacetylene, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: The azido derivative of N,-C terminal protected L-serine (1.0equiv) was taken in a 5:1 dry THF and water mixture solvent anddegassed it for 5 min with nitrogen gas. Then, terminal alkyne(1.1 equiv) was added with continuing stirring and degassing forthe next 5 min. Then 6 mol% sodium ascorbate and 1 mol% powderCuSO4 were added. The reaction mixture was degassed and allowed to proceed 18-20 h about 65-70 C. After total consumptionof the starting azide, the reaction mixture evaporatedcompletely and work up done by EtOAc and NH4Cl solution. Theorganic layer was washed with brine, dried over Na2SO4. Thesynthesized trizolyl amino acids were separated by column chromatography(si-gel, PE/EA = 1:1) and characterized. The averageyields were 50-85%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3,5-Dimethoxyphenylacetylene, and friends who are interested can also refer to it.

Reference:
Article; Bag, Subhendu Sekhar; Jana, Subhashis; Pradhan, Manoj Kumar; Bioorganic and Medicinal Chemistry; vol. 24; 16; (2016); p. 3579 – 3595;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

171290-52-1, name is 3,5-Dimethoxyphenylacetylene, belongs to ethers-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. category: ethers-buliding-blocks

Formula 7 of the azide compound (300 mumol), alkynyl (750 mumol), CuSO4 (9.6 mg, 60 mumol) and Na. An ascorbate (60.0 mg, 300 mumol) 1: was dissolved in 1 t-BuOH / H2O (3 mL). The mixture was stirred at room temperature for 2 hours. After the reaction was completed, the mixture was filtered of and washed using H2O (70 mL) (solid A). The filtrate was extracted with EtOAc (3 × 70 mL). The combined organic extracts were then dried using anhydrous MgSO4, filtered and concentrated by rotaryevaporation (residue B). It was combined and the solid residue A and B, was purified by column chromatography to give the compound of formula 2 and 3. Formula 2 for the general method in accordance with, 1:1 t-BuOH/H2O (3 mL) in a compound 7c (80.8 mg, 300 mumol), 1-ethynyl -3,5-dimethoxybenzene (121 mg, 750 mumol), CuSO4 (9.6 mg, 60 mumol) and Na. Using ascorbate (60.0 mg, 300 mumol) was prepared in the desired compound. After stirring at room temperature for 5.5 hours the reaction mixture was purified by column chromatography (5: 1 hexane / EtOAc ? 20: 1 CH2Cl2 / MeOH) Compound 2c was obtained using as a brown solid (104mg, 80%).

The synthetic route of 171290-52-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; EWHA UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION; YOO, JAE SANG; SONG, DOO HUI; (33 pag.)KR2015/134731; (2015); A;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 171290-52-1, name is 3,5-Dimethoxyphenylacetylene, This compound has unique chemical properties. The synthetic route is as follows., Application In Synthesis of 3,5-Dimethoxyphenylacetylene

General procedure: Azide 13 (300 mumol), alkyne (750 mumol), CuSO4 (9.6 mg, 60 mumol) and sodium ascorbate (60.0 mg, 300 mumol) were dissolved in 1:1 t-BuOH/H2O (3 mL). The mixture was stirred for 2 h at rt. After the completion of the reaction, the mixture was filtered and washed with H2O (70 mL) (solid A). The filtrate was extracted with EtOAc (3 * 70 mL). The combined organic extracts were dried over anhyd MgSO4, filtered, and concentrated by rotary evaporation (residue B). The solid A and residue B were combined and purified by column chromatography to afford 8 or 9.

According to the analysis of related databases, 171290-52-1, the application of this compound in the production field has become more and more popular.

Reference:
Article; Song, Doohee; Park, Yunjeong; Yoon, Jieun; Aman, Waqar; Hah, Jung-Mi; Ryu, Jae-Sang; Bioorganic and Medicinal Chemistry; vol. 22; 17; (2014); p. 4855 – 4866;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthetic Route of 171290-52-1, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 171290-52-1, name is 3,5-Dimethoxyphenylacetylene, This compound has unique chemical properties. The synthetic route is as follows.

General procedure: A mixture of 2 (0.50 g, 1.40 mmol), dichlorobis(triphenylphosphine)palladium(II) (0.05 g, 0.07 mmol), copper(I) iodide (0.03 g,0.14 mmol), triphenylphosphine (0.02 g, 0.08 mmol) and triethylamine(0.17 g, 1.68 mmol) in 4:1 DMF-water (v/v, 20 mL) was placed in a two necked round-bottomed flask equipped with a stirrer bar, condenser and a rubber septum. The mixture was flushed with argon gas for30 min and a solution of phenylacetylene derivative (1.2 equiv.) in DMF(2 mL) was introduced via a rubber septum by means of a syringe. A balloon filled with argon was connected to the top of the condenser andthe mixture was left to stir at 70 C for 2 h. The mixture was allowed to cool and then poured into crushed ice. The product was extracted into chloroform and the combined organic phases were washed with water and dried over anhydrous MgSO4. The salt was filtered off and the solvent was evaporated under reduced pressure on a rotary evaporator.The residue was purified by column chromatography on using silica gelusing 9:1 toluene-ethyl acetate mixture (v/v) as an eluent. The following compounds were prepared in this fashion.

The chemical industry reduces the impact on the environment during synthesis 3,5-Dimethoxyphenylacetylene. I believe this compound will play a more active role in future production and life.

Reference:
Article; Olomola, Temitope O.; Mphahlele, Malose J.; Journal of Fluorine Chemistry; vol. 229; (2020);,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthetic Route of 171290-52-1, These common heterocyclic compound, 171290-52-1, name is 3,5-Dimethoxyphenylacetylene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

5-(Benzenesulfonyl)-2-[2-(3,5-dimethoxyphenyl)ethynyl]-5H-pyrrolo[2,3-b]pyrazine 5-(Benzenesulfonyl)-2-bromo-5H-pyrrolo[2,3-b]pyrazine (3.50 g, 10.35 mmol), copper(1+) iodide (197.1 mg, 1.03 mmol) and palladium tetrakis triphenylphospine (597.7 mg, 0.52 mmol) were dissolved in MeCN (40 ml). Reaction mixture was degassed with nitrogen for 5 mins. 1-ethynyl-3,5-dimethoxybenzene (2.52 g, 15.52 mmol) and DIPEA (8.96 ml, 51.75 mmol) were added and reaction heated to 80C, under a nitrogen atmosphere, for 2 h. Reaction mixture was allowed to cool to RT, then to 0C and left to stand overnight. The beige precipitate formed after this time was filtered off, dissolved in EtOAc, washed with water and concentrated. Crude material was re-crystallised from EtOAc to give the title compound as a yellow solid (3.16 g, 73%). 1H NMR (500 MHz, Chloroform-d) delta 8.55 (s, 1H), 8.24 – 8.13 (m, 2H), 8.04 (d, J = 3.7 Hz, 1H), 7.66 – 7.60 (m, 1H), 7.52 (t, J = 7.9 Hz, 2H), 6.82 (s, 1H), 6.77 (d, J = 2.2 Hz, 2H), 6.51 (t, J = 2.2 Hz, 1H), 3.80 (s, 6H). M/Z: 419.09, M+1: 419.95, tR= 1.59 min (System 1).

The synthetic route of 171290-52-1 has been constantly updated, and we look forward to future research findings.